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Entry version 148 (02 Jun 2021)
Sequence version 3 (13 Nov 2007)
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Protein

Uncharacterized outer membrane protein YpjA

Gene

ypjA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7382-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized outer membrane protein YpjA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ypjA
Ordered Locus Names:b2647, JW5422
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020473330 – 1526Uncharacterized outer membrane protein YpjAAdd BLAST1497

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P52143

PRoteomics IDEntifications database

More...
PRIDEi
P52143

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259215, 237 interactors

Database of interacting proteins

More...
DIPi
DIP-12834N

Protein interaction database and analysis system

More...
IntActi
P52143, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2647

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P52143

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1258 – 1526AutotransporterPROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1173 – 1223DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1207 – 1221Pro residuesSequence analysisAdd BLAST15

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3468, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004643_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P52143

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P52143

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 4 hits
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030930, AIDA
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR004899, Pertactin_central
IPR003991, Pertactin_virulence_factor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16168, AIDA, 6 hits
PF03797, Autotransporter, 1 hit
PF03212, Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01484, PRTACTNFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01414, autotrans_barl, 1 hit
TIGR04415, O_hepto_targRPT, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P52143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRTSPYYCR RSVLSLLISA LIYAPPGMAA FTTNVIGVVN DETVDGNQKV
60 70 80 90 100
DERGTTNNTH IINHGQQNVH GGVSNGSLIE SGGYQDIGSH NNFVGQANNT
110 120 130 140 150
TINGGRQSIH DGGISTGTTI ESGNQDVYKG GISNGTTIKG GASRVEGGSA
160 170 180 190 200
NGILIDGGSQ IVKVQGHADG TTINKSGSQD VVQGSLATNT TINGGRQYVE
210 220 230 240 250
QSTVETTTIK NGGEQRVYES RALDTTIEGG TQSLNSKSTA KNTHIYSGGT
260 270 280 290 300
QIVDNTSTSD VIEVYSGGVL DVRGGTATNV TQHDGAILKT NTNGTTVSGT
310 320 330 340 350
NSEGAFSIHN HVADNVLLEN GGHLDINAYG SANKTIIKDK GTMSVLTNAK
360 370 380 390 400
ADATRIDNGG VMDVAGNATN TIINGGTQNI NNYGIATGTN INSGTQNIKS
410 420 430 440 450
GGKADTTIIS SGSRQVVEKD GTAIGSNISA GGSLIVYTGG IAHGVNQETG
460 470 480 490 500
SALVANTGAG TDIEGYNKLS HFTITGGEAN YVVLENTGEL TVVAKTSAKN
510 520 530 540 550
TTIDTGGKLI VQKEAKTDST RLNNGGVLEV QDGGEAKHVE QQSGGALIAS
560 570 580 590 600
TTSGTLIEGT NSYGDAFYIR NSEAKNVVLE NAGSLTVVTG SRAVDTIINA
610 620 630 640 650
NGKMDVYGKD VGTVLNSAGT QTIYASATSD KANIKGGKQT VYGLATEANI
660 670 680 690 700
ESGEQIVDGG STEKTHINGG TQTVQNYGKA INTDIVSGLQ QIMANGTAEG
710 720 730 740 750
SIINGGSQVV NEGGLAENSV LNDGGTLDVR EKGSATGIQQ SSQGALVATT
760 770 780 790 800
RATRVTGTRA DGVAFSIEQG AANNILLANG GVLTVESDTS SDKTQVNMGG
810 820 830 840 850
REIVKTKATA TGTTLTGGEQ IVEGVANETT INDGGIQTVS ANGEAIKTKI
860 870 880 890 900
NEGGTLTVND NGKATDIVQN SGAALQTSTA NGIEISGTHQ YGTFSISGNL
910 920 930 940 950
ATNMLLENGG NLLVLAGTEA RDSTVGKGGA MQNLGQDSAT KVNSGGQYTL
960 970 980 990 1000
GRSKDEFQAL ARAEDLQVAG GTAIVYAGTL ADASVSGATG SLSLMTPRDN
1010 1020 1030 1040 1050
VTPVKLEGAV RITDSATLTL GNGVDTTLAD LTAASRGSVW LNSNNSCAGT
1060 1070 1080 1090 1100
SNCEYRVNSL LLNDGDVYLS AQTAAPATTN GIYNTLTTNE LSGSGNFYLH
1110 1120 1130 1140 1150
TNVAGSRGDQ LVVNNNATGN FKIFVQDTGV SPQSDDAMTL VKTGGGDASF
1160 1170 1180 1190 1200
TLGNTGGFVD LGTYEYVLKS DGNSNWNLTN DVKPNPDPIP NPKPDPKPDP
1210 1220 1230 1240 1250
KPDPNPKPDP TPDPTPTPVP EKRITPSTAA VLNMAATLPL VFDAELNSIR
1260 1270 1280 1290 1300
ERLNIMKASP HNNNVWGATY NTRNNVTTDA GAGFEQTLTG MTVGIDSRND
1310 1320 1330 1340 1350
IPEGITTLGA FMGYSHSHIG FDRGGHGSVG SYSLGGYASW EHESGFYLDG
1360 1370 1380 1390 1400
VVKLNRFKSN VAGKMSSGGA ANGSYHSNGL GGHIETGMRF TDGNWNLTPY
1410 1420 1430 1440 1450
ASLTGFTADN PEYHLSNGMK SKSVDTRSIY RELGATLSYN MRLGNGMEVE
1460 1470 1480 1490 1500
PWLKAAVRKE FVDDNRVKVN SDGNFVNYLS GRRGIYQAGI KASFSSTLSG
1510 1520
HLGVGYSHSA GVESPWNAVA GVNWSF
Length:1,526
Mass (Da):157,500
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8EEEFA907364EB6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U36840 Genomic DNA Translation: AAA79815.1 Sequence problems.
U00096 Genomic DNA Translation: AAC75695.2
AP009048 Genomic DNA Translation: BAA16514.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A65044

NCBI Reference Sequences

More...
RefSeqi
NP_417134.2, NC_000913.3
WP_010723187.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75695; AAC75695; b2647
BAA16514; BAA16514; BAA16514

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5422
eco:b2647

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4091

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36840 Genomic DNA Translation: AAA79815.1 Sequence problems.
U00096 Genomic DNA Translation: AAC75695.2
AP009048 Genomic DNA Translation: BAA16514.2
PIRiA65044
RefSeqiNP_417134.2, NC_000913.3
WP_010723187.1, NZ_LN832404.1

3D structure databases

SMRiP52143
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4259215, 237 interactors
DIPiDIP-12834N
IntActiP52143, 2 interactors
STRINGi511145.b2647

Proteomic databases

PaxDbiP52143
PRIDEiP52143

Genome annotation databases

EnsemblBacteriaiAAC75695; AAC75695; b2647
BAA16514; BAA16514; BAA16514
GeneIDi948630
KEGGiecj:JW5422
eco:b2647
PATRICifig|1411691.4.peg.4091

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3005

Phylogenomic databases

eggNOGiCOG3468, Bacteria
HOGENOMiCLU_004643_1_0_6
InParanoidiP52143
PhylomeDBiP52143

Enzyme and pathway databases

BioCyciEcoCyc:G7382-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P52143

Family and domain databases

Gene3Di2.160.20.20, 4 hits
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR030930, AIDA
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR004899, Pertactin_central
IPR003991, Pertactin_virulence_factor
PfamiView protein in Pfam
PF16168, AIDA, 6 hits
PF03797, Autotransporter, 1 hit
PF03212, Pertactin, 1 hit
PRINTSiPR01484, PRTACTNFAMLY
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit
TIGRFAMsiTIGR01414, autotrans_barl, 1 hit
TIGR04415, O_hepto_targRPT, 6 hits
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYPJA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P52143
Secondary accession number(s): P76610, P77017, P77019
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 13, 2007
Last modified: June 2, 2021
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
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