UniProtKB - P52410 (KASC1_ARATH)
3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
KAS1
Functioni
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).
By similarityCatalytic activityi
- EC:2.3.1.41
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 224 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | ARA:AT5G46290-MONOMER |
BRENDAi | 2.3.1.41, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic (EC:2.3.1.41)Alternative name(s): Beta-ketoacyl-ACP synthase I Short name: KAS I |
Gene namesi | Name:KAS1 Ordered Locus Names:At5g46290 ORF Names:MPL12.7 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G46290 |
Subcellular locationi
Chloroplast
- chloroplast stroma 1 Publication
Chloroplast
- chloroplast stroma Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 46 | ChloroplastSequence analysisAdd BLAST | 46 | |
ChainiPRO_0000000586 | 47 – 473 | 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplasticAdd BLAST | 427 |
Proteomic databases
PaxDbi | P52410 |
PRIDEi | P52410 |
ProteomicsDBi | 250616 [P52410-1] |
Expressioni
Gene expression databases
ExpressionAtlasi | P52410, baseline and differential |
Genevisiblei | P52410, AT |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 19920, 1 interactor |
STRINGi | 3702.AT5G46290.3 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1394, Eukaryota |
HOGENOMi | CLU_000022_69_2_1 |
InParanoidi | P52410 |
OMAi | AEADPEC |
PhylomeDBi | P52410 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQALQSSSLR ASPPNPLRLP SNRQSHQLIT NARPLRRQQR SFISASASTV
60 70 80 90 100
SAPKRETDPK KRVVITGMGL VSVFGNDVDA YYEKLLSGES GISLIDRFDA
110 120 130 140 150
SKFPTRFGGQ IRGFSSEGYI DGKNERRLDD CLKYCIVAGK KALESANLGG
160 170 180 190 200
DKLNTIDKRK AGVLVGTGMG GLTVFSEGVQ NLIEKGHRRI SPFFIPYAIT
210 220 230 240 250
NMGSALLAID LGLMGPNYSI STACATSNYC FYAAANHIRR GEADMMIAGG
260 270 280 290 300
TEAAIIPIGL GGFVACRALS QRNDDPQTAS RPWDKARDGF VMGEGAGVLV
310 320 330 340 350
MESLEHAMKR GAPIVAEYLG GAVNCDAHHM TDPRADGLGV SSCIERCLED
360 370 380 390 400
AGVSPEEVNY INAHATSTLA GDLAEINAIK KVFKSTSGIK INATKSMIGH
410 420 430 440 450
CLGAAGGLEA IATVKAINTG WLHPSINQFN PEQAVDFDTV PNEKKQHEVD
460 470
VAISNSFGFG GHNSVVAFSA FKP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4KHF4 | F4KHF4_ARATH | Beta-ketoacyl-[acyl-carrier-protein... | KASI KAS1, KETOACYL-ACP SYNTHASE 1, MPL12.7, MPL12_7, At5g46290 | 489 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | F → C in AAC49118 (Ref. 1) Curated | 1 | |
Sequence conflicti | 238 – 239 | IR → NH in AAC49118 (Ref. 1) Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040746 | 198 – 252 | Missing in isoform 2. CuratedAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24177 mRNA Translation: AAC49118.1 AB010698 Genomic DNA Translation: BAB11084.1 CP002688 Genomic DNA Translation: AED95363.1 CP002688 Genomic DNA Translation: AED95364.1 AY037261 mRNA Translation: AAK59862.1 AY094005 mRNA Translation: AAM16266.1 AY123979 mRNA Translation: AAM74493.1 AY087843 mRNA Translation: AAM65396.1 |
RefSeqi | NP_001032018.1, NM_001036941.1 [P52410-2] NP_199441.1, NM_123998.3 [P52410-1] |
Genome annotation databases
EnsemblPlantsi | AT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1] AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2] |
GeneIDi | 834671 |
Gramenei | AT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1] AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2] |
KEGGi | ath:AT5G46290 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24177 mRNA Translation: AAC49118.1 AB010698 Genomic DNA Translation: BAB11084.1 CP002688 Genomic DNA Translation: AED95363.1 CP002688 Genomic DNA Translation: AED95364.1 AY037261 mRNA Translation: AAK59862.1 AY094005 mRNA Translation: AAM16266.1 AY123979 mRNA Translation: AAM74493.1 AY087843 mRNA Translation: AAM65396.1 |
RefSeqi | NP_001032018.1, NM_001036941.1 [P52410-2] NP_199441.1, NM_123998.3 [P52410-1] |
3D structure databases
SMRi | P52410 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 19920, 1 interactor |
STRINGi | 3702.AT5G46290.3 |
Proteomic databases
PaxDbi | P52410 |
PRIDEi | P52410 |
ProteomicsDBi | 250616 [P52410-1] |
Genome annotation databases
EnsemblPlantsi | AT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1] AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2] |
GeneIDi | 834671 |
Gramenei | AT5G46290.1; AT5G46290.1; AT5G46290 [P52410-1] AT5G46290.2; AT5G46290.2; AT5G46290 [P52410-2] |
KEGGi | ath:AT5G46290 |
Organism-specific databases
Araporti | AT5G46290 |
Phylogenomic databases
eggNOGi | KOG1394, Eukaryota |
HOGENOMi | CLU_000022_69_2_1 |
InParanoidi | P52410 |
OMAi | AEADPEC |
PhylomeDBi | P52410 |
Enzyme and pathway databases
BioCyci | ARA:AT5G46290-MONOMER |
BRENDAi | 2.3.1.41, 399 |
Miscellaneous databases
PROi | PR:P52410 |
Gene expression databases
ExpressionAtlasi | P52410, baseline and differential |
Genevisiblei | P52410, AT |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KASC1_ARATH | |
Accessioni | P52410Primary (citable) accession number: P52410 Secondary accession number(s): Q2V312, Q9FL32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | March 27, 2002 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families