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UniProtKB - P52630 (STAT2_HUMAN)

Entry version 207 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Signal transducer and activator of transcription 2

Gene

STAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734).

In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510).

Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188).

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processAntiviral defense, Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P52630

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8854691, Interleukin-20 family signaling
R-HSA-909733, Interferon alpha/beta signaling
R-HSA-912694, Regulation of IFNA signaling
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P52630

SIGNOR Signaling Network Open Resource

More...SIGNORi		P52630

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcription 2
Alternative name(s):
p113
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11363, STAT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600556, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52630

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170581.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency 44 (IMD44)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation.
Related information in OMIM
Pseudo-TORCH syndrome 3 (PTORCH3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by developmental delay with acute episodes of fever and multisystemic organ involvement, including coagulopathy, elevated liver enzymes, and proteinuria, often associated with thrombotic microangiopathy. Brain imaging shows progressive intracranial calcifications, white matter abnormalities, and sometimes cerebral or cerebellar atrophy. Disease onset is in the neonatal period, and death in early childhood is common.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084450148R → Q in PTORCH3; increased cellular sensitivity to type I IFNs; fails to appropriately traffic USP18 thereby preventing USP18 to inhibit responses to IFN-I. 1 Publication1
Natural variantiVAR_084451148R → W in PTORCH3; increased cellular sensitivity to type I IFNs; loss of interaction with USP18 thereby preventing USP18 to inhibit responses to IFN-I. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi374R → A: Prevents the nuclear import; when associated with A-375. 1 Publication1
Mutagenesisi375K → A: Prevents the nuclear import; when associated with A-374. 1 Publication1
Mutagenesisi409R → A: Prevents the nuclear import; when associated with A-415. 1 Publication1
Mutagenesisi415K → A: Prevents the nuclear import; when associated with A-409. 1 Publication1
Mutagenesisi690Y → F: Reduces phosphorylation of STAT1 in response to IFN-ALPHA. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6773

MalaCards human disease database

More...MalaCardsi		STAT2
MIMi616636, phenotype
618886, phenotype

Open Targets

More...OpenTargetsi		ENSG00000170581

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36184

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52630, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523239

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STAT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1711552

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001824131 – 851Signal transducer and activator of transcription 2Add BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei283Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1
Modified residuei294Phosphothreonine1 Publication1
Modified residuei690Phosphotyrosine; by JAK2 Publications1
Modified residuei753PhosphoserineCombined sources1
Modified residuei800PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.4 Publications
'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation.1 Publication
(Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1273
CPTAC-1274

Encyclopedia of Proteome Dynamics

More...EPDi		P52630

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P52630

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52630

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52630

PeptideAtlas

More...PeptideAtlasi		P52630

PRoteomics IDEntifications database

More...PRIDEi		P52630

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32682
56498 [P52630-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52630

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P52630

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52630

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170581, Expressed in oviduct epithelium and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52630, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52630, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170581, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation (By similarity). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm (By similarity).

Interacts with CRSP2 and CRSP6 (PubMed:12509459). Can form a homodimer upon IFN-alpha induced phosphorylation (PubMed:9020188).

Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453).

Interacts with IFNAR2; the interaction is direct (PubMed:9121453, PubMed:28165510, PubMed:31836668, PubMed:32092142).

Interacts with ARL2BP (By similarity).

Interacts with E3 ubiquitin ligase DCST1; the interaction results in STAT2 ubiquitin-mediated proteasomal degradation (PubMed:27782195).

Interacts with USP18; the interaction is direct and allows the recruitment of USP18 to IFNAR2.

By similarity7 Publications

(Microbial infection) Interacts with vaccinia virus protein C6.

1 Publication

(Microbial infection) Interacts with Simian virus 5 protein V.

1 Publication

(Microbial infection) Interacts with Rabies virus phosphoprotein.

1 Publication

(Microbial infection) Interacts with Human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth.

1 Publication

(Microbial infection) Interacts with Dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation.

2 Publications

(Microbial infection) Interacts with Zika virus NS5; this interaction targets STAT2 for degradation.

2 Publications

(Microbial infection) Interacts with human cytomegalovirus (HHV-5) immediate early protein IE1; this interaction promotes viral growth and counteracts the antiviral interferon response.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112650, 55 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6016, ISGF3 complex
CPX-6047, STAT2/STAT6 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P52630

Database of interacting proteins

More...DIPi		DIP-38511N

Protein interaction database and analysis system

More...IntActi		P52630, 83 interactors

Molecular INTeraction database

More...MINTi		P52630

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52630, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1851
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52630

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P52630

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini572 – 667SH2PROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni138 – 572Mediates interaction with USP181 PublicationAdd BLAST435

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014189_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52630

Identification of Orthologs from Complete Genome Data

More...OMAi		FTIKYTY

Database of Orthologous Groups

More...OrthoDBi		327469at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52630

TreeFam database of animal gene trees

More...TreeFami		TF318648

Family and domain databases

Conserved Domains Database

More...CDDi		cd10373, SH2_STAT2, 1 hit

Database of protein disorder

More...DisProti		DP00961

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00053

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR022756, STAT2_C
IPR035854, STAT2_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction

The PANTHER Classification System

More...PANTHERi		PTHR11801, PTHR11801, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00017, SH2, 1 hit
PF12188, STAT2_C, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00252, SH2, 1 hit
SM00964, STAT_int, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52630-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG 
        60         70         80         90        100
SDDSKATMLF FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD 
       110        120        130        140        150
PTQLAEMIFN LLLEEKRILI QAQRAQLEQG EPVLETPVES QQHEIESRIL 
       160        170        180        190        200
DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ AKGKTPSLDP HQTKEQKILQ 
       210        220        230        240        250
ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA QQQKACIRAP 
       260        270        280        290        300
IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR 
       310        320        330        340        350
NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL 
       360        370        380        390        400
QEGNESLTVE VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF 
       410        420        430        440        450
GYLTLVEQRS GGSGKGSNKG PLGVTEELHI ISFTVKYTYQ GLKQELKTDT 
       460        470        480        490        500
LPVVIISNMN QLSIAWASVL WFNLLSPNLQ NQQFFSNPPK APWSLLGPAL 
       510        520        530        540        550
SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD FTKRESPPGK 
       560        570        580        590        600
LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL 
       610        620        630        640        650
RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL 
       660        670        680        690        700
LTEENIPENP LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN 
       710        720        730        740        750
RQVDELQQPL ELKPEPELES LELELGLVPE PELSLDLEPL LKAGLDLGPE 
       760        770        780        790        800
LESVLESTLE PVIEPTLCMV SQTVPEPDQG PVSQPVPEPD LPCDLRHLNT 
       810        820        830        840        850
EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF YTDGPLMPSD 

F
Length:851
Mass (Da):97,916
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4C74674CB7A3215
GO
Isoform 2 (identifier: P52630-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-99: Missing.

Note: May be due to competing acceptor splice site.Curated
Show »
Length:847
Mass (Da):97,457
Checksum:i3587443D40AF5E5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C164A0A494C164_HUMAN
Signal transducer and activator of ...
STAT2
818Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DLC8B4DLC8_HUMAN
Signal transducer and activator of ...
STAT2
460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHE0B4DHE0_HUMAN
Signal transducer and activator of ...
STAT2
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0B5A0A494C0B5_HUMAN
Signal transducer and activator of ...
STAT2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1L3A0A494C1L3_HUMAN
Signal transducer and activator of ...
STAT2
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V319G3V319_HUMAN
Signal transducer and activator of ...
STAT2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB36226 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAB36227 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti240A → T in BAG59489 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01489666Q → H. Corresponds to variant dbSNP:rs2066816Ensembl.1
Natural variantiVAR_084450148R → Q in PTORCH3; increased cellular sensitivity to type I IFNs; fails to appropriately traffic USP18 thereby preventing USP18 to inhibit responses to IFN-I. 1 Publication1
Natural variantiVAR_084451148R → W in PTORCH3; increased cellular sensitivity to type I IFNs; loss of interaction with USP18 thereby preventing USP18 to inhibit responses to IFN-I. 1 Publication1
Natural variantiVAR_014897220L → P. Corresponds to variant dbSNP:rs2066817Ensembl.1
Natural variantiVAR_052072246C → S. Corresponds to variant dbSNP:rs2228259Ensembl.1
Natural variantiVAR_014898448T → M1 PublicationCorresponds to variant dbSNP:rs2066815EnsemblClinVar.1
Natural variantiVAR_014899464I → V1 PublicationCorresponds to variant dbSNP:rs2066811EnsemblClinVar.1
Natural variantiVAR_014900501S → I. Corresponds to variant dbSNP:rs2066809Ensembl.1
Natural variantiVAR_014901594M → I1 PublicationCorresponds to variant dbSNP:rs2066807EnsemblClinVar.1
Natural variantiVAR_019213826Q → H1 PublicationCorresponds to variant dbSNP:rs2229363EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04670596 – 99Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M97934 mRNA No translation available.
U18671 Genomic DNA Translation: AAA98760.1
S81491 Genomic DNA Translation: AAB36226.1 Sequence problems.
S81491 Genomic DNA Translation: AAB36227.1 Sequence problems.
AY525126 Genomic DNA Translation: AAS00091.1
AK296939 mRNA Translation: BAG59489.1
AC025574 Genomic DNA No translation available.
BC051284 mRNA Translation: AAH51284.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55836.1 [P52630-4]
CCDS8917.1 [P52630-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A46160

NCBI Reference Sequences

More...RefSeqi		NP_005410.1, NM_005419.3 [P52630-3]
NP_938146.1, NM_198332.1 [P52630-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314128; ENSP00000315768; ENSG00000170581 [P52630-3]
ENST00000557235; ENSP00000450751; ENSG00000170581 [P52630-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6773

UCSC genome browser

More...UCSCi		uc001sld.4, human [P52630-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97934 mRNA No translation available.
U18671 Genomic DNA Translation: AAA98760.1
S81491 Genomic DNA Translation: AAB36226.1 Sequence problems.
S81491 Genomic DNA Translation: AAB36227.1 Sequence problems.
AY525126 Genomic DNA Translation: AAS00091.1
AK296939 mRNA Translation: BAG59489.1
AC025574 Genomic DNA No translation available.
BC051284 mRNA Translation: AAH51284.1
CCDSiCCDS55836.1 [P52630-4]
CCDS8917.1 [P52630-3]
PIRiA46160
RefSeqiNP_005410.1, NM_005419.3 [P52630-3]
NP_938146.1, NM_198332.1 [P52630-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KA4NMR-B786-838[»]
6UX2X-ray3.01A1-713[»]
6WCZelectron microscopy4.00A1-851[»]
SMRiP52630
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112650, 55 interactors
ComplexPortaliCPX-6016, ISGF3 complex
CPX-6047, STAT2/STAT6 complex
CORUMiP52630
DIPiDIP-38511N
IntActiP52630, 83 interactors
MINTiP52630
STRINGi9606.ENSP00000315768

Chemistry databases

ChEMBLiCHEMBL4523239

PTM databases

iPTMnetiP52630
MetOSiteiP52630
PhosphoSitePlusiP52630

Genetic variation databases

BioMutaiSTAT2
DMDMi1711552

Proteomic databases

CPTACiCPTAC-1273
CPTAC-1274
EPDiP52630
jPOSTiP52630
MassIVEiP52630
PaxDbiP52630
PeptideAtlasiP52630
PRIDEiP52630
ProteomicsDBi32682
56498 [P52630-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P52630, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3552, 1009 antibodies

The DNASU plasmid repository

More...DNASUi		6773

Genome annotation databases

EnsembliENST00000314128; ENSP00000315768; ENSG00000170581 [P52630-3]
ENST00000557235; ENSP00000450751; ENSG00000170581 [P52630-4]
GeneIDi6773
KEGGihsa:6773
UCSCiuc001sld.4, human [P52630-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6773
DisGeNETi6773

GeneCards: human genes, protein and diseases

More...GeneCardsi		STAT2
HGNCiHGNC:11363, STAT2
HPAiENSG00000170581, Low tissue specificity
MalaCardsiSTAT2
MIMi600556, gene
616636, phenotype
618886, phenotype
neXtProtiNX_P52630
OpenTargetsiENSG00000170581
Orphaneti431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
PharmGKBiPA36184
VEuPathDBiHostDB:ENSG00000170581.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3667, Eukaryota
GeneTreeiENSGT01030000234663
HOGENOMiCLU_014189_0_0_1
InParanoidiP52630
OMAiFTIKYTY
OrthoDBi327469at2759
PhylomeDBiP52630
TreeFamiTF318648

Enzyme and pathway databases

PathwayCommonsiP52630
ReactomeiR-HSA-8854691, Interleukin-20 family signaling
R-HSA-909733, Interferon alpha/beta signaling
R-HSA-912694, Regulation of IFNA signaling
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiP52630
SIGNORiP52630

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6773, 10 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STAT2, human
EvolutionaryTraceiP52630

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6773
PharosiP52630, Tbio

Protein Ontology

More...PROi		PR:P52630
RNActiP52630, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170581, Expressed in oviduct epithelium and 221 other tissues
ExpressionAtlasiP52630, baseline and differential
GenevisibleiP52630, HS

Family and domain databases

CDDicd10373, SH2_STAT2, 1 hit
DisProtiDP00961
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
IDEALiIID00053
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR001217, STAT
IPR022756, STAT2_C
IPR035854, STAT2_SH2
IPR036535, STAT_N_sf
IPR013800, STAT_TF_alpha
IPR015988, STAT_TF_coiled-coil
IPR013801, STAT_TF_DNA-bd
IPR012345, STAT_TF_DNA-bd_N
IPR013799, STAT_TF_prot_interaction
PANTHERiPTHR11801, PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF12188, STAT2_C, 1 hit
PF01017, STAT_alpha, 1 hit
PF02864, STAT_bind, 1 hit
PF02865, STAT_int, 1 hit
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00964, STAT_int, 1 hit
SUPFAMiSSF47655, SSF47655, 1 hit
SSF48092, SSF48092, 1 hit
SSF49417, SSF49417, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52630
Secondary accession number(s): B4DLC7
, G3V2M6, Q16430, Q16431, Q9UDL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 2, 2021
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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