UniProtKB - P52612 (FLII_ECOLI)
Protein
Flagellum-specific ATP synthase
Gene
fliI
Organism
Escherichia coli (strain K12)
Status
Functioni
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.
Catalytic activityi
- EC:7.1.2.2PROSITE-ProRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 182 – 189 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- proton-transporting ATPase activity, rotational mechanism Source: UniProtKB-EC
- proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-EC
GO - Biological processi
- bacterial-type flagellum assembly Source: InterPro
- bacterial-type flagellum-dependent cell motility Source: InterPro
- protein secretion by the type III secretion system Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G377-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fliI Synonyms:fla AIII, flaC Ordered Locus Names:b1941, JW1925 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- proton-transporting ATP synthase complex, catalytic core F(1) Source: GO_Central
- type III protein secretion system complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144694 | 1 – 457 | Flagellum-specific ATP synthaseAdd BLAST | 457 |
Proteomic databases
PaxDbi | P52612 |
PRIDEi | P52612 |
Interactioni
Binary interactionsi
P52612
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-1118363,EBI-1118363 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4260388, 18 interactors 850811, 5 interactors |
DIPi | DIP-9655N |
IntActi | P52612, 23 interactors |
STRINGi | 511145.b1941 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATPase alpha/beta chains family.Curated
Phylogenomic databases
eggNOGi | COG1157, Bacteria |
HOGENOMi | CLU_022398_5_1_6 |
InParanoidi | P52612 |
PhylomeDBi | P52612 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR020003, ATPase_a/bsu_AS IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR032463, ATPase_T3SS_FliI IPR005714, ATPase_T3SS_FliI/YscN IPR020005, FliI_clade1 IPR027417, P-loop_NTPase IPR040627, T3SS_ATPase_C |
PANTHERi | PTHR15184:SF9, PTHR15184:SF9, 1 hit |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF18269, T3SS_ATPase_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03496, FliI_clade1, 1 hit TIGR01026, fliI_yscN, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
P52612-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTRLTRWLT TLDNFEAKMA QLPAVRRYGR LTRATGLVLE ATGLQLPLGA
60 70 80 90 100
TCVIERQNGS ETHEVESEVV GFNGQRLFLM PLEEVEGVLP GARVYAKNIS
110 120 130 140 150
AEGLQSGKQL PLGPALLGRV LDGSGKPLDG LPSPDTTETG ALITPPFNPL
160 170 180 190 200
QRTPIEHVLD TGVRPINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR
210 220 230 240 250
ADVIVVGLIG ERGREVKDFI ENILGAEGRA RSVVIAAPAD VSPLLRMQGA
260 270 280 290 300
AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS
310 320 330 340 350
VFAKLPALVE RAGNGISGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH
360 370 380 390 400
IVLSRRLAEA GHYPAIDIEA SISRAMTALI SEQHYARVRT FKQLLSSFQR
410 420 430 440 450
NRDLVSVGAY AKGSDPMLDK AIALWPQLEG YLQQGIFERA DWEASLQGLE
RIFPTVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 112 – 113 | LG → SV in AAA82637 (Ref. 1) Curated | 2 | |
Sequence conflicti | 185 | G → A in AAA82637 (Ref. 1) Curated | 1 | |
Sequence conflicti | 239 | A → R in AAA82637 (Ref. 1) Curated | 1 | |
Sequence conflicti | 248 – 250 | QGA → RMP in AAA82637 (Ref. 1) Curated | 3 | |
Sequence conflicti | 278 | A → G in AAA82637 (Ref. 1) Curated | 1 | |
Sequence conflicti | 399 – 400 | QR → HG in AAA82637 (Ref. 1) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49147 Genomic DNA Translation: AAA82637.1 U00096 Genomic DNA Translation: AAC75008.1 AP009048 Genomic DNA Translation: BAA15766.1 |
PIRi | B64958 |
RefSeqi | NP_416451.1, NC_000913.3 WP_000213294.1, NZ_SSZK01000066.1 |
Genome annotation databases
EnsemblBacteriai | AAC75008; AAC75008; b1941 BAA15766; BAA15766; BAA15766 |
GeneIDi | 946457 |
KEGGi | ecj:JW1925 eco:b1941 |
PATRICi | fig|1411691.4.peg.310 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49147 Genomic DNA Translation: AAA82637.1 U00096 Genomic DNA Translation: AAC75008.1 AP009048 Genomic DNA Translation: BAA15766.1 |
PIRi | B64958 |
RefSeqi | NP_416451.1, NC_000913.3 WP_000213294.1, NZ_SSZK01000066.1 |
3D structure databases
SMRi | P52612 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260388, 18 interactors 850811, 5 interactors |
DIPi | DIP-9655N |
IntActi | P52612, 23 interactors |
STRINGi | 511145.b1941 |
Proteomic databases
PaxDbi | P52612 |
PRIDEi | P52612 |
Genome annotation databases
EnsemblBacteriai | AAC75008; AAC75008; b1941 BAA15766; BAA15766; BAA15766 |
GeneIDi | 946457 |
KEGGi | ecj:JW1925 eco:b1941 |
PATRICi | fig|1411691.4.peg.310 |
Organism-specific databases
EchoBASEi | EB4163 |
Phylogenomic databases
eggNOGi | COG1157, Bacteria |
HOGENOMi | CLU_022398_5_1_6 |
InParanoidi | P52612 |
PhylomeDBi | P52612 |
Enzyme and pathway databases
BioCyci | EcoCyc:G377-MONOMER |
Miscellaneous databases
PROi | PR:P52612 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR020003, ATPase_a/bsu_AS IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR032463, ATPase_T3SS_FliI IPR005714, ATPase_T3SS_FliI/YscN IPR020005, FliI_clade1 IPR027417, P-loop_NTPase IPR040627, T3SS_ATPase_C |
PANTHERi | PTHR15184:SF9, PTHR15184:SF9, 1 hit |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF18269, T3SS_ATPase_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03496, FliI_clade1, 1 hit TIGR01026, fliI_yscN, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLII_ECOLI | |
Accessioni | P52612Primary (citable) accession number: P52612 Secondary accession number(s): P78073 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families