UniProtKB - P52347 (MCP_HHV7J)
Protein
Major capsid protein
Gene
MCP
Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Functioni
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid proteinUniRule annotationShort name: MCPUniRule annotation |
Gene namesi | Name:MCPUniRule annotation Synonyms:U57 |
Organismi | Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) |
Taxonomic identifieri | 57278 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
- T=16 icosahedral viral capsid Source: UniProtKB-UniRule
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=16 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115706 | 1 – 1345 | Major capsid proteinAdd BLAST | 1345 |
Interactioni
Subunit structurei
Homomultimer. Makes the hexons and eleven out of twelve pentons.
Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.
Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.
Interacts with capsid vertex component 2/CVC2.
Interacts with the small capsomere-interacting protein/SCP.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae major capsid protein family.UniRule annotation
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
i Sequence
Sequence statusi: Complete.
P52347-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENWRTAEIF PKLDVSPNVF DDIRTQTAEQ LFENLRLYYG DDSDRYNISF
60 70 80 90 100
EALLGIYCNR TEWIDFFHTS IAVAANVIRF NDLDKMSLGK ILFYIQLPRV
110 120 130 140 150
ATGNDVTAPK ETTVLVTKYS EKHPINISFE LSAACLAHLE NTFKNTILDQ
160 170 180 190 200
MLNINAIHTV LRSLKNSADS LQRGLIYAFI KTILKKAPPQ FILKTMLENK
210 220 230 240 250
VNSKQILSKV QRSNMFQNFK NKLINSLFFL NRTSNVSFIY RYLCEMVDST
260 270 280 290 300
TESILNNTNS YVLKDGTPIN GVLLGTPNTI QILSNALSQH ISQMTMSVPV
310 320 330 340 350
SYGTFVMGKE NAVTAIAYQA IMADFSNYTK NVATETQDQN KKSEIFENQT
360 370 380 390 400
QHADLKTNII QLSDKTVVLD HLKKVYKNTN IEDPLEQKLE LTFFFPMGLY
410 420 430 440 450
ISKDSGFSTM DSRLKLNDTM ENNLPTSIYF YNKDKLLQRI DYSDLLPSLC
460 470 480 490 500
HPIIFDCSVS ERIFKNAAKP TGESFNQLCQ VEFVREPPST FLSNLYNLYE
510 520 530 540 550
MKKEIPKTTN MLKNELTTED FYKSENFTLK TELHPFFDFT YIQKNRSTDV
560 570 580 590 600
LCSPRILLGN IPLPLAPSSF HEARTNQMIE QAKTNNLNYD YTLKLVVESL
610 620 630 640 650
TNTAYPELAY IIELLIHGNK TAFQILKDVV SQCITYWYNI KHILLFCNNF
660 670 680 690 700
EMIWLITTYL GDESIPGIAY THYKNIISIL KLVKRTISIS NFNEQLCGEP
710 720 730 740 750
LVGFVNALFD NRLFPPFLNS LPKNEANAII TAGNTPLTQN TVKLRNYEVS
760 770 780 790 800
DLNRMNLLDS TEIFTDVDRP SFETIVLSKI FYFCFLPALT NNKMCGAGFD
810 820 830 840 850
VKSFILDFFY TEPFILPDDN FCELPITNNV LIELITEAVG PSHALTDLSC
860 870 880 890 900
IGKQLFKSIL YLTENTKILE IESSLDPSQR HGSSSNFKSL QHVLYNGLCL
910 920 930 940 950
VSPINVLKRY FKPIPFNRFF SDPIICGLMN IEVQTYLNIF PHYQRNDGGF
960 970 980 990 1000
PLPQALSHEF HNWQRTPFFV YASCCSNSLL SIMTLATMHC KLSPIAIILQ
1010 1020 1030 1040 1050
SRQKIHPGFA ATLVRTDCFD INCLLYSSKS ATSIMIDDPT VSTEVKDIST
1060 1070 1080 1090 1100
TYNLTQHISF LDMGLGFSSS TAIANLKRVK TDMGSKVQDL FSVFPMHAYT
1110 1120 1130 1140 1150
NPTVNSWVRH HVGIEKPNPS ETDALNILSF GKINKQSQSI LLHGQQAICE
1160 1170 1180 1190 1200
VVITPVTSDI NFYKTPKNPR GRASCMMGVD PHNESEARKS LYDHSRVDSD
1210 1220 1230 1240 1250
AFVATTNPWA SQEGSLSDVL YNINHRDQLG YNPKSYSPNA VFFTDTEIFK
1260 1270 1280 1290 1300
TNKFMFKLIS DYSIKTKTCL DSDTDIQYSC SEGTDDVTHR PCQFLQIAFP
1310 1320 1330 1340
IHCSSNQALL ESRSKNGMTQ LSETHFANFA IGECIPLQNI IESLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43400 Genomic DNA Translation: AAC54720.1 |
PIRi | T41960 |
RefSeqi | YP_073799.1, NC_001716.2 |
Genome annotation databases
GeneIDi | 3289517 |
KEGGi | vg:3289517 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43400 Genomic DNA Translation: AAC54720.1 |
PIRi | T41960 |
RefSeqi | YP_073799.1, NC_001716.2 |
3D structure databases
SMRi | P52347 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 3289517 |
KEGGi | vg:3289517 |
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_HHV7J | |
Accessioni | P52347Primary (citable) accession number: P52347 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families