UniProtKB - P52630 (STAT2_HUMAN)
Signal transducer and activator of transcription 2
STAT2
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- ubiquitin-like protein ligase binding Source: UniProtKB
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- defense response Source: GO_Central
- defense response to virus Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- receptor signaling pathway via JAK-STAT Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of mitochondrial fission Source: UniProtKB
- regulation of protein phosphorylation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: ProtInc
- response to peptide hormone Source: GO_Central
- type I interferon signaling pathway Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P52630 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling |
SignaLinki | P52630 |
SIGNORi | P52630 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcription 2Alternative name(s): p113 |
Gene namesi | Name:STAT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170581.13 |
HGNCi | HGNC:11363, STAT2 |
MIMi | 600556, gene |
neXtProti | NX_P52630 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 44 (IMD44)2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 374 | R → A: Prevents the nuclear import; when associated with A-375. 1 Publication | 1 | |
Mutagenesisi | 375 | K → A: Prevents the nuclear import; when associated with A-374. 1 Publication | 1 | |
Mutagenesisi | 409 | R → A: Prevents the nuclear import; when associated with A-415. 1 Publication | 1 | |
Mutagenesisi | 415 | K → A: Prevents the nuclear import; when associated with A-409. 1 Publication | 1 | |
Mutagenesisi | 690 | Y → F: Reduces phosphorylation of STAT1 in response to IFN-ALPHA. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6773 |
MalaCardsi | STAT2 |
MIMi | 616636, phenotype |
OpenTargetsi | ENSG00000170581 |
Orphaneti | 431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
PharmGKBi | PA36184 |
Miscellaneous databases
Pharosi | P52630, Tbio |
Polymorphism and mutation databases
BioMutai | STAT2 |
DMDMi | 1711552 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182413 | 1 – 851 | Signal transducer and activator of transcription 2Add BLAST | 851 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 283 | Phosphoserine1 Publication | 1 | |
Modified residuei | 287 | Phosphoserine1 Publication | 1 | |
Modified residuei | 294 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 690 | Phosphotyrosine; by JAK2 Publications | 1 | |
Modified residuei | 753 | PhosphoserineCombined sources | 1 | |
Modified residuei | 800 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1273 CPTAC-1274 |
EPDi | P52630 |
jPOSTi | P52630 |
MassIVEi | P52630 |
PaxDbi | P52630 |
PeptideAtlasi | P52630 |
PRIDEi | P52630 |
ProteomicsDBi | 32682 56498 [P52630-3] |
PTM databases
iPTMneti | P52630 |
MetOSitei | P52630 |
PhosphoSitePlusi | P52630 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170581, Expressed in oviduct epithelium and 220 other tissues |
ExpressionAtlasi | P52630, baseline and differential |
Genevisiblei | P52630, HS |
Organism-specific databases
HPAi | ENSG00000170581, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation (By similarity). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm (By similarity).
Interacts with CRSP2 and CRSP6 (PubMed:12509459). Can form a homodimer upon IFN-alpha induced phosphorylation (PubMed:9020188).
Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453).
Interacts with IFNAR2 (PubMed:9121453).
Interacts with ARL2BP (By similarity).
Interacts with E3 ubiquitin ligase DCST1; the interaction results in STAT2 ubiquitin-mediated proteasomal degradation (PubMed:27782195).
By similarity4 Publications(Microbial infection) Interacts with vaccinia virus protein C6.
1 Publication(Microbial infection) Interacts with Simian virus 5 protein V.
1 Publication(Microbial infection) Interacts with Rabies virus phosphoprotein.
1 Publication(Microbial infection) Interacts with Human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth.
1 Publication(Microbial infection) Interacts with Dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation.
2 Publications(Microbial infection) Interacts with Zika virus NS5; this interaction targets STAT2 for degradation.
2 PublicationsBinary interactionsi
Hide detailsP52630
GO - Molecular functioni
- identical protein binding Source: IntAct
- ubiquitin-like protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112650, 50 interactors |
CORUMi | P52630 |
DIPi | DIP-38511N |
IntActi | P52630, 80 interactors |
MINTi | P52630 |
STRINGi | 9606.ENSP00000315768 |
Miscellaneous databases
RNActi | P52630, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P52630 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52630 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 572 – 667 | SH2PROSITE-ProRule annotationAdd BLAST | 96 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT01010000222348 |
HOGENOMi | CLU_014189_0_0_1 |
InParanoidi | P52630 |
OMAi | FTIKYTY |
OrthoDBi | 327469at2759 |
PhylomeDBi | P52630 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
DisProti | DP00961 |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID00053 |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG
60 70 80 90 100
SDDSKATMLF FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD
110 120 130 140 150
PTQLAEMIFN LLLEEKRILI QAQRAQLEQG EPVLETPVES QQHEIESRIL
160 170 180 190 200
DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ AKGKTPSLDP HQTKEQKILQ
210 220 230 240 250
ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA QQQKACIRAP
260 270 280 290 300
IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR
310 320 330 340 350
NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL
360 370 380 390 400
QEGNESLTVE VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF
410 420 430 440 450
GYLTLVEQRS GGSGKGSNKG PLGVTEELHI ISFTVKYTYQ GLKQELKTDT
460 470 480 490 500
LPVVIISNMN QLSIAWASVL WFNLLSPNLQ NQQFFSNPPK APWSLLGPAL
510 520 530 540 550
SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD FTKRESPPGK
560 570 580 590 600
LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL
610 620 630 640 650
RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL
660 670 680 690 700
LTEENIPENP LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN
710 720 730 740 750
RQVDELQQPL ELKPEPELES LELELGLVPE PELSLDLEPL LKAGLDLGPE
760 770 780 790 800
LESVLESTLE PVIEPTLCMV SQTVPEPDQG PVSQPVPEPD LPCDLRHLNT
810 820 830 840 850
EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF YTDGPLMPSD
F
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494C164 | A0A494C164_HUMAN | Signal transducer and activator of ... | STAT2 | 818 | Annotation score: | ||
B4DLC8 | B4DLC8_HUMAN | Signal transducer and activator of ... | STAT2 | 460 | Annotation score: | ||
B4DHE0 | B4DHE0_HUMAN | Signal transducer and activator of ... | STAT2 | 203 | Annotation score: | ||
A0A494C0B5 | A0A494C0B5_HUMAN | Signal transducer and activator of ... | STAT2 | 199 | Annotation score: | ||
A0A494C1L3 | A0A494C1L3_HUMAN | Signal transducer and activator of ... | STAT2 | 261 | Annotation score: | ||
G3V319 | G3V319_HUMAN | Signal transducer and activator of ... | STAT2 | 65 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 240 | A → T in BAG59489 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014896 | 66 | Q → H. Corresponds to variant dbSNP:rs2066816Ensembl. | 1 | |
Natural variantiVAR_014897 | 220 | L → P. Corresponds to variant dbSNP:rs2066817Ensembl. | 1 | |
Natural variantiVAR_052072 | 246 | C → S. Corresponds to variant dbSNP:rs2228259Ensembl. | 1 | |
Natural variantiVAR_014898 | 448 | T → M1 PublicationCorresponds to variant dbSNP:rs2066815EnsemblClinVar. | 1 | |
Natural variantiVAR_014899 | 464 | I → V1 PublicationCorresponds to variant dbSNP:rs2066811EnsemblClinVar. | 1 | |
Natural variantiVAR_014900 | 501 | S → I. Corresponds to variant dbSNP:rs2066809Ensembl. | 1 | |
Natural variantiVAR_014901 | 594 | M → I1 PublicationCorresponds to variant dbSNP:rs2066807EnsemblClinVar. | 1 | |
Natural variantiVAR_019213 | 826 | Q → H1 PublicationCorresponds to variant dbSNP:rs2229363EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046705 | 96 – 99 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97934 mRNA No translation available. U18671 Genomic DNA Translation: AAA98760.1 S81491 Genomic DNA Translation: AAB36226.1 Sequence problems. S81491 Genomic DNA Translation: AAB36227.1 Sequence problems. AY525126 Genomic DNA Translation: AAS00091.1 AK296939 mRNA Translation: BAG59489.1 AC025574 Genomic DNA No translation available. BC051284 mRNA Translation: AAH51284.1 |
CCDSi | CCDS55836.1 [P52630-4] CCDS8917.1 [P52630-3] |
PIRi | A46160 |
RefSeqi | NP_005410.1, NM_005419.3 [P52630-3] NP_938146.1, NM_198332.1 [P52630-4] |
Genome annotation databases
Ensembli | ENST00000314128; ENSP00000315768; ENSG00000170581 [P52630-3] ENST00000557235; ENSP00000450751; ENSG00000170581 [P52630-4] |
GeneIDi | 6773 |
KEGGi | hsa:6773 |
UCSCi | uc001sld.4, human [P52630-3] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97934 mRNA No translation available. U18671 Genomic DNA Translation: AAA98760.1 S81491 Genomic DNA Translation: AAB36226.1 Sequence problems. S81491 Genomic DNA Translation: AAB36227.1 Sequence problems. AY525126 Genomic DNA Translation: AAS00091.1 AK296939 mRNA Translation: BAG59489.1 AC025574 Genomic DNA No translation available. BC051284 mRNA Translation: AAH51284.1 |
CCDSi | CCDS55836.1 [P52630-4] CCDS8917.1 [P52630-3] |
PIRi | A46160 |
RefSeqi | NP_005410.1, NM_005419.3 [P52630-3] NP_938146.1, NM_198332.1 [P52630-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KA4 | NMR | - | B | 786-838 | [»] | |
6UX2 | X-ray | 3.01 | A | 1-713 | [»] | |
6WCZ | electron microscopy | 4.00 | A | 1-851 | [»] | |
SMRi | P52630 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112650, 50 interactors |
CORUMi | P52630 |
DIPi | DIP-38511N |
IntActi | P52630, 80 interactors |
MINTi | P52630 |
STRINGi | 9606.ENSP00000315768 |
PTM databases
iPTMneti | P52630 |
MetOSitei | P52630 |
PhosphoSitePlusi | P52630 |
Polymorphism and mutation databases
BioMutai | STAT2 |
DMDMi | 1711552 |
Proteomic databases
CPTACi | CPTAC-1273 CPTAC-1274 |
EPDi | P52630 |
jPOSTi | P52630 |
MassIVEi | P52630 |
PaxDbi | P52630 |
PeptideAtlasi | P52630 |
PRIDEi | P52630 |
ProteomicsDBi | 32682 56498 [P52630-3] |
Protocols and materials databases
ABCDi | P52630, 1 sequenced antibody |
Antibodypediai | 3552, 988 antibodies |
Genome annotation databases
Ensembli | ENST00000314128; ENSP00000315768; ENSG00000170581 [P52630-3] ENST00000557235; ENSP00000450751; ENSG00000170581 [P52630-4] |
GeneIDi | 6773 |
KEGGi | hsa:6773 |
UCSCi | uc001sld.4, human [P52630-3] |
Organism-specific databases
CTDi | 6773 |
DisGeNETi | 6773 |
EuPathDBi | HostDB:ENSG00000170581.13 |
GeneCardsi | STAT2 |
HGNCi | HGNC:11363, STAT2 |
HPAi | ENSG00000170581, Low tissue specificity |
MalaCardsi | STAT2 |
MIMi | 600556, gene 616636, phenotype |
neXtProti | NX_P52630 |
OpenTargetsi | ENSG00000170581 |
Orphaneti | 431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
PharmGKBi | PA36184 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3667, Eukaryota |
GeneTreei | ENSGT01010000222348 |
HOGENOMi | CLU_014189_0_0_1 |
InParanoidi | P52630 |
OMAi | FTIKYTY |
OrthoDBi | 327469at2759 |
PhylomeDBi | P52630 |
TreeFami | TF318648 |
Enzyme and pathway databases
PathwayCommonsi | P52630 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling |
SignaLinki | P52630 |
SIGNORi | P52630 |
Miscellaneous databases
BioGRID-ORCSi | 6773, 4 hits in 866 CRISPR screens |
ChiTaRSi | STAT2, human |
EvolutionaryTracei | P52630 |
GeneWikii | STAT2 |
GenomeRNAii | 6773 |
Pharosi | P52630, Tbio |
PROi | PR:P52630 |
RNActi | P52630, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170581, Expressed in oviduct epithelium and 220 other tissues |
ExpressionAtlasi | P52630, baseline and differential |
Genevisiblei | P52630, HS |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
DisProti | DP00961 |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID00053 |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAT2_HUMAN | |
Accessioni | P52630Primary (citable) accession number: P52630 Secondary accession number(s): B4DLC7 Q9UDL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations