UniProtKB - P52633 (STAT6_MOUSE)
Protein
Signal transducer and transcription activator 6
Gene
Stat6
Organism
Mus musculus (Mouse)
Status
Functioni
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: MGI
- protein phosphatase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
GO - Biological processi
- cellular response to hydrogen peroxide Source: MGI
- cellular response to reactive nitrogen species Source: MGI
- cytokine-mediated signaling pathway Source: MGI
- defense response Source: GO_Central
- growth hormone receptor signaling pathway via JAK-STAT Source: GO_Central
- interleukin-4-mediated signaling pathway Source: UniProtKB
- mammary gland epithelial cell proliferation Source: MGI
- mammary gland morphogenesis Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of type 2 immune response Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of isotype switching to IgE isotypes Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- receptor signaling pathway via JAK-STAT Source: GO_Central
- regulation of cell population proliferation Source: MGI
- response to cytokine Source: MGI
- response to peptide hormone Source: GO_Central
- signal transduction Source: MGI
- T-helper 1 cell lineage commitment Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-186763, Downstream signal transduction R-MMU-3249367, STAT6-mediated induction of chemokines R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and transcription activator 6 |
Gene namesi | Name:Stat6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103034, Stat6 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- membrane raft Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000182434 | 2 – 837 | Signal transducer and transcription activator 6Add BLAST | 836 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 641 | Phosphotyrosine; by JAKBy similarity | 1 |
Post-translational modificationi
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.1 Publication
Mono-ADP-ribosylated by PARP14.By similarity
Keywords - PTMi
Acetylation, ADP-ribosylation, PhosphoproteinProteomic databases
EPDi | P52633 |
MaxQBi | P52633 |
PaxDbi | P52633 |
PeptideAtlasi | P52633 |
PRIDEi | P52633 |
PTM databases
iPTMneti | P52633 |
PhosphoSitePlusi | P52633 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000002147, Expressed in granulocyte and 279 other tissues |
Genevisiblei | P52633, MM |
Interactioni
Subunit structurei
Forms a homodimer or a heterodimer with a related family member.
Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity).
By similarityBinary interactionsi
P52633
With | #Exp. | IntAct |
---|---|---|
Parp14 [Q2EMV9] | 3 | EBI-647085,EBI-1534943 |
GO - Molecular functioni
- identical protein binding Source: MGI
- protein phosphatase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203527, 6 interactors |
DIPi | DIP-49680N |
IntActi | P52633, 9 interactors |
STRINGi | 10090.ENSMUSP00000089708 |
Chemistry databases
BindingDBi | P52633 |
Miscellaneous databases
RNActi | P52633, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 517 – 632 | SH2PROSITE-ProRule annotationAdd BLAST | 116 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 793 – 797 | LXXLL motif | 5 |
Sequence similaritiesi
Belongs to the transcription factor STAT family.Curated
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_2_1_1 |
InParanoidi | P52633 |
OMAi | FPQGTWI |
OrthoDBi | 327469at2759 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10377, SH2_STAT6, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR028187, STAT6_C IPR035857, STAT6_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF14596, STAT6_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52633-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES
160 170 180 190 200
LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS
360 370 380 390 400
IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE
710 720 730 740 750
ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP
760 770 780 790 800
MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN
810 820 830
QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YU28 | D3YU28_MOUSE | Signal transducer and transcription... | Stat6 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | A → P in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 138 | Q → H in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 152 – 155 | QQGA → HLGP in AAA79006 (PubMed:7760829).Curated | 4 | |
Sequence conflicti | 170 | V → L in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 180 – 182 | ATM → PTI in AAA79006 (PubMed:7760829).Curated | 3 | |
Sequence conflicti | 192 | A → T in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 195 | A → P in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 199 | K → L in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 239 | Q → H in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 306 | A → T in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 327 | A → S in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 409 | P → S in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 443 | A → G in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 461 | A → V in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 753 | C → W in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 786 | M → L in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 804 | A → G in AAA79006 (PubMed:7760829).Curated | 1 | |
Sequence conflicti | 815 | Q → K in AAA79006 (PubMed:7760829).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47650 mRNA Translation: AAA79006.1 AF481809 mRNA Translation: AAL82638.1 AK163053 mRNA Translation: BAE37172.1 CH466578 Genomic DNA Translation: EDL24514.1 BC127054 mRNA Translation: AAI27055.1 |
CCDSi | CCDS36082.1 |
PIRi | I57557 |
RefSeqi | NP_033310.2, NM_009284.2 |
Genome annotation databases
Ensembli | ENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147 |
GeneIDi | 20852 |
KEGGi | mmu:20852 |
UCSCi | uc007hka.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L47650 mRNA Translation: AAA79006.1 AF481809 mRNA Translation: AAL82638.1 AK163053 mRNA Translation: BAE37172.1 CH466578 Genomic DNA Translation: EDL24514.1 BC127054 mRNA Translation: AAI27055.1 |
CCDSi | CCDS36082.1 |
PIRi | I57557 |
RefSeqi | NP_033310.2, NM_009284.2 |
3D structure databases
SMRi | P52633 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203527, 6 interactors |
DIPi | DIP-49680N |
IntActi | P52633, 9 interactors |
STRINGi | 10090.ENSMUSP00000089708 |
Chemistry databases
BindingDBi | P52633 |
ChEMBLi | CHEMBL2189147 |
PTM databases
iPTMneti | P52633 |
PhosphoSitePlusi | P52633 |
Proteomic databases
EPDi | P52633 |
MaxQBi | P52633 |
PaxDbi | P52633 |
PeptideAtlasi | P52633 |
PRIDEi | P52633 |
Protocols and materials databases
Antibodypediai | 662, 1396 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147 |
GeneIDi | 20852 |
KEGGi | mmu:20852 |
UCSCi | uc007hka.1, mouse |
Organism-specific databases
CTDi | 6778 |
MGIi | MGI:103034, Stat6 |
Phylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_2_1_1 |
InParanoidi | P52633 |
OMAi | FPQGTWI |
OrthoDBi | 327469at2759 |
TreeFami | TF318648 |
Enzyme and pathway databases
Reactomei | R-MMU-186763, Downstream signal transduction R-MMU-3249367, STAT6-mediated induction of chemokines R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling |
Miscellaneous databases
BioGRID-ORCSi | 20852, 2 hits in 19 CRISPR screens |
ChiTaRSi | Stat6, mouse |
PROi | PR:P52633 |
RNActi | P52633, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002147, Expressed in granulocyte and 279 other tissues |
Genevisiblei | P52633, MM |
Family and domain databases
CDDi | cd10377, SH2_STAT6, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR028187, STAT6_C IPR035857, STAT6_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF14596, STAT6_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAT6_MOUSE | |
Accessioni | P52633Primary (citable) accession number: P52633 Secondary accession number(s): Q8R2F1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families