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UniProtKB - P52179 (MYOM1_HUMAN)

Entry version 170 (17 Jun 2020)
Sequence version 2 (04 Nov 2008)
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Protein

Myomesin-1

Gene

MYOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myomesin-1
Alternative name(s):
190 kDa connectin-associated protein
190 kDa titin-associated protein
Myomesin family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYOM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000101605.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:7613 MYOM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603508 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P52179

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8736

Open Targets

More...OpenTargetsi		ENSG00000101605

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31418

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P52179 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYOM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276443

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726841 – 1685Myomesin-1Add BLAST1685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphoserineBy similarity1
Modified residuei883PhosphoserineBy similarity1
Modified residuei887PhosphoserineBy similarity1
Modified residuei1054PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1160 ↔ 1210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P52179

MaxQB - The MaxQuant DataBase

More...MaxQBi		P52179

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P52179

PeptideAtlas

More...PeptideAtlasi		P52179

PRoteomics IDEntifications database

More...PRIDEi		P52179

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56469 [P52179-1]
56470 [P52179-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P52179

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P52179

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P52179

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101605 Expressed in heart left ventricle and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P52179 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P52179 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101605 Group enriched (heart muscle, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with TTN/titin (By similarity).

Interacts with PNKD.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114273, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P52179

Database of interacting proteins

More...DIPi		DIP-59649N

Protein interaction database and analysis system

More...IntActi		P52179, 16 interactors

Molecular INTeraction database

More...MINTi		P52179

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P52179 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11685
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P52179

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P52179

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati182 – 18716
Repeati188 – 19326
Repeati194 – 19936
Repeati200 – 20546
Repeati206 – 21156
Repeati212 – 21766
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 368Ig-like C2-type 1Add BLAST92
Domaini396 – 498Ig-like C2-type 2Add BLAST103
Domaini512 – 607Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini640 – 734Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini741 – 834Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini933 – 1034Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST102
Domaini1041 – 1140Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1132 – 1230Ig-like C2-type 3Add BLAST99
Domaini1358 – 1444Ig-like C2-type 4Add BLAST87
Domaini1573 – 1662Ig-like C2-type 5Add BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 2176 X 6 AA tandem repeatsAdd BLAST36

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410INWB Eukaryota
ENOG411180Q LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154982

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P52179

Identification of Orthologs from Complete Genome Data

More...OMAi		CDQMSPN

Database of Orthologous Groups

More...OrthoDBi		57219at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P52179

TreeFam database of animal gene trees

More...TreeFami		TF331825

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 5 hits

Database of protein disorder

More...DisProti		DP00517

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P52179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPFYQRCH QHYDLSYRNK DVRSTVSHYQ REKKRSAVYT QGSTAYSSRS 
        60         70         80         90        100
SAAHRRESEA FRRASASSSQ QQASQHALSS EVSRKAASAY DYGSSHGLTD 
       110        120        130        140        150
SSLLLDDYSS KLSPKPKRAK HSLLSGEEKE NLPSDYMVPI FSGRQKHVSG 
       160        170        180        190        200
ITDTEEERIK EAAAYIAQRN LLASEEGITT SKQSTASKQT TASKQSTASK 
       210        220        230        240        250
QSTASKQSTA SRQSTASRQS VVSKQATSAL QQEETSEKKS RKVVIREKAE 
       260        270        280        290        300
RLSLRKTLEE TETYHAKLNE DHLLHAPEFI IKPRSHTVWE KENVKLHCSI 
       310        320        330        340        350
AGWPEPRVTW YKNQVPINVH ANPGKYIIES RYGMHTLEIN GCDFEDTAQY 
       360        370        380        390        400
RASAMNVKGE LSAYASVVVK RYKGEFDETR FHAGASTMPL SFGVTPYGYA 
       410        420        430        440        450
SRFEIHFDDK FDVSFGREGE TMSLGCRVVI TPEIKHFQPE IQWYRNGVPL 
       460        470        480        490        500
SPSKWVQTLW SGERATLTFS HLNKEDEGLY TIRVRMGEYY EQYSAYVFVR 
       510        520        530        540        550
DADAEIEGAP AAPLDVKCLE ANKDYIIISW KQPAVDGGSP ILGYFIDKCE 
       560        570        580        590        600
VGTDSWSQCN DTPVKFARFP VTGLIEGRSY IFRVRAVNKM GIGFPSRVSE 
       610        620        630        640        650
PVAALDPAEK ARLKSRPSAP WTGQIIVTEE EPSEGIVPGP PTDLSVTEAT 
       660        670        680        690        700
RSYVVLSWKP PGQRGHEGIM YFVEKCEAGT ENWQRVNTEL PVKSPRFALF 
       710        720        730        740        750
DLAEGKSYCF RVRCSNSAGV GEPSEATEVT VVGDKLDIPK APGKIIPSRN 
       760        770        780        790        800
TDTSVVVSWE ESKDAKELVG YYIEASVAGS GKWEPCNNNP VKGSRFTCHG 
       810        820        830        840        850
LVTGQSYIFR VRAVNAAGLS EYSQDSEAIE VKAAIGGGVS PDVCPALSDE 
       860        870        880        890        900
PGGLTASRGR VHEASPPTFQ KDALLGSKPN KPSLPSSSQN LGQTEVSKVS 
       910        920        930        940        950
ETVQEELTPP PQKAAPQGKS KSDPLKKKTD RAPPSPPCDI TCLESFRDSM 
       960        970        980        990       1000
VLGWKQPDKI GGAEITGYYV NYREVIDGVP GKWREANVKA VSEEAYKISN 
      1010       1020       1030       1040       1050
LKENMVYQFQ VAAMNMAGLG APSAVSECFK CEEWTIAVPG PPHSLKCSEV 
      1060       1070       1080       1090       1100
RKDSLVLQWK PPVHSGRTPV TGYFVDLKEA KAKEDQWRGL NEAAIKNVYL 
      1110       1120       1130       1140       1150
KVRGLKEGVS YVFRVRAINQ AGVGKPSDLA GPVVAETRPG TKEVVVNVDD 
      1160       1170       1180       1190       1200
DGVISLNFEC DKMTPKSEFS WSKDYVSTED SPRLEVESKG NKTKMTFKDL 
      1210       1220       1230       1240       1250
GMDDLGIYSC DVTDTDGIAS SYLIDEEELK RLLALSHEHK FPTVPVKSEL 
      1260       1270       1280       1290       1300
AVEILEKGQV RFWMQAEKLS GNAKVNYIFN EKEIFEGPKY KMHIDRNTGI 
      1310       1320       1330       1340       1350
IEMFMEKLQD EDEGTYTFQL QDGKATNHST VVLVGDVFKK LQKEAEFQRQ 
      1360       1370       1380       1390       1400
EWIRKQGPHF VEYLSWEVTG ECNVLLKCKV ANIKKETHIV WYKDEREISV 
      1410       1420       1430       1440       1450
DEKHDFKDGI CTLLITEFSK KDAGIYEVIL KDDRGKDKSR LKLVDEAFKE 
      1460       1470       1480       1490       1500
LMMEVCKKIA LSATDLKIQS TAEGIQLYSF VTYYVEDLKV NWSHNGSAIR 
      1510       1520       1530       1540       1550
YSDRVKTGVT GEQIWLQINE PTPNDKGKYV MELFDGKTGH QKTVDLSGQA 
      1560       1570       1580       1590       1600
YDEAYAEFQR LKQAAIAEKN RARVLGGLPD VVTIQEGKAL NLTCNVWGDP 
      1610       1620       1630       1640       1650
PPEVSWLKNE KALASDDHCN LKFEAGRTAY FTINGVSTAD SGKYGLVVKN 
      1660       1670       1680 
KYGSETSDFT VSVFIPEEEA RMAALESLKG GKKAK
Length:1,685
Mass (Da):187,627
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0DBB25EB6323DF8
GO
Isoform 2 (identifier: P52179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     836-931: Missing.

Show »
Length:1,589
Mass (Da):177,700
Checksum:iAB161B6C31ED4FDC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX12A8MX12_HUMAN
Myomesin-1
MYOM1
1,452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRK2J3KRK2_HUMAN
Myomesin-1
MYOM1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA48833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247E → G in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti442Q → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti599S → F in AAI16184 (PubMed:15489334).Curated1
Sequence conflicti601P → A in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti615S → G in AAI16184 (PubMed:15489334).Curated1
Sequence conflicti616 – 625RPSAPWTGQI → PLSTLDWTV in CAA48833 (PubMed:7505783).Curated10
Sequence conflicti776S → N in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti793 – 794GS → TH in CAA48833 (PubMed:7505783).Curated2
Sequence conflicti992S → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1001L → S in BAC86128 (PubMed:14702039).Curated1
Sequence conflicti1080Missing in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1141T → R in CAA48833 (PubMed:7505783).Curated1
Sequence conflicti1615 – 1616SD → QT in CAA48833 (PubMed:7505783).Curated2
Sequence conflicti1617D → G in BAC86128 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04722122V → L. Corresponds to variant dbSNP:rs1791085EnsemblClinVar.1
Natural variantiVAR_047222181S → P3 PublicationsCorresponds to variant dbSNP:rs1962519EnsemblClinVar.1
Natural variantiVAR_047223215T → M. Corresponds to variant dbSNP:rs2230165EnsemblClinVar.1
Natural variantiVAR_047224341G → A4 PublicationsCorresponds to variant dbSNP:rs8099021EnsemblClinVar.1
Natural variantiVAR_047225600E → V. Corresponds to variant dbSNP:rs9807556EnsemblClinVar.1
Natural variantiVAR_047226960I → T3 PublicationsCorresponds to variant dbSNP:rs1071600EnsemblClinVar.1
Natural variantiVAR_0472271408D → N. Corresponds to variant dbSNP:rs3765623EnsemblClinVar.1
Natural variantiVAR_0472281453M → T. Corresponds to variant dbSNP:rs16944397EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035663836 – 931Missing in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ621424 mRNA Translation: CAF18565.1
AK125322 mRNA Translation: BAC86128.1
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.
BC116183 mRNA Translation: AAI16184.1
X69090 mRNA Translation: CAA48833.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45823.1 [P52179-2]
CCDS45824.1 [P52179-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S42167

NCBI Reference Sequences

More...RefSeqi		NP_003794.3, NM_003803.3 [P52179-1]
NP_062830.1, NM_019856.1 [P52179-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2]
ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8736

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8736

UCSC genome browser

More...UCSCi		uc002klp.3 human [P52179-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621424 mRNA Translation: CAF18565.1
AK125322 mRNA Translation: BAC86128.1
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.
BC116183 mRNA Translation: AAI16184.1
X69090 mRNA Translation: CAA48833.1 Different initiation.
CCDSiCCDS45823.1 [P52179-2]
CCDS45824.1 [P52179-1]
PIRiS42167
RefSeqiNP_003794.3, NM_003803.3 [P52179-1]
NP_062830.1, NM_019856.1 [P52179-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R15X-ray2.24A/B1459-1667[»]
2Y23X-ray2.50A1141-1447[»]
2Y25X-ray3.50A/B/C/D1357-1667[»]
3RBSX-ray1.85A1247-1447[»]
5FM4X-ray2.80A/B/C/D/E/F510-618[»]
5FM5X-ray3.10M/N510-739[»]
5FM8X-ray2.05A/B/C/D510-618[»]
SMRiP52179
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114273, 1 interactor
CORUMiP52179
DIPiDIP-59649N
IntActiP52179, 16 interactors
MINTiP52179
STRINGi9606.ENSP00000348821

PTM databases

CarbonylDBiP52179
iPTMnetiP52179
PhosphoSitePlusiP52179

Polymorphism and mutation databases

BioMutaiMYOM1
DMDMi212276443

Proteomic databases

MassIVEiP52179
MaxQBiP52179
PaxDbiP52179
PeptideAtlasiP52179
PRIDEiP52179
ProteomicsDBi56469 [P52179-1]
56470 [P52179-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2827 159 antibodies

Genome annotation databases

EnsembliENST00000261606; ENSP00000261606; ENSG00000101605 [P52179-2]
ENST00000356443; ENSP00000348821; ENSG00000101605 [P52179-1]
GeneIDi8736
KEGGihsa:8736
UCSCiuc002klp.3 human [P52179-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8736
DisGeNETi8736
EuPathDBiHostDB:ENSG00000101605.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYOM1
HGNCiHGNC:7613 MYOM1
HPAiENSG00000101605 Group enriched (heart muscle, skeletal muscle, tongue)
MIMi603508 gene
neXtProtiNX_P52179
OpenTargetsiENSG00000101605
PharmGKBiPA31418

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410INWB Eukaryota
ENOG411180Q LUCA
GeneTreeiENSGT00940000154982
InParanoidiP52179
OMAiCDQMSPN
OrthoDBi57219at2759
PhylomeDBiP52179
TreeFamiTF331825

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8736 0 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYOM1 human
EvolutionaryTraceiP52179

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYOM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8736
PharosiP52179 Tbio

Protein Ontology

More...PROi		PR:P52179
RNActiP52179 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101605 Expressed in heart left ventricle and 160 other tissues
ExpressionAtlasiP52179 baseline and differential
GenevisibleiP52179 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
DisProtiDP00517
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52179
Secondary accession number(s): Q14BD6, Q6H969, Q6ZUU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: June 17, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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