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Protein

Parathyroid hormone

Gene

PTH

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-CFA-373080 Class B/2 (Secretin family receptors)
R-CFA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:PTH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:45153 PTH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
PropeptideiPRO_000002324526 – 31By similarity6
ChainiPRO_000002324632 – 115Parathyroid hormoneAdd BLAST84

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP52212

Expressioni

Gene expression databases

BgeeiENSCAFG00000008177 Expressed in 2 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012029

Structurei

3D structure databases

ProteinModelPortaliP52212
SMRiP52212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 69Important for receptor bindingBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
InParanoidiP52212
KOiK05261
OMAiEIQFMHN
OrthoDBiEOG091G13ZF
TreeFamiTF336197

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52212-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSAKDMVKV MIVMFAICFL AKSDGKPVKK RSVSEIQFMH NLGKHLSSME
60 70 80 90 100
RVEWLRKKLQ DVHNFVALGA PIAHRDGSSQ RPLKKEDNVL VESYQKSLGE
110
ADKADVDVLT KAKSQ
Length:115
Mass (Da):12,957
Last modified:October 1, 1996 - v1
Checksum:iFC38F77F1C8CFE56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15662 mRNA Translation: AAA82584.1
PIRiJC4202
RefSeqiNP_001003302.1, NM_001003302.1
XP_005633342.1, XM_005633285.2
XP_013977895.1, XM_014122420.1
UniGeneiCfa.3855

Genome annotation databases

EnsembliENSCAFT00000012999; ENSCAFP00000012029; ENSCAFG00000008177
GeneIDi403986
KEGGicfa:403986

Similar proteinsi

Entry informationi

Entry nameiPTHY_CANLF
AccessioniPrimary (citable) accession number: P52212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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