UniProtKB - P52333 (JAK3_HUMAN)
Tyrosine-protein kinase JAK3
JAK3
Functioni
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
4 PublicationsCatalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 855 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 949 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 828 – 836 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein phosphatase binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: BHF-UCL
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- B cell differentiation Source: BHF-UCL
- cytokine-mediated signaling pathway Source: GO_Central
- enzyme linked receptor protein signaling pathway Source: BHF-UCL
- erythrocyte differentiation Source: GO_Central
- growth hormone receptor signaling pathway via JAK-STAT Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- interleukin-2-mediated signaling pathway Source: Reactome
- interleukin-4-mediated signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: BHF-UCL
- negative regulation of dendritic cell cytokine production Source: BHF-UCL
- negative regulation of FasL production Source: BHF-UCL
- negative regulation of interleukin-10 production Source: BHF-UCL
- negative regulation of interleukin-12 production Source: BHF-UCL
- negative regulation of T cell activation Source: BHF-UCL
- negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
- negative regulation of thymocyte apoptotic process Source: BHF-UCL
- peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of activated T cell proliferation Source: Ensembl
- positive regulation of calcium ion transport Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
- positive regulation of T cell proliferation Source: GO_Central
- protein phosphorylation Source: ProtInc
- regulation of apoptotic process Source: GO_Central
- regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- regulation of T cell apoptotic process Source: BHF-UCL
- response to interleukin-15 Source: BHF-UCL
- response to interleukin-2 Source: BHF-UCL
- response to interleukin-4 Source: BHF-UCL
- response to interleukin-9 Source: BHF-UCL
- T cell homeostasis Source: BHF-UCL
- tyrosine phosphorylation of STAT protein Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P52333 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-201556, Signaling by ALK R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8854691, Interleukin-20 family signaling R-HSA-8983432, Interleukin-15 signaling R-HSA-8985947, Interleukin-9 signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P52333 |
SIGNORi | P52333 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase JAK3Curated (EC:2.7.10.2)Alternative name(s): Janus kinase 3 Short name: JAK-3 Leukocyte janus kinase Short name: L-JAK |
Gene namesi | Name:JAK3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6193, JAK3 |
MIMi | 600173, gene |
neXtProti | NX_P52333 |
VEuPathDBi | HostDB:ENSG00000105639 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Endomembrane system By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019337 | 58 | Missing in T(-)B(+)NK(-) SCID. 1 Publication | 1 | |
Natural variantiVAR_006284 | 100 | Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar. | 1 | |
Natural variantiVAR_010492 | 151 | P → R in T(-)B(+)NK(-) SCID; likely benign variant. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar. | 1 | |
Natural variantiVAR_019338 | 169 | D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709EnsemblClinVar. | 1 | |
Natural variantiVAR_010493 | 481 | E → G in T(-)B(+)NK(-) SCID. 1 Publication | 1 | |
Natural variantiVAR_010494 | 582 | R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar. | 1 | |
Natural variantiVAR_010495 | 586 – 592 | Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication | 7 | |
Natural variantiVAR_019339 | 589 | G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar. | 1 | |
Natural variantiVAR_010497 | 759 | C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication | 1 | |
Natural variantiVAR_010498 | 910 | L → S in T(-)B(+)NK(-) SCID. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 785 | Y → F: Strong decrease of JAK3 phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 855 | K → A: More than 90% loss of STAT5a activation. 1 Publication | 1 | |
Mutagenesisi | 904 | Y → F: About 40% loss of STAT5a activation. 1 Publication | 1 | |
Mutagenesisi | 939 | Y → F: About 80% loss of STAT5a activation. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, SCIDOrganism-specific databases
DisGeNETi | 3718 |
MalaCardsi | JAK3 |
MIMi | 600802, phenotype |
OpenTargetsi | ENSG00000105639 |
Orphaneti | 35078, T-B+ severe combined immunodeficiency due to JAK3 deficiency |
PharmGKBi | PA29990 |
Miscellaneous databases
Pharosi | P52333, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2148 |
DrugBanki | DB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one DB11817, Baricitinib DB12010, Fostamatinib DB06321, R-348 DB08877, Ruxolitinib DB08895, Tofacitinib DB15035, Zanubrutinib |
DrugCentrali | P52333 |
GuidetoPHARMACOLOGYi | 2049 |
Genetic variation databases
BioMutai | JAK3 |
DMDMi | 50403745 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088115 | 1 – 1124 | Tyrosine-protein kinase JAK3Add BLAST | 1124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineBy similarity | 1 | |
Modified residuei | 785 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 904 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 939 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 980 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 981 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P52333 |
MassIVEi | P52333 |
MaxQBi | P52333 |
PaxDbi | P52333 |
PeptideAtlasi | P52333 |
PRIDEi | P52333 |
ProteomicsDBi | 56482 [P52333-1] 56483 [P52333-2] 71591 |
PTM databases
iPTMneti | P52333 |
PhosphoSitePlusi | P52333 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105639, Expressed in blood and 179 other tissues |
ExpressionAtlasi | P52333, baseline and differential |
Genevisiblei | P52333, HS |
Organism-specific databases
HPAi | ENSG00000105639, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with STAM2 and MYO18A (By similarity).
Interacts with SHB.
By similarity3 PublicationsBinary interactionsi
P52333
With | #Exp. | IntAct |
---|---|---|
KHDRBS1 [Q07666] | 2 | EBI-518246,EBI-1364 |
MAGED2 [Q9UNF1] | 4 | EBI-518246,EBI-725832 |
NAP1L1 [P55209] | 4 | EBI-518246,EBI-356392 |
GO - Molecular functioni
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109921, 86 interactors |
DIPi | DIP-274N |
IntActi | P52333, 85 interactors |
MINTi | P52333 |
STRINGi | 9606.ENSP00000391676 |
Chemistry databases
BindingDBi | P52333 |
Miscellaneous databases
RNActi | P52333, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P52333 |
SMRi | P52333 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52333 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 356 | FERMPROSITE-ProRule annotationAdd BLAST | 333 | |
Domaini | 375 – 475 | SH2; atypicalAdd BLAST | 101 | |
Domaini | 521 – 781 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 261 | |
Domaini | 822 – 1111 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 223 | Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd BLAST | 223 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH2 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161827 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | P52333 |
OMAi | TEDLKCW |
OrthoDBi | 58906at2759 |
PhylomeDBi | P52333 |
TreeFami | TF327041 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020775, Tyr_kinase_non-rcpt_Jak3 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01826, JANUSKINASE3 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA
60 70 80 90 100
EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY
110 120 130 140 150
RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL
160 170 180 190 200
PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD
210 220 230 240 250
LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA
260 270 280 290 300
AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD
310 320 330 340 350
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR
360 370 380 390 400
LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV
410 420 430 440 450
LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL
460 470 480 490 500
RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV
510 520 530 540 550
QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK
560 570 580 590 600
TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ
610 620 630 640 650
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA
660 670 680 690 700
RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ
710 720 730 740 750
TLSLEADKWG FGATVWEVFS GVTMPISALD PAKKLQFYED RQQLPAPKWT
760 770 780 790 800
ELALLIQQCM AYEPVQRPSF RAVIRDLNSL ISSDYELLSD PTPGALAPRD
810 820 830 840 850
GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR YDPLGDNTGA
860 870 880 890 900
LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL
910 920 930 940 950
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL
960 970 980 990 1000
AARNILVESE AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS
1010 1020 1030 1040 1050
DNIFSRQSDV WSFGVVLYEL FTYCDKSCSP SAEFLRMMGC ERDVPALCRL
1060 1070 1080 1090 1100
LELLEEGQRL PAPPACPAEV HELMKLCWAP SPQDRPSFSA LGPQLDMLWS
1110 1120
GSRGCETHAF TAHPEGKHHS LSFS
The sequence of this isoform differs from the canonical sequence as follows:
1071-1124: HELMKLCWAP...EGKHHSLSFS → SAAGLASVSQSVDWAGVSGKPAGA
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | G → A in AAA19626 (PubMed:8022790).Curated | 1 | |
Sequence conflicti | 45 | F → S in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 103 | R → RS in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 147 | Missing in AAC50542 (PubMed:8662778).Curated | 1 | |
Sequence conflicti | 187 | T → A in AAC50542 (PubMed:8662778).Curated | 1 | |
Sequence conflicti | 212 | R → A in AAA19626 (PubMed:8022790).Curated | 1 | |
Sequence conflicti | 212 | R → A in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 222 | R → P in AAA19626 (PubMed:8022790).Curated | 1 | |
Sequence conflicti | 222 | R → P in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 271 | L → F in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 287 | Missing in AAC50950 (PubMed:8921370).Curated | 1 | |
Sequence conflicti | 610 | M → I in AAC50226 (PubMed:7559633).Curated | 1 | |
Sequence conflicti | 845 – 846 | GD → AH in AAA19626 (PubMed:8022790).Curated | 2 | |
Sequence conflicti | 895 – 897 | RQS → EPE in AAC50950 (PubMed:8921370).Curated | 3 | |
Sequence conflicti | 896 – 897 | QS → PE in AAA19626 (PubMed:8022790).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041722 | 12 | P → L1 PublicationCorresponds to variant dbSNP:rs56061056EnsemblClinVar. | 1 | |
Natural variantiVAR_041723 | 40 | R → H1 PublicationCorresponds to variant dbSNP:rs56384680EnsemblClinVar. | 1 | |
Natural variantiVAR_019337 | 58 | Missing in T(-)B(+)NK(-) SCID. 1 Publication | 1 | |
Natural variantiVAR_006284 | 100 | Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar. | 1 | |
Natural variantiVAR_019336 | 132 | P → T2 PublicationsCorresponds to variant dbSNP:rs3212723EnsemblClinVar. | 1 | |
Natural variantiVAR_010492 | 151 | P → R in T(-)B(+)NK(-) SCID; likely benign variant. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar. | 1 | |
Natural variantiVAR_019338 | 169 | D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709EnsemblClinVar. | 1 | |
Natural variantiVAR_010493 | 481 | E → G in T(-)B(+)NK(-) SCID. 1 Publication | 1 | |
Natural variantiVAR_041724 | 521 | L → V1 PublicationCorresponds to variant dbSNP:rs55666418EnsemblClinVar. | 1 | |
Natural variantiVAR_041725 | 527 | L → P in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_010494 | 582 | R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar. | 1 | |
Natural variantiVAR_010495 | 586 – 592 | Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication | 7 | |
Natural variantiVAR_019339 | 589 | G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar. | 1 | |
Natural variantiVAR_041726 | 688 | I → F1 PublicationCorresponds to variant dbSNP:rs35785705EnsemblClinVar. | 1 | |
Natural variantiVAR_010496 | 722 | V → I4 PublicationsCorresponds to variant dbSNP:rs3213409EnsemblClinVar. | 1 | |
Natural variantiVAR_010497 | 759 | C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication | 1 | |
Natural variantiVAR_010498 | 910 | L → S in T(-)B(+)NK(-) SCID. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054165 | 597 – 619 | TMVQE…RGHLV → ESPPPTHPTPASPKSRLFFP PLF in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_054166 | 620 – 1124 | Missing in isoform 3. 1 PublicationAdd BLAST | 505 | |
Alternative sequenceiVSP_004989 | 1071 – 1124 | HELMK…SLSFS → SAAGLASVSQSVDWAGVSGK PAGA in isoform 1. 1 PublicationAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09607 mRNA Translation: AAA19626.1 U31601 mRNA Translation: AAC50226.1 U31602 mRNA Translation: AAC50227.1 Sequence problems. U70065 Genomic DNA Translation: AAC50950.1 AF513860 Genomic DNA Translation: AAM44860.1 AC007201 Genomic DNA Translation: AAD22741.1 CH471106 Genomic DNA Translation: EAW84639.1 BC028068 mRNA Translation: AAH28068.1 U57096 mRNA Translation: AAC50542.1 |
CCDSi | CCDS12366.1 [P52333-1] |
PIRi | A55747 |
RefSeqi | NP_000206.2, NM_000215.3 [P52333-1] |
Genome annotation databases
Ensembli | ENST00000458235.7; ENSP00000391676.1; ENSG00000105639.20 ENST00000527670.5; ENSP00000432511.1; ENSG00000105639.20 ENST00000534444.1; ENSP00000436421.1; ENSG00000105639.20 [P52333-2] |
GeneIDi | 3718 |
KEGGi | hsa:3718 |
MANE-Selecti | ENST00000458235.7; ENSP00000391676.1; NM_000215.4; NP_000206.2 |
UCSCi | uc002nhn.5, human [P52333-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
JAK3base JAK3 mutation db |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09607 mRNA Translation: AAA19626.1 U31601 mRNA Translation: AAC50226.1 U31602 mRNA Translation: AAC50227.1 Sequence problems. U70065 Genomic DNA Translation: AAC50950.1 AF513860 Genomic DNA Translation: AAM44860.1 AC007201 Genomic DNA Translation: AAD22741.1 CH471106 Genomic DNA Translation: EAW84639.1 BC028068 mRNA Translation: AAH28068.1 U57096 mRNA Translation: AAC50542.1 |
CCDSi | CCDS12366.1 [P52333-1] |
PIRi | A55747 |
RefSeqi | NP_000206.2, NM_000215.3 [P52333-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YVJ | X-ray | 2.55 | A | 814-1103 | [»] | |
3LXK | X-ray | 2.00 | A | 806-1124 | [»] | |
3LXL | X-ray | 1.74 | A | 806-1124 | [»] | |
3PJC | X-ray | 2.20 | A | 812-1124 | [»] | |
3ZC6 | X-ray | 2.42 | A/B/C/D | 813-1100 | [»] | |
3ZEP | X-ray | 2.35 | A/B/C/D | 813-1047 | [»] | |
A/B/C/D | 813-1100 | [»] | ||||
4HVD | X-ray | 1.85 | A | 811-1124 | [»] | |
4HVG | X-ray | 2.75 | A | 811-1124 | [»] | |
4HVH | X-ray | 2.30 | A | 811-1124 | [»] | |
4HVI | X-ray | 2.40 | A | 811-1124 | [»] | |
4I6Q | X-ray | 1.85 | A | 811-1124 | [»] | |
4QPS | X-ray | 1.80 | A/C | 811-1103 | [»] | |
4QT1 | X-ray | 2.40 | A | 811-1124 | [»] | |
4RIO | X-ray | 2.69 | A | 810-1100 | [»] | |
4V0G | X-ray | 3.00 | A/B | 816-1098 | [»] | |
4Z16 | X-ray | 2.90 | A/B/C/D | 811-1124 | [»] | |
5LWM | X-ray | 1.55 | A | 812-1103 | [»] | |
5LWN | X-ray | 1.60 | A | 812-1103 | [»] | |
5TOZ | X-ray | 1.98 | A | 812-1124 | [»] | |
5TTS | X-ray | 2.34 | A | 812-1124 | [»] | |
5TTU | X-ray | 1.72 | A | 812-1124 | [»] | |
5TTV | X-ray | 1.93 | A | 812-1124 | [»] | |
5VO6 | X-ray | 2.65 | A | 812-1100 | [»] | |
5W86 | X-ray | 2.61 | A/B/C/D | 814-1100 | [»] | |
5WFJ | X-ray | 2.48 | A | 810-1100 | [»] | |
6AAK | X-ray | 2.67 | A/B/C/D | 814-1100 | [»] | |
6DA4 | X-ray | 2.90 | A | 812-1124 | [»] | |
6DB3 | X-ray | 1.97 | A | 812-1124 | [»] | |
6DB4 | X-ray | 1.66 | A | 812-1124 | [»] | |
6DUD | X-ray | 1.66 | A | 812-1124 | [»] | |
6GL9 | X-ray | 1.70 | A/B | 812-1103 | [»] | |
6GLA | X-ray | 1.92 | A/B | 812-1103 | [»] | |
6GLB | X-ray | 2.00 | A/B | 812-1103 | [»] | |
6HZV | X-ray | 2.46 | A/B/C/D | 815-1099 | [»] | |
6NY4 | X-ray | 2.33 | A | 810-1100 | [»] | |
7APF | X-ray | 1.95 | A/B | 812-1103 | [»] | |
7APG | X-ray | 2.40 | A/B/C/D | 812-1103 | [»] | |
7C3N | X-ray | 1.98 | A | 812-1124 | [»] | |
AlphaFoldDBi | P52333 | |||||
SMRi | P52333 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109921, 86 interactors |
DIPi | DIP-274N |
IntActi | P52333, 85 interactors |
MINTi | P52333 |
STRINGi | 9606.ENSP00000391676 |
Chemistry databases
BindingDBi | P52333 |
ChEMBLi | CHEMBL2148 |
DrugBanki | DB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one DB11817, Baricitinib DB12010, Fostamatinib DB06321, R-348 DB08877, Ruxolitinib DB08895, Tofacitinib DB15035, Zanubrutinib |
DrugCentrali | P52333 |
GuidetoPHARMACOLOGYi | 2049 |
PTM databases
iPTMneti | P52333 |
PhosphoSitePlusi | P52333 |
Genetic variation databases
BioMutai | JAK3 |
DMDMi | 50403745 |
Proteomic databases
jPOSTi | P52333 |
MassIVEi | P52333 |
MaxQBi | P52333 |
PaxDbi | P52333 |
PeptideAtlasi | P52333 |
PRIDEi | P52333 |
ProteomicsDBi | 56482 [P52333-1] 56483 [P52333-2] 71591 |
Protocols and materials databases
Antibodypediai | 35352, 466 antibodies from 35 providers |
DNASUi | 3718 |
Genome annotation databases
Ensembli | ENST00000458235.7; ENSP00000391676.1; ENSG00000105639.20 ENST00000527670.5; ENSP00000432511.1; ENSG00000105639.20 ENST00000534444.1; ENSP00000436421.1; ENSG00000105639.20 [P52333-2] |
GeneIDi | 3718 |
KEGGi | hsa:3718 |
MANE-Selecti | ENST00000458235.7; ENSP00000391676.1; NM_000215.4; NP_000206.2 |
UCSCi | uc002nhn.5, human [P52333-1] |
Organism-specific databases
CTDi | 3718 |
DisGeNETi | 3718 |
GeneCardsi | JAK3 |
HGNCi | HGNC:6193, JAK3 |
HPAi | ENSG00000105639, Tissue enhanced (lymphoid) |
MalaCardsi | JAK3 |
MIMi | 600173, gene 600802, phenotype |
neXtProti | NX_P52333 |
OpenTargetsi | ENSG00000105639 |
Orphaneti | 35078, T-B+ severe combined immunodeficiency due to JAK3 deficiency |
PharmGKBi | PA29990 |
VEuPathDBi | HostDB:ENSG00000105639 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161827 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | P52333 |
OMAi | TEDLKCW |
OrthoDBi | 58906at2759 |
PhylomeDBi | P52333 |
TreeFami | TF327041 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P52333 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-201556, Signaling by ALK R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8854691, Interleukin-20 family signaling R-HSA-8983432, Interleukin-15 signaling R-HSA-8985947, Interleukin-9 signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P52333 |
SIGNORi | P52333 |
Miscellaneous databases
BioGRID-ORCSi | 3718, 14 hits in 1108 CRISPR screens |
EvolutionaryTracei | P52333 |
GeneWikii | Janus_kinase_3 |
GenomeRNAii | 3718 |
Pharosi | P52333, Tclin |
PROi | PR:P52333 |
RNActi | P52333, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105639, Expressed in blood and 179 other tissues |
ExpressionAtlasi | P52333, baseline and differential |
Genevisiblei | P52333, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020775, Tyr_kinase_non-rcpt_Jak3 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01826, JANUSKINASE3 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JAK3_HUMAN | |
Accessioni | P52333Primary (citable) accession number: P52333 Secondary accession number(s): Q13259 Q9Y6S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 19, 2004 | |
Last modified: | May 25, 2022 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families