UniProtKB - P52043 (SCPC_ECOLI)
Protein
Propionyl-CoA:succinate CoA transferase
Gene
scpC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate.1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 286 | 5-glutamyl coenzyme A thioester intermediateBy similarity | 1 | |
Binding sitei | 376 | Coenzyme ABy similarity | 1 | |
Binding sitei | 380 | Coenzyme A; via amide nitrogenBy similarity | 1 |
GO - Molecular functioni
- acetate CoA-transferase activity Source: GO_Central
- acetyl-CoA hydrolase activity Source: GO_Central
- propionyl-CoA:succinate CoA-transferase activity Source: EcoCyc
GO - Biological processi
- acetate metabolic process Source: GO_Central
- acetyl-CoA metabolic process Source: InterPro
- propionate metabolic process, methylcitrate cycle Source: InterPro
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:G7517-MONOMER MetaCyc:G7517-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:scpC Synonyms:ygfH Ordered Locus Names:b2920, JW2887 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215527 | 1 – 492 | Propionyl-CoA:succinate CoA transferaseAdd BLAST | 492 |
Proteomic databases
PaxDbi | P52043 |
PRIDEi | P52043 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262329, 6 interactors |
DIPi | DIP-12167N |
IntActi | P52043, 9 interactors |
STRINGi | 511145.b2920 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 264 | Coenzyme A bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the acetyl-CoA hydrolase/transferase family.Curated
Phylogenomic databases
eggNOGi | COG0427, Bacteria |
HOGENOMi | CLU_019748_3_0_6 |
InParanoidi | P52043 |
PhylomeDBi | P52043 |
Family and domain databases
Gene3Di | 3.40.1080.20, 1 hit |
InterProi | View protein in InterPro IPR026888, AcetylCoA_hyd_C IPR038460, AcetylCoA_hyd_C_sf IPR003702, ActCoA_hydro IPR037171, NagB/RpiA_transferase-like IPR017821, Succinate_CoA_transferase |
Pfami | View protein in Pfam PF13336, AcetylCoA_hyd_C, 1 hit PF02550, AcetylCoA_hydro, 1 hit |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR03458, YgfH_subfam, 1 hit |
i Sequence
Sequence statusi: Complete.
P52043-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METQWTRMTA NEAAEIIQHN DMVAFSGFTP AGSPKALPTA IARRANEQHE
60 70 80 90 100
AKKPYQIRLL TGASISAAAD DVLSDADAVS WRAPYQTSSG LRKKINQGAV
110 120 130 140 150
SFVDLHLSEV AQMVNYGFFG DIDVAVIEAS ALAPDGRVWL TSGIGNAPTW
160 170 180 190 200
LLRAKKVIIE LNHYHDPRVA ELADIVIPGA PPRRNSVSIF HAMDRVGTRY
210 220 230 240 250
VQIDPKKIVA VVETNLPDAG NMLDKQNPMC QQIADNVVTF LLQEMAHGRI
260 270 280 290 300
PPEFLPLQSG VGNINNAVMA RLGENPVIPP FMMYSEVLQE SVVHLLETGK
310 320 330 340 350
ISGASASSLT ISADSLRKIY DNMDYFASRI VLRPQEISNN PEIIRRLGVI
360 370 380 390 400
ALNVGLEFDI YGHANSTHVA GVDLMNGIGG SGDFERNAYL SIFMAPSIAK
410 420 430 440 450
EGKISTVVPM CSHVDHSEHS VKVIITEQGI ADLRGLSPLQ RARTIIDNCA
460 470 480 490
HPMYRDYLHR YLENAPGGHI HHDLSHVFDL HRNLIATGSM LG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69087.1 U00096 Genomic DNA Translation: AAC75957.1 AP009048 Genomic DNA Translation: BAE76984.1 |
PIRi | G65076 |
RefSeqi | NP_417395.1, NC_000913.3 WP_000449965.1, NZ_SSZK01000003.1 |
Genome annotation databases
EnsemblBacteriai | AAC75957; AAC75957; b2920 BAE76984; BAE76984; BAE76984 |
GeneIDi | 947402 |
KEGGi | ecj:JW2887 eco:b2920 |
PATRICi | fig|1411691.4.peg.3812 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69087.1 U00096 Genomic DNA Translation: AAC75957.1 AP009048 Genomic DNA Translation: BAE76984.1 |
PIRi | G65076 |
RefSeqi | NP_417395.1, NC_000913.3 WP_000449965.1, NZ_SSZK01000003.1 |
3D structure databases
SMRi | P52043 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262329, 6 interactors |
DIPi | DIP-12167N |
IntActi | P52043, 9 interactors |
STRINGi | 511145.b2920 |
Proteomic databases
PaxDbi | P52043 |
PRIDEi | P52043 |
Genome annotation databases
EnsemblBacteriai | AAC75957; AAC75957; b2920 BAE76984; BAE76984; BAE76984 |
GeneIDi | 947402 |
KEGGi | ecj:JW2887 eco:b2920 |
PATRICi | fig|1411691.4.peg.3812 |
Organism-specific databases
EchoBASEi | EB2800 |
Phylogenomic databases
eggNOGi | COG0427, Bacteria |
HOGENOMi | CLU_019748_3_0_6 |
InParanoidi | P52043 |
PhylomeDBi | P52043 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7517-MONOMER MetaCyc:G7517-MONOMER |
Miscellaneous databases
PROi | PR:P52043 |
Family and domain databases
Gene3Di | 3.40.1080.20, 1 hit |
InterProi | View protein in InterPro IPR026888, AcetylCoA_hyd_C IPR038460, AcetylCoA_hyd_C_sf IPR003702, ActCoA_hydro IPR037171, NagB/RpiA_transferase-like IPR017821, Succinate_CoA_transferase |
Pfami | View protein in Pfam PF13336, AcetylCoA_hyd_C, 1 hit PF02550, AcetylCoA_hydro, 1 hit |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR03458, YgfH_subfam, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCPC_ECOLI | |
Accessioni | P52043Primary (citable) accession number: P52043 Secondary accession number(s): Q2M9S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families