Signal transducer and transcription activator 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching."
    Harris M.B., Chang C.C., Berton M.T., Danial N.N., Zhang J., Kuehner D., Ye B.H., Kvatyuk M., Pandolfi P.P., Cattoretti G., Dalla-Favera R., Rothman P.B.
    Mol. Cell. Biol. 19:7264-7275(1999) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
• identical protein binding Source: MGI
• protein phosphatase binding Source: MGI
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3."
    Oliver C.H., Khaled W.T., Frend H., Nichols J., Watson C.J.
    Genes Dev. 26:1086-1097(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function."
    Harris M.B., Mostecki J., Rothman P.B.
    J. Biol. Chem. 280:13114-13121(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to hydrogen peroxide Source: MGI
• cellular response to reactive nitrogen species Source: MGI
• cytokine-mediated signaling pathway Source: MGI
• defense response Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• growth hormone receptor signaling pathway via JAK-STAT Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-4-mediated signaling pathway Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."
    Lu X., Chen J., Sasmono R.T., Hsi E.D., Sarosiek K.A., Tiganis T., Lossos I.S.
    Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN IL4/INTERLEUKIN-4 SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.
• mammary gland epithelial cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3."
    Oliver C.H., Khaled W.T., Frend H., Nichols J., Watson C.J.
    Genes Dev. 26:1086-1097(2012) [PubMed] [Europe PMC] [Abstract]
• mammary gland morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3."
    Oliver C.H., Khaled W.T., Frend H., Nichols J., Watson C.J.
    Genes Dev. 26:1086-1097(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells."
    Onodera A., Yamashita M., Endo Y., Kuwahara M., Tofukuji S., Hosokawa H., Kanai A., Suzuki Y., Nakayama T.
    J. Exp. Med. 207:2493-2506(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of type 2 immune response Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major."
    Dent A.L., Doherty T.M., Paul W.E., Sher A., Staudt L.M.
    J. Immunol. 163:2098-2103(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat."
    Qiu Y., Nguyen K.D., Odegaard J.I., Cui X., Tian X., Locksley R.M., Palmiter R.D., Chawla A.
    Cell 157:1292-1308(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of isotype switching to IgE isotypes Source: MGIInferred from genetic interactionⁱ
  • "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching."
    Harris M.B., Chang C.C., Berton M.T., Danial N.N., Zhang J., Kuehner D., Ye B.H., Kvatyuk M., Pandolfi P.P., Cattoretti G., Dalla-Favera R., Rothman P.B.
    Mol. Cell. Biol. 19:7264-7275(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)."
    Li Z., Zhang Y., Liu Z., Wu X., Zheng Y., Tao Z., Mao K., Wang J., Lin G., Tian L., Ji Y., Qin M., Sun S., Zhu X., Sun B.
    Nat. Immunol. 12:178-185(2011) [PubMed] [Europe PMC] [Abstract]
• receptor signaling pathway via JAK-STAT Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: MGIInferred from direct assayⁱ
  • "Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism."
    Suzuki K., Nakajima H., Kagami S., Suto A., Ikeda K., Hirose K., Hiwasa T., Takeda K., Saito Y., Akira S., Iwamoto I.
    J. Exp. Med. 196:27-38(2002) [PubMed] [Europe PMC] [Abstract]
• response to cytokine Source: MGI
• response to peptide hormone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: MGIInferred from mutant phenotypeⁱ
  • "Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch."
    Amsen D., Antov A., Jankovic D., Sher A., Radtke F., Souabni A., Busslinger M., McCright B., Gridley T., Flavell R.A.
    Immunity 27:89-99(2007) [PubMed] [Europe PMC] [Abstract]
• T-helper 1 cell lineage commitment Source: MGIInferred from genetic interactionⁱ
  • "The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells."
    Wang L., Carr T., Xiong Y., Wildt K.F., Zhu J., Feigenbaum L., Bendelac A., Bosselut R.
    Eur. J. Immunol. 40:2385-2390(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• protein phosphatase binding Source: MGI

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY 
        60         70         80         90        100
NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR 
       110        120        130        140        150
QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES 
       160        170        180        190        200
LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR 
       210        220        230        240        250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE 
       260        270        280        290        300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 
       310        320        330        340        350
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS 
       360        370        380        390        400
IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL 
       410        420        430        440        450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK 
       460        470        480        490        500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS 
       510        520        530        540        550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL 
       560        570        580        590        600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 
       610        620        630        640        650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV 
       660        670        680        690        700
ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE 
       710        720        730        740        750
ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP 
       760        770        780        790        800
MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN 
       810        820        830 
QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW               

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot