MAP2K6

Functionⁱ

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.8 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated by dual phosphorylation on Ser-207 and Thr-211 in response to a variety of cellular stresses, including UV radiation, osmotic shock, hypoxia, inflammatory cytokines, interferon gamma (IFNG), and less often by growth factors. MAP2K6/MKK6 is activated by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	82	ATPPROSITE-ProRule annotation		1
Active siteⁱ	179	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	59 – 67	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19141286
MAP kinase kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8663524
- 9218798
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8663524
- 9218798
activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
apoptotic process Source: UniProtKB-KW
cardiac muscle contraction Source: Ensembl
cell cycle arrest
Source: ProtInc
Traceable author statementⁱ
- 10848581
cellular response to sorbitol Source: Ensembl
DNA damage induced protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 10848581
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 29021624
nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
ovulation cycle process Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
positive regulation of prostaglandin secretion Source: Ensembl
response to drug Source: Ensembl
response to ischemia Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8621675
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological process	Apoptosis, Stress response, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-375170 CDO in myogenesis R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-6811555 PI5P Regulates TP53 Acetylation R-HSA-9020702 Interleukin-1 signaling
SignaLinkⁱ	P52564
SIGNORⁱ	P52564

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity mitogen-activated protein kinase kinase 6 (EC:2.7.12.2) Short name: MAP kinase kinase 6 Short name: MAPKK 6 Alternative name(s): MAPK/ERK kinase 6 Short name: MEK 6 Stress-activated protein kinase kinase 3 Short name: SAPK kinase 3 Short name: SAPKK-3 Short name: SAPKK3
Gene namesⁱ	Name:MAP2K6 Synonyms:MEK6, MKK6, PRKMK6, SKK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108984.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6846 MAP2K6
MIMⁱ	601254 gene
neXtProtⁱ	NX_P52564

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	207	S → A: Inactivation.	1
Mutagenesisⁱ	207	S → E: Constitutive activation according to PubMed:8622669, but not to PubMed:8621675.	1
Mutagenesisⁱ	211	T → A: Inactivation.	1
Mutagenesisⁱ	211	T → E: Constitutive activation according to PubMed:8622669, but not to PubMed:8621675.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5608
Open Targets More...OpenTargetsⁱ	ENSG00000108984
PharmGKBⁱ	PA30591

Chemistry databases

ChEMBLⁱ	CHEMBL2171
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2067

Polymorphism and mutation databases

BioMutaⁱ	MAP2K6
DMDMⁱ	1709088

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086386	1 – 334	Dual specificity mitogen-activated protein kinase kinase 6Add BLAST		334

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	207	O-acetylserine; by Yersinia yopJ; alternate1 Publication	1
Modified residueⁱ	207	Phosphoserine; by MAP3K; alternate1 Publication	1
Modified residueⁱ	211	O-acetylthreonine; by Yersinia yopJ; alternate1 Publication	1
Modified residueⁱ	211	Phosphothreonine; by MAP3K; alternate1 Publication	1

Post-translational modificationⁱ

Weakly autophosphorylated. Phosphorylated at Ser-207 and Thr-211 by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.1 Publication

Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	14 – 15	Cleavage; by anthrax lethal factor		2

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P52564
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P52564
PaxDbⁱ	P52564
PeptideAtlas More...PeptideAtlasⁱ	P52564
PRIDEⁱ	P52564
ProteomicsDBⁱ	56487 56488 [P52564-2]

PTM databases

iPTMnetⁱ	P52564
PhosphoSitePlusⁱ	P52564

Miscellaneous databases

PMAP-CutDBⁱ	P52564

PMAP-CutDBⁱ

P52564

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.1 Publication

Inductionⁱ

Strongly activated by UV, anisomycin, and osmotic shock but not by phorbol esters, NGF or EGF.

Gene expression databases

Bgeeⁱ	ENSG00000108984 Expressed in 203 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MAP2K6
ExpressionAtlasⁱ	P52564 baseline and differential
Genevisibleⁱ	P52564 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB007744 HPA031134

HPAⁱ

CAB007744
HPA031134

Interactionⁱ

Subunit structureⁱ

Dimer. Interacts with Yersinia yopJ. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GADD45A	P24522	2	EBI-448135,EBI-448167
LRRK2	Q5S007	4	EBI-448135,EBI-5323863
MAP3K4	Q9Y6R4	2	EBI-448135,EBI-448104

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19141286
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111594, 27 interactors
Database of interacting proteins More...DIPⁱ	DIP-31346N
ELMⁱ	P52564
IntActⁱ	P52564, 12 interactors
Molecular INTeraction database More...MINTⁱ	P52564
STRINGⁱ	9606.ENSP00000468348

Chemistry databases

BindingDBⁱ

P52564

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	50 – 52	Combined sources	3
Beta strandⁱ	53 – 61	Combined sources	9
Beta strandⁱ	63 – 72	Combined sources	10
Turnⁱ	73 – 76	Combined sources	4
Beta strandⁱ	77 – 84	Combined sources	8
Helixⁱ	90 – 104	Combined sources	15
Turnⁱ	110 – 112	Combined sources	3
Beta strandⁱ	115 – 120	Combined sources	6
Beta strandⁱ	122 – 130	Combined sources	9
Beta strandⁱ	133 – 135	Combined sources	3
Helixⁱ	136 – 145	Combined sources	10
Helixⁱ	152 – 172	Combined sources	21
Helixⁱ	182 – 184	Combined sources	3
Beta strandⁱ	185 – 187	Combined sources	3
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	201 – 203	Combined sources	3
Helixⁱ	207 – 212	Combined sources	6
Helixⁱ	222 – 225	Combined sources	4
Helixⁱ	236 – 252	Combined sources	17
Helixⁱ	263 – 272	Combined sources	10
Turnⁱ	280 – 282	Combined sources	3
Helixⁱ	285 – 294	Combined sources	10
Helixⁱ	299 – 301	Combined sources	3
Helixⁱ	305 – 308	Combined sources	4
Helixⁱ	312 – 319	Combined sources	8
Helixⁱ	324 – 332	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P52564
SMRⁱ	P52564
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P52564

EvolutionaryTraceⁱ

P52564

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	53 – 314	Protein kinasePROSITE-ProRule annotationAdd BLAST		262

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	4 – 19	D domainBy similarityAdd BLAST		16
Regionⁱ	311 – 334	DVD domainAdd BLAST		24

Domainⁱ

The DVD domain (residues 311-334) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.1 Publication

The D domain (residues 4-19) contains a conserved docking site and is required for the binding to MAPK substrates.By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P52564
KEGG Orthology (KO) More...KOⁱ	K04433
OMAⁱ	WGTPFEQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9H
PhylomeDBⁱ	P52564

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P52564-1) [UniParc]FASTA Add to basket

Also known as: MKK6b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA 
        60         70         80         90        100
DDLEPIMELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL 
       110        120        130        140        150
DISMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI 
       160        170        180        190        200
PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINAL GQVKMCDFGI 
       210        220        230        240        250
SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL 
       260        270        280        290        300
AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK 
       310        320        330 
ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD

Length:334

Mass (Da):37,492

Last modified:October 1, 1996 - v1

Checksum:ⁱ4ECA8014522216AF

GO

Isoform 2 (identifier: P52564-2) [UniParc]FASTA Add to basket

Also known as: MKK6

The sequence of this isoform differs from the canonical sequence as follows:
1-56: Missing.

« Hide

        10         20         30         40         50
MELGRGAYGV VEKMRHVPSG QIMAVKRIRA TVNSQEQKRL LMDLDISMRT 
        60         70         80         90        100
VDCPFTVTFY GALFREGDVW ICMELMDTSL DKFYKQVIDK GQTIPEDILG 
       110        120        130        140        150
KIAVSIVKAL EHLHSKLSVI HRDVKPSNVL INALGQVKMC DFGISGYLVD 
       160        170        180        190        200
SVAKTIDAGC KPYMAPERIN PELNQKGYSV KSDIWSLGIT MIELAILRFP 
       210        220        230        240        250
YDSWGTPFQQ LKQVVEEPSP QLPADKFSAE FVDFTSQCLK KNSKERPTYP 
       260        270 
ELMQHPFFTL HESKGTDVAS FVKLILGD

Show »

Length:278

Mass (Da):31,339

Checksum:ⁱ1EE7FC1B26B11AE4

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EIW3	K7EIW3_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 6	MAP2K6	128	Annotation score:
K7ELM6	K7ELM6_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 6	MAP2K6	84	Annotation score:
A0A0A0MRF7	A0A0A0MRF7_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 6	MAP2K6	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	125	V → M in AAB03705 (PubMed:8621675).Curated		1
Sequence conflictⁱ	125	V → M in AAB03708 (PubMed:8621675).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004882	1 – 56	Missing in isoform 2. 1 PublicationAdd BLAST		56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39657 mRNA Translation: AAC50389.1 U39656 mRNA Translation: AAC50388.1 U49732 mRNA Translation: AAB05035.1 U39065 mRNA Translation: AAB03705.1 U39064 mRNA Translation: AAB03708.1 D87905 mRNA Translation: BAA13496.1 X96757 mRNA Translation: CAA65532.1 BC012009 mRNA Translation: AAH12009.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11686.1 [P52564-1] CCDS82194.1 [P52564-2]
PIRⁱ	S71631
NCBI Reference Sequences More...RefSeqⁱ	NP_002749.2, NM_002758.3 [P52564-1]
UniGeneⁱ	Hs.463978 Hs.49329

Genome annotation databases

Ensemblⁱ	ENST00000589647; ENSP00000467213; ENSG00000108984 [P52564-2] ENST00000590474; ENSP00000468348; ENSG00000108984 [P52564-1] ENST00000613873; ENSP00000477701; ENSG00000108984 [P52564-2]
GeneIDⁱ	5608
KEGGⁱ	hsa:5608
UCSC genome browser More...UCSCⁱ	uc002jij.4 human [P52564-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52564	Mitogen-activated protein kinase kinase 6		HUMAN		334	UniRef100_P52564
MAP2K6 isoform 1		PANTR		334
Dual specificity mitogen-activated protein kinase kinase 6		MACMU		334
MAP2K6 isoform 1		PONAB		334
Uncharacterized protein		CERAT		334
+25

Protein	Similar proteins		Species	Score	Length	Source
P52564	Mitogen-activated protein kinase kinase 6		HUMAN		334	UniRef90_P52564
MAP2K6 isoform 1		PANTR		334
Dual specificity mitogen-activated protein kinase kinase 6		MACMU		334
MAP2K6 isoform 1		PONAB		334
Uncharacterized protein		CERAT		334
+105

Protein	Similar proteins		Species	Score	Length	Source
P52564	Dual specificity mitogen-activated protein kinase kinase 6		DANRE		361	UniRef50_P52564
Dual specificity mitogen-activated protein kinase kinase 6		BOVIN		334
Dual specificity mitogen-activated protein kinase kinase 6		MOUSE		334
Mitogen-activated protein kinase kinase 6		HUMAN		334
MAP2K6 isoform 1		PANTR		334
+490

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39657 mRNA Translation: AAC50389.1 U39656 mRNA Translation: AAC50388.1 U49732 mRNA Translation: AAB05035.1 U39065 mRNA Translation: AAB03705.1 U39064 mRNA Translation: AAB03708.1 D87905 mRNA Translation: BAA13496.1 X96757 mRNA Translation: CAA65532.1 BC012009 mRNA Translation: AAH12009.1
CCDSⁱ	CCDS11686.1 [P52564-1] CCDS82194.1 [P52564-2]
PIRⁱ	S71631
RefSeqⁱ	NP_002749.2, NM_002758.3 [P52564-1]
UniGeneⁱ	Hs.463978 Hs.49329

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Y8O	X-ray	1.95	B	4-17	[»]
	3ENM	X-ray	2.35	A/B/C/D	45-332	[»]
	3FME	X-ray	2.26	A	47-334	[»]
	3VN9	X-ray	2.60	A	1-334	[»]
	5ETF	X-ray	2.40	B	4-17	[»]
ProteinModelPortalⁱ	P52564
SMRⁱ	P52564
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111594, 27 interactors
DIPⁱ	DIP-31346N
ELMⁱ	P52564
IntActⁱ	P52564, 12 interactors
MINTⁱ	P52564
STRINGⁱ	9606.ENSP00000468348

Chemistry databases

BindingDBⁱ	P52564
ChEMBLⁱ	CHEMBL2171
GuidetoPHARMACOLOGYⁱ	2067

PTM databases

iPTMnetⁱ	P52564
PhosphoSitePlusⁱ	P52564

Polymorphism and mutation databases

BioMutaⁱ	MAP2K6
DMDMⁱ	1709088

Proteomic databases

EPDⁱ	P52564
MaxQBⁱ	P52564
PaxDbⁱ	P52564
PeptideAtlasⁱ	P52564
PRIDEⁱ	P52564
ProteomicsDBⁱ	56487 56488 [P52564-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5608
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000589647; ENSP00000467213; ENSG00000108984 [P52564-2] ENST00000590474; ENSP00000468348; ENSG00000108984 [P52564-1] ENST00000613873; ENSP00000477701; ENSG00000108984 [P52564-2]
GeneIDⁱ	5608
KEGGⁱ	hsa:5608
UCSCⁱ	uc002jij.4 human [P52564-1]

Organism-specific databases

CTDⁱ	5608
DisGeNETⁱ	5608
EuPathDBⁱ	HostDB:ENSG00000108984.13
GeneCardsⁱ	MAP2K6
HGNCⁱ	HGNC:6846 MAP2K6
HPAⁱ	CAB007744 HPA031134
MIMⁱ	601254 gene
neXtProtⁱ	NX_P52564
OpenTargetsⁱ	ENSG00000108984
PharmGKBⁱ	PA30591
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P52564
KOⁱ	K04433
OMAⁱ	WGTPFEQ
OrthoDBⁱ	EOG091G0A9H
PhylomeDBⁱ	P52564

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-375170 CDO in myogenesis R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-6811555 PI5P Regulates TP53 Acetylation R-HSA-9020702 Interleukin-1 signaling
SignaLinkⁱ	P52564
SIGNORⁱ	P52564

Miscellaneous databases

ChiTaRSⁱ	MAP2K6 human
EvolutionaryTraceⁱ	P52564
GeneWikiⁱ	MAP2K6
GenomeRNAiⁱ	5608
PMAP-CutDBⁱ	P52564
Protein Ontology More...PROⁱ	PR:P52564
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108984 Expressed in 203 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MAP2K6
ExpressionAtlasⁱ	P52564 baseline and differential
Genevisibleⁱ	P52564 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MP2K6_HUMAN
Accessionⁱ	P52564Primary (citable) accession number: P52564
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P52564 (MP2K6_HUMAN)

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Dual specificity mitogen-activated protein kinase kinase 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ