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UniProtKB - P52389 (CDC2_VIGUN)
Protein
Cell division control protein 2 homolog
Gene
CDC2
Organism
Vigna unguiculata (Cowpea)
Status
Functioni
Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Catalytic activityi
Activity regulationi
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 127 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDC2 |
Organismi | Vigna unguiculata (Cowpea) |
Taxonomic identifieri | 3917 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › indigoferoid/millettioid clade › Phaseoleae › Vigna |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085761 | 1 – 294 | Cell division control protein 2 homologAdd BLAST | 294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 15 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 161 | Phosphothreonine; by CAKBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | P52389 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 287 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 284 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P52389-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQYEKVEKI GEGTYGVVYK ARDRVTDETI ALKKIRLEQE DEGVPSTAIR
60 70 80 90 100
EISLLKEMQH RNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSSPEFVKD
110 120 130 140 150
PRQVKMFLYQ ILCGIAYCHS HRVLHRDLKP QNLLIDRRTN SLKLADFGLA
160 170 180 190 200
RAFGIPVRTF THEVVTLWYR APEILLGSRH YSTPVDVWSV GCLFAEMVNR
210 220 230 240 250
RPLFPGDSEI DELFKIFRIL GTPNEETWPG VTALPDFKST FPKWPPKDLA
260 270 280 290
TMVPNLDAAG LNLLSSMLSL DPSKRITARI AVEHEYFKDI KFVP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89400 mRNA Translation: CAA61581.1 |
PIRi | S57928 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89400 mRNA Translation: CAA61581.1 |
PIRi | S57928 |
3D structure databases
AlphaFoldDBi | P52389 |
SMRi | P52389 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P52389 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC2_VIGUN | |
Accessioni | P52389Primary (citable) accession number: P52389 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |