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UniProtKB - P52333 (JAK3_HUMAN)

Entry version 227 (25 May 2022)
Sequence version 2 (19 Jul 2004)
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Protein

Tyrosine-protein kinase JAK3

Gene

JAK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei855ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei949Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi828 – 836ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processAdaptive immunity, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P52333

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1266695, Interleukin-7 signaling
R-HSA-201556, Signaling by ALK
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8854691, Interleukin-20 family signaling
R-HSA-8983432, Interleukin-15 signaling
R-HSA-8985947, Interleukin-9 signaling
R-HSA-9020558, Interleukin-2 signaling
R-HSA-9020958, Interleukin-21 signaling
R-HSA-912526, Interleukin receptor SHC signaling
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P52333

SIGNOR Signaling Network Open Resource

More...SIGNORi		P52333

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase JAK3Curated (EC:2.7.10.2)
Alternative name(s):
Janus kinase 3
Short name:
JAK-3
Leukocyte janus kinase
Short name:
L-JAK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6193, JAK3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600173, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52333

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01933758Missing in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_006284100Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar.1
Natural variantiVAR_010492151P → R in T(-)B(+)NK(-) SCID; likely benign variant. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar.1
Natural variantiVAR_019338169D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709EnsemblClinVar.1
Natural variantiVAR_010493481E → G in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_010494582R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar.1
Natural variantiVAR_010495586 – 592Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication7
Natural variantiVAR_019339589G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar.1
Natural variantiVAR_010497759C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication1
Natural variantiVAR_010498910L → S in T(-)B(+)NK(-) SCID. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi785Y → F: Strong decrease of JAK3 phosphorylation. 1 Publication1
Mutagenesisi855K → A: More than 90% loss of STAT5a activation. 1 Publication1
Mutagenesisi904Y → F: About 40% loss of STAT5a activation. 1 Publication1
Mutagenesisi939Y → F: About 80% loss of STAT5a activation. 1 Publication1

Keywords - Diseasei

Disease variant, SCID

Organism-specific databases

DisGeNET

More...DisGeNETi		3718

MalaCards human disease database

More...MalaCardsi		JAK3
MIMi600802, phenotype

Open Targets

More...OpenTargetsi		ENSG00000105639

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		35078, T-B+ severe combined immunodeficiency due to JAK3 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29990

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52333, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2148

Drug and drug target database

More...DrugBanki		DB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
DB11817, Baricitinib
DB12010, Fostamatinib
DB06321, R-348
DB08877, Ruxolitinib
DB08895, Tofacitinib
DB15035, Zanubrutinib

DrugCentral

More...DrugCentrali		P52333

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2049

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JAK3

Domain mapping of disease mutations (DMDM)

More...DMDMi		50403745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881151 – 1124Tyrosine-protein kinase JAK3Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
Modified residuei785Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei904Phosphotyrosine1 Publication1
Modified residuei939Phosphotyrosine1 Publication1
Modified residuei980Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei981Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P52333

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52333

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52333

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52333

PeptideAtlas

More...PeptideAtlasi		P52333

PRoteomics IDEntifications database

More...PRIDEi		P52333

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56482 [P52333-1]
56483 [P52333-2]
71591

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105639, Expressed in blood and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52333, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52333, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105639, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAM2 and MYO18A (By similarity).

Interacts with SHB.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109921, 86 interactors

Database of interacting proteins

More...DIPi		DIP-274N

Protein interaction database and analysis system

More...IntActi		P52333, 85 interactors

Molecular INTeraction database

More...MINTi		P52333

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000391676

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P52333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52333, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P52333

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52333

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P52333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 356FERMPROSITE-ProRule annotationAdd BLAST333
Domaini375 – 475SH2; atypicalAdd BLAST101
Domaini521 – 781Protein kinase 1PROSITE-ProRule annotationAdd BLAST261
Domaini822 – 1111Protein kinase 2PROSITE-ProRule annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 223Interaction with cytokine/interferon/growth hormone receptorsBy similarityAdd BLAST223

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0197, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161827

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008155_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52333

Identification of Orthologs from Complete Genome Data

More...OMAi		TEDLKCW

Database of Orthologous Groups

More...OrthoDBi		58906at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52333

TreeFam database of animal gene trees

More...TreeFami		TF327041

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019749, Band_41_domain
IPR000299, FERM_domain
IPR041155, FERM_F1
IPR041046, FERM_F2
IPR041381, Jak1_PHL_dom
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020775, Tyr_kinase_non-rcpt_Jak3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18379, FERM_F1, 1 hit
PF18377, FERM_F2, 1 hit
PF17887, Jak1_Phl, 1 hit
PF07714, PK_Tyr_Ser-Thr, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000636, TyrPK_Jak, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01823, JANUSKINASE
PR01826, JANUSKINASE3
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00295, B41, 1 hit
SM00252, SH2, 1 hit
SM00219, TyrKc, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50057, FERM_3, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: P52333-1) [UniParc]FASTAAdd to basket
Also known as: JAK3S, Spleen-JAK3

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA 
        60         70         80         90        100
EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY 
       110        120        130        140        150
RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL 
       160        170        180        190        200
PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD 
       210        220        230        240        250
LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA 
       260        270        280        290        300
AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 
       310        320        330        340        350
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR 
       360        370        380        390        400
LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV 
       410        420        430        440        450
LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL 
       460        470        480        490        500
RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV 
       510        520        530        540        550
QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK 
       560        570        580        590        600
TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ 
       610        620        630        640        650
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA 
       660        670        680        690        700
RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ 
       710        720        730        740        750
TLSLEADKWG FGATVWEVFS GVTMPISALD PAKKLQFYED RQQLPAPKWT 
       760        770        780        790        800
ELALLIQQCM AYEPVQRPSF RAVIRDLNSL ISSDYELLSD PTPGALAPRD 
       810        820        830        840        850
GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR YDPLGDNTGA 
       860        870        880        890        900
LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 
       910        920        930        940        950
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL 
       960        970        980        990       1000
AARNILVESE AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS 
      1010       1020       1030       1040       1050
DNIFSRQSDV WSFGVVLYEL FTYCDKSCSP SAEFLRMMGC ERDVPALCRL 
      1060       1070       1080       1090       1100
LELLEEGQRL PAPPACPAEV HELMKLCWAP SPQDRPSFSA LGPQLDMLWS 
      1110       1120 
GSRGCETHAF TAHPEGKHHS LSFS
Length:1,124
Mass (Da):125,099
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i895D8563439B2B7C
GO
Isoform 1 (identifier: P52333-2) [UniParc]FASTAAdd to basket
Also known as: JAK3B, Breast-JAK3

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1124: HELMKLCWAP...EGKHHSLSFS → SAAGLASVSQSVDWAGVSGKPAGA

Note: May be inactive as it lacks some part of the kinase domain.Curated
Show »
Length:1,094
Mass (Da):121,268
Checksum:iD491FADB3D772693
GO
Isoform 3 (identifier: P52333-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-619: TMVQEFVHLGAIDMYLRKRGHLV → ESPPPTHPTPASPKSRLFFPPLF
     620-1124: Missing.

Show »
Length:619
Mass (Da):68,279
Checksum:i2DA342038998636C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50227 differs from that shown. Wrong choice of CDS. Was erroneously described as an isoform JAK3M while it is a fragmentary mRNA of INSL3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34G → A in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti45F → S in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti103R → RS in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti147Missing in AAC50542 (PubMed:8662778).Curated1
Sequence conflicti187T → A in AAC50542 (PubMed:8662778).Curated1
Sequence conflicti212R → A in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti212R → A in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti222R → P in AAA19626 (PubMed:8022790).Curated1
Sequence conflicti222R → P in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti271L → F in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti287Missing in AAC50950 (PubMed:8921370).Curated1
Sequence conflicti610M → I in AAC50226 (PubMed:7559633).Curated1
Sequence conflicti845 – 846GD → AH in AAA19626 (PubMed:8022790).Curated2
Sequence conflicti895 – 897RQS → EPE in AAC50950 (PubMed:8921370).Curated3
Sequence conflicti896 – 897QS → PE in AAA19626 (PubMed:8022790).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04172212P → L1 PublicationCorresponds to variant dbSNP:rs56061056EnsemblClinVar.1
Natural variantiVAR_04172340R → H1 PublicationCorresponds to variant dbSNP:rs56384680EnsemblClinVar.1
Natural variantiVAR_01933758Missing in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_006284100Y → C in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs137852624EnsemblClinVar.1
Natural variantiVAR_019336132P → T2 PublicationsCorresponds to variant dbSNP:rs3212723EnsemblClinVar.1
Natural variantiVAR_010492151P → R in T(-)B(+)NK(-) SCID; likely benign variant. 2 PublicationsCorresponds to variant dbSNP:rs55778349EnsemblClinVar.1
Natural variantiVAR_019338169D → E in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs147181709EnsemblClinVar.1
Natural variantiVAR_010493481E → G in T(-)B(+)NK(-) SCID. 1 Publication1
Natural variantiVAR_041724521L → V1 PublicationCorresponds to variant dbSNP:rs55666418EnsemblClinVar.1
Natural variantiVAR_041725527L → P in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_010494582R → W in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs193922361EnsemblClinVar.1
Natural variantiVAR_010495586 – 592Missing in T(-)B(+)NK(-) SCID; lack of phosphorylation in response to cytokine stimulation. 1 Publication7
Natural variantiVAR_019339589G → S in T(-)B(+)NK(-) SCID. 1 PublicationCorresponds to variant dbSNP:rs886039394EnsemblClinVar.1
Natural variantiVAR_041726688I → F1 PublicationCorresponds to variant dbSNP:rs35785705EnsemblClinVar.1
Natural variantiVAR_010496722V → I4 PublicationsCorresponds to variant dbSNP:rs3213409EnsemblClinVar.1
Natural variantiVAR_010497759C → R in T(-)B(+)NK(-) SCID; constitutive phosphorylation. 1 Publication1
Natural variantiVAR_010498910L → S in T(-)B(+)NK(-) SCID. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054165597 – 619TMVQE…RGHLV → ESPPPTHPTPASPKSRLFFP PLF in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_054166620 – 1124Missing in isoform 3. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0049891071 – 1124HELMK…SLSFS → SAAGLASVSQSVDWAGVSGK PAGA in isoform 1. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09607 mRNA Translation: AAA19626.1
U31601 mRNA Translation: AAC50226.1
U31602 mRNA Translation: AAC50227.1 Sequence problems.
U70065 Genomic DNA Translation: AAC50950.1
AF513860 Genomic DNA Translation: AAM44860.1
AC007201 Genomic DNA Translation: AAD22741.1
CH471106 Genomic DNA Translation: EAW84639.1
BC028068 mRNA Translation: AAH28068.1
U57096 mRNA Translation: AAC50542.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12366.1 [P52333-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A55747

NCBI Reference Sequences

More...RefSeqi		NP_000206.2, NM_000215.3 [P52333-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000458235.7; ENSP00000391676.1; ENSG00000105639.20
ENST00000527670.5; ENSP00000432511.1; ENSG00000105639.20
ENST00000534444.1; ENSP00000436421.1; ENSG00000105639.20 [P52333-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3718

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000458235.7; ENSP00000391676.1; NM_000215.4; NP_000206.2

UCSC genome browser

More...UCSCi		uc002nhn.5, human [P52333-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
JAK3base

JAK3 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09607 mRNA Translation: AAA19626.1
U31601 mRNA Translation: AAC50226.1
U31602 mRNA Translation: AAC50227.1 Sequence problems.
U70065 Genomic DNA Translation: AAC50950.1
AF513860 Genomic DNA Translation: AAM44860.1
AC007201 Genomic DNA Translation: AAD22741.1
CH471106 Genomic DNA Translation: EAW84639.1
BC028068 mRNA Translation: AAH28068.1
U57096 mRNA Translation: AAC50542.1
CCDSiCCDS12366.1 [P52333-1]
PIRiA55747
RefSeqiNP_000206.2, NM_000215.3 [P52333-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YVJX-ray2.55A814-1103[»]
3LXKX-ray2.00A806-1124[»]
3LXLX-ray1.74A806-1124[»]
3PJCX-ray2.20A812-1124[»]
3ZC6X-ray2.42A/B/C/D813-1100[»]
3ZEPX-ray2.35A/B/C/D813-1047[»]
A/B/C/D813-1100[»]
4HVDX-ray1.85A811-1124[»]
4HVGX-ray2.75A811-1124[»]
4HVHX-ray2.30A811-1124[»]
4HVIX-ray2.40A811-1124[»]
4I6QX-ray1.85A811-1124[»]
4QPSX-ray1.80A/C811-1103[»]
4QT1X-ray2.40A811-1124[»]
4RIOX-ray2.69A810-1100[»]
4V0GX-ray3.00A/B816-1098[»]
4Z16X-ray2.90A/B/C/D811-1124[»]
5LWMX-ray1.55A812-1103[»]
5LWNX-ray1.60A812-1103[»]
5TOZX-ray1.98A812-1124[»]
5TTSX-ray2.34A812-1124[»]
5TTUX-ray1.72A812-1124[»]
5TTVX-ray1.93A812-1124[»]
5VO6X-ray2.65A812-1100[»]
5W86X-ray2.61A/B/C/D814-1100[»]
5WFJX-ray2.48A810-1100[»]
6AAKX-ray2.67A/B/C/D814-1100[»]
6DA4X-ray2.90A812-1124[»]
6DB3X-ray1.97A812-1124[»]
6DB4X-ray1.66A812-1124[»]
6DUDX-ray1.66A812-1124[»]
6GL9X-ray1.70A/B812-1103[»]
6GLAX-ray1.92A/B812-1103[»]
6GLBX-ray2.00A/B812-1103[»]
6HZVX-ray2.46A/B/C/D815-1099[»]
6NY4X-ray2.33A810-1100[»]
7APFX-ray1.95A/B812-1103[»]
7APGX-ray2.40A/B/C/D812-1103[»]
7C3NX-ray1.98A812-1124[»]
AlphaFoldDBiP52333
SMRiP52333
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109921, 86 interactors
DIPiDIP-274N
IntActiP52333, 85 interactors
MINTiP52333
STRINGi9606.ENSP00000391676

Chemistry databases

BindingDBiP52333
ChEMBLiCHEMBL2148
DrugBankiDB04716, 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
DB11817, Baricitinib
DB12010, Fostamatinib
DB06321, R-348
DB08877, Ruxolitinib
DB08895, Tofacitinib
DB15035, Zanubrutinib
DrugCentraliP52333
GuidetoPHARMACOLOGYi2049

PTM databases

iPTMnetiP52333
PhosphoSitePlusiP52333

Genetic variation databases

BioMutaiJAK3
DMDMi50403745

Proteomic databases

jPOSTiP52333
MassIVEiP52333
MaxQBiP52333
PaxDbiP52333
PeptideAtlasiP52333
PRIDEiP52333
ProteomicsDBi56482 [P52333-1]
56483 [P52333-2]
71591

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35352, 466 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		3718

Genome annotation databases

EnsembliENST00000458235.7; ENSP00000391676.1; ENSG00000105639.20
ENST00000527670.5; ENSP00000432511.1; ENSG00000105639.20
ENST00000534444.1; ENSP00000436421.1; ENSG00000105639.20 [P52333-2]
GeneIDi3718
KEGGihsa:3718
MANE-SelectiENST00000458235.7; ENSP00000391676.1; NM_000215.4; NP_000206.2
UCSCiuc002nhn.5, human [P52333-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3718
DisGeNETi3718

GeneCards: human genes, protein and diseases

More...GeneCardsi		JAK3
HGNCiHGNC:6193, JAK3
HPAiENSG00000105639, Tissue enhanced (lymphoid)
MalaCardsiJAK3
MIMi600173, gene
600802, phenotype
neXtProtiNX_P52333
OpenTargetsiENSG00000105639
Orphaneti35078, T-B+ severe combined immunodeficiency due to JAK3 deficiency
PharmGKBiPA29990
VEuPathDBiHostDB:ENSG00000105639

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0197, Eukaryota
GeneTreeiENSGT00940000161827
HOGENOMiCLU_008155_1_0_1
InParanoidiP52333
OMAiTEDLKCW
OrthoDBi58906at2759
PhylomeDBiP52333
TreeFamiTF327041

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP52333
ReactomeiR-HSA-1266695, Interleukin-7 signaling
R-HSA-201556, Signaling by ALK
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8854691, Interleukin-20 family signaling
R-HSA-8983432, Interleukin-15 signaling
R-HSA-8985947, Interleukin-9 signaling
R-HSA-9020558, Interleukin-2 signaling
R-HSA-9020958, Interleukin-21 signaling
R-HSA-912526, Interleukin receptor SHC signaling
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiP52333
SIGNORiP52333

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3718, 14 hits in 1108 CRISPR screens
EvolutionaryTraceiP52333

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Janus_kinase_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3718
PharosiP52333, Tclin

Protein Ontology

More...PROi		PR:P52333
RNActiP52333, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105639, Expressed in blood and 179 other tissues
ExpressionAtlasiP52333, baseline and differential
GenevisibleiP52333, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR000299, FERM_domain
IPR041155, FERM_F1
IPR041046, FERM_F2
IPR041381, Jak1_PHL_dom
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020775, Tyr_kinase_non-rcpt_Jak3
PfamiView protein in Pfam
PF18379, FERM_F1, 1 hit
PF18377, FERM_F2, 1 hit
PF17887, Jak1_Phl, 1 hit
PF07714, PK_Tyr_Ser-Thr, 2 hits
PIRSFiPIRSF000636, TyrPK_Jak, 1 hit
PRINTSiPR01823, JANUSKINASE
PR01826, JANUSKINASE3
PR00109, TYRKINASE
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00252, SH2, 1 hit
SM00219, TyrKc, 2 hits
SUPFAMiSSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 2 hits
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAK3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52333
Secondary accession number(s): Q13259
, Q13260, Q13611, Q8N1E8, Q99699, Q9Y6S2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2004
Last modified: May 25, 2022
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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