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Protein

Rho GDP-dissociation inhibitor 2

Gene

ARHGDIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • GTPase activity Source: CACAO
  • Rac GTPase binding Source: UniProtKB
  • Rho GDP-dissociation inhibitor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P52566

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 2
Short name:
Rho GDI 2
Alternative name(s):
Ly-GDI1 Publication
Rho-GDI beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGDIB
Synonyms:GDIA2, GDID4, RAP1GN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111348.8

Human Gene Nomenclature Database

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HGNCi
HGNC:679 ARHGDIB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602843 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52566

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
397

Open Targets

More...
OpenTargetsi
ENSG00000111348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24964

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGDIB

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190162 – 201Rho GDP-dissociation inhibitor 2Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonine1 Publication1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei24PhosphotyrosineCombined sources1
Modified residuei25N6-acetyllysineCombined sources1
Modified residuei40N6-acetyllysineCombined sources1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei124N6-acetyllysineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei175N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P52566

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P52566

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52566

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52566

PeptideAtlas

More...
PeptideAtlasi
P52566

PRoteomics IDEntifications database

More...
PRIDEi
P52566

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56490

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P52566

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P52566

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P52566

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52566

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52566

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P52566

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P52566

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in bone marrow, thymus and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111348 Expressed in 230 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARHGDIB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52566 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52566 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018584
HPA051235

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA (PubMed:20400958). Interacts with RAC1 (PubMed:7512369). Interacts with RAC2 (PubMed:10655614). Interacts with CDC42 (PubMed:7512369).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106890, 16 interactors

Database of interacting proteins

More...
DIPi
DIP-40959N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P52566

Protein interaction database and analysis system

More...
IntActi
P52566, 10 interactors

Molecular INTeraction database

More...
MINTi
P52566

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS6X-ray2.35B23-199[»]
5H1DX-ray1.49A61-201[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P52566

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52566

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P52566

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3205 Eukaryota
ENOG4111K44 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000175765

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000206

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52566

KEGG Orthology (KO)

More...
KOi
K12462

Identification of Orthologs from Complete Genome Data

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OMAi
LTWEWNL

Database of Orthologous Groups

More...
OrthoDBi
1265661at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52566

TreeFam database of animal gene trees

More...
TreeFami
TF105387

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10980 PTHR10980, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02115 Rho_GDI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00492 RHOGDI

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P52566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK
60 70 80 90 100
TLLGDGPVVT DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV
110 120 130 140 150
LKEGSEYRVK IHFKVNRDIV SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP
160 170 180 190 200
EEYEFLTPVE EAPKGMLARG TYHNKSFFTD DDKQDHLSWE WNLSIKKEWT

E
Length:201
Mass (Da):22,988
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1E840134F643E5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGX7H0YGX7_HUMAN
Rho GDP-dissociation inhibitor 2
ARHGDIB
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6Q0F5H6Q0_HUMAN
Rho GDP-dissociation inhibitor 2
ARHGDIB
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2R5F5H2R5_HUMAN
Rho GDP-dissociation inhibitor 2
ARHGDIB
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3P3F5H3P3_HUMAN
Rho GDP-dissociation inhibitor 2
ARHGDIB
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153Y → V AA sequence (PubMed:2226408).Curated1
Sequence conflicti169 – 170RG → QD in L07916 (PubMed:8434008).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L20688 mRNA Translation: AAA59539.1
X69549 mRNA Translation: CAA49280.1
L07916 mRNA No translation available.
AF498927 mRNA Translation: AAM21075.1
AB451315 mRNA Translation: BAG70129.1
AB451445 mRNA Translation: BAG70259.1
CH471094 Genomic DNA Translation: EAW96336.1
BC009200 mRNA Translation: AAH09200.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8671.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47742

NCBI Reference Sequences

More...
RefSeqi
NP_001166.3, NM_001175.6
NP_001308349.1, NM_001321420.1
NP_001308350.1, NM_001321421.1
NP_001308351.1, NM_001321422.1
NP_001308352.1, NM_001321423.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.504877

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228945; ENSP00000228945; ENSG00000111348
ENST00000541546; ENSP00000440560; ENSG00000111348
ENST00000541644; ENSP00000444860; ENSG00000111348

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:397

UCSC genome browser

More...
UCSCi
uc001rcq.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20688 mRNA Translation: AAA59539.1
X69549 mRNA Translation: CAA49280.1
L07916 mRNA No translation available.
AF498927 mRNA Translation: AAM21075.1
AB451315 mRNA Translation: BAG70129.1
AB451445 mRNA Translation: BAG70259.1
CH471094 Genomic DNA Translation: EAW96336.1
BC009200 mRNA Translation: AAH09200.1
CCDSiCCDS8671.1
PIRiA47742
RefSeqiNP_001166.3, NM_001175.6
NP_001308349.1, NM_001321420.1
NP_001308350.1, NM_001321421.1
NP_001308351.1, NM_001321422.1
NP_001308352.1, NM_001321423.1
UniGeneiHs.504877

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS6X-ray2.35B23-199[»]
5H1DX-ray1.49A61-201[»]
ProteinModelPortaliP52566
SMRiP52566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106890, 16 interactors
DIPiDIP-40959N
ELMiP52566
IntActiP52566, 10 interactors
MINTiP52566
STRINGi9606.ENSP00000228945

PTM databases

iPTMnetiP52566
PhosphoSitePlusiP52566
SwissPalmiP52566

Polymorphism and mutation databases

BioMutaiARHGDIB

2D gel databases

OGPiP52566
SWISS-2DPAGEiP52566

Proteomic databases

EPDiP52566
jPOSTiP52566
MaxQBiP52566
PaxDbiP52566
PeptideAtlasiP52566
PRIDEiP52566
ProteomicsDBi56490
TopDownProteomicsiP52566

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228945; ENSP00000228945; ENSG00000111348
ENST00000541546; ENSP00000440560; ENSG00000111348
ENST00000541644; ENSP00000444860; ENSG00000111348
GeneIDi397
KEGGihsa:397
UCSCiuc001rcq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397
DisGeNETi397
EuPathDBiHostDB:ENSG00000111348.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGDIB

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0036989
HGNCiHGNC:679 ARHGDIB
HPAiCAB018584
HPA051235
MIMi602843 gene
neXtProtiNX_P52566
OpenTargetsiENSG00000111348
PharmGKBiPA24964

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3205 Eukaryota
ENOG4111K44 LUCA
GeneTreeiENSGT00390000006233
HOGENOMiHOG000175765
HOVERGENiHBG000206
InParanoidiP52566
KOiK12462
OMAiLTWEWNL
OrthoDBi1265661at2759
PhylomeDBiP52566
TreeFamiTF105387

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SIGNORiP52566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGDIB human
EvolutionaryTraceiP52566

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARHGDIB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
397
PMAP-CutDBiP52566

Protein Ontology

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PROi
PR:P52566

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000111348 Expressed in 230 organ(s), highest expression level in blood
CleanExiHS_ARHGDIB
ExpressionAtlasiP52566 baseline and differential
GenevisibleiP52566 HS

Family and domain databases

Gene3Di2.70.50.30, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf
PANTHERiPTHR10980 PTHR10980, 1 hit
PfamiView protein in Pfam
PF02115 Rho_GDI, 1 hit
PRINTSiPR00492 RHOGDI
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDIR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52566
Secondary accession number(s): B5BU79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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