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Protein

Adenylyl cyclase-associated protein 2

Gene

Cap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a regulatory bifunctional role.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 2
Short name:
CAP 2
Gene namesi
Name:Cap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620310 Cap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002057022 – 477Adenylyl cyclase-associated protein 2Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei301PhosphoserineCombined sources1
Modified residuei309PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP52481
PRIDEiP52481

PTM databases

iPTMnetiP52481
PhosphoSitePlusiP52481

Expressioni

Tissue specificityi

Found at relatively high levels in testes, at moderate levels in brain, heart and skeletal muscle, at lower levels in lung, skin, kidney and small intestine, and is undetectable in liver or spleen.

Gene expression databases

BgeeiENSRNOG00000043350
GenevisibleiP52481 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250538, 1 interactor
STRINGi10116.ENSRNOP00000062591

Structurei

3D structure databases

ProteinModelPortaliP52481
SMRiP52481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 455C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi233 – 247Poly-ProAdd BLAST15

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOVERGENiHBG003080
InParanoidiP52481
KOiK17261
OMAiDIQIQVM
OrthoDBiEOG091G0DLX
PhylomeDBiP52481

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028418 CAP2
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF2 PTHR10652:SF2, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMLGLMQR LEFAVSRLER LSSGLHEPPG GCGEVNSLSR GIVAPSVEAF
60 70 80 90 100
DKLINSMVAE FLKNSRVLAG DVETHAEMVH GAFQAQRAFL LMVSQHQQPQ
110 120 130 140 150
ENEVAVLLKP ISEKIQEIQT FRERNRGSDM FNHLSAVSES IAALGWIAVS
160 170 180 190 200
PKPGPYVKEM NDAATFYTNR VLRDYKHSDL RHVDWVRSYL KIWSELQAYI
210 220 230 240 250
KEHHTTGLTW SKTGPVASTA SAFSILSSGP GLPPPPPPPP PPGPPPPFEN
260 270 280 290 300
EGGKEEPSPS RSALFAQLNQ GEAITKGLRH VTDDKKIYKN PSLRAQGQIR
310 320 330 340 350
SPTKTRTPSP TSSKSNSPQK HAPVLELEGK KWRVEYQEDR NDLVISETEL
360 370 380 390 400
KQVAYIFKCD KSTLQIKGKV NSITVDNCKK FGLVFDHVVG IVEVINSKDI
410 420 430 440 450
QIQVMGRVPT ISINKTEGCH LYLSKDALDC EIVSAKSSEM NVLVPQGDDY
460 470
REFPIPEQFK TIWDGSKLIT EPAEIMA
Length:477
Mass (Da):52,912
Last modified:October 1, 1996 - v1
Checksum:iCFCD65E8F256655B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31935 mRNA Translation: AAA92298.1
PIRiJC4386
RefSeqiNP_446326.1, NM_053874.1
XP_006253815.1, XM_006253753.3
XP_006253816.1, XM_006253754.2
UniGeneiRn.10229

Genome annotation databases

EnsembliENSRNOT00000065742; ENSRNOP00000062591; ENSRNOG00000043350
ENSRNOT00000078992; ENSRNOP00000074020; ENSRNOG00000043350
GeneIDi116653
KEGGirno:116653

Similar proteinsi

Entry informationi

Entry nameiCAP2_RAT
AccessioniPrimary (citable) accession number: P52481
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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