UniProtKB - P52033 (GPXC_DIRIM)
Protein
Glutathione peroxidase
Gene
N/A
Organism
Dirofilaria immitis (Canine heartworm)
Status
Functioni
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 72 | By similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: UniProtKB-EC
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 3752, DiGPx01 |
Names & Taxonomyi
Protein namesi | |
Organismi | Dirofilaria immitis (Canine heartworm) |
Taxonomic identifieri | 6287 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Spirurina › Spiruromorpha › Filarioidea › Onchocercidae › Dirofilaria |
Subcellular locationi
Extracellular region or secreted
- extracellular space By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000013094 | 20 – 221 | Glutathione peroxidaseAdd BLAST | 202 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 87 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Homotetramer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P52033-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFIQLLILSY AILLQLIATQ VADKQLPNLT KQCEPTSQTI YDFHVPTLDG
60 70 80 90 100
SEKSLAEYRG KVLLLVNVAT YCAYTFQYND FNPMLENNSN GTLKILAFPC
110 120 130 140 150
NQFLLQEPAE NHELLNGLKY VRPGNGWEPH GNMHIFGKVE VNGDDHHPLY
160 170 180 190 200
KFLKEHCPQT VPIIGDRHQL MYNPIGTNDI IWNFEKFLID KKGHPRYRFH
210 220
PSAWVQGSVI APFIDELERE I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04693 mRNA Translation: AAA16224.1 U87457 mRNA Translation: AAB58573.1 U87458 Genomic DNA Translation: AAB58574.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04693 mRNA Translation: AAA16224.1 U87457 mRNA Translation: AAB58573.1 U87458 Genomic DNA Translation: AAB58574.1 |
3D structure databases
SMRi | P52033 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 3752, DiGPx01 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPXC_DIRIM | |
Accessioni | P52033Primary (citable) accession number: P52033 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 11, 2019 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |