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Protein

Rho-related GTP-binding protein RhoN

Gene

RND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central
  • protein N-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoN
Alternative name(s):
Rho family GTPase 2
Rho-related GTP-binding protein Rho7
Rnd2
Gene namesi
Name:RND2
Synonyms:ARHN, RHO7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108830.9
HGNCiHGNC:18315 RND2
MIMi601555 gene
neXtProtiNX_P52198

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108830
PharmGKBiPA134936989

Polymorphism and mutation databases

BioMutaiRND2
DMDMi2507301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988761 – 224Rho-related GTP-binding protein RhoNAdd BLAST224
PropeptideiPRO_0000281228225 – 227Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224Cysteine methyl esterBy similarity1
Lipidationi224S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP52198
PaxDbiP52198
PeptideAtlasiP52198
PRIDEiP52198
ProteomicsDBi56471

PTM databases

iPTMnetiP52198
PhosphoSitePlusiP52198

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiENSG00000108830 Expressed in 166 organ(s), highest expression level in medial globus pallidus
CleanExiHS_RND2
GenevisibleiP52198 HS

Organism-specific databases

HPAiHPA077757

Interactioni

Subunit structurei

Interacts with the Rho-GAP domain of RACGAP1 (PubMed:12590651). Interacts with UBXD5 (PubMed:11940653). Interacts with PRAG1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Fnbp1Q8R5112EBI-1111436,EBI-1111424From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113810, 9 interactors
IntActiP52198, 1 interactor
STRINGi9606.ENSP00000466680

Structurei

3D structure databases

ProteinModelPortaliP52198
SMRiP52198
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP52198
KOiK07858
OMAiMGAVAYV
OrthoDBiEOG091G0M4M
PhylomeDBiP52198

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI
60 70 80 90 100
DKRRIELNMW DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK
110 120 130 140 150
WQGETQEFCP NAKVVLVGCK LDMRTDLATL RELSKQRLIP VTHEQGTVLA
160 170 180 190 200
KQVGAVSYVE CSSRSSERSV RDVFHVATVA SLGRGHRQLR RTDSRRGMQR
210 220
SAQLSGRPDR GNEGEIHKDR AKSCNLM
Length:227
Mass (Da):25,369
Last modified:November 1, 1997 - v2
Checksum:iDB2127B97B468F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95456 mRNA Translation: CAA64726.1
L78833 Genomic DNA Translation: AAC37595.1
AF498968 mRNA Translation: AAM21115.1
BT019394 mRNA Translation: AAV38201.1
AK290199 mRNA Translation: BAF82888.1
CH471152 Genomic DNA Translation: EAW60920.1
BC094842 mRNA Translation: AAH94842.1
BC104986 mRNA Translation: AAI04987.1
BC104990 mRNA Translation: AAI04991.1
CCDSiCCDS11452.1
RefSeqiNP_005431.1, NM_005440.4
UniGeneiHs.603111

Genome annotation databases

EnsembliENST00000587250; ENSP00000466680; ENSG00000108830
GeneIDi8153
KEGGihsa:8153
UCSCiuc002icn.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95456 mRNA Translation: CAA64726.1
L78833 Genomic DNA Translation: AAC37595.1
AF498968 mRNA Translation: AAM21115.1
BT019394 mRNA Translation: AAV38201.1
AK290199 mRNA Translation: BAF82888.1
CH471152 Genomic DNA Translation: EAW60920.1
BC094842 mRNA Translation: AAH94842.1
BC104986 mRNA Translation: AAI04987.1
BC104990 mRNA Translation: AAI04991.1
CCDSiCCDS11452.1
RefSeqiNP_005431.1, NM_005440.4
UniGeneiHs.603111

3D structure databases

ProteinModelPortaliP52198
SMRiP52198
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113810, 9 interactors
IntActiP52198, 1 interactor
STRINGi9606.ENSP00000466680

PTM databases

iPTMnetiP52198
PhosphoSitePlusiP52198

Polymorphism and mutation databases

BioMutaiRND2
DMDMi2507301

Proteomic databases

EPDiP52198
PaxDbiP52198
PeptideAtlasiP52198
PRIDEiP52198
ProteomicsDBi56471

Protocols and materials databases

DNASUi8153
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587250; ENSP00000466680; ENSG00000108830
GeneIDi8153
KEGGihsa:8153
UCSCiuc002icn.4 human

Organism-specific databases

CTDi8153
EuPathDBiHostDB:ENSG00000108830.9
GeneCardsiRND2
HGNCiHGNC:18315 RND2
HPAiHPA077757
MIMi601555 gene
neXtProtiNX_P52198
OpenTargetsiENSG00000108830
PharmGKBiPA134936989
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP52198
KOiK07858
OMAiMGAVAYV
OrthoDBiEOG091G0M4M
PhylomeDBiP52198

Miscellaneous databases

ChiTaRSiRND2 human
GeneWikiiRnd2
GenomeRNAii8153
PROiPR:P52198
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108830 Expressed in 166 organ(s), highest expression level in medial globus pallidus
CleanExiHS_RND2
GenevisibleiP52198 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRND2_HUMAN
AccessioniPrimary (citable) accession number: P52198
Secondary accession number(s): A8K2D4
, O00690, O00734, Q5U0P6, Q99535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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