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UniProtKB - P52612 (FLII_ECOLI)

Entry version 158 (10 Feb 2021)
Sequence version 2 (01 Nov 1997)
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Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi182 – 189ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G377-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:7.1.2.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fliI
Synonyms:fla AIII, flaC
Ordered Locus Names:b1941, JW1925
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001446941 – 457Flagellum-specific ATP synthaseAdd BLAST457

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52612

PRoteomics IDEntifications database

More...PRIDEi		P52612

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P52612
With#Exp.IntAct
itself4EBI-1118363,EBI-1118363

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260388, 18 interactors
850811, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5885, Flagellar export complex

Database of interacting proteins

More...DIPi		DIP-9655N

Protein interaction database and analysis system

More...IntActi		P52612, 23 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1941

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52612

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1157, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022398_5_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52612

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52612

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR020003, ATPase_a/bsu_AS
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005714, ATPase_T3SS_FliI/YscN
IPR020005, FliI_clade1
IPR027417, P-loop_NTPase
IPR040627, T3SS_ATPase_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF18269, T3SS_ATPase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03496, FliI_clade1, 1 hit
TIGR01026, fliI_yscN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P52612-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRLTRWLT TLDNFEAKMA QLPAVRRYGR LTRATGLVLE ATGLQLPLGA 
        60         70         80         90        100
TCVIERQNGS ETHEVESEVV GFNGQRLFLM PLEEVEGVLP GARVYAKNIS 
       110        120        130        140        150
AEGLQSGKQL PLGPALLGRV LDGSGKPLDG LPSPDTTETG ALITPPFNPL 
       160        170        180        190        200
QRTPIEHVLD TGVRPINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR 
       210        220        230        240        250
ADVIVVGLIG ERGREVKDFI ENILGAEGRA RSVVIAAPAD VSPLLRMQGA 
       260        270        280        290        300
AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS 
       310        320        330        340        350
VFAKLPALVE RAGNGISGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH 
       360        370        380        390        400
IVLSRRLAEA GHYPAIDIEA SISRAMTALI SEQHYARVRT FKQLLSSFQR 
       410        420        430        440        450
NRDLVSVGAY AKGSDPMLDK AIALWPQLEG YLQQGIFERA DWEASLQGLE 

RIFPTVS
Length:457
Mass (Da):49,316
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i962D4268E8428C93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112 – 113LG → SV in AAA82637 (Ref. 1) Curated2
Sequence conflicti185G → A in AAA82637 (Ref. 1) Curated1
Sequence conflicti239A → R in AAA82637 (Ref. 1) Curated1
Sequence conflicti248 – 250QGA → RMP in AAA82637 (Ref. 1) Curated3
Sequence conflicti278A → G in AAA82637 (Ref. 1) Curated1
Sequence conflicti399 – 400QR → HG in AAA82637 (Ref. 1) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L49147 Genomic DNA Translation: AAA82637.1
U00096 Genomic DNA Translation: AAC75008.1
AP009048 Genomic DNA Translation: BAA15766.1

Protein sequence database of the Protein Information Resource

More...PIRi		B64958

NCBI Reference Sequences

More...RefSeqi		NP_416451.1, NC_000913.3
WP_000213294.1, NZ_SSZK01000066.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75008; AAC75008; b1941
BAA15766; BAA15766; BAA15766

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57731333
946457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1925
eco:b1941

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49147 Genomic DNA Translation: AAA82637.1
U00096 Genomic DNA Translation: AAC75008.1
AP009048 Genomic DNA Translation: BAA15766.1
PIRiB64958
RefSeqiNP_416451.1, NC_000913.3
WP_000213294.1, NZ_SSZK01000066.1

3D structure databases

SMRiP52612
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260388, 18 interactors
850811, 5 interactors
ComplexPortaliCPX-5885, Flagellar export complex
DIPiDIP-9655N
IntActiP52612, 23 interactors
STRINGi511145.b1941

Proteomic databases

PaxDbiP52612
PRIDEiP52612

Genome annotation databases

EnsemblBacteriaiAAC75008; AAC75008; b1941
BAA15766; BAA15766; BAA15766
GeneIDi57731333
946457
KEGGiecj:JW1925
eco:b1941
PATRICifig|1411691.4.peg.310

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB4163

Phylogenomic databases

eggNOGiCOG1157, Bacteria
HOGENOMiCLU_022398_5_1_6
InParanoidiP52612
PhylomeDBiP52612

Enzyme and pathway databases

BioCyciEcoCyc:G377-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P52612

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR020003, ATPase_a/bsu_AS
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005714, ATPase_T3SS_FliI/YscN
IPR020005, FliI_clade1
IPR027417, P-loop_NTPase
IPR040627, T3SS_ATPase_C
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF18269, T3SS_ATPase_C, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR03496, FliI_clade1, 1 hit
TIGR01026, fliI_yscN, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLII_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52612
Secondary accession number(s): P78073
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: February 10, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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