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Protein

Triosephosphate isomerase, glycosomal

Gene
N/A
Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase, glycosomal, Triosephosphate isomerase, Triosephosphate isomerase (C4B63_28g114), Triosephosphate isomerase (C3747_11g414), Triosephosphate isomerase (C3747_69g188)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateBy similarity1
Binding sitei14SubstrateBy similarity1
Active sitei96ElectrophileBy similarity1
Active sitei168Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BRENDAi5.3.1.1 6524
SABIO-RKiP52270
UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase, glycosomal (EC:5.3.1.1)
Short name:
TIM
Short name:
Triose-phosphate isomerase
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Glycosome, Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5834
DrugBankiDB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901431 – 251Triosephosphate isomerase, glycosomalAdd BLAST251

Proteomic databases

PRIDEiP52270

Interactioni

Subunit structurei

Homodimer.

Chemistry databases

BindingDBiP52270

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52270
SMRiP52270
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52270

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52270-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKPQPIAA ANWKCNGSES LLVPLIETLN AATFDHDVQC VVAPTFLHIP
60 70 80 90 100
MTKARLTNPK FQIAAQNAIT RSGAFTGEVS LQILKDYGIS WVVLGHSERR
110 120 130 140 150
LYYGETNEIV AEKVAQACAA GFHVIVCVGE TNEEREAGRT AAVVLTQLAA
160 170 180 190 200
VAQKLSKEAW SRVVIAYEPV WAIGTGKVAT PQQAQEVHEL LRRWVRSKLG
210 220 230 240 250
TDIAAQLRIL YGGSVTAKNA RTLYQMRDIN GFLVGGASLK PEFVEIIEAT

K
Length:251
Mass (Da):27,329
Last modified:October 1, 1996 - v1
Checksum:i03010B66586C186D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53867 Genomic DNA Translation: AAB58349.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53867 Genomic DNA Translation: AAB58349.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CI1X-ray2.00A/B1-251[»]
1SUXX-ray2.00A/B1-251[»]
1TCDX-ray1.83A/B3-251[»]
2OMAX-ray2.15A/B2-251[»]
2V5BX-ray2.00A1-251[»]
3Q37X-ray1.65A/B/C/D37-92[»]
A/B/C/D121-251[»]
4HHPX-ray1.50A/B1-251[»]
ProteinModelPortaliP52270
SMRiP52270
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP52270
ChEMBLiCHEMBL5834
DrugBankiDB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid

Proteomic databases

PRIDEiP52270

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

BRENDAi5.3.1.1 6524
SABIO-RKiP52270

Miscellaneous databases

EvolutionaryTraceiP52270

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_TRYCR
AccessioniPrimary (citable) accession number: P52270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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