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Protein

Tyrosine-protein kinase JAK3

Gene

JAK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei855ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei949Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi828 – 836ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processAdaptive immunity, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.2 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1266695 Interleukin-7 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P52333

SIGNOR Signaling Network Open Resource

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SIGNORi
P52333

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase JAK3 (EC:2.7.10.2)
Alternative name(s):
Janus kinase 3
Short name:
JAK-3
Leukocyte janus kinase
Short name:
L-JAK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105639.18

Human Gene Nomenclature Database

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HGNCi
HGNC:6193 JAK3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600173 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P52333

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
See also OMIM:600802
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01933758Missing in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_006284100Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar.1
Natural variantiVAR_010492151P → R in T(-)B(+)NK(-) SCID. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar.1
Natural variantiVAR_019338169D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709Ensembl.1
Natural variantiVAR_010493481E → G in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_010494582R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar.1
Natural variantiVAR_010495586 – 592Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication7
Natural variantiVAR_019339589G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar.1
Natural variantiVAR_010497759C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication1
Natural variantiVAR_010498910L → S in T(-)B(+)NK(-) SCID. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi785Y → F: Strong decrease of JAK3 phosphorylation. 1 Publication1
Mutagenesisi855K → A: More than 90% loss of STAT5a activation. 1 Publication1
Mutagenesisi904Y → F: About 40% loss of STAT5a activation. 1 Publication1
Mutagenesisi939Y → F: About 80% loss of STAT5a activation. 1 Publication1

Keywords - Diseasei

Disease mutation, SCID

Organism-specific databases

DisGeNET

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DisGeNETi
3718

MalaCards human disease database

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MalaCardsi
JAK3
MIMi600802 phenotype

Open Targets

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OpenTargetsi
ENSG00000105639

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
35078 T-B+ severe combined immunodeficiency due to JAK3 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29990

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2148

Drug and drug target database

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DrugBanki
DB08895 Tofacitinib

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2049

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
JAK3

Domain mapping of disease mutations (DMDM)

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DMDMi
50403745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881151 – 1124Tyrosine-protein kinase JAK3Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
Modified residuei785Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei904Phosphotyrosine1 Publication1
Modified residuei939Phosphotyrosine1 Publication1
Modified residuei980Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei981Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P52333

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P52333

PeptideAtlas

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PeptideAtlasi
P52333

PRoteomics IDEntifications database

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PRIDEi
P52333

ProteomicsDB human proteome resource

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ProteomicsDBi
56482
56483 [P52333-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P52333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P52333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105639 Expressed in 163 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_JAK3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P52333 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P52333 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA070314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109921, 73 interactors

Database of interacting proteins

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DIPi
DIP-274N

Protein interaction database and analysis system

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IntActi
P52333, 50 interactors

Molecular INTeraction database

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MINTi
P52333

STRING: functional protein association networks

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STRINGi
9606.ENSP00000391676

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P52333

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P52333

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52333

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P52333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 356FERMPROSITE-ProRule annotationAdd BLAST333
Domaini375 – 475SH2; atypicalAdd BLAST101
Domaini521 – 781Protein kinase 1PROSITE-ProRule annotationAdd BLAST261
Domaini822 – 1111Protein kinase 2PROSITE-ProRule annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 223Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd BLAST223

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.By similarity1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0197 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161827

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049158

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG102690

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P52333

KEGG Orthology (KO)

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KOi
K11218

Identification of Orthologs from Complete Genome Data

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OMAi
NCMESFL

Database of Orthologous Groups

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OrthoDBi
EOG091G01IS

Database for complete collections of gene phylogenies

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PhylomeDBi
P52333

TreeFam database of animal gene trees

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TreeFami
TF327041

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020775 Tyr_kinase_non-rcpt_Jak3

Pfam protein domain database

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Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000636 TyrPK_Jak, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01823 JANUSKINASE
PR01826 JANUSKINASE3
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: P52333-1) [UniParc]FASTAAdd to basket
Also known as: JAK3S, Spleen-JAK3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA
60 70 80 90 100
EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY
110 120 130 140 150
RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL
160 170 180 190 200
PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD
210 220 230 240 250
LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA
260 270 280 290 300
AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD
310 320 330 340 350
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR
360 370 380 390 400
LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV
410 420 430 440 450
LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL
460 470 480 490 500
RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV
510 520 530 540 550
QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK
560 570 580 590 600
TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ
610 620 630 640 650
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA
660 670 680 690 700
RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ
710 720 730 740 750
TLSLEADKWG FGATVWEVFS GVTMPISALD PAKKLQFYED RQQLPAPKWT
760 770 780 790 800
ELALLIQQCM AYEPVQRPSF RAVIRDLNSL ISSDYELLSD PTPGALAPRD
810 820 830 840 850
GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR YDPLGDNTGA
860 870 880 890 900
LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL
910 920 930 940 950
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL
960 970 980 990 1000
AARNILVESE AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS
1010 1020 1030 1040 1050
DNIFSRQSDV WSFGVVLYEL FTYCDKSCSP SAEFLRMMGC ERDVPALCRL
1060 1070 1080 1090 1100
LELLEEGQRL PAPPACPAEV HELMKLCWAP SPQDRPSFSA LGPQLDMLWS
1110 1120
GSRGCETHAF TAHPEGKHHS LSFS
Length:1,124
Mass (Da):125,099
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i895D8563439B2B7C
GO
Isoform 1 (identifier: P52333-2) [UniParc]FASTAAdd to basket
Also known as: JAK3B, Breast-JAK3

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1124: HELMKLCWAP...EGKHHSLSFS → SAAGLASVSQSVDWAGVSGKPAGA

Note: May be inactive as it lacks some part of the kinase domain.
Show »
Length:1,094
Mass (Da):121,268
Checksum:iD491FADB3D772693
GO
Isoform 3 (identifier: P52333-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-619: TMVQEFVHLGAIDMYLRKRGHLV → ESPPPTHPTPASPKSRLFFPPLF
     620-1124: Missing.

Note: No experimental confirmation available.
Show »
Length:619
Mass (Da):68,279
Checksum:i2DA342038998636C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50227 differs from that shown. Wrong choice of CDS. Was erroneously described as an isoform JAK3M while it is a fragmentary mRNA of INSL3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34G → A in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti45F → S in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti103R → RS in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti147Missing in AAC50542 (PubMed:8662778).Curated1
Sequence conflicti187T → A in AAC50542 (PubMed:8662778).Curated1
Sequence conflicti212R → A in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti212R → A in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti222R → P in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti222R → P in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti271L → F in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti287Missing in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti610M → I in AAC50226 (PubMed:7559633).Curated1
Sequence conflicti845 – 846GD → AH in AAA19626 (PubMed:8022790).Curated2
Sequence conflicti895 – 897RQS → EPE in AAC50950 (PubMed:8921370).Curated3
Sequence conflicti896 – 897QS → PE in AAA19626 (PubMed:8022790).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04172212P → L1 PublicationCorresponds to variant dbSNP:rs56061056EnsemblClinVar.1
Natural variantiVAR_04172340R → H1 PublicationCorresponds to variant dbSNP:rs56384680EnsemblClinVar.1
Natural variantiVAR_01933758Missing in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_006284100Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar.1
Natural variantiVAR_019336132P → T2 PublicationsCorresponds to variant dbSNP:rs3212723EnsemblClinVar.1
Natural variantiVAR_010492151P → R in T(-)B(+)NK(-) SCID. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar.1
Natural variantiVAR_019338169D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709Ensembl.1
Natural variantiVAR_010493481E → G in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_041724521L → V1 PublicationCorresponds to variant dbSNP:rs55666418EnsemblClinVar.1
Natural variantiVAR_041725527L → P in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_010494582R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar.1
Natural variantiVAR_010495586 – 592Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication7
Natural variantiVAR_019339589G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar.1
Natural variantiVAR_041726688I → F1 PublicationCorresponds to variant dbSNP:rs35785705EnsemblClinVar.1
Natural variantiVAR_010496722V → I4 PublicationsCorresponds to variant dbSNP:rs3213409EnsemblClinVar.1
Natural variantiVAR_010497759C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication1
Natural variantiVAR_010498910L → S in T(-)B(+)NK(-) SCID. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054165597 – 619TMVQE…RGHLV → ESPPPTHPTPASPKSRLFFP PLF in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_054166620 – 1124Missing in isoform 3. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0049891071 – 1124HELMK…SLSFS → SAAGLASVSQSVDWAGVSGK PAGA in isoform 1. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09607 mRNA Translation: AAA19626.1
U31601 mRNA Translation: AAC50226.1
U31602 mRNA Translation: AAC50227.1 Sequence problems.
U70065 Genomic DNA Translation: AAC50950.1
AF513860 Genomic DNA Translation: AAM44860.1
AC007201 Genomic DNA Translation: AAD22741.1
CH471106 Genomic DNA Translation: EAW84639.1
BC028068 mRNA Translation: AAH28068.1
U57096 mRNA Translation: AAC50542.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12366.1 [P52333-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A55747

NCBI Reference Sequences

More...
RefSeqi
NP_000206.2, NM_000215.3 [P52333-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.515247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000458235; ENSP00000391676; ENSG00000105639 [P52333-1]
ENST00000527670; ENSP00000432511; ENSG00000105639 [P52333-1]
ENST00000534444; ENSP00000436421; ENSG00000105639 [P52333-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3718

UCSC genome browser

More...
UCSCi
uc002nhn.5 human [P52333-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
JAK3base

JAK3 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09607 mRNA Translation: AAA19626.1
U31601 mRNA Translation: AAC50226.1
U31602 mRNA Translation: AAC50227.1 Sequence problems.
U70065 Genomic DNA Translation: AAC50950.1
AF513860 Genomic DNA Translation: AAM44860.1
AC007201 Genomic DNA Translation: AAD22741.1
CH471106 Genomic DNA Translation: EAW84639.1
BC028068 mRNA Translation: AAH28068.1
U57096 mRNA Translation: AAC50542.1
CCDSiCCDS12366.1 [P52333-1]
PIRiA55747
RefSeqiNP_000206.2, NM_000215.3 [P52333-1]
UniGeneiHs.515247

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YVJX-ray2.55A814-1103[»]
3LXKX-ray2.00A806-1124[»]
3LXLX-ray1.74A806-1124[»]
3PJCX-ray2.20A812-1124[»]
3ZC6X-ray2.42A/B/C/D813-1100[»]
3ZEPX-ray2.35A/B/C/D813-1047[»]
A/B/C/D813-1100[»]
4HVDX-ray1.85A811-1124[»]
4HVGX-ray2.75A811-1124[»]
4HVHX-ray2.30A811-1124[»]
4HVIX-ray2.40A811-1124[»]
4I6QX-ray1.85A811-1124[»]
4QPSX-ray1.80A/C811-1103[»]
4QT1X-ray2.40A811-1124[»]
4RIOX-ray2.69A810-1100[»]
4V0GX-ray3.00A/B816-1098[»]
4Z16X-ray2.90A/B/C/D811-1124[»]
5LWMX-ray1.55A812-1103[»]
5LWNX-ray1.60A812-1103[»]
5TOZX-ray1.98A812-1124[»]
5TTSX-ray2.34A812-1124[»]
5TTUX-ray1.72A812-1124[»]
5TTVX-ray1.93A812-1124[»]
5VO6X-ray2.65A812-1100[»]
5W86X-ray2.61A/B/C/D814-1100[»]
5WFJX-ray2.48A810-1100[»]
6AAKX-ray2.67A/B/C/D814-1100[»]
6GL9X-ray1.70A/B812-1103[»]
6GLAX-ray1.92A/B812-1103[»]
6GLBX-ray2.00A/B812-1103[»]
ProteinModelPortaliP52333
SMRiP52333
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109921, 73 interactors
DIPiDIP-274N
IntActiP52333, 50 interactors
MINTiP52333
STRINGi9606.ENSP00000391676

Chemistry databases

BindingDBiP52333
ChEMBLiCHEMBL2148
DrugBankiDB08895 Tofacitinib
GuidetoPHARMACOLOGYi2049

PTM databases

iPTMnetiP52333
PhosphoSitePlusiP52333

Polymorphism and mutation databases

BioMutaiJAK3
DMDMi50403745

Proteomic databases

MaxQBiP52333
PaxDbiP52333
PeptideAtlasiP52333
PRIDEiP52333
ProteomicsDBi56482
56483 [P52333-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3718
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458235; ENSP00000391676; ENSG00000105639 [P52333-1]
ENST00000527670; ENSP00000432511; ENSG00000105639 [P52333-1]
ENST00000534444; ENSP00000436421; ENSG00000105639 [P52333-2]
GeneIDi3718
KEGGihsa:3718
UCSCiuc002nhn.5 human [P52333-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3718
DisGeNETi3718
EuPathDBiHostDB:ENSG00000105639.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
JAK3
HGNCiHGNC:6193 JAK3
HPAiHPA070314
MalaCardsiJAK3
MIMi600173 gene
600802 phenotype
neXtProtiNX_P52333
OpenTargetsiENSG00000105639
Orphaneti35078 T-B+ severe combined immunodeficiency due to JAK3 deficiency
PharmGKBiPA29990

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000161827
HOGENOMiHOG000049158
HOVERGENiHBG102690
InParanoidiP52333
KOiK11218
OMAiNCMESFL
OrthoDBiEOG091G01IS
PhylomeDBiP52333
TreeFamiTF327041

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-1266695 Interleukin-7 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP52333
SIGNORiP52333

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
JAK3 human
EvolutionaryTraceiP52333

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Janus_kinase_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3718

Protein Ontology

More...
PROi
PR:P52333

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105639 Expressed in 163 organ(s), highest expression level in blood
CleanExiHS_JAK3
ExpressionAtlasiP52333 baseline and differential
GenevisibleiP52333 HS

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020775 Tyr_kinase_non-rcpt_Jak3
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR01826 JANUSKINASE3
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52333
Secondary accession number(s): Q13259
, Q13260, Q13611, Q8N1E8, Q99699, Q9Y6S2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2004
Last modified: December 5, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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