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UniProtKB - P52435 (RPB11_HUMAN)

Entry version 190 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

DNA-directed RNA polymerase II subunit RPB11-a

Gene

POLR2J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P52435

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-113418, Formation of the Early Elongation Complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158, Formation of the HIV-1 Early Elongation Complex
R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-203927, MicroRNA (miRNA) biogenesis
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529, FGFR2 alternative splicing
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-72086, mRNA Capping
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-75955, RNA Polymerase II Transcription Elongation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708, Signaling by FGFR2 IIIa TM
R-HSA-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11-a
Short name:
RNA polymerase II subunit B11-a
Short name:
RPB11a
Alternative name(s):
DNA-directed RNA polymerase II subunit J-1
RNA polymerase II 13.3 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR2J
Synonyms:POLR2J1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000005075.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:9197, POLR2J

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52435

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5439

Open Targets

More...OpenTargetsi		ENSG00000005075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33517

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52435, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLR2J

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001493091 – 117DNA-directed RNA polymerase II subunit RPB11-aAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P52435

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P52435

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52435

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52435

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52435

PeptideAtlas

More...PeptideAtlasi		P52435

PRoteomics IDEntifications database

More...PRIDEi		P52435

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56486

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52435

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52435

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. High expression was found in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000005075, Expressed in gastrocnemius and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52435, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52435, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000005075, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

Interacts with AATF.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111435, 95 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P52435

Database of interacting proteins

More...DIPi		DIP-32913N

Protein interaction database and analysis system

More...IntActi		P52435, 45 interactors

Molecular INTeraction database

More...MINTi		P52435

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52435, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52435

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4392, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_090381_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52435

KEGG Orthology (KO)

More...KOi		K03008

Identification of Orthologs from Complete Genome Data

More...OMAi		HKFVLRI

Database of Orthologous Groups

More...OrthoDBi		1398114at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52435

TreeFam database of animal gene trees

More...TreeFami		TF103044

Family and domain databases

Conserved Domains Database

More...CDDi		cd06926, RNAP_II_RPB11, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1360.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037685, RBP11
IPR036603, RBP11-like
IPR009025, RBP11-like_dimer
IPR008193, RNA_pol_Rpb11_13-16kDa_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13656, RNA_pol_L_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55257, SSF55257, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01154, RNA_POL_L_13KD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P52435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAPPAFESF LLFEGEKKIT INKDTKVPNA CLFTINKEDH TLGNIIKSQL 
        60         70         80         90        100
LKDPQVLFAG YKVPHPLEHK IIIRVQTTPD YSPQEAFTNA ITDLISELSL 
       110 
LEERFRVAIK DKQEGIE
Length:117
Mass (Da):13,293
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F78AB256EF8F647
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S314F6S314_HUMAN
DNA-directed RNA polymerase II subu...
POLR2J
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82385 mRNA Translation: CAA57785.1
L37127 mRNA Translation: AAD05361.1
X98433 mRNA Translation: CAA67075.1
AK290515 mRNA Translation: BAF83204.1
AC093668 Genomic DNA No translation available.
BC024165 mRNA Translation: AAH24165.1
BC065711 mRNA Translation: AAH65711.1
BC139902 mRNA Translation: AAI39903.1
BC141830 mRNA Translation: AAI41831.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5724.1

Protein sequence database of the Protein Information Resource

More...PIRi		S71325

NCBI Reference Sequences

More...RefSeqi		NP_006225.1, NM_006234.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292614; ENSP00000292614; ENSG00000005075

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5439

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5439

UCSC genome browser

More...UCSCi		uc003uzp.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82385 mRNA Translation: CAA57785.1
L37127 mRNA Translation: AAD05361.1
X98433 mRNA Translation: CAA67075.1
AK290515 mRNA Translation: BAF83204.1
AC093668 Genomic DNA No translation available.
BC024165 mRNA Translation: AAH24165.1
BC065711 mRNA Translation: AAH65711.1
BC139902 mRNA Translation: AAI39903.1
BC141830 mRNA Translation: AAI41831.1
CCDSiCCDS5724.1
PIRiS71325
RefSeqiNP_006225.1, NM_006234.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IY6electron microscopy7.20K1-117[»]
5IY7electron microscopy8.60K1-117[»]
5IY8electron microscopy7.90K1-117[»]
5IY9electron microscopy6.30K1-117[»]
5IYAelectron microscopy5.40K1-117[»]
5IYBelectron microscopy3.90K1-117[»]
5IYCelectron microscopy3.90K1-117[»]
5IYDelectron microscopy3.90K1-117[»]
6DRDelectron microscopy3.90K1-117[»]
6O9Lelectron microscopy7.20K1-117[»]
SMRiP52435
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111435, 95 interactors
CORUMiP52435
DIPiDIP-32913N
IntActiP52435, 45 interactors
MINTiP52435
STRINGi9606.ENSP00000292614

PTM databases

iPTMnetiP52435
PhosphoSitePlusiP52435

Polymorphism and mutation databases

BioMutaiPOLR2J

Proteomic databases

EPDiP52435
jPOSTiP52435
MassIVEiP52435
MaxQBiP52435
PaxDbiP52435
PeptideAtlasiP52435
PRIDEiP52435
ProteomicsDBi56486

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31080, 283 antibodies

The DNASU plasmid repository

More...DNASUi		5439

Genome annotation databases

EnsembliENST00000292614; ENSP00000292614; ENSG00000005075
GeneIDi5439
KEGGihsa:5439
UCSCiuc003uzp.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5439
DisGeNETi5439
EuPathDBiHostDB:ENSG00000005075.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLR2J
HGNCiHGNC:9197, POLR2J
HPAiENSG00000005075, Low tissue specificity
MIMi604150, gene
neXtProtiNX_P52435
OpenTargetsiENSG00000005075
PharmGKBiPA33517

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4392, Eukaryota
GeneTreeiENSGT00550000074975
HOGENOMiCLU_090381_2_2_1
InParanoidiP52435
KOiK03008
OMAiHKFVLRI
OrthoDBi1398114at2759
PhylomeDBiP52435
TreeFamiTF103044

Enzyme and pathway databases

PathwayCommonsiP52435
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-113418, Formation of the Early Elongation Complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158, Formation of the HIV-1 Early Elongation Complex
R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-203927, MicroRNA (miRNA) biogenesis
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529, FGFR2 alternative splicing
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-72086, mRNA Capping
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-75955, RNA Polymerase II Transcription Elongation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708, Signaling by FGFR2 IIIa TM
R-HSA-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5439, 408 hits in 512 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLR2J, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POLR2J

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5439
PharosiP52435, Tbio

Protein Ontology

More...PROi		PR:P52435
RNActiP52435, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000005075, Expressed in gastrocnemius and 125 other tissues
ExpressionAtlasiP52435, baseline and differential
GenevisibleiP52435, HS

Family and domain databases

CDDicd06926, RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685, RBP11
IPR036603, RBP11-like
IPR009025, RBP11-like_dimer
IPR008193, RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656, RNA_pol_L_2, 1 hit
SUPFAMiSSF55257, SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154, RNA_POL_L_13KD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPB11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52435
Secondary accession number(s): A5D6V8, O43375
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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