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UniProtKB - P52655 (TF2AA_HUMAN)

Entry version 199 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Transcription initiation factor IIA subunit 1

Gene

GTF2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

More...SIGNORi		P52655

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 1
Alternative name(s):
General transcription factor IIA subunit 1
TFIIAL
Transcription initiation factor TFIIA 42 kDa subunit
Short name:
TFIIA-42
Cleaved into the following 2 chains:
Transcription initiation factor IIA alpha chain
Alternative name(s):
TFIIA p35 subunit
Transcription initiation factor IIA beta chain
Alternative name(s):
TFIIA p19 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF2A1
Synonyms:TF2A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165417.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:4646 GTF2A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600520 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52655

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi270V → A: Slightly affects cleavage and yields elevated levels of the precursor. 1 Publication1
Mutagenesisi272Q → A: Abolishes cleavage. 1 Publication1
Mutagenesisi273V → A: Abolishes cleavage. 1 Publication1
Mutagenesisi274D → A: Abolishes cleavage. 1 Publication1
Mutagenesisi275G → A: Abolishes cleavage. 1 Publication1
Mutagenesisi276T → A: Does not affect cleavage. 1 Publication1
Mutagenesisi277G → A: Does not affect cleavage. 1 Publication1
Mutagenesisi278D → A: Significant reduction of cleavage. 1 Publication1
Mutagenesisi280S → A: Slightly affects cleavage, yields elevated levels of the precursor. Eliminates phosphorylation; when associated with A-281; A-316 and A-321. 2 Publications1
Mutagenesisi281S → A: Eliminates phosphorylation; when associated with A-280; A-316 and A-321. 1 Publication1
Mutagenesisi282E → A: Slightly affects cleavage and yields elevated levels of the precursor. 1 Publication1
Mutagenesisi316S → A: Strongly reduces phosphorylation; when associated with A-321. Eliminates phosphorylation; when associated with A-280; A-281 and A-321. 1 Publication1
Mutagenesisi321S → A: Strongly reduces phosphorylation; when associated with A-316. Eliminates phosphorylation; when associated with A-280; A-281 and A-316. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2957

Open Targets

More...OpenTargetsi		ENSG00000165417

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29033

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52655 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4832

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GTF2A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1711663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000224812 – 376Transcription initiation factor IIA subunit 1Add BLAST375
ChainiPRO_00000425932 – 274Transcription initiation factor IIA alpha chainAdd BLAST273
ChainiPRO_0000042594275 – 376Transcription initiation factor IIA beta chainAdd BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei280Phosphoserine; by TAF11 Publication1
Modified residuei281Phosphoserine; by TAF11 Publication1
Modified residuei316Phosphoserine; by TAF1Combined sources1 Publication1
Modified residuei321Phosphoserine; by TAF1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei274 – 275Cleavage; by TASP12

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P52655

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P52655

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52655

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52655

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52655

PeptideAtlas

More...PeptideAtlasi		P52655

PRoteomics IDEntifications database

More...PRIDEi		P52655

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56499 [P52655-1]
56500 [P52655-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52655

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52655

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165417 Expressed in forebrain and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52655 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52655 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165417 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109212, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-519 Transcription factor complex TFIIA

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P52655

Database of interacting proteins

More...DIPi		DIP-33225N

Protein interaction database and analysis system

More...IntActi		P52655, 18 interactors

Molecular INTeraction database

More...MINTi		P52655

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000452454

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P52655

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52655 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52655

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P52655

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 80Poly-Gln10
Compositional biasi81 – 87Poly-His7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIA subunit 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IPCF Eukaryota
ENOG4111M8K LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030027_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52655

KEGG Orthology (KO)

More...KOi		K03122

Identification of Orthologs from Complete Genome Data

More...OMAi		MLCTYDK

Database of Orthologous Groups

More...OrthoDBi		1443035at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52655

TreeFam database of animal gene trees

More...TreeFami		TF350445

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.18.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00555

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004855 TFIIA_asu/bsu
IPR009088 TFIIA_b-brl

The PANTHER Classification System

More...PANTHERi		PTHR12694 PTHR12694, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03153 TFIIA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01371 TFIIA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50784 SSF50784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 42 kDa (identifier: P52655-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL 
        60         70         80         90        100
MQSRAVDGFH SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA 
       110        120        130        140        150
QTQQVLIPAS QQATAPQVIV PDSKLIQHMN ASNMSAAATA ATLALPAGVT 
       160        170        180        190        200
PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ SVVLQQQVIP QMQPGGVQAP 
       210        220        230        240        250
VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV AAPTPAQAQI 
       260        270        280        290        300
TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE 
       310        320        330        340        350
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK 
       360        370 
FHLKDGIMNL NGRDYIFSKA IGDAEW
Length:376
Mass (Da):41,514
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BAE1853E7E89218
GO
Isoform 37 kDa (identifier: P52655-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:337
Mass (Da):37,152
Checksum:i81D62BCC81399DE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNC0J3KNC0_HUMAN
Transcription initiation factor IIA...
GTF2A1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03566730L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054043109A → P. Corresponds to variant dbSNP:rs17111579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187981 – 39Missing in isoform 37 kDa. CuratedAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X75383 mRNA Translation: CAA53151.1
X75383 mRNA Translation: CAA53152.1
X77225 mRNA Translation: CAA54442.1
D14887 mRNA Translation: BAA03604.1
D14886 mRNA Translation: BAA03603.1
AC010582 Genomic DNA Translation: AAF26776.1
BC107155 mRNA Translation: AAI07156.1
BC107156 mRNA Translation: AAI07157.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9873.1 [P52655-1]
CCDS9874.1 [P52655-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A49077

NCBI Reference Sequences

More...RefSeqi		NP_001265869.1, NM_001278940.1
NP_056943.1, NM_015859.3 [P52655-1]
NP_963889.1, NM_201595.2 [P52655-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000434192; ENSP00000409492; ENSG00000165417 [P52655-2]
ENST00000553612; ENSP00000452454; ENSG00000165417 [P52655-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2957

UCSC genome browser

More...UCSCi		uc001xvf.4 human [P52655-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75383 mRNA Translation: CAA53151.1
X75383 mRNA Translation: CAA53152.1
X77225 mRNA Translation: CAA54442.1
D14887 mRNA Translation: BAA03604.1
D14886 mRNA Translation: BAA03603.1
AC010582 Genomic DNA Translation: AAF26776.1
BC107155 mRNA Translation: AAI07156.1
BC107156 mRNA Translation: AAI07157.1
CCDSiCCDS9873.1 [P52655-1]
CCDS9874.1 [P52655-2]
PIRiA49077
RefSeqiNP_001265869.1, NM_001278940.1
NP_056943.1, NM_015859.3 [P52655-1]
NP_963889.1, NM_201595.2 [P52655-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NVPX-ray2.10B2-58[»]
C303-376[»]
5FURelectron microscopy8.50B9-51[»]
C330-376[»]
5IY6electron microscopy7.20N1-376[»]
5IY7electron microscopy8.60N1-376[»]
5IY8electron microscopy7.90N1-376[»]
5IY9electron microscopy6.30N1-376[»]
5IYAelectron microscopy5.40N1-376[»]
5IYBelectron microscopy3.90N1-376[»]
5IYCelectron microscopy3.90N1-376[»]
5IYDelectron microscopy3.90N1-376[»]
5M4SX-ray2.38A2-58[»]
A328-376[»]
6MZMelectron microscopy7.50W9-376[»]
6O9Lelectron microscopy7.20N1-376[»]
SMRiP52655
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109212, 58 interactors
ComplexPortaliCPX-519 Transcription factor complex TFIIA
CORUMiP52655
DIPiDIP-33225N
IntActiP52655, 18 interactors
MINTiP52655
STRINGi9606.ENSP00000452454

Chemistry databases

BindingDBiP52655
ChEMBLiCHEMBL4832

PTM databases

iPTMnetiP52655
PhosphoSitePlusiP52655

Polymorphism and mutation databases

BioMutaiGTF2A1
DMDMi1711663

Proteomic databases

EPDiP52655
jPOSTiP52655
MassIVEiP52655
MaxQBiP52655
PaxDbiP52655
PeptideAtlasiP52655
PRIDEiP52655
ProteomicsDBi56499 [P52655-1]
56500 [P52655-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		76 297 antibodies

The DNASU plasmid repository

More...DNASUi		2957

Genome annotation databases

EnsembliENST00000434192; ENSP00000409492; ENSG00000165417 [P52655-2]
ENST00000553612; ENSP00000452454; ENSG00000165417 [P52655-1]
GeneIDi2957
KEGGihsa:2957
UCSCiuc001xvf.4 human [P52655-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2957
DisGeNETi2957
EuPathDBiHostDB:ENSG00000165417.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		GTF2A1
HGNCiHGNC:4646 GTF2A1
HPAiENSG00000165417 Low tissue specificity
MIMi600520 gene
neXtProtiNX_P52655
OpenTargetsiENSG00000165417
PharmGKBiPA29033

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IPCF Eukaryota
ENOG4111M8K LUCA
GeneTreeiENSGT00940000156726
HOGENOMiCLU_030027_5_0_1
InParanoidiP52655
KOiK03122
OMAiMLCTYDK
OrthoDBi1443035at2759
PhylomeDBiP52655
TreeFamiTF350445

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-9018519 Estrogen-dependent gene expression
SIGNORiP52655

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2957 592 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GTF2A1 human
EvolutionaryTraceiP52655

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GTF2A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2957
PharosiP52655 Tchem

Protein Ontology

More...PROi		PR:P52655
RNActiP52655 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165417 Expressed in forebrain and 208 other tissues
ExpressionAtlasiP52655 baseline and differential
GenevisibleiP52655 HS

Family and domain databases

Gene3Di2.30.18.10, 1 hit
IDEALiIID00555
InterProiView protein in InterPro
IPR004855 TFIIA_asu/bsu
IPR009088 TFIIA_b-brl
PANTHERiPTHR12694 PTHR12694, 2 hits
PfamiView protein in Pfam
PF03153 TFIIA, 2 hits
SMARTiView protein in SMART
SM01371 TFIIA, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF2AA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52655
Secondary accession number(s): Q3KNQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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