hisQ

Functionⁱ

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity

GO - Molecular functionⁱ

high-affinity L-histidine transmembrane transporter activity
Source: EcoCyc
Traceable author statementⁱ
- 6449635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

L-histidine import across plasma membrane
Source: EcoCyc
Traceable author statementⁱ
- 6449635
L-histidine transmembrane transport
Source: EcoCyc
Traceable author statementⁱ
- 6449635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Transport

Biological process

Amino-acid transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:HISQ-MONOMER

BioCycⁱ

EcoCyc:HISQ-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.3.29 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.3.29 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histidine transport system permease protein HisQ
Gene namesⁱ	Name:hisQ Ordered Locus Names:b2308, JW2305
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12125 hisQ

EcoGeneⁱ

EG12125 hisQ

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, TOPOLOGY [LARGE SCALE ANALYSIS].
; Multi-pass membrane protein
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00441
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, TOPOLOGY [LARGE SCALE ANALYSIS].

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 12	PeriplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	13 – 33	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	34 – 58	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	59 – 79	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	80 – 87	PeriplasmicSequence analysis	8
Transmembraneⁱ	88 – 108	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	109 – 152	CytoplasmicSequence analysisAdd BLAST	44
Transmembraneⁱ	153 – 173	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	174 – 194	PeriplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	195 – 215	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	216 – 228	CytoplasmicSequence analysisAdd BLAST	13

GO - Cellular componentⁱ

ATP-binding cassette (ABC) transporter complex Source: InterPro
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000060050	1 – 228	Histidine transport system permease protein HisQAdd BLAST		228

Proteomic databases

PaxDbⁱ	P52094
PRIDEⁱ	P52094

Interactionⁱ

Subunit structureⁱ

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridⁱ	4260523, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-9912N
STRINGⁱ	316385.ECDH10B_2470

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52094
SMRⁱ	P52094
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 212	ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST		200

Sequence similaritiesⁱ

Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105DSP Bacteria COG4215 LUCA
HOGENOMⁱ	HOG000267551
InParanoidⁱ	P52094
KEGG Orthology (KO) More...KOⁱ	K10016
OMAⁱ	CYTSAFI
PhylomeDBⁱ	P52094

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit
InterProⁱ	View protein in InterPro IPR010065 AA_ABC_transptr_permease_3TM IPR030199 HisQ IPR000515 MetI-like IPR035906 MetI-like_sf
PANTHERⁱ	PTHR30133:SF1 PTHR30133:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
TIGRFAMsⁱ	TIGR01726 HEQRo_perm_3TM, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P52094-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLYGFSGVIL QGALVTLELA ISSVVLAVII GLIGAGGKLS QNRLSGLIFE 
        60         70         80         90        100
GYTTLIRGVP DLVLMLLIFY GLQIALNTVT EAMGVGQIDI DPMVAGIITL 
       110        120        130        140        150
GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTRGQVFRR IMFPSMMRYA 
       160        170        180        190        200
LPGIGNNWQV ILKSTALVSL LGLEDVVKAT QLAGKSTWEP FYFAIVCGVI 
       210        220 
YLVFTTVSNG VLLFLERRYS VGVKRADL

Length:228

Mass (Da):24,649

Last modified:November 1, 1997 - v2

Checksum:ⁱE30595A18C1B8E2C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	V → C in AAA85770 (Ref. 1) Curated	1
Sequence conflictⁱ	61	D → Y in AAA85770 (Ref. 1) Curated	1
Sequence conflictⁱ	88	I → M in AAA85770 (Ref. 1) Curated	1
Sequence conflictⁱ	114	G → C in AAA85770 (Ref. 1) Curated	1
Sequence conflictⁱ	120	P → A in AAA85770 (Ref. 1) Curated	1
Sequence conflictⁱ	137 – 138	VF → MC in AAA85770 (Ref. 1) Curated	2
Sequence conflictⁱ	199	V → L in AAA85770 (Ref. 1) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U47027 Genomic DNA Translation: AAA85770.1 U00096 Genomic DNA Translation: AAC75368.1 AP009048 Genomic DNA Translation: BAA16154.1
PIRⁱ	B65003
NCBI Reference Sequences More...RefSeqⁱ	NP_416811.1, NC_000913.3 WP_000965522.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75368; AAC75368; b2308 BAA16154; BAA16154; BAA16154
GeneIDⁱ	947235
KEGGⁱ	ecj:JW2305 eco:b2308
PATRICⁱ	fig\|1411691.4.peg.4426

Protein	Similar proteins		Species	Score	Length
P52094	Histidine ABC transporter, permease protein HisQ (TC 3.A.1.3.1)		Klebsiella pneumoniae IS22		228
Amino acid ABC transporter permease		ECOLX		228
Histidine ABC transporter permease		SHIBO		228
Histidine transport system permease protein hisQ		Escherichia coli 1-110-08_S3_C1		228
Histidine transport system permease protein HisQ		Escherichia coli UMNK88		228
+688

Protein	Similar proteins		Species	Score	Length
P52094	Histidine ABC transporter, permease protein HisQ (TC 3.A.1.3.1)		Klebsiella pneumoniae IS22		228
Amino acid ABC transporter permease		ECOLX		228
Histidine ABC transporter permease		SHIBO		228
Histidine transport system permease protein hisQ		Escherichia coli 1-110-08_S3_C1		228
Histidine transport system permease protein HisQ		Escherichia coli UMNK88		228
+2344

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U47027 Genomic DNA Translation: AAA85770.1 U00096 Genomic DNA Translation: AAC75368.1 AP009048 Genomic DNA Translation: BAA16154.1
PIRⁱ	B65003
NCBI Reference Sequences More...RefSeqⁱ	NP_416811.1, NC_000913.3 WP_000965522.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P52094
SMRⁱ	P52094
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260523, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-9912N
STRINGⁱ	316385.ECDH10B_2470

Protein family/group databases

TCDBⁱ	3.A.1.3.29 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.3.29 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P52094
PRIDEⁱ	P52094

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75368; AAC75368; b2308 BAA16154; BAA16154; BAA16154
GeneIDⁱ	947235
KEGGⁱ	ecj:JW2305 eco:b2308
PATRICⁱ	fig\|1411691.4.peg.4426

Organism-specific databases

EchoBASEⁱ	EB2046
EcoGeneⁱ	EG12125 hisQ

Phylogenomic databases

eggNOGⁱ	ENOG4105DSP Bacteria COG4215 LUCA
HOGENOMⁱ	HOG000267551
InParanoidⁱ	P52094
KEGG Orthology (KO) More...KOⁱ	K10016
OMAⁱ	CYTSAFI
PhylomeDBⁱ	P52094

Enzyme and pathway databases

BioCycⁱ	EcoCyc:HISQ-MONOMER

BioCycⁱ

EcoCyc:HISQ-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P52094

PROⁱ

PR:P52094

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit
InterProⁱ	View protein in InterPro IPR010065 AA_ABC_transptr_permease_3TM IPR030199 HisQ IPR000515 MetI-like IPR035906 MetI-like_sf
PANTHERⁱ	PTHR30133:SF1 PTHR30133:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
TIGRFAMsⁱ	TIGR01726 HEQRo_perm_3TM, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HISQ_ECOLI
Accessionⁱ	P52094Primary (citable) accession number: P52094 Secondary accession number(s): P77635
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 1, 1997
	Last modified:	March 28, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P52094 (HISQ_ECOLI)

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Histidine transport system permease protein HisQ

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ