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Protein

Protein max

Gene

Max

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Protein maxBy similarity
Alternative name(s):
Myc-associated factor XBy similarity
Gene namesi
Name:MaxImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621101 Max

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001272712 – 160Protein maxAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei153N6-acetyllysineBy similarity1
Modified residuei154N6-acetyllysineBy similarity1
Isoform Short (identifier: P52164-2)
Modified residuei2PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP52164
PRIDEiP52164

PTM databases

iPTMnetiP52164
PhosphoSitePlusiP52164

Expressioni

Gene expression databases

BgeeiENSRNOG00000008049 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiP52164 baseline and differential
GenevisibleiP52164 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiP52164, 3 interactors
MINTiP52164
STRINGi10116.ENSRNOP00000010954

Structurei

3D structure databases

ProteinModelPortaliP52164
SMRiP52164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 74bHLHPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 102Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the MAX family.Curated

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
GeneTreeiENSGT00530000064011
HOGENOMiHOG000293257
HOVERGENiHBG008542
InParanoidiP52164
KOiK04453
OMAiYTNRKGS
PhylomeDBiP52164
TreeFamiTF318841

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR037933 MAX
PANTHERiPTHR10328 PTHR10328, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: P52164-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDNDDIEVE SDEEQPRFQS AADKRAHHNA LERKRRDHIK DSFHSLRDSV
60 70 80 90 100
PSLQGEKASR AQILDKATEY IQYMRRKNHT HQQDIDDLKR QNALLEQQVR
110 120 130 140 150
ALEKARSSAQ LQTNYPSSDN SLYTNAKGGT ISAFDGGSDS SSESEPEEPQ
160
NRKKLRMEAS
Length:160
Mass (Da):18,272
Last modified:October 1, 1996 - v1
Checksum:i86CB1A137727A57A
GO
Isoform Short (identifier: P52164-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-21: Missing.

Show »
Length:151
Mass (Da):17,199
Checksum:iA6B21FF5F39793EF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q499S8Q499S8_RAT
Max protein
Max
97Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00211913 – 21Missing in isoform Short. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14447 mRNA Translation: BAA03337.1
D14448 mRNA Translation: BAA03338.1
PIRiS39792
RefSeqiNP_071546.1, NM_022210.1 [P52164-1]
XP_006240310.1, XM_006240248.3 [P52164-2]
UniGeneiRn.4210

Genome annotation databases

EnsembliENSRNOT00000041442; ENSRNOP00000040275; ENSRNOG00000008049 [P52164-2]
ENSRNOT00000083286; ENSRNOP00000072268; ENSRNOG00000008049 [P52164-1]
GeneIDi60661
KEGGirno:60661
UCSCiRGD:621101 rat [P52164-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14447 mRNA Translation: BAA03337.1
D14448 mRNA Translation: BAA03338.1
PIRiS39792
RefSeqiNP_071546.1, NM_022210.1 [P52164-1]
XP_006240310.1, XM_006240248.3 [P52164-2]
UniGeneiRn.4210

3D structure databases

ProteinModelPortaliP52164
SMRiP52164
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52164, 3 interactors
MINTiP52164
STRINGi10116.ENSRNOP00000010954

PTM databases

iPTMnetiP52164
PhosphoSitePlusiP52164

Proteomic databases

PaxDbiP52164
PRIDEiP52164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041442; ENSRNOP00000040275; ENSRNOG00000008049 [P52164-2]
ENSRNOT00000083286; ENSRNOP00000072268; ENSRNOG00000008049 [P52164-1]
GeneIDi60661
KEGGirno:60661
UCSCiRGD:621101 rat [P52164-1]

Organism-specific databases

CTDi4149
RGDi621101 Max

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
GeneTreeiENSGT00530000064011
HOGENOMiHOG000293257
HOVERGENiHBG008542
InParanoidiP52164
KOiK04453
OMAiYTNRKGS
PhylomeDBiP52164
TreeFamiTF318841

Enzyme and pathway databases

ReactomeiR-RNO-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

PROiPR:P52164

Gene expression databases

BgeeiENSRNOG00000008049 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiP52164 baseline and differential
GenevisibleiP52164 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR037933 MAX
PANTHERiPTHR10328 PTHR10328, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAX_RAT
AccessioniPrimary (citable) accession number: P52164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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