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Protein

Serum paraoxonase/arylesterase 1

Gene

Pon1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.By similarity

Miscellaneous

The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei115Proton acceptorBy similarity1
Metal bindingi117Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi168Calcium 1; catalyticBy similarity1
Metal bindingi169Calcium 2By similarity1
Metal bindingi224Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1
Metal bindingi270Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2 3474
3.1.1.25 3474
3.1.8.1 3474
ReactomeiR-MMU-2142688 Synthesis of 5-eicosatetraenoic acids

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 1 (EC:3.1.1.21 Publication, EC:3.1.1.811 Publication, EC:3.1.8.11 Publication)
Short name:
PON 1
Alternative name(s):
Aromatic esterase 1
Short name:
A-esterase 1
Serum aryldialkylphosphatase 1
Gene namesi
Name:Pon1
Synonyms:Pon
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:103295 Pon1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232821 – 355Serum paraoxonase/arylesterase 1Add BLAST355
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 353By similarity
Glycosylationi253N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP52430
PaxDbiP52430
PeptideAtlasiP52430
PRIDEiP52430

PTM databases

iPTMnetiP52430
PhosphoSitePlusiP52430
SwissPalmiP52430

Expressioni

Tissue specificityi

Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.

Gene expression databases

BgeeiENSMUSG00000002588 Expressed in 98 organ(s), highest expression level in pigmented layer of retina
CleanExiMM_PON1
ExpressionAtlasiP52430 baseline and differential
GenevisibleiP52430 MM

Interactioni

Subunit structurei

Homodimer. Interacts with CLU.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP52430, 2 interactors
MINTiP52430
STRINGi10090.ENSMUSP00000002663

Structurei

3D structure databases

ProteinModelPortaliP52430
SMRiP52430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOGENOMiHOG000252960
HOVERGENiHBG003604
InParanoidiP52430
KOiK01045
OMAiNCNLVKG
OrthoDBiEOG091G0AV9
PhylomeDBiP52430
TreeFamiTF322436

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008363 Paraoxonase1
PANTHERiPTHR11799:SF16 PTHR11799:SF16, 1 hit
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01786 PARAOXONASE1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P52430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKLLALTLV GLVLALYKNH RSSYQTRLNA FREVTPVELP NCNLVKGIET
60 70 80 90 100
GAEDLEILPN GLTFFSTGLK YPGIKSFDPS KPGKILLMDL NKKEPAVSEL
110 120 130 140 150
EIIGNTLDIS SFNPHGISTF TDEDNTVYLL VVNHPDSSST VEVFKFQEEE
160 170 180 190 200
RSLLHLKTIT HELLPSINDI AAIGPESFYA TNDHYFADPY LRSWEMYLGL
210 220 230 240 250
SWSNVVYYSP DKVQVVAEGF DFANGIGISL DGKYVYIAEL LAHKIHVYEK
260 270 280 290 300
HANWTLTPLK VLNFDTLVDN ISVDPVTGDL WVGCHPNGMR IFFYDAENPP
310 320 330 340 350
GSEVLRIQNI LSEDPKITVV YAENGTVLQG TTVASVYKGK LLIGTVFHKA

LYCDL
Length:355
Mass (Da):39,565
Last modified:January 23, 2007 - v2
Checksum:iFFA0A71445BB80B4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BK03H3BK03_MOUSE
Serum paraoxonase/arylesterase 1
Pon1
236Annotation score:
H3BLB8H3BLB8_MOUSE
Paraoxonase 1, isoform CRA_c
Pon1 mCG_128293
181Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61G → E in AAH12706 (PubMed:15489334).Curated1
Sequence conflicti186F → L in AAC52496 (PubMed:8601628).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40488 Genomic DNA Translation: AAA99445.1
U32684 mRNA Translation: AAC52496.1
U72636 mRNA Translation: AAB17394.1
BC012706 mRNA Translation: AAH12706.1
CCDSiCCDS19898.1
PIRiT10082
RefSeqiNP_035264.2, NM_011134.3
UniGeneiMm.237657

Genome annotation databases

EnsembliENSMUST00000002663; ENSMUSP00000002663; ENSMUSG00000002588
GeneIDi18979
KEGGimmu:18979
UCSCiuc009awd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40488 Genomic DNA Translation: AAA99445.1
U32684 mRNA Translation: AAC52496.1
U72636 mRNA Translation: AAB17394.1
BC012706 mRNA Translation: AAH12706.1
CCDSiCCDS19898.1
PIRiT10082
RefSeqiNP_035264.2, NM_011134.3
UniGeneiMm.237657

3D structure databases

ProteinModelPortaliP52430
SMRiP52430
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52430, 2 interactors
MINTiP52430
STRINGi10090.ENSMUSP00000002663

PTM databases

iPTMnetiP52430
PhosphoSitePlusiP52430
SwissPalmiP52430

Proteomic databases

MaxQBiP52430
PaxDbiP52430
PeptideAtlasiP52430
PRIDEiP52430

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002663; ENSMUSP00000002663; ENSMUSG00000002588
GeneIDi18979
KEGGimmu:18979
UCSCiuc009awd.2 mouse

Organism-specific databases

CTDi5444
MGIiMGI:103295 Pon1

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOGENOMiHOG000252960
HOVERGENiHBG003604
InParanoidiP52430
KOiK01045
OMAiNCNLVKG
OrthoDBiEOG091G0AV9
PhylomeDBiP52430
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 3474
3.1.1.25 3474
3.1.8.1 3474
ReactomeiR-MMU-2142688 Synthesis of 5-eicosatetraenoic acids

Miscellaneous databases

PROiPR:P52430
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002588 Expressed in 98 organ(s), highest expression level in pigmented layer of retina
CleanExiMM_PON1
ExpressionAtlasiP52430 baseline and differential
GenevisibleiP52430 MM

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008363 Paraoxonase1
PANTHERiPTHR11799:SF16 PTHR11799:SF16, 1 hit
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01786 PARAOXONASE1
ProtoNetiSearch...

Entry informationi

Entry nameiPON1_MOUSE
AccessioniPrimary (citable) accession number: P52430
Secondary accession number(s): Q91X30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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