UniProtKB - P52556 (BLVRB_BOVIN)
Protein
Flavin reductase (NADPH)
Gene
BLVRB
Organism
Bos taurus (Bovine)
Status
Functioni
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe3+ iron to Fe2+ in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | NADPBy similarity | 1 | |
Binding sitei | 132 | NADPBy similarity | 1 | |
Binding sitei | 153 | SubstrateBy similarity | 1 | |
Binding sitei | 154 | NADP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 15 | NADPBy similarity | 6 | |
Nucleotide bindingi | 54 – 55 | NADPBy similarity | 2 | |
Nucleotide bindingi | 75 – 78 | NADPBy similarity | 4 |
GO - Molecular functioni
- biliberdin reductase NAD+ activity Source: UniProtKB-EC
- biliverdin reductase (NAD(P)+) activity Source: UniProtKB
- biliverdin reductase (NADP+) activity Source: UniProtKB-EC
- riboflavin reductase (NADPH) activity Source: UniProtKB
GO - Biological processi
- heme catabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Flavin reductase (NADPH) (EC:1.5.1.30By similarity)Short name: FR Alternative name(s): Biliverdin-IX beta-reductase Green heme-binding protein Short name: GHBP NADPH-dependent diaphorase NADPH-flavin reductase Short name: FLR |
Gene namesi | Name:BLVRB |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:26511, BLVRB |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000064947 | 2 – 206 | Flavin reductase (NADPH)Add BLAST | 205 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphoserineBy similarity | 1 | |
Modified residuei | 82 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P52556 |
PeptideAtlasi | P52556 |
PRIDEi | P52556 |
Expressioni
Tissue specificityi
At least expressed in the liver and erythrocyte.
Gene expression databases
Bgeei | ENSBTAG00000010508, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | P52556, baseline and differential |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013889 |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502RY9R, Eukaryota |
GeneTreei | ENSGT00390000014810 |
HOGENOMi | CLU_025711_2_0_1 |
InParanoidi | P52556 |
OMAi | MTGECAV |
OrthoDBi | 1166292at2759 |
TreeFami | TF324063 |
Family and domain databases
InterProi | View protein in InterPro IPR016040, NAD(P)-bd_dom IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF13460, NAD_binding_10, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P52556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVVKKIALFG ATGNTGLTTL AQAVQAGYEV TVLVRDPSRL PSEGPQPAHV
60 70 80 90 100
VVGDVRQPAD VDKTVAGQDA VIVLLGTRND LSPTTVMSEG AQNIVAAMKA
110 120 130 140 150
HGVDKVVACT SAFLLWDPSK VPPRLQDVTD DHIRMHKVLQ QSGLKYVAVM
160 170 180 190 200
PPHIGDHPLT GAYTVTLDGR GPSRVISKHD LGHFMLHCLT TDKYDGHTTY
PSHVYE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1NNJ3 | A0A3Q1NNJ3_BOVIN | Flavin reductase (NADPH) | BLVRB | 190 | Annotation score: |
Mass spectrometryi
Molecular mass is 21994 Da. Determined by ESI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35045 mRNA Translation: AAC37323.1 BC102269 mRNA Translation: AAI02270.1 |
PIRi | S68597 |
RefSeqi | NP_776676.1, NM_174251.1 |
Genome annotation databases
Ensembli | ENSBTAT00000013889; ENSBTAP00000013889; ENSBTAG00000010508 |
GeneIDi | 281650 |
KEGGi | bta:281650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35045 mRNA Translation: AAC37323.1 BC102269 mRNA Translation: AAI02270.1 |
PIRi | S68597 |
RefSeqi | NP_776676.1, NM_174251.1 |
3D structure databases
SMRi | P52556 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013889 |
Proteomic databases
PaxDbi | P52556 |
PeptideAtlasi | P52556 |
PRIDEi | P52556 |
Genome annotation databases
Ensembli | ENSBTAT00000013889; ENSBTAP00000013889; ENSBTAG00000010508 |
GeneIDi | 281650 |
KEGGi | bta:281650 |
Organism-specific databases
CTDi | 645 |
VGNCi | VGNC:26511, BLVRB |
Phylogenomic databases
eggNOGi | ENOG502RY9R, Eukaryota |
GeneTreei | ENSGT00390000014810 |
HOGENOMi | CLU_025711_2_0_1 |
InParanoidi | P52556 |
OMAi | MTGECAV |
OrthoDBi | 1166292at2759 |
TreeFami | TF324063 |
Gene expression databases
Bgeei | ENSBTAG00000010508, Expressed in spleen and 18 other tissues |
ExpressionAtlasi | P52556, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR016040, NAD(P)-bd_dom IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF13460, NAD_binding_10, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BLVRB_BOVIN | |
Accessioni | P52556Primary (citable) accession number: P52556 Secondary accession number(s): Q3T0T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |