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Protein

Myomesin-1

Gene

MYOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Myomesin-1
Alternative name(s):
190 kDa connectin-associated protein
190 kDa titin-associated protein
Myomesin family member 1
Gene namesi
Name:MYOM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101605.12
HGNCiHGNC:7613 MYOM1
MIMi603508 gene
neXtProtiNX_P52179

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi8736
OpenTargetsiENSG00000101605
PharmGKBiPA31418

Polymorphism and mutation databases

BioMutaiMYOM1
DMDMi212276443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726841 – 1685Myomesin-1Add BLAST1685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineBy similarity1
Modified residuei883PhosphoserineBy similarity1
Modified residuei887PhosphoserineBy similarity1
Modified residuei1054PhosphoserineBy similarity1
Disulfide bondi1160 ↔ 1210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP52179
PaxDbiP52179
PeptideAtlasiP52179
PRIDEiP52179
ProteomicsDBi56469
56470 [P52179-2]

PTM databases

CarbonylDBiP52179
iPTMnetiP52179
PhosphoSitePlusiP52179

Expressioni

Gene expression databases

BgeeiENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExiHS_MYOM1
ExpressionAtlasiP52179 baseline and differential
GenevisibleiP52179 HS

Organism-specific databases

HPAiHPA014305
HPA049193

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with TTN/titin (By similarity). Interacts with PNKD.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114273, 1 interactor
CORUMiP52179
DIPiDIP-59649N
IntActiP52179, 14 interactors
MINTiP52179
STRINGi9606.ENSP00000348821

Structurei

Secondary structure

11685
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00517
ProteinModelPortaliP52179
SMRiP52179
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52179

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 18716
Repeati188 – 19326
Repeati194 – 19936
Repeati200 – 20546
Repeati206 – 21156
Repeati212 – 21766
Domaini277 – 368Ig-like C2-type 1Add BLAST92
Domaini396 – 498Ig-like C2-type 2Add BLAST103
Domaini512 – 607Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini640 – 734Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini741 – 834Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini933 – 1034Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST102
Domaini1041 – 1140Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1132 – 1230Ig-like C2-type 3Add BLAST99
Domaini1358 – 1444Ig-like C2-type 4Add BLAST87
Domaini1573 – 1662Ig-like C2-type 5Add BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 2176 X 6 AA tandem repeatsAdd BLAST36

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410INWB Eukaryota
ENOG411180Q LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000293283
HOVERGENiHBG004977
InParanoidiP52179
OMAiQRGHEGI
OrthoDBiEOG091G0095
PhylomeDBiP52179
TreeFamiTF331825

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS
60 70 80 90 100
SAAHRRESEA FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD
110 120 130 140 150
SSLLLDDYSS KLSPKPKRAK HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG
160 170 180 190 200
ITDTEEERIK EAAAYIAQRN LLASEEGITT SKQSTASKQT TASKQSTASK
210 220 230 240 250
QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS RKVVIREKAE
260 270 280 290 300
RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI
310 320 330 340 350
AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY
360 370 380 390 400
RASAMNVKGE LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA
410 420 430 440 450
SRFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL
460 470 480 490 500
SPSKWVQTLW SGERATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR
510 520 530 540 550
DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP ILGYFIDKCE
560 570 580 590 600
VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE
610 620 630 640 650
PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT
660 670 680 690 700
RSYVVLSWKP PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF
710 720 730 740 750
DLAEGKSYCF RVRCSNSAGV GEPSEATEVT VVGDKLDIPK APGKIIPSRN
760 770 780 790 800
TDTSVVVSWE ESKDAKELVG YYIEASVAGS GKWEPCNNNP VKGSRFTCHG
810 820 830 840 850
LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS PDVCPALSDE
860 870 880 890 900
PGGLTASRGR VHEASPPTFQ KDALLGSKPN KPSLPSSSQN LGQTEVSKVS
910 920 930 940 950
ETVQEELTPP PQKAAPQGKS KSDPLKKKTD RAPPSPPCDI TCLESFRDSM
960 970 980 990 1000
VLGWKQPDKI GGAEITGYYV NYREVIDGVP GKWREANVKA VSEEAYKISN
1010 1020 1030 1040 1050
LKENMVYQFQ VAAMNMAGLG APSAVSECFK CEEWTIAVPG PPHSLKCSEV
1060 1070 1080 1090 1100
RKDSLVLQWK PPVHSGRTPV TGYFVDLKEA KAKEDQWRGL NEAAIKNVYL
1110 1120 1130 1140 1150
KVRGLKEGVS YVFRVRAINQ AGVGKPSDLA GPVVAETRPG TKEVVVNVDD
1160 1170 1180 1190 1200
DGVISLNFEC DKMTPKSEFS WSKDYVSTED SPRLEVESKG NKTKMTFKDL
1210 1220 1230 1240 1250
GMDDLGIYSC DVTDTDGIAS SYLIDEEELK RLLALSHEHK FPTVPVKSEL
1260 1270 1280 1290 1300
AVEILEKGQV RFWMQAEKLS GNAKVNYIFN EKEIFEGPKY KMHIDRNTGI
1310 1320 1330 1340 1350
IEMFMEKLQD EDEGTYTFQL QDGKATNHST VVLVGDVFKK LQKEAEFQRQ
1360 1370 1380 1390 1400
EWIRKQGPHF VEYLSWEVTG ECNVLLKCKV ANIKKETHIV WYKDEREISV
1410 1420 1430 1440 1450
DEKHDFKDGI CTLLITEFSK KDAGIYEVIL KDDRGKDKSR LKLVDEAFKE
1460 1470 1480 1490 1500
LMMEVCKKIA LSATDLKIQS TAEGIQLYSF VTYYVEDLKV NWSHNGSAIR
1510 1520 1530 1540 1550
YSDRVKTGVT GEQIWLQINE PTPNDKGKYV MELFDGKTGH QKTVDLSGQA
1560 1570 1580 1590 1600
YDEAYAEFQR LKQAAIAEKN RARVLGGLPD VVTIQEGKAL NLTCNVWGDP
1610 1620 1630 1640 1650
PPEVSWLKNE KALASDDHCN LKFEAGRTAY FTINGVSTAD SGKYGLVVKN
1660 1670 1680
KYGSETSDFT VSVFIPEEEA RMAALESLKG GKKAK
Length:1,685
Mass (Da):187,627
Last modified:November 4, 2008 - v2
Checksum:iF0DBB25EB6323DF8
GO
Isoform 2 (identifier: P52179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     836-931: Missing.

Show »
Length:1,589
Mass (Da):177,700
Checksum:iAB161B6C31ED4FDC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX12A8MX12_HUMAN
Myomesin-1
MYOM1
1,452Annotation score:
J3KRK2J3KRK2_HUMAN
Myomesin-1
MYOM1
121Annotation score:

Sequence cautioni

The sequence CAA48833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247E → G in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti442Q → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti599S → F in AAI16184 (PubMed:15489334).Curated1
Sequence conflicti601P → A in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti615S → G in AAI16184 (PubMed:15489334).Curated1
Sequence conflicti616 – 625RPSAPWTGQI → PLSTLDWTV in CAA48833 (PubMed:7505783).Curated10
Sequence conflicti776S → N in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti793 – 794GS → TH in CAA48833 (PubMed:7505783).Curated2
Sequence conflicti992S → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1001L → S in BAC86128 (PubMed:14702039).Curated1
Sequence conflicti1080Missing in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1141T → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1615 – 1616SD → QT in CAA48833 (PubMed:7505783).Curated2
Sequence conflicti1617D → G in BAC86128 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04722122V → L. Corresponds to variant dbSNP:rs1791085EnsemblClinVar.1
Natural variantiVAR_047222181S → P3 PublicationsCorresponds to variant dbSNP:rs1962519EnsemblClinVar.1
Natural variantiVAR_047223215T → M. Corresponds to variant dbSNP:rs2230165EnsemblClinVar.1
Natural variantiVAR_047224341G → A4 PublicationsCorresponds to variant dbSNP:rs8099021EnsemblClinVar.1
Natural variantiVAR_047225600E → V. Corresponds to variant dbSNP:rs9807556EnsemblClinVar.1
Natural variantiVAR_047226960I → T3 PublicationsCorresponds to variant dbSNP:rs1071600EnsemblClinVar.1
Natural variantiVAR_0472271408D → N. Corresponds to variant dbSNP:rs3765623EnsemblClinVar.1
Natural variantiVAR_0472281453M → T. Corresponds to variant dbSNP:rs16944397EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035663836 – 931Missing in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621424 mRNA Translation: CAF18565.1
AK125322 mRNA Translation: BAC86128.1
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.
BC116183 mRNA Translation: AAI16184.1
X69090 mRNA Translation: CAA48833.1 Different initiation.
CCDSiCCDS45823.1 [P52179-2]
CCDS45824.1 [P52179-1]
PIRiS42167
RefSeqiNP_003794.3, NM_003803.3 [P52179-1]
NP_062830.1, NM_019856.1 [P52179-2]
UniGeneiHs.464469

Genome annotation databases

EnsembliENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2]
ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]
GeneIDi8736
KEGGihsa:8736
UCSCiuc002klp.3 human [P52179-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621424 mRNA Translation: CAF18565.1
AK125322 mRNA Translation: BAC86128.1
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.
BC116183 mRNA Translation: AAI16184.1
X69090 mRNA Translation: CAA48833.1 Different initiation.
CCDSiCCDS45823.1 [P52179-2]
CCDS45824.1 [P52179-1]
PIRiS42167
RefSeqiNP_003794.3, NM_003803.3 [P52179-1]
NP_062830.1, NM_019856.1 [P52179-2]
UniGeneiHs.464469

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R15X-ray2.24A/B1459-1667[»]
2Y23X-ray2.50A1141-1447[»]
2Y25X-ray3.50A/B/C/D1357-1667[»]
3RBSX-ray1.85A1247-1447[»]
5FM4X-ray2.80A/B/C/D/E/F510-618[»]
5FM5X-ray3.10M/N510-739[»]
5FM8X-ray2.05A/B/C/D510-618[»]
DisProtiDP00517
ProteinModelPortaliP52179
SMRiP52179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114273, 1 interactor
CORUMiP52179
DIPiDIP-59649N
IntActiP52179, 14 interactors
MINTiP52179
STRINGi9606.ENSP00000348821

PTM databases

CarbonylDBiP52179
iPTMnetiP52179
PhosphoSitePlusiP52179

Polymorphism and mutation databases

BioMutaiMYOM1
DMDMi212276443

Proteomic databases

MaxQBiP52179
PaxDbiP52179
PeptideAtlasiP52179
PRIDEiP52179
ProteomicsDBi56469
56470 [P52179-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2]
ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]
GeneIDi8736
KEGGihsa:8736
UCSCiuc002klp.3 human [P52179-1]

Organism-specific databases

CTDi8736
DisGeNETi8736
EuPathDBiHostDB:ENSG00000101605.12
GeneCardsiMYOM1
H-InvDBiHIX0017329
HGNCiHGNC:7613 MYOM1
HPAiHPA014305
HPA049193
MIMi603508 gene
neXtProtiNX_P52179
OpenTargetsiENSG00000101605
PharmGKBiPA31418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INWB Eukaryota
ENOG411180Q LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000293283
HOVERGENiHBG004977
InParanoidiP52179
OMAiQRGHEGI
OrthoDBiEOG091G0095
PhylomeDBiP52179
TreeFamiTF331825

Miscellaneous databases

ChiTaRSiMYOM1 human
EvolutionaryTraceiP52179
GeneWikiiMYOM1
GenomeRNAii8736
PROiPR:P52179
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExiHS_MYOM1
ExpressionAtlasiP52179 baseline and differential
GenevisibleiP52179 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYOM1_HUMAN
AccessioniPrimary (citable) accession number: P52179
Secondary accession number(s): Q14BD6, Q6H969, Q6ZUU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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