KPNA1

Functionⁱ

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

GO - Molecular functionⁱ

nuclear import signal receptor activity Source: InterPro
nuclear localization sequence binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic DNA fragmentation Source: Reactome
intracellular transport of virus Source: Reactome
modulation by virus of host process Source: Reactome
NLS-bearing protein import into nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
postsynapse to nucleus signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of DNA recombination
Source: ProtInc
Traceable author statementⁱ
- 8052633

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Protein transport, Transport

Biological process

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-162592 Integration of provirus R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-211227 Activation of DNA fragmentation factor
SignaLinkⁱ	P52294

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Importin subunit alpha-5 Alternative name(s): Karyopherin subunit alpha-1 Nucleoprotein interactor 1 Short name: NPI-1 RAG cohort protein 2 SRP1-beta Cleaved into the following chain: Importin subunit alpha-5, N-terminally processed
Gene namesⁱ	Name:KPNA1 Synonyms:RCH2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114030.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6394 KPNA1
MIMⁱ	600686 gene
neXtProtⁱ	NX_P52294

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3836
Open Targets More...OpenTargetsⁱ	ENSG00000114030
PharmGKBⁱ	PA30185

Polymorphism and mutation databases

BioMutaⁱ	KPNA1
DMDMⁱ	296439328

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000120719	1 – 538	Importin subunit alpha-5Add BLAST	538
Initiator methionineⁱ		Removed; alternateCombined sources
ChainⁱPRO_0000424491	2 – 538	Importin subunit alpha-5, N-terminally processedAdd BLAST	537

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	2	N-acetylthreonine; in Importin subunit alpha-5, N-terminally processedCombined sources	1
Modified residueⁱ	3	PhosphothreonineCombined sources	1
Modified residueⁱ	63	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Polyubiquitinated in the presence of RAG1 (in vitro).1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P52294
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P52294
PaxDbⁱ	P52294
PeptideAtlas More...PeptideAtlasⁱ	P52294
PRIDEⁱ	P52294
ProteomicsDBⁱ	56476

PTM databases

iPTMnetⁱ	P52294
PhosphoSitePlusⁱ	P52294

Miscellaneous databases

PMAP-CutDBⁱ	P52294

PMAP-CutDBⁱ

P52294

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously.

Gene expression databases

Bgeeⁱ	ENSG00000114030 Expressed in 225 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_KPNA1
ExpressionAtlasⁱ	P52294 baseline and differential
Genevisibleⁱ	P52294 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053627 HPA063426

HPAⁱ

HPA053627
HPA063426

Interactionⁱ

Subunit structureⁱ

Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with NSMF; the interaction occurs in a calcium-independent manner after synaptic NMDA receptor stimulation and is required for nuclear import of NSMF but is competed by CABP1 (By similarity). Interacts with APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS). Interacts with SNAI1 (via zinc fingers). Interacts with DCAF8.By similarity6 Publications

(Microbial infection) Interacts with human cytomegalovirus/HCMV UL84.1 Publication

(Microbial infection) Interacts with HIV-1 Vpr.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q9WMX2	2	EBI-358383,EBI-6863741	From Hepatitis C virus genotype 1b (isolate Con1).
AICDA	Q9GZX7	2	EBI-358383,EBI-3834328
ANP32B	Q92688	7	EBI-358383,EBI-762428
CLK4	Q9HAZ1	3	EBI-358383,EBI-633400
DCAF8	Q5TAQ9	2	EBI-358383,EBI-740686
GRM1	Q13255	2	EBI-358383,EBI-8527352
KPNB1	Q14974	2	EBI-358383,EBI-286758
LMNB1	P20700	3	EBI-358383,EBI-968218
NUP50	Q9UKX7	6	EBI-358383,EBI-2371082
PB2	B4URF7	2	EBI-358383,EBI-6050648	From Influenza A virus (strain A/Wilson-Smith/1933 H1N1).
PB2	P31345	3	EBI-358383,EBI-6051231	From Influenza A virus (strain A/Victoria/3/1975 H3N2).
SF1	Q15637	3	EBI-358383,EBI-744603
TAF9	Q16594	4	EBI-358383,EBI-712521

Protein-protein interaction databases

BioGridⁱ	110034, 129 interactors
ComplexPortalⁱ	CPX-1055 Importin complex, KPNA1 variant
CORUMⁱ	P52294
Database of interacting proteins More...DIPⁱ	DIP-29296N
ELMⁱ	P52294
IntActⁱ	P52294, 92 interactors
Molecular INTeraction database More...MINTⁱ	P52294
STRINGⁱ	9606.ENSP00000343701

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	85 – 92	Combined sources	8
Helixⁱ	96 – 111	Combined sources	16
Beta strandⁱ	112 – 115	Combined sources	4
Helixⁱ	118 – 122	Combined sources	5
Helixⁱ	127 – 135	Combined sources	9
Helixⁱ	141 – 155	Combined sources	15
Helixⁱ	159 – 167	Combined sources	9
Helixⁱ	170 – 177	Combined sources	8
Helixⁱ	183 – 197	Combined sources	15
Helixⁱ	201 – 209	Combined sources	9
Helixⁱ	213 – 219	Combined sources	7
Helixⁱ	226 – 240	Combined sources	15
Beta strandⁱ	243 – 245	Combined sources	3
Helixⁱ	249 – 251	Combined sources	3
Helixⁱ	253 – 255	Combined sources	3
Helixⁱ	256 – 262	Combined sources	7
Helixⁱ	268 – 281	Combined sources	14
Beta strandⁱ	283 – 285	Combined sources	3
Helixⁱ	286 – 294	Combined sources	9
Turnⁱ	295 – 297	Combined sources	3
Helixⁱ	298 – 304	Combined sources	7
Helixⁱ	310 – 323	Combined sources	14
Helixⁱ	328 – 335	Combined sources	8
Turnⁱ	336 – 338	Combined sources	3
Helixⁱ	339 – 346	Combined sources	8
Helixⁱ	352 – 365	Combined sources	14
Helixⁱ	370 – 378	Combined sources	9
Helixⁱ	381 – 391	Combined sources	11
Helixⁱ	394 – 410	Combined sources	17
Helixⁱ	413 – 422	Combined sources	10
Helixⁱ	425 – 430	Combined sources	6
Helixⁱ	431 – 433	Combined sources	3
Helixⁱ	437 – 460	Combined sources	24
Beta strandⁱ	461 – 463	Combined sources	3
Helixⁱ	468 – 476	Combined sources	9
Helixⁱ	478 – 485	Combined sources	8
Helixⁱ	487 – 504	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	P52294
SMRⁱ	P52294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P52294

EvolutionaryTraceⁱ

P52294

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 57	IBBPROSITE-ProRule annotationAdd BLAST	57
Repeatⁱ	77 – 117	ARM 1; truncatedAdd BLAST	41
Repeatⁱ	118 – 161	ARM 2Add BLAST	44
Repeatⁱ	162 – 206	ARM 3Add BLAST	45
Repeatⁱ	207 – 245	ARM 4Add BLAST	39
Repeatⁱ	246 – 290	ARM 5Add BLAST	45
Repeatⁱ	291 – 330	ARM 6Add BLAST	40
Repeatⁱ	331 – 372	ARM 7Add BLAST	42
Repeatⁱ	373 – 412	ARM 8Add BLAST	40
Repeatⁱ	413 – 457	ARM 9Add BLAST	45
Repeatⁱ	460 – 504	ARM 10; atypicalAdd BLAST	45

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	149 – 241	NLS binding site (major)By similarityAdd BLAST	93
Regionⁱ	245 – 437	Binding to RAG1Add BLAST	193
Regionⁱ	318 – 406	NLS binding site (minor)By similarityAdd BLAST	89

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	42 – 51	Nuclear localization signalBy similarity		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	25 – 28	Poly-Arg		4

Domainⁱ

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.1 Publication

The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).By similarity

The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the importin alpha family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0166 Eukaryota COG5064 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119094
HOGENOMⁱ	HOG000167616
HOVERGENⁱ	HBG001846
InParanoidⁱ	P52294
KEGG Orthology (KO) More...KOⁱ	K15042
OMAⁱ	TSHQTRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G095Z
PhylomeDBⁱ	P52294
TreeFamⁱ	TF354205

Family and domain databases

Gene3Dⁱ	1.20.5.690, 1 hit 1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR032413 Arm_3 IPR000225 Armadillo IPR002652 Importin-a_IBB IPR036975 Importin-a_IBB_sf IPR024931 Importing_su_alpha
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00514 Arm, 8 hits PF16186 Arm_3, 1 hit PF01749 IBB, 1 hit
PIRSFⁱ	PIRSF005673 Importin_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00185 ARM, 8 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 4 hits PS51214 IBB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P52294-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV 
        60         70         80         90        100
ATAEEETEEE VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL 
       110        120        130        140        150
SATQKFRKLL SKEPNPPIDE VISTPGVVAR FVEFLKRKEN CTLQFESAWV 
       160        170        180        190        200
LTNIASGNSL QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS 
       210        220        230        240        250
TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC RGKSPPPEFA 
       260        270        280        290        300
KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR 
       310        320        330        340        350
LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLSSP 
       360        370        380        390        400
KESIKKEACW TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA 
       410        420        430        440        450
AWAITNATSG GSAEQIKYLV ELGCIKPLCD LLTVMDSKIV QVALNGLENI 
       460        470        480        490        500
LRLGEQEAKR NGTGINPYCA LIEEAYGLDK IEFLQSHENQ EIYQKAFDLI 
       510        520        530 
EHYFGTEDED SSIAPQVDLN QQQYIFQQCE APMEGFQL

Length:538

Mass (Da):60,222

Last modified:May 18, 2010 - v3

Checksum:ⁱE8407A3352D6051C

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JWD9	C9JWD9_HUMAN	Importin subunit alpha-5 Importin subunit alpha-5	KPNA1	174	Annotation score:
C9JYI4	C9JYI4_HUMAN	Importin subunit alpha-5 Importin subunit alpha-5	KPNA1	328	Annotation score:
C9J4U1	C9J4U1_HUMAN	Importin subunit alpha-5 Importin subunit alpha-5	KPNA1	214	Annotation score:
C9J352	C9J352_HUMAN	Importin subunit alpha-5 Importin subunit alpha-5	KPNA1	169	Annotation score:
F2Z3G4	F2Z3G4_HUMAN	Importin subunit alpha-5 Importin subunit alpha-5	KPNA1	182	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	142	T → S in AAC60648 (PubMed:7831767).Curated		1
Sequence conflictⁱ	169	G → R in AAC60648 (PubMed:7831767).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050002	73	S → N4 PublicationsCorresponds to variant dbSNP:rs4678193Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S75295 mRNA Translation: AAC60648.1 BT006959 mRNA Translation: AAP35605.1 CR456743 mRNA Translation: CAG33024.1 AC083798 Genomic DNA No translation available. AC096861 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79482.1 CH471052 Genomic DNA Translation: EAW79483.1 BC002374 mRNA Translation: AAH02374.1 BC003009 mRNA Translation: AAH03009.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3013.1
PIRⁱ	I59931
NCBI Reference Sequences More...RefSeqⁱ	NP_002255.3, NM_002264.3 XP_005247494.1, XM_005247437.3
UniGeneⁱ	Hs.161008

Genome annotation databases

Ensemblⁱ	ENST00000344337; ENSP00000343701; ENSG00000114030
GeneIDⁱ	3836
KEGGⁱ	hsa:3836
UCSC genome browser More...UCSCⁱ	uc003efe.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52294	Importin subunit alpha-5 (Fragment)		HUMAN		174	UniRef100_P52294
Importin subunit alpha-5 (Fragment)		HUMAN		214
Importin subunit alpha-5 (Fragment)		HUMAN		328
UPI0002380B0F		HUMAN		447
UPI0005D037CC		HUMAN		477

Protein	Similar proteins		Species	Score	Length	Source
P52294	Importin subunit alpha-5		RAT		538	UniRef90_P52294
Importin subunit alpha-5		PONAB		538
Importin subunit alpha-5		MOUSE		538
Importin subunit alpha-5		CHICK		538
Importin subunit alpha-5		BOVIN		538
+203

Protein	Similar proteins		Species	Score	Length	Source
P52294	Importin subunit alpha-5		PONAB		538	UniRef50_P52294
Importin subunit alpha-5		RAT		538
Importin subunit alpha-5		BOVIN		538
Importin subunit alpha-5		CHICK		538
Importin subunit alpha-5		MOUSE		538
+227

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S75295 mRNA Translation: AAC60648.1 BT006959 mRNA Translation: AAP35605.1 CR456743 mRNA Translation: CAG33024.1 AC083798 Genomic DNA No translation available. AC096861 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79482.1 CH471052 Genomic DNA Translation: EAW79483.1 BC002374 mRNA Translation: AAH02374.1 BC003009 mRNA Translation: AAH03009.1
CCDSⁱ	CCDS3013.1
PIRⁱ	I59931
RefSeqⁱ	NP_002255.3, NM_002264.3 XP_005247494.1, XM_005247437.3
UniGeneⁱ	Hs.161008

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JDQ	X-ray	2.20	A/B	66-512	[»]
	3TJ3	X-ray	2.70	A/B	66-512	[»]
	4B18	X-ray	2.52	A	66-512	[»]
ProteinModelPortalⁱ	P52294
SMRⁱ	P52294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110034, 129 interactors
ComplexPortalⁱ	CPX-1055 Importin complex, KPNA1 variant
CORUMⁱ	P52294
DIPⁱ	DIP-29296N
ELMⁱ	P52294
IntActⁱ	P52294, 92 interactors
MINTⁱ	P52294
STRINGⁱ	9606.ENSP00000343701

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	P52294
PhosphoSitePlusⁱ	P52294

Polymorphism and mutation databases

BioMutaⁱ	KPNA1
DMDMⁱ	296439328

Proteomic databases

EPDⁱ	P52294
MaxQBⁱ	P52294
PaxDbⁱ	P52294
PeptideAtlasⁱ	P52294
PRIDEⁱ	P52294
ProteomicsDBⁱ	56476

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3836
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344337; ENSP00000343701; ENSG00000114030
GeneIDⁱ	3836
KEGGⁱ	hsa:3836
UCSCⁱ	uc003efe.3 human

Organism-specific databases

CTDⁱ	3836
DisGeNETⁱ	3836
EuPathDBⁱ	HostDB:ENSG00000114030.12
GeneCardsⁱ	KPNA1
HGNCⁱ	HGNC:6394 KPNA1
HPAⁱ	HPA053627 HPA063426
MIMⁱ	600686 gene
neXtProtⁱ	NX_P52294
OpenTargetsⁱ	ENSG00000114030
PharmGKBⁱ	PA30185
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0166 Eukaryota COG5064 LUCA
GeneTreeⁱ	ENSGT00760000119094
HOGENOMⁱ	HOG000167616
HOVERGENⁱ	HBG001846
InParanoidⁱ	P52294
KOⁱ	K15042
OMAⁱ	TSHQTRV
OrthoDBⁱ	EOG091G095Z
PhylomeDBⁱ	P52294
TreeFamⁱ	TF354205

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-162592 Integration of provirus R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-211227 Activation of DNA fragmentation factor
SignaLinkⁱ	P52294

Miscellaneous databases

ChiTaRSⁱ	KPNA1 human
EvolutionaryTraceⁱ	P52294
GeneWikiⁱ	Karyopherin_alpha_1
GenomeRNAiⁱ	3836
PMAP-CutDBⁱ	P52294
Protein Ontology More...PROⁱ	PR:P52294
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114030 Expressed in 225 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_KPNA1
ExpressionAtlasⁱ	P52294 baseline and differential
Genevisibleⁱ	P52294 HS

Family and domain databases

Gene3Dⁱ	1.20.5.690, 1 hit 1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR032413 Arm_3 IPR000225 Armadillo IPR002652 Importin-a_IBB IPR036975 Importin-a_IBB_sf IPR024931 Importing_su_alpha
Pfamⁱ	View protein in Pfam PF00514 Arm, 8 hits PF16186 Arm_3, 1 hit PF01749 IBB, 1 hit
PIRSFⁱ	PIRSF005673 Importin_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00185 ARM, 8 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 4 hits PS51214 IBB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IMA5_HUMAN
Accessionⁱ	P52294Primary (citable) accession number: P52294 Secondary accession number(s): D3DN93, Q6IBQ9, Q9BQ56
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P52294 (IMA5_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Importin subunit alpha-5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ