UniProtKB - P52042 (ACDS_CLOAB)
Protein
Acyl-CoA dehydrogenase, short-chain specific
Gene
bcd
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Functioni
Catalytic activityi
- butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
- a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]1 PublicationEC:1.3.8.11 Publication
Cofactori
: butanoate metabolism Pathwayi
This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.
GO - Molecular functioni
- acyl-CoA dehydrogenase activity Source: InterPro
- butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
- flavin adenine dinucleotide binding Source: InterPro
GO - Biological processi
- butyrate metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BioCyci | MetaCyc:BCDCLOS-MONOMER |
UniPathwayi | UPA00863 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA dehydrogenase, short-chain specific (EC:1.3.8.1)Alternative name(s): Butyryl-CoA dehydrogenase SCAD |
Gene namesi | Name:bcd Ordered Locus Names:CA_C2711 |
Organismi | Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) |
Taxonomic identifieri | 272562 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201189 | 1 – 379 | Acyl-CoA dehydrogenase, short-chain specificAdd BLAST | 379 |
Family & Domainsi
Sequence similaritiesi
Belongs to the acyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_0_2_9 |
OMAi | NMATWML |
OrthoDBi | 760677at2 |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P52042-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFNLTREQE LVRQMVREFA ENEVKPIAAE IDETERFPME NVKKMGQYGM
60 70 80 90 100
MGIPFSKEYG GAGGDVLSYI IAVEELSKVC GTTGVILSAH TSLCASLINE
110 120 130 140 150
HGTEEQKQKY LVPLAKGEKI GAYGLTEPNA GTDSGAQQTV AVLEGDHYVI
160 170 180 190 200
NGSKIFITNG GVADTFVIFA MTDRTKGTKG ISAFIIEKGF KGFSIGKVEQ
210 220 230 240 250
KLGIRASSTT ELVFEDMIVP VENMIGKEGK GFPIAMKTLD GGRIGIAAQA
260 270 280 290 300
LGIAEGAFNE ARAYMKERKQ FGRSLDKFQG LAWMMADMDV AIESARYLVY
310 320 330 340 350
KAAYLKQAGL PYTVDAARAK LHAANVAMDV TTKAVQLFGG YGYTKDYPVE
360 370
RMMRDAKITE IYEGTSEVQK LVISGKIFR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17110 Genomic DNA Translation: AAA95968.1 AE001437 Genomic DNA Translation: AAK80657.1 |
PIRi | F97233 T47262 |
RefSeqi | NP_349317.1, NC_003030.1 WP_010965998.1, NC_003030.1 |
Genome annotation databases
EnsemblBacteriai | AAK80657; AAK80657; CA_C2711 |
GeneIDi | 44999200 |
KEGGi | cac:CA_C2711 |
PATRICi | fig|272562.8.peg.2901 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17110 Genomic DNA Translation: AAA95968.1 AE001437 Genomic DNA Translation: AAK80657.1 |
PIRi | F97233 T47262 |
RefSeqi | NP_349317.1, NC_003030.1 WP_010965998.1, NC_003030.1 |
3D structure databases
SMRi | P52042 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272562.CA_C2711 |
Genome annotation databases
EnsemblBacteriai | AAK80657; AAK80657; CA_C2711 |
GeneIDi | 44999200 |
KEGGi | cac:CA_C2711 |
PATRICi | fig|272562.8.peg.2901 |
Phylogenomic databases
eggNOGi | COG1960, Bacteria |
HOGENOMi | CLU_018204_0_2_9 |
OMAi | NMATWML |
OrthoDBi | 760677at2 |
Enzyme and pathway databases
UniPathwayi | UPA00863 |
BioCyci | MetaCyc:BCDCLOS-MONOMER |
Family and domain databases
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR006089, Acyl-CoA_DH_CS IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR013786, AcylCoA_DH/ox_N IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF02771, Acyl-CoA_dh_N, 1 hit |
SUPFAMi | SSF47203, SSF47203, 1 hit SSF56645, SSF56645, 1 hit |
PROSITEi | View protein in PROSITE PS00072, ACYL_COA_DH_1, 1 hit PS00073, ACYL_COA_DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACDS_CLOAB | |
Accessioni | P52042Primary (citable) accession number: P52042 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families