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Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).By similarity
Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
LigandCalcium

Enzyme and pathway databases

ReactomeiR-CFA-373080 Class B/2 (Secretin family receptors)
R-CFA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone-related protein
Short name:
PTH-rP
Short name:
PTHrP
Cleaved into the following chain:
Gene namesi
Name:PTHLH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:45157 PTHLH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002322025 – 34By similarity10
ChainiPRO_000002322137 – 177Parathyroid hormone-related proteinAdd BLAST141
PeptideiPRO_0000023222143 – 175OsteostatinBy similarityAdd BLAST33

Post-translational modificationi

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP52211

Expressioni

Gene expression databases

BgeeiENSCAFG00000010955

Interactioni

Subunit structurei

PTHrP interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000016137

Structurei

3D structure databases

ProteinModelPortaliP52211
SMRiP52211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 68Important for receptor bindingBy similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi108 – 129Nuclear localization signalBy similarityAdd BLAST22

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW2I Eukaryota
ENOG41126XH LUCA
GeneTreeiENSGT00390000004933
HOGENOMiHOG000115765
HOVERGENiHBG003236
InParanoidiP52211
KOiK22608

Family and domain databases

InterProiView protein in InterPro
IPR003626 PTH-rel
IPR001415 PTH/PTH-rel
PANTHERiPTHR17223 PTHR17223, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRLVQQWG VAVFLLSYSV PSCGRSVEEL GRRLKRAVSE HQLLHDKGKS
60 70 80 90 100
IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE
110 120 130 140 150
GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRKEQEKKK RRTRSAWLNS
160 170
GVAESGLEGD HPYDISATSL ELNLRRH
Length:177
Mass (Da):20,299
Last modified:October 1, 1996 - v1
Checksum:i93F57235C188A2CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15593 mRNA Translation: AAA82583.1
PIRiJC4201
RefSeqiNP_001003303.1, NM_001003303.1
XP_005636738.1, XM_005636681.2
XP_013963722.1, XM_014108247.1
XP_013963723.1, XM_014108248.1
XP_013963724.1, XM_014108249.1
XP_013963725.1, XM_014108250.1
UniGeneiCfa.3856

Genome annotation databases

EnsembliENSCAFT00000039639; ENSCAFP00000035520; ENSCAFG00000010955
ENSCAFT00000049938; ENSCAFP00000035896; ENSCAFG00000010955
GeneIDi403987
KEGGicfa:403987

Similar proteinsi

Entry informationi

Entry nameiPTHR_CANLF
AccessioniPrimary (citable) accession number: P52211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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