UniProtKB - P52279 (PIP_XANCI)
Protein
Proline iminopeptidase
Gene
pip
Organism
Xanthomonas citri (Xanthomonas campestris pv. citri)
Status
Functioni
May be involved in proline metabolism and sensitivity to ascamycin. Has ascamycin dealanylating activity.
Catalytic activityi
- Release of N-terminal proline from a peptide. EC:3.4.11.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 110 | Nucleophile1 Publication | 1 | |
Active sitei | 266 | 1 Publication | 1 | |
Active sitei | 294 | Proton donor1 Publication | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease |
Protein family/group databases
ESTHERi | xanca-impep, Proline_iminopeptidase |
MEROPSi | S33.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline iminopeptidase (EC:3.4.11.5)Short name: PIP Alternative name(s): Prolyl aminopeptidase Short name: PAP |
Gene namesi | Name:pip Synonyms:xap |
Organismi | Xanthomonas citri (Xanthomonas campestris pv. citri) |
Taxonomic identifieri | 346 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080847 | 1 – 313 | Proline iminopeptidaseAdd BLAST | 313 |
Interactioni
Subunit structurei
Homooligomer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P52279 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P52279 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 298 | AB hydrolase-1Sequence analysisAdd BLAST | 264 |
Sequence similaritiesi
Belongs to the peptidase S33 family.Curated
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR002410, Peptidase_S33 IPR005944, Pro_iminopeptidase |
PANTHERi | PTHR43722, PTHR43722, 1 hit |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
PIRSFi | PIRSF006431, Pept_S33, 1 hit |
PRINTSi | PR00793, PROAMNOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01249, pro_imino_pep_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P52279-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTLYPEITP YQQGSLKVDD RHTLYFEQCG NPHGKPVVML HGGPGGGCND
60 70 80 90 100
KMRRFHDPAK YRIVLFDQRG SGRSTPHADL VDNTTWDLVA DIERLRTHLG
110 120 130 140 150
VDRWQVFGGS WGSTLALAYA ADPSAAGHQL VLRGIFLLRR FELEWFYQEG
160 170 180 190 200
ASRLFPDAWE HYLNAIPPVE RADLMSAFHR RLTSDDEATR LAAAKAWSVW
210 220 230 240 250
EGATSFLHVD EDFVTGHEDA HFALAFARIE NHYFVNGGFF EVEDQLLRDA
260 270 280 290 300
HRIADIPGVI VHGRYDVVCP LQSAWDLHKA WPKAQLQISP ASGHSAFEPE
310
NVDALVRATD GFA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 | L → V in BAA11623 (PubMed:8870654).Curated | 1 | |
Sequence conflicti | 121 – 129 | ADPSAAGHQ → QTHPQQVTE in BAA11623 (PubMed:8870654).Curated | 9 | |
Sequence conflicti | 245 – 251 | QLLRDAH → SCCATD in BAA11623 (PubMed:8870654).Curated | 7 | |
Sequence conflicti | 284 | Missing in BAA11623 (PubMed:8870654).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54150 Genomic DNA Translation: CAA90864.1 D82882 Genomic DNA Translation: BAA11623.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54150 Genomic DNA Translation: CAA90864.1 D82882 Genomic DNA Translation: BAA11623.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AZW | X-ray | 2.70 | A/B | 1-313 | [»] | |
SMRi | P52279 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
ESTHERi | xanca-impep, Proline_iminopeptidase |
MEROPSi | S33.001 |
Miscellaneous databases
EvolutionaryTracei | P52279 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR002410, Peptidase_S33 IPR005944, Pro_iminopeptidase |
PANTHERi | PTHR43722, PTHR43722, 1 hit |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
PIRSFi | PIRSF006431, Pept_S33, 1 hit |
PRINTSi | PR00793, PROAMNOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01249, pro_imino_pep_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PIP_XANCI | |
Accessioni | P52279Primary (citable) accession number: P52279 Secondary accession number(s): P96186 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 11, 2019 | |
This is version 95 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries