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Protein

Histidine transport system permease protein HisQ

Gene

hisQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity

GO - Molecular functioni

  • high-affinity L-histidine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • L-histidine import across plasma membrane Source: EcoCyc
  • L-histidine transmembrane transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:HISQ-MONOMER

Protein family/group databases

TCDBi3.A.1.3.29 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport system permease protein HisQ
Gene namesi
Name:hisQ
Ordered Locus Names:b2308, JW2305
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12125 hisQ

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12PeriplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini34 – 58CytoplasmicSequence analysisAdd BLAST25
Transmembranei59 – 79HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini80 – 87PeriplasmicSequence analysis8
Transmembranei88 – 108HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini109 – 152CytoplasmicSequence analysisAdd BLAST44
Transmembranei153 – 173HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini174 – 194PeriplasmicSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini216 – 228CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600501 – 228Histidine transport system permease protein HisQAdd BLAST228

Proteomic databases

PaxDbiP52094
PRIDEiP52094

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4260523, 8 interactors
DIPiDIP-9912N
STRINGi316385.ECDH10B_2470

Structurei

3D structure databases

ProteinModelPortaliP52094
SMRiP52094
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 212ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DSP Bacteria
COG4215 LUCA
HOGENOMiHOG000267551
InParanoidiP52094
KOiK10016
OMAiCYTSAFI
PhylomeDBiP52094

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR010065 AA_ABC_transptr_permease_3TM
IPR030199 HisQ
IPR000515 MetI-like
IPR035906 MetI-like_sf
PANTHERiPTHR30133:SF1 PTHR30133:SF1, 1 hit
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
TIGRFAMsiTIGR01726 HEQRo_perm_3TM, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P52094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYGFSGVIL QGALVTLELA ISSVVLAVII GLIGAGGKLS QNRLSGLIFE
60 70 80 90 100
GYTTLIRGVP DLVLMLLIFY GLQIALNTVT EAMGVGQIDI DPMVAGIITL
110 120 130 140 150
GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTRGQVFRR IMFPSMMRYA
160 170 180 190 200
LPGIGNNWQV ILKSTALVSL LGLEDVVKAT QLAGKSTWEP FYFAIVCGVI
210 220
YLVFTTVSNG VLLFLERRYS VGVKRADL
Length:228
Mass (Da):24,649
Last modified:November 1, 1997 - v2
Checksum:iE30595A18C1B8E2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15V → C in AAA85770 (Ref. 1) Curated1
Sequence conflicti61D → Y in AAA85770 (Ref. 1) Curated1
Sequence conflicti88I → M in AAA85770 (Ref. 1) Curated1
Sequence conflicti114G → C in AAA85770 (Ref. 1) Curated1
Sequence conflicti120P → A in AAA85770 (Ref. 1) Curated1
Sequence conflicti137 – 138VF → MC in AAA85770 (Ref. 1) Curated2
Sequence conflicti199V → L in AAA85770 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47027 Genomic DNA Translation: AAA85770.1
U00096 Genomic DNA Translation: AAC75368.1
AP009048 Genomic DNA Translation: BAA16154.1
PIRiB65003
RefSeqiNP_416811.1, NC_000913.3
WP_000965522.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75368; AAC75368; b2308
BAA16154; BAA16154; BAA16154
GeneIDi947235
KEGGiecj:JW2305
eco:b2308
PATRICifig|1411691.4.peg.4426

Similar proteinsi

Entry informationi

Entry nameiHISQ_ECOLI
AccessioniPrimary (citable) accession number: P52094
Secondary accession number(s): P77635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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