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Entry version 157 (03 Jul 2019)
Sequence version 3 (04 Nov 2008)
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Protein

Rap1 GTPase-GDP dissociation stimulator 1

Gene

RAP1GDS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P52306

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P52306

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rap1 GTPase-GDP dissociation stimulator 1
Alternative name(s):
Exchange factor smgGDS
SMG GDS protein
SMG P21 stimulatory GDP/GTP exchange protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9859 RAP1GDS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
179502 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P52306

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5910

Open Targets

More...
OpenTargetsi
ENSG00000138698

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34221

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAP1GDS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567591 – 607Rap1 GTPase-GDP dissociation stimulator 1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P52306

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P52306

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P52306

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52306

PeptideAtlas

More...
PeptideAtlasi
P52306

PRoteomics IDEntifications database

More...
PRIDEi
P52306

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56479
56480 [P52306-2]
56481 [P52306-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P52306

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P52306

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P52306

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138698 Expressed in 233 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52306 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52306 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019060

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111845, 91 interactors

Database of interacting proteins

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DIPi
DIP-61080N

Protein interaction database and analysis system

More...
IntActi
P52306, 21 interactors

Molecular INTeraction database

More...
MINTi
P52306

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340454

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52306

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 118ARM 1Add BLAST42
Repeati169 – 211ARM 2Add BLAST43
Repeati346 – 390ARM 3Add BLAST45
Repeati391 – 431ARM 4Add BLAST41
Repeati479 – 519ARM 5Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4500 Eukaryota
ENOG410Z64F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088636

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52306

Identification of Orthologs from Complete Genome Data

More...
OMAi
HENKTVA

Database of Orthologous Groups

More...
OrthoDBi
561489at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52306

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR040144 RAP1GDS1

The PANTHER Classification System

More...
PANTHERi
PTHR10957 PTHR10957, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514 Arm, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI
60 70 80 90 100
LQLFASLLTP QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS
110 120 130 140 150
KDQEVLLQTG RALGNICYDS HEGRSAVDQA GGAQIVIDHL RSLCSITDPA
160 170 180 190 200
NEKLLTVFCG MLMNYSNEND SLQAQLINMG VIPTLVKLLG IHCQNAALTE
210 220 230 240 250
MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK REMIFEVLAP
260 270 280 290 300
LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
310 320 330 340 350
LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC
360 370 380 390 400
IHMVDNGIVE KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS
410 420 430 440 450
AGVTEAVLKF LKSEMPPVQF KLLGTLRMLI DAQAEAAEQL GKNVKLVERL
460 470 480 490 500
VEWCEAKDHA GVMGESNRLL SALIRHSKSK DVIKTIVQSG GIKHLVTMAT
510 520 530 540 550
SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR LLADERSAPE
560 570 580 590 600
IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE

QRLTVES
Length:607
Mass (Da):66,317
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED0F359DFA3F0510
GO
Isoform 2 (identifier: P52306-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-170: Missing.

Show »
Length:558
Mass (Da):61,037
Checksum:i7DCE981DA08F4629
GO
Isoform 3 (identifier: P52306-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     122-170: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):61,108
Checksum:i2BF086E5908DC6BD
GO
Isoform 4 (identifier: P52306-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     434-434: Missing.

Note: No experimental confirmation available.
Show »
Length:607
Mass (Da):66,317
Checksum:i8196856D628A428C
GO
Isoform 5 (identifier: P52306-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA

Show »
Length:608
Mass (Da):66,388
Checksum:iB73C1010A184A971
GO
Isoform 6 (identifier: P52306-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MA
     121-213: HEGRSAVDQA...VAFGNLAELE → Q

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):56,536
Checksum:iD508C3FD684CA75D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQJ4U3KQJ4_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHZ7D6RHZ7_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHH8D6RHH8_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8M2H0Y8M2_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB97D6RB97_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REZ0D6REZ0_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBC6D6RBC6_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC85D6RC85_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC12D6RC12_HUMAN
Rap1 GTPase-GDP dissociation stimul...
RAP1GDS1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237E → G in AAH98269 (PubMed:15489334).Curated1
Sequence conflicti376T → P in AAF43211 (Ref. 3) Curated1
Sequence conflicti394N → D in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti394N → D in AAF32290 (PubMed:11948427).Curated1
Sequence conflicti593A → R in CAA45067 (PubMed:1549351).Curated1
Sequence conflicti593A → R in AAF32290 (PubMed:11948427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06914956S → T1 PublicationCorresponds to variant dbSNP:rs17849535Ensembl.1
Natural variantiVAR_049158314K → E. Corresponds to variant dbSNP:rs34392334Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436601M → MA in isoform 3, isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_047041121 – 213HEGRS…LAELE → Q in isoform 6. CuratedAdd BLAST93
Alternative sequenceiVSP_001658122 – 170Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_046214434Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63465 mRNA Translation: CAA45067.1
AF215923 mRNA Translation: AAF32290.1
AF237413 mRNA Translation: AAF43211.1
AC019077 Genomic DNA No translation available.
AC058823 Genomic DNA No translation available.
AC078961 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06069.1
CH471057 Genomic DNA Translation: EAX06071.1
BC001816 mRNA Translation: AAH01816.1
BC001851 mRNA Translation: AAH01851.2
BT006837 mRNA Translation: AAP35483.1
BC098269 mRNA Translation: AAH98269.1
BC098334 mRNA Translation: AAH98334.1
BC099708 mRNA Translation: AAH99708.1
BC099845 mRNA Translation: AAH99845.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43253.1 [P52306-1]
CCDS43254.1 [P52306-2]
CCDS47105.1 [P52306-5]
CCDS47106.1 [P52306-4]
CCDS47107.1 [P52306-3]
CCDS47108.1 [P52306-6]

Protein sequence database of the Protein Information Resource

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PIRi
I37456

NCBI Reference Sequences

More...
RefSeqi
NP_001093896.1, NM_001100426.1 [P52306-5]
NP_001093897.1, NM_001100427.1 [P52306-1]
NP_001093898.1, NM_001100428.1 [P52306-3]
NP_001093899.1, NM_001100429.1 [P52306-2]
NP_001093900.1, NM_001100430.1 [P52306-6]
NP_066982.3, NM_021159.4 [P52306-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264572; ENSP00000264572; ENSG00000138698 [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698 [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698 [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698 [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698 [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698 [P52306-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5910

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5910

UCSC genome browser

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UCSCi
uc003htv.5 human [P52306-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63465 mRNA Translation: CAA45067.1
AF215923 mRNA Translation: AAF32290.1
AF237413 mRNA Translation: AAF43211.1
AC019077 Genomic DNA No translation available.
AC058823 Genomic DNA No translation available.
AC078961 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06069.1
CH471057 Genomic DNA Translation: EAX06071.1
BC001816 mRNA Translation: AAH01816.1
BC001851 mRNA Translation: AAH01851.2
BT006837 mRNA Translation: AAP35483.1
BC098269 mRNA Translation: AAH98269.1
BC098334 mRNA Translation: AAH98334.1
BC099708 mRNA Translation: AAH99708.1
BC099845 mRNA Translation: AAH99845.1
CCDSiCCDS43253.1 [P52306-1]
CCDS43254.1 [P52306-2]
CCDS47105.1 [P52306-5]
CCDS47106.1 [P52306-4]
CCDS47107.1 [P52306-3]
CCDS47108.1 [P52306-6]
PIRiI37456
RefSeqiNP_001093896.1, NM_001100426.1 [P52306-5]
NP_001093897.1, NM_001100427.1 [P52306-1]
NP_001093898.1, NM_001100428.1 [P52306-3]
NP_001093899.1, NM_001100429.1 [P52306-2]
NP_001093900.1, NM_001100430.1 [P52306-6]
NP_066982.3, NM_021159.4 [P52306-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XGCX-ray2.10A61-607[»]
5ZHXX-ray3.50A/B/C/D77-607[»]
SMRiP52306
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111845, 91 interactors
DIPiDIP-61080N
IntActiP52306, 21 interactors
MINTiP52306
STRINGi9606.ENSP00000340454

PTM databases

iPTMnetiP52306
PhosphoSitePlusiP52306
SwissPalmiP52306

Polymorphism and mutation databases

BioMutaiRAP1GDS1
DMDMi212276504

Proteomic databases

EPDiP52306
jPOSTiP52306
MaxQBiP52306
PaxDbiP52306
PeptideAtlasiP52306
PRIDEiP52306
ProteomicsDBi56479
56480 [P52306-2]
56481 [P52306-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264572; ENSP00000264572; ENSG00000138698 [P52306-6]
ENST00000339360; ENSP00000340454; ENSG00000138698 [P52306-5]
ENST00000380158; ENSP00000369503; ENSG00000138698 [P52306-3]
ENST00000408900; ENSP00000386223; ENSG00000138698 [P52306-2]
ENST00000408927; ENSP00000386153; ENSG00000138698 [P52306-1]
ENST00000453712; ENSP00000407157; ENSG00000138698 [P52306-4]
GeneIDi5910
KEGGihsa:5910
UCSCiuc003htv.5 human [P52306-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5910
DisGeNETi5910

GeneCards: human genes, protein and diseases

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GeneCardsi
RAP1GDS1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004387
HGNCiHGNC:9859 RAP1GDS1
HPAiHPA019060
MIMi179502 gene
neXtProtiNX_P52306
OpenTargetsiENSG00000138698
PharmGKBiPA34221

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4500 Eukaryota
ENOG410Z64F LUCA
GeneTreeiENSGT00390000014293
HOGENOMiHOG000088636
InParanoidiP52306
OMAiHENKTVA
OrthoDBi561489at2759
PhylomeDBiP52306

Enzyme and pathway databases

SignaLinkiP52306
SIGNORiP52306

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RAP1GDS1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RAP1GDS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5910

Protein Ontology

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PROi
PR:P52306

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138698 Expressed in 233 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP52306 baseline and differential
GenevisibleiP52306 HS

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR040144 RAP1GDS1
PANTHERiPTHR10957 PTHR10957, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 4 hits
SMARTiView protein in SMART
SM00185 ARM, 5 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52306
Secondary accession number(s): E9PH06
, G5E9P9, Q499L7, Q4KMV2, Q4QQI8, Q9BUW9, Q9BUX6, Q9NYM2, Q9NZA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: July 3, 2019
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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