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Entry version 121 (17 Jun 2020)
Sequence version 2 (02 Feb 2004)
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Protein

Protein lethal(3)malignant blood neoplasm 1

Gene

l(3)mbn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for differentiation of the phagocytic blood-cell type, the plasmatocyte.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lethal(3)malignant blood neoplasm 1
Alternative name(s):
Mbn(83)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:l(3)mbn
Synonyms:l(3)mbn-1
ORF Names:CG12755
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002440 l(3)mbn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001961821 – 653Protein lethal(3)malignant blood neoplasm 1Add BLAST653

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52302

PRoteomics IDEntifications database

More...
PRIDEi
P52302

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Blood cells and other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002440 Expressed in larva and 7 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P52302 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P52302 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
64156, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0076770

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P52302

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 91Chitin-binding type R&R 1PROSITE-ProRule annotationAdd BLAST64
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati307 – 3271-1Add BLAST21
Repeati328 – 3481-2Add BLAST21
Repeati433 – 4552-1Add BLAST23
Repeati456 – 4752-2Add BLAST20
Repeati476 – 4972-3Add BLAST22
Repeati498 – 5152-4Add BLAST18
Repeati516 – 5332-5Add BLAST18
Repeati534 – 5512-6Add BLAST18
Repeati552 – 5682-7Add BLAST17
Domaini572 – 640Chitin-binding type R&R 2PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 3482 X 21 AA repeatsAdd BLAST42
Regioni433 – 5687 X approximate tandem repeats, Gly/Ser-richAdd BLAST136

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J4ZH Eukaryota
ENOG4112CT1 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52302

Database of Orthologous Groups

More...
OrthoDBi
1361828at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52302

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000618 Insect_cuticle

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00379 Chitin_bind_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51155 CHIT_BIND_RR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P52302-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLKLMAFVC ALLLLCTLTH VLSAATTVRP YKFGFTIDEQ QHRAEKRDER
60 70 80 90 100
GIIMGEFGFI TADGIYHVTV YATDEEGKFR IISMKSYPYA GPVGSKSVPV
110 120 130 140 150
TTTPKVLLPA APVALPKYNF NSEACSGCFL KKSPPKTEIR TLSQPLAPVQ
160 170 180 190 200
PGKPDGSSDI GLNVQLPFRE SIAQTVASRL GLLQDTLQTS NTNTNAPNTK
210 220 230 240 250
TIELGLNIAM STYYTTKNAV TGHVSTQTSN SQTPSANTKI DYNVGVVEKA
260 270 280 290 300
SPPVYRPLNI RLNEDVMRQA ITYGNTIPGH VPLPNQPLVE TSLLPASQVK
310 320 330 340 350
IFALDGNAKV PLASNIQSVA QHPNAGLNAK VPLASNIQSV AQHPNAGLNA
360 370 380 390 400
KVPLASNIQS VAQHPNAGLK NINRSGVSSA KTLANTKTRP PHTFNPHQTP
410 420 430 440 450
LLSSATAPGI SGVTANTPTG NVPSNGGGIA AGKAPGNPQA GGSGGIIGAG
460 470 480 490 500
APGGRKVSAG GIGSGSAIGG VSGGSKASGN GGAIGSGSAI GGGATGSKAS
510 520 530 540 550
GFGFGSNIGG GVSGSKPSGF GSESKIGGPD SGSKALGFGS GSKIGGGITG
560 570 580 590 600
TKASGFGGEI GSGRGSASSA TGDLYKFKYI LDYNGHEETG GRNGDKQGSY
610 620 630 640 650
FAIGEDAVQR TIEYIANEFG FQPHVSWRKL DAKEALPEEN SLKHYEFKWF

NQE
Length:653
Mass (Da):67,144
Last modified:February 2, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2303B9FE417F81E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S0WGW8A0A0S0WGW8_DROME
Lethal (3) malignant blood neoplasm...
l(3)mbn Dmel\CG12755, l(3)malignant blood neoplasm1, l(3)mbn-1, l(3)mbn1, MBN
402Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0WNZ2A0A0S0WNZ2_DROME
Lethal (3) malignant blood neoplasm...
l(3)mbn Dmel\CG12755, l(3)malignant blood neoplasm1, l(3)mbn-1, l(3)mbn1, MBN
596Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50879 differs from that shown. Intron retention.Curated
The sequence CAA87654 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56E → Q in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti67H → Q in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti72A → P in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti109P → H in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti189T → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti208I → L in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti226T → R in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti422V → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti529P → A in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti536L → S in CAA87654 (PubMed:8174791).Curated1
Sequence conflicti556F → L in CAA87654 (PubMed:8174791).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z47722 Genomic DNA Translation: CAA87654.1 Frameshift.
AE014296 Genomic DNA Translation: AAN12238.2
AY119019 mRNA Translation: AAM50879.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
S57844

NCBI Reference Sequences

More...
RefSeqi
NP_729143.2, NM_168157.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077062; FBpp0076770; FBgn0002440

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG12755

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47722 Genomic DNA Translation: CAA87654.1 Frameshift.
AE014296 Genomic DNA Translation: AAN12238.2
AY119019 mRNA Translation: AAM50879.1 Sequence problems.
PIRiS57844
RefSeqiNP_729143.2, NM_168157.2

3D structure databases

SMRiP52302
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi64156, 3 interactors
STRINGi7227.FBpp0076770

Proteomic databases

PaxDbiP52302
PRIDEiP52302

Genome annotation databases

EnsemblMetazoaiFBtr0077062; FBpp0076770; FBgn0002440
GeneIDi38701
KEGGidme:Dmel_CG12755

Organism-specific databases

FlyBaseiFBgn0002440 l(3)mbn

Phylogenomic databases

eggNOGiENOG410J4ZH Eukaryota
ENOG4112CT1 LUCA
InParanoidiP52302
OrthoDBi1361828at2759
PhylomeDBiP52302

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38701 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38701

Protein Ontology

More...
PROi
PR:P52302

Gene expression databases

BgeeiFBgn0002440 Expressed in larva and 7 other tissues
ExpressionAtlasiP52302 differential
GenevisibleiP52302 DM

Family and domain databases

InterProiView protein in InterPro
IPR000618 Insect_cuticle
PfamiView protein in Pfam
PF00379 Chitin_bind_4, 1 hit
PROSITEiView protein in PROSITE
PS51155 CHIT_BIND_RR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52302
Secondary accession number(s): Q59E19, Q8MS87, Q9VRU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 2, 2004
Last modified: June 17, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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