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UniProtKB - P52306 (GDS1_HUMAN)

Entry version 171 (29 Sep 2021)
Sequence version 3 (04 Nov 2008)
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Protein

Rap1 GTPase-GDP dissociation stimulator 1

Gene

RAP1GDS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427).

Able to promote the Ca2+ release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca2+ uptake (PubMed:24349085).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P52306

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013419, RHOT2 GTPase cycle
R-HSA-9013425, RHOT1 GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P52306

SIGNOR Signaling Network Open Resource

More...SIGNORi		P52306

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rap1 GTPase-GDP dissociation stimulator 1Curated
Alternative name(s):
Exchange factor smgGDS1 Publication
SMG GDS protein1 Publication
SMG P21 stimulatory GDP/GTP exchange protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAP1GDS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9859, RAP1GDS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179502, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52306

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138698

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving RAP1GDS1 has been found in M0 type acute myeloid leukemia. Translocation (t4;11)(q23;p15) with NUP98.1 Publication
A chromosomal aberration involving RAP1GDS1 has been found in T-cell acute lymphocytic leukemia. Translocation t(4;11)(q23;p15) with NUP98.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1 – 2Breakpoint for translocation to form the NUP98-RAP1GDS1 fusion protein2 Publications2

Organism-specific databases

DisGeNET

More...DisGeNETi		5910

Open Targets

More...OpenTargetsi		ENSG00000138698

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34221

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52306, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAP1GDS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567591 – 607Rap1 GTPase-GDP dissociation stimulator 1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P52306

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P52306

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52306

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52306

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52306

PeptideAtlas

More...PeptideAtlasi		P52306

PRoteomics IDEntifications database

More...PRIDEi		P52306

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20432
34006
56479 [P52306-1]
56480 [P52306-2]
56481 [P52306-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P52306, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52306

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P52306

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52306

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P52306

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138698, Expressed in frontal cortex and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52306, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52306, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138698, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RABL3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111845, 106 interactors

Database of interacting proteins

More...DIPi		DIP-61080N

Protein interaction database and analysis system

More...IntActi		P52306, 53 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340454

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52306, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52306

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 118ARM 1Add BLAST42
Repeati169 – 211ARM 2Add BLAST43
Repeati346 – 390ARM 3Add BLAST45
Repeati391 – 431ARM 4Add BLAST41
Repeati479 – 519ARM 5Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4500, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021124_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52306

Identification of Orthologs from Complete Genome Data

More...OMAi		IMQQLQR

Database of Orthologous Groups

More...OrthoDBi		561489at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52306

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR040144, RAP1GDS1

The PANTHER Classification System

More...PANTHERi		PTHR10957, PTHR10957, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00514, Arm, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00185, ARM, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50176, ARM_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI 
        60         70         80         90        100
LQLFASLLTP QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS 
       110        120        130        140        150
KDQEVLLQTG RALGNICYDS HEGRSAVDQA GGAQIVIDHL RSLCSITDPA 
       160        170        180        190        200
NEKLLTVFCG MLMNYSNEND SLQAQLINMG VIPTLVKLLG IHCQNAALTE 
       210        220        230        240        250
MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK REMIFEVLAP 
       260        270        280        290        300
LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL 
       310        320        330        340        350
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC 
       360        370        380        390        400
IHMVDNGIVE KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS 
       410        420        430        440        450
AGVTEAVLKF LKSEMPPVQF KLLGTLRMLI DAQAEAAEQL GKNVKLVERL 
       460        470        480        490        500
VEWCEAKDHA GVMGESNRLL SALIRHSKSK DVIKTIVQSG GIKHLVTMAT 
       510        520        530        540        550
SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR LLADERSAPE 
       560        570        580        590        600
IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE 

QRLTVES
Length:607
Mass (Da):66,317
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED0F359DFA3F0510
GO
Isoform 2 (identifier: P52306-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-170: Missing.

Show »
Length:558
Mass (Da):61,037
Checksum:i7DCE981DA08F4629
GO
Isoform 3 (identifier: P52306-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     122-170: Missing.

Show »
Length:559
Mass (Da):61,108
Checksum:i2BF086E5908DC6BD
GO
Isoform 4 (identifier: P52306-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     434-434: Missing.

Show »
Length:607
Mass (Da):66,317
Checksum:i8196856D628A428C
GO
Isoform 5 (identifier: P52306-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA

Show »
Length:608
Mass (Da):66,388
Checksum:iB73C1010A184A971
GO
Isoform 6 (identifier: P52306-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     121-213: HEGRSAVDQA...VAFGNLAELE → Q

Show »
Length:516
Mass (Da):56,536
Checksum:iD508C3FD684CA75D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8M2H0Y8M2_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHH8D6RHH8_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHZ7D6RHZ7_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB97D6RB97_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQJ4U3KQJ4_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REZ0D6REZ0_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBC6D6RBC6_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC12D6RC12_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC85D6RC85_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237E → G in AAH98269 (PubMed:15489334).Curated1
Sequence conflicti376T → P in AAF43211 (Ref. 3) Curated1
Sequence conflicti394N → D in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti394N → D in AAF32290 (PubMed:11948427).Curated1
Sequence conflicti593A → R in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti593A → R in AAF32290 (PubMed:11948427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06914956S → T1 PublicationCorresponds to variant dbSNP:rs17849535Ensembl.1
Natural variantiVAR_049158314K → E. Corresponds to variant dbSNP:rs34392334Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436601M → MA in isoform 3, isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_047041121 – 213HEGRS…LAELE → Q in isoform 6. CuratedAdd BLAST93
Alternative sequenceiVSP_001658122 – 170Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_046214434Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X63465 mRNA Translation: CAA45067.1
AF215923 mRNA Translation: AAF32290.1
AF237413 mRNA Translation: AAF43211.1
AC019077 Genomic DNA No translation available.
AC058823 Genomic DNA No translation available.
AC078961 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06069.1
CH471057 Genomic DNA Translation: EAX06071.1
BC001816 mRNA Translation: AAH01816.1
BC001851 mRNA Translation: AAH01851.2
BT006837 mRNA Translation: AAP35483.1
BC098269 mRNA Translation: AAH98269.1
BC098334 mRNA Translation: AAH98334.1
BC099708 mRNA Translation: AAH99708.1
BC099845 mRNA Translation: AAH99845.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43253.1 [P52306-1]
CCDS43254.1 [P52306-2]
CCDS47105.1 [P52306-5]
CCDS47106.1 [P52306-4]
CCDS47107.1 [P52306-3]
CCDS47108.1 [P52306-6]

Protein sequence database of the Protein Information Resource

More...PIRi		I37456

NCBI Reference Sequences

More...RefSeqi		NP_001093896.1, NM_001100426.1 [P52306-5]
NP_001093897.1, NM_001100427.1 [P52306-1]
NP_001093898.1, NM_001100428.1 [P52306-3]
NP_001093899.1, NM_001100429.1 [P52306-2]
NP_001093900.1, NM_001100430.1 [P52306-6]
NP_066982.3, NM_021159.4 [P52306-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264572; ENSP00000264572; ENSG00000138698 [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698 [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698 [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698 [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698 [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698 [P52306-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5910

UCSC genome browser

More...UCSCi		uc003htv.5, human [P52306-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63465 mRNA Translation: CAA45067.1
AF215923 mRNA Translation: AAF32290.1
AF237413 mRNA Translation: AAF43211.1
AC019077 Genomic DNA No translation available.
AC058823 Genomic DNA No translation available.
AC078961 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06069.1
CH471057 Genomic DNA Translation: EAX06071.1
BC001816 mRNA Translation: AAH01816.1
BC001851 mRNA Translation: AAH01851.2
BT006837 mRNA Translation: AAP35483.1
BC098269 mRNA Translation: AAH98269.1
BC098334 mRNA Translation: AAH98334.1
BC099708 mRNA Translation: AAH99708.1
BC099845 mRNA Translation: AAH99845.1
CCDSiCCDS43253.1 [P52306-1]
CCDS43254.1 [P52306-2]
CCDS47105.1 [P52306-5]
CCDS47106.1 [P52306-4]
CCDS47107.1 [P52306-3]
CCDS47108.1 [P52306-6]
PIRiI37456
RefSeqiNP_001093896.1, NM_001100426.1 [P52306-5]
NP_001093897.1, NM_001100427.1 [P52306-1]
NP_001093898.1, NM_001100428.1 [P52306-3]
NP_001093899.1, NM_001100429.1 [P52306-2]
NP_001093900.1, NM_001100430.1 [P52306-6]
NP_066982.3, NM_021159.4 [P52306-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XGCX-ray2.10A61-607[»]
5ZHXX-ray3.50A/B/C/D77-607[»]
SMRiP52306
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111845, 106 interactors
DIPiDIP-61080N
IntActiP52306, 53 interactors
STRINGi9606.ENSP00000340454

PTM databases

GlyGeniP52306, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP52306
MetOSiteiP52306
PhosphoSitePlusiP52306
SwissPalmiP52306

Genetic variation databases

BioMutaiRAP1GDS1
DMDMi212276504

Proteomic databases

EPDiP52306
jPOSTiP52306
MassIVEiP52306
MaxQBiP52306
PaxDbiP52306
PeptideAtlasiP52306
PRIDEiP52306
ProteomicsDBi20432
34006
56479 [P52306-1]
56480 [P52306-2]
56481 [P52306-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6907, 148 antibodies

The DNASU plasmid repository

More...DNASUi		5910

Genome annotation databases

EnsembliENST00000264572; ENSP00000264572; ENSG00000138698 [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698 [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698 [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698 [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698 [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698 [P52306-4]
GeneIDi5910
KEGGihsa:5910
UCSCiuc003htv.5, human [P52306-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5910
DisGeNETi5910

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAP1GDS1
HGNCiHGNC:9859, RAP1GDS1
HPAiENSG00000138698, Low tissue specificity
MIMi179502, gene
neXtProtiNX_P52306
OpenTargetsiENSG00000138698
PharmGKBiPA34221
VEuPathDBiHostDB:ENSG00000138698

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4500, Eukaryota
GeneTreeiENSGT00390000014293
HOGENOMiCLU_021124_1_0_1
InParanoidiP52306
OMAiIMQQLQR
OrthoDBi561489at2759
PhylomeDBiP52306

Enzyme and pathway databases

PathwayCommonsiP52306
ReactomeiR-HSA-9013419, RHOT2 GTPase cycle
R-HSA-9013425, RHOT1 GTPase cycle
SignaLinkiP52306
SIGNORiP52306

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5910, 15 hits in 1029 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAP1GDS1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAP1GDS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5910
PharosiP52306, Tbio

Protein Ontology

More...PROi		PR:P52306
RNActiP52306, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138698, Expressed in frontal cortex and 247 other tissues
ExpressionAtlasiP52306, baseline and differential
GenevisibleiP52306, HS

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR040144, RAP1GDS1
PANTHERiPTHR10957, PTHR10957, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 4 hits
SMARTiView protein in SMART
SM00185, ARM, 5 hits
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52306
Secondary accession number(s): E9PH06
, G5E9P9, Q499L7, Q4KMV2, Q4QQI8, Q9BUW9, Q9BUX6, Q9NYM2, Q9NZA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: September 29, 2021
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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