UniProtKB - P52179 (MYOM1_HUMAN)

BLAST

>sp|P52179|MYOM1_HUMAN Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2
MSLPFYQRCHQHYDLSYRNKDVRSTVSHYQREKKRSAVYTQGSTAYSSRSSAAHRRESEA
FRRASASSSQQQASQHALSSEVSRKAASAYDYGSSHGLTDSSLLLDDYSSKLSPKPKRAK
HSLLSGEEKENLPSDYMVPIFSGRQKHVSGITDTEEERIKEAAAYIAQRNLLASEEGITT
SKQSTASKQTTASKQSTASKQSTASKQSTASRQSTASRQSVVSKQATSALQQEETSEKKS
RKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSI
AGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMHTLEINGCDFEDTAQYRASAMNVKGE
LSAYASVVVKRYKGEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGE
TMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLY
TIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSP
ILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSE
PVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKP
PGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGV
GEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAKELVGYYIEASVAGS
GKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGGGVS
PDVCPALSDEPGGLTASRGRVHEASPPTFQKDALLGSKPNKPSLPSSSQNLGQTEVSKVS
ETVQEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVLGWKQPDKI
GGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLG
APSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEA
KAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVAETRPG
TKEVVVNVDDDGVISLNFECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDL
GMDDLGIYSCDVTDTDGIASSYLIDEEELKRLLALSHEHKFPTVPVKSELAVEILEKGQV
RFWMQAEKLSGNAKVNYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQL
QDGKATNHSTVVLVGDVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKV
ANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRGKDKSR
LKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIR
YSDRVKTGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKTVDLSGQAYDEAYAEFQR
LKQAAIAEKNRARVLGGLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCN
LKFEAGRTAYFTINGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLKG
GKKAK

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History
Entry version 156 (12 Sep 2018)
Sequence version 2 (04 Nov 2008)
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Protein

Myomesin-1

Gene

MYOM1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

GO - Molecular functionⁱ

actin filament binding Source: GO_Central
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18059477
- 22347812
kinase binding
Source: CAFA
Inferred from physical interactionⁱ
- 12972258
muscle alpha-actinin binding Source: GO_Central
protein homodimerization activity Source: UniProtKB
structural constituent of muscle
Source: ProtInc
Traceable author statementⁱ
- 7505783
structural molecule activity conferring elasticity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: GO_Central
extraocular skeletal muscle development Source: Ensembl
positive regulation of gene expression
Source: CAFA
Inferred from mutant phenotypeⁱ
- 25152160
positive regulation of protein secretion
Source: CAFA
Inferred from mutant phenotypeⁱ
- 25152160
protein kinase A signaling
Source: CAFA
Inferred from mutant phenotypeⁱ
- 25152160
sarcomere organization Source: GO_Central
striated muscle contraction Source: GO_Central
striated muscle myosin thick filament assembly Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Muscle protein

Molecular function

Muscle protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myomesin-1 Alternative name(s): 190 kDa connectin-associated protein 190 kDa titin-associated protein Myomesin family member 1
Gene namesⁱ	Name:MYOM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101605.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7613 MYOM1
MIMⁱ	603508 gene
neXtProtⁱ	NX_P52179

Keywords - Cellular componentⁱ

Cytoplasm, Thick filament

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8736
Open Targets More...OpenTargetsⁱ	ENSG00000101605
PharmGKBⁱ	PA31418

Polymorphism and mutation databases

BioMutaⁱ	MYOM1
DMDMⁱ	212276443

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072684	1 – 1685	Myomesin-1Add BLAST		1685

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	113	PhosphoserineBy similarity	1
Modified residueⁱ	883	PhosphoserineBy similarity	1
Modified residueⁱ	887	PhosphoserineBy similarity	1
Modified residueⁱ	1054	PhosphoserineBy similarity	1
Disulfide bondⁱ	1160 ↔ 1210	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P52179
PaxDbⁱ	P52179
PeptideAtlas More...PeptideAtlasⁱ	P52179
PRIDEⁱ	P52179
ProteomicsDBⁱ	56469 56470 [P52179-2]

PTM databases

CarbonylDBⁱ	P52179
iPTMnetⁱ	P52179
PhosphoSitePlusⁱ	P52179

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MYOM1
ExpressionAtlasⁱ	P52179 baseline and differential
Genevisibleⁱ	P52179 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014305 HPA049193

HPAⁱ

HPA014305
HPA049193

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with TTN/titin (By similarity). Interacts with PNKD.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-5353249,EBI-5353249
DYSF	O75923	3	EBI-5353249,EBI-2799016

GO - Molecular functionⁱ

actin filament binding Source: GO_Central
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18059477
- 22347812
kinase binding
Source: CAFA
Inferred from physical interactionⁱ
- 12972258
muscle alpha-actinin binding Source: GO_Central
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114273, 1 interactor
CORUMⁱ	P52179
Database of interacting proteins More...DIPⁱ	DIP-59649N
IntActⁱ	P52179, 14 interactors
Molecular INTeraction database More...MINTⁱ	P52179
STRINGⁱ	9606.ENSP00000348821

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	514 – 521	Combined sources	8
Beta strandⁱ	526 – 531	Combined sources	6
Beta strandⁱ	543 – 550	Combined sources	8
Beta strandⁱ	556 – 559	Combined sources	4
Beta strandⁱ	564 – 571	Combined sources	8
Beta strandⁱ	579 – 588	Combined sources	10
Beta strandⁱ	591 – 595	Combined sources	5
Helixⁱ	609 – 612	Combined sources	4
Beta strandⁱ	626 – 630	Combined sources	5
Beta strandⁱ	1145 – 1148	Combined sources	4
Beta strandⁱ	1154 – 1159	Combined sources	6
Beta strandⁱ	1169 – 1173	Combined sources	5
Beta strandⁱ	1184 – 1189	Combined sources	6
Beta strandⁱ	1192 – 1199	Combined sources	8
Helixⁱ	1202 – 1204	Combined sources	3
Beta strandⁱ	1206 – 1215	Combined sources	10
Beta strandⁱ	1220 – 1224	Combined sources	5
Helixⁱ	1226 – 1240	Combined sources	15
Beta strandⁱ	1248 – 1254	Combined sources	7
Helixⁱ	1256 – 1258	Combined sources	3
Beta strandⁱ	1260 – 1265	Combined sources	6
Beta strandⁱ	1274 – 1279	Combined sources	6
Beta strandⁱ	1282 – 1284	Combined sources	3
Beta strandⁱ	1286 – 1289	Combined sources	4
Beta strandⁱ	1291 – 1294	Combined sources	4
Turnⁱ	1296 – 1298	Combined sources	3
Beta strandⁱ	1300 – 1306	Combined sources	7
Helixⁱ	1310 – 1312	Combined sources	3
Beta strandⁱ	1314 – 1322	Combined sources	9
Beta strandⁱ	1325 – 1333	Combined sources	9
Helixⁱ	1336 – 1355	Combined sources	20
Beta strandⁱ	1357 – 1369	Combined sources	13
Turnⁱ	1370 – 1372	Combined sources	3
Beta strandⁱ	1373 – 1382	Combined sources	10
Beta strandⁱ	1388 – 1393	Combined sources	6
Beta strandⁱ	1396 – 1398	Combined sources	3
Beta strandⁱ	1407 – 1415	Combined sources	9
Helixⁱ	1420 – 1422	Combined sources	3
Beta strandⁱ	1424 – 1432	Combined sources	9
Beta strandⁱ	1435 – 1443	Combined sources	9
Helixⁱ	1446 – 1460	Combined sources	15
Beta strandⁱ	1467 – 1470	Combined sources	4
Beta strandⁱ	1472 – 1483	Combined sources	12
Beta strandⁱ	1489 – 1494	Combined sources	6
Beta strandⁱ	1503 – 1510	Combined sources	8
Beta strandⁱ	1513 – 1520	Combined sources	8
Helixⁱ	1523 – 1525	Combined sources	3
Beta strandⁱ	1527 – 1534	Combined sources	8
Beta strandⁱ	1539 – 1546	Combined sources	8
Helixⁱ	1548 – 1570	Combined sources	23
Beta strandⁱ	1573 – 1577	Combined sources	5
Beta strandⁱ	1580 – 1585	Combined sources	6
Beta strandⁱ	1590 – 1597	Combined sources	8
Beta strandⁱ	1603 – 1608	Combined sources	6
Beta strandⁱ	1611 – 1613	Combined sources	3
Beta strandⁱ	1617 – 1624	Combined sources	8
Turnⁱ	1625 – 1627	Combined sources	3
Beta strandⁱ	1628 – 1635	Combined sources	8
Helixⁱ	1638 – 1640	Combined sources	3
Beta strandⁱ	1642 – 1650	Combined sources	9
Beta strandⁱ	1653 – 1664	Combined sources	12

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00517
ProteinModelPortalⁱ	P52179
SMRⁱ	P52179
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P52179

EvolutionaryTraceⁱ

P52179

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	182 – 187	1	6
Repeatⁱ	188 – 193	2	6
Repeatⁱ	194 – 199	3	6
Repeatⁱ	200 – 205	4	6
Repeatⁱ	206 – 211	5	6
Repeatⁱ	212 – 217	6	6
Domainⁱ	277 – 368	Ig-like C2-type 1Add BLAST	92
Domainⁱ	396 – 498	Ig-like C2-type 2Add BLAST	103
Domainⁱ	512 – 607	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	640 – 734	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	741 – 834	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	933 – 1034	Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	1041 – 1140	Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST	100
Domainⁱ	1132 – 1230	Ig-like C2-type 3Add BLAST	99
Domainⁱ	1358 – 1444	Ig-like C2-type 4Add BLAST	87
Domainⁱ	1573 – 1662	Ig-like C2-type 5Add BLAST	90

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	182 – 217	6 X 6 AA tandem repeatsAdd BLAST		36

Keywords - Domainⁱ

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410INWB Eukaryota ENOG411180Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133685
HOGENOMⁱ	HOG000293283
HOVERGENⁱ	HBG004977
InParanoidⁱ	P52179
OMAⁱ	QRGHEGI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0095
PhylomeDBⁱ	P52179
TreeFamⁱ	TF331825

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 5 hits
Gene3Dⁱ	2.60.40.10, 12 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 5 hits PF07679 I-set, 5 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 5 hits SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits SSF49265 SSF49265, 3 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 5 hits PS50835 IG_LIKE, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P52179-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS 
        60         70         80         90        100
SAAHRRESEA FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD 
       110        120        130        140        150
SSLLLDDYSS KLSPKPKRAK HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG 
       160        170        180        190        200
ITDTEEERIK EAAAYIAQRN LLASEEGITT SKQSTASKQT TASKQSTASK 
       210        220        230        240        250
QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS RKVVIREKAE 
       260        270        280        290        300
RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI 
       310        320        330        340        350
AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY 
       360        370        380        390        400
RASAMNVKGE LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA 
       410        420        430        440        450
SRFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL 
       460        470        480        490        500
SPSKWVQTLW SGERATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR 
       510        520        530        540        550
DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP ILGYFIDKCE 
       560        570        580        590        600
VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE 
       610        620        630        640        650
PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT 
       660        670        680        690        700
RSYVVLSWKP PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF 
       710        720        730        740        750
DLAEGKSYCF RVRCSNSAGV GEPSEATEVT VVGDKLDIPK APGKIIPSRN 
       760        770        780        790        800
TDTSVVVSWE ESKDAKELVG YYIEASVAGS GKWEPCNNNP VKGSRFTCHG 
       810        820        830        840        850
LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS PDVCPALSDE 
       860        870        880        890        900
PGGLTASRGR VHEASPPTFQ KDALLGSKPN KPSLPSSSQN LGQTEVSKVS 
       910        920        930        940        950
ETVQEELTPP PQKAAPQGKS KSDPLKKKTD RAPPSPPCDI TCLESFRDSM 
       960        970        980        990       1000
VLGWKQPDKI GGAEITGYYV NYREVIDGVP GKWREANVKA VSEEAYKISN 
      1010       1020       1030       1040       1050
LKENMVYQFQ VAAMNMAGLG APSAVSECFK CEEWTIAVPG PPHSLKCSEV 
      1060       1070       1080       1090       1100
RKDSLVLQWK PPVHSGRTPV TGYFVDLKEA KAKEDQWRGL NEAAIKNVYL 
      1110       1120       1130       1140       1150
KVRGLKEGVS YVFRVRAINQ AGVGKPSDLA GPVVAETRPG TKEVVVNVDD 
      1160       1170       1180       1190       1200
DGVISLNFEC DKMTPKSEFS WSKDYVSTED SPRLEVESKG NKTKMTFKDL 
      1210       1220       1230       1240       1250
GMDDLGIYSC DVTDTDGIAS SYLIDEEELK RLLALSHEHK FPTVPVKSEL 
      1260       1270       1280       1290       1300
AVEILEKGQV RFWMQAEKLS GNAKVNYIFN EKEIFEGPKY KMHIDRNTGI 
      1310       1320       1330       1340       1350
IEMFMEKLQD EDEGTYTFQL QDGKATNHST VVLVGDVFKK LQKEAEFQRQ 
      1360       1370       1380       1390       1400
EWIRKQGPHF VEYLSWEVTG ECNVLLKCKV ANIKKETHIV WYKDEREISV 
      1410       1420       1430       1440       1450
DEKHDFKDGI CTLLITEFSK KDAGIYEVIL KDDRGKDKSR LKLVDEAFKE 
      1460       1470       1480       1490       1500
LMMEVCKKIA LSATDLKIQS TAEGIQLYSF VTYYVEDLKV NWSHNGSAIR 
      1510       1520       1530       1540       1550
YSDRVKTGVT GEQIWLQINE PTPNDKGKYV MELFDGKTGH QKTVDLSGQA 
      1560       1570       1580       1590       1600
YDEAYAEFQR LKQAAIAEKN RARVLGGLPD VVTIQEGKAL NLTCNVWGDP 
      1610       1620       1630       1640       1650
PPEVSWLKNE KALASDDHCN LKFEAGRTAY FTINGVSTAD SGKYGLVVKN 
      1660       1670       1680 
KYGSETSDFT VSVFIPEEEA RMAALESLKG GKKAK

Length:1,685

Mass (Da):187,627

Last modified:November 4, 2008 - v2

Checksum:ⁱF0DBB25EB6323DF8

Isoform 2 (identifier: P52179-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
836-931: Missing.

« Hide

        10         20         30         40         50
MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS 
        60         70         80         90        100
SAAHRRESEA FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD 
       110        120        130        140        150
SSLLLDDYSS KLSPKPKRAK HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG 
       160        170        180        190        200
ITDTEEERIK EAAAYIAQRN LLASEEGITT SKQSTASKQT TASKQSTASK 
       210        220        230        240        250
QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS RKVVIREKAE 
       260        270        280        290        300
RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI 
       310        320        330        340        350
AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY 
       360        370        380        390        400
RASAMNVKGE LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA 
       410        420        430        440        450
SRFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL 
       460        470        480        490        500
SPSKWVQTLW SGERATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR 
       510        520        530        540        550
DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP ILGYFIDKCE 
       560        570        580        590        600
VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE 
       610        620        630        640        650
PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT 
       660        670        680        690        700
RSYVVLSWKP PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF 
       710        720        730        740        750
DLAEGKSYCF RVRCSNSAGV GEPSEATEVT VVGDKLDIPK APGKIIPSRN 
       760        770        780        790        800
TDTSVVVSWE ESKDAKELVG YYIEASVAGS GKWEPCNNNP VKGSRFTCHG 
       810        820        830        840        850
LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIAPPSP PCDITCLESF 
       860        870        880        890        900
RDSMVLGWKQ PDKIGGAEIT GYYVNYREVI DGVPGKWREA NVKAVSEEAY 
       910        920        930        940        950
KISNLKENMV YQFQVAAMNM AGLGAPSAVS ECFKCEEWTI AVPGPPHSLK 
       960        970        980        990       1000
CSEVRKDSLV LQWKPPVHSG RTPVTGYFVD LKEAKAKEDQ WRGLNEAAIK 
      1010       1020       1030       1040       1050
NVYLKVRGLK EGVSYVFRVR AINQAGVGKP SDLAGPVVAE TRPGTKEVVV 
      1060       1070       1080       1090       1100
NVDDDGVISL NFECDKMTPK SEFSWSKDYV STEDSPRLEV ESKGNKTKMT 
      1110       1120       1130       1140       1150
FKDLGMDDLG IYSCDVTDTD GIASSYLIDE EELKRLLALS HEHKFPTVPV 
      1160       1170       1180       1190       1200
KSELAVEILE KGQVRFWMQA EKLSGNAKVN YIFNEKEIFE GPKYKMHIDR 
      1210       1220       1230       1240       1250
NTGIIEMFME KLQDEDEGTY TFQLQDGKAT NHSTVVLVGD VFKKLQKEAE 
      1260       1270       1280       1290       1300
FQRQEWIRKQ GPHFVEYLSW EVTGECNVLL KCKVANIKKE THIVWYKDER 
      1310       1320       1330       1340       1350
EISVDEKHDF KDGICTLLIT EFSKKDAGIY EVILKDDRGK DKSRLKLVDE 
      1360       1370       1380       1390       1400
AFKELMMEVC KKIALSATDL KIQSTAEGIQ LYSFVTYYVE DLKVNWSHNG 
      1410       1420       1430       1440       1450
SAIRYSDRVK TGVTGEQIWL QINEPTPNDK GKYVMELFDG KTGHQKTVDL 
      1460       1470       1480       1490       1500
SGQAYDEAYA EFQRLKQAAI AEKNRARVLG GLPDVVTIQE GKALNLTCNV 
      1510       1520       1530       1540       1550
WGDPPPEVSW LKNEKALASD DHCNLKFEAG RTAYFTINGV STADSGKYGL 
      1560       1570       1580 
VVKNKYGSET SDFTVSVFIP EEEARMAALE SLKGGKKAK

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Length:1,589

Mass (Da):177,700

Checksum:ⁱAB161B6C31ED4FDC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A8MX12	A8MX12_HUMAN	Myomesin-1 Myomesin-1	MYOM1	1,452	Annotation score:
J3KRK2	J3KRK2_HUMAN	Myomesin-1 Myomesin-1	MYOM1	121	Annotation score:

Sequence cautionⁱ

The sequence CAA48833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	247	E → G in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	442	Q → R in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	599	S → F in AAI16184 (PubMed:15489334).Curated	1
Sequence conflictⁱ	601	P → A in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	615	S → G in AAI16184 (PubMed:15489334).Curated	1
Sequence conflictⁱ	616 – 625	RPSAPWTGQI → PLSTLDWTV in CAA48833 (PubMed:7505783).Curated	10
Sequence conflictⁱ	776	S → N in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	793 – 794	GS → TH in CAA48833 (PubMed:7505783).Curated	2
Sequence conflictⁱ	992	S → R in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	1001	L → S in BAC86128 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1080	Missing in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	1141	T → R in CAA48833 (PubMed:7505783).Curated	1
Sequence conflictⁱ	1615 – 1616	SD → QT in CAA48833 (PubMed:7505783).Curated	2
Sequence conflictⁱ	1617	D → G in BAC86128 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047221	22	V → L. Corresponds to variant dbSNP:rs1791085EnsemblClinVar.	1
Natural variantⁱVAR_047222	181	S → P3 PublicationsCorresponds to variant dbSNP:rs1962519EnsemblClinVar.	1
Natural variantⁱVAR_047223	215	T → M. Corresponds to variant dbSNP:rs2230165EnsemblClinVar.	1
Natural variantⁱVAR_047224	341	G → A4 PublicationsCorresponds to variant dbSNP:rs8099021EnsemblClinVar.	1
Natural variantⁱVAR_047225	600	E → V. Corresponds to variant dbSNP:rs9807556EnsemblClinVar.	1
Natural variantⁱVAR_047226	960	I → T3 PublicationsCorresponds to variant dbSNP:rs1071600EnsemblClinVar.	1
Natural variantⁱVAR_047227	1408	D → N. Corresponds to variant dbSNP:rs3765623EnsemblClinVar.	1
Natural variantⁱVAR_047228	1453	M → T. Corresponds to variant dbSNP:rs16944397EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035663	836 – 931	Missing in isoform 2. 2 PublicationsAdd BLAST		96

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ621424 mRNA Translation: CAF18565.1 AK125322 mRNA Translation: BAC86128.1 AP005329 Genomic DNA No translation available. AP005431 Genomic DNA No translation available. BC116183 mRNA Translation: AAI16184.1 X69090 mRNA Translation: CAA48833.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45823.1 [P52179-2] CCDS45824.1 [P52179-1]
PIRⁱ	S42167
NCBI Reference Sequences More...RefSeqⁱ	NP_003794.3, NM_003803.3 [P52179-1] NP_062830.1, NM_019856.1 [P52179-2]
UniGeneⁱ	Hs.464469

Genome annotation databases

Ensemblⁱ	ENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2] ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]
GeneIDⁱ	8736
KEGGⁱ	hsa:8736
UCSC genome browser More...UCSCⁱ	uc002klp.3 human [P52179-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P52179	MYOM1 isoform 1		PANTR		1685	UniRef90_P52179
Uncharacterized protein		PANPA		1685
Uncharacterized protein		NOMLE		1685
Myomesin family member 1		MACFA		1682
Uncharacterized protein		MACNE		1679
+34
P52179-2	MYOM1 isoform 2		PANTR		1589	UniRef90_P52179-2
Uncharacterized protein		PANPA		1589
Uncharacterized protein		NOMLE		1589
myomesin-1 isoform X2		ODORO		1586
Uncharacterized protein		MACNE		1583
+46

Protein	Similar proteins		Species	Score	Length	Source
P52179	Myomesin-1	)	MOUSE		1667	UniRef50_P52179
Uncharacterized protein		NOMLE		1685
MYOM1 isoform 1		PANTR		1685
Uncharacterized protein		PANPA		1685
Myomesin family member 1		MACFA		1682
+217
P52179-2	Uncharacterized protein		PANPA		1589	UniRef50_P52179-2
Uncharacterized protein		NOMLE		1589
MYOM1 isoform 2		PANTR		1589
myomesin-1 isoform X2		ODORO		1586
Uncharacterized protein		MACFA		1583
+124

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ621424 mRNA Translation: CAF18565.1 AK125322 mRNA Translation: BAC86128.1 AP005329 Genomic DNA No translation available. AP005431 Genomic DNA No translation available. BC116183 mRNA Translation: AAI16184.1 X69090 mRNA Translation: CAA48833.1 Different initiation.
CCDSⁱ	CCDS45823.1 [P52179-2] CCDS45824.1 [P52179-1]
PIRⁱ	S42167
RefSeqⁱ	NP_003794.3, NM_003803.3 [P52179-1] NP_062830.1, NM_019856.1 [P52179-2]
UniGeneⁱ	Hs.464469

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2R15	X-ray	2.24	A/B	1459-1667	[»]
	2Y23	X-ray	2.50	A	1141-1447	[»]
	2Y25	X-ray	3.50	A/B/C/D	1357-1667	[»]
	3RBS	X-ray	1.85	A	1247-1447	[»]
	5FM4	X-ray	2.80	A/B/C/D/E/F	510-618	[»]
	5FM5	X-ray	3.10	M/N	510-739	[»]
	5FM8	X-ray	2.05	A/B/C/D	510-618	[»]
DisProtⁱ	DP00517
ProteinModelPortalⁱ	P52179
SMRⁱ	P52179
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114273, 1 interactor
CORUMⁱ	P52179
DIPⁱ	DIP-59649N
IntActⁱ	P52179, 14 interactors
MINTⁱ	P52179
STRINGⁱ	9606.ENSP00000348821

PTM databases

CarbonylDBⁱ	P52179
iPTMnetⁱ	P52179
PhosphoSitePlusⁱ	P52179

Polymorphism and mutation databases

BioMutaⁱ	MYOM1
DMDMⁱ	212276443

Proteomic databases

MaxQBⁱ	P52179
PaxDbⁱ	P52179
PeptideAtlasⁱ	P52179
PRIDEⁱ	P52179
ProteomicsDBⁱ	56469 56470 [P52179-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2] ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]
GeneIDⁱ	8736
KEGGⁱ	hsa:8736
UCSCⁱ	uc002klp.3 human [P52179-1]

Organism-specific databases

CTDⁱ	8736
DisGeNETⁱ	8736
EuPathDBⁱ	HostDB:ENSG00000101605.12
GeneCardsⁱ	MYOM1
H-InvDBⁱ	HIX0017329
HGNCⁱ	HGNC:7613 MYOM1
HPAⁱ	HPA014305 HPA049193
MIMⁱ	603508 gene
neXtProtⁱ	NX_P52179
OpenTargetsⁱ	ENSG00000101605
PharmGKBⁱ	PA31418
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INWB Eukaryota ENOG411180Q LUCA
GeneTreeⁱ	ENSGT00860000133685
HOGENOMⁱ	HOG000293283
HOVERGENⁱ	HBG004977
InParanoidⁱ	P52179
OMAⁱ	QRGHEGI
OrthoDBⁱ	EOG091G0095
PhylomeDBⁱ	P52179
TreeFamⁱ	TF331825

Miscellaneous databases

ChiTaRSⁱ	MYOM1 human
EvolutionaryTraceⁱ	P52179
GeneWikiⁱ	MYOM1
GenomeRNAiⁱ	8736
Protein Ontology More...PROⁱ	PR:P52179
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MYOM1
ExpressionAtlasⁱ	P52179 baseline and differential
Genevisibleⁱ	P52179 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 5 hits
Gene3Dⁱ	2.60.40.10, 12 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2
Pfamⁱ	View protein in Pfam PF00041 fn3, 5 hits PF07679 I-set, 5 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 5 hits SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits SSF49265 SSF49265, 3 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 5 hits PS50835 IG_LIKE, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYOM1_HUMAN
Accessionⁱ	P52179Primary (citable) accession number: P52179 Secondary accession number(s): Q14BD6, Q6H969, Q6ZUU0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 4, 2008
	Last modified:	September 12, 2018
	This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

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UniProtKB - P52179 (MYOM1_HUMAN)

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Myomesin-1

MYOM1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ