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Protein

Peptidyl-prolyl cis-trans isomerase 3

Gene

cyn-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: WormBase

GO - Biological processi

  • protein folding Source: WormBase
  • protein peptidyl-prolyl isomerization Source: WormBase

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase 3 (EC:5.2.1.8)
Short name:
PPIase 3
Alternative name(s):
Cyclophilin-3
Rotamase 3
Gene namesi
Name:cyn-3
Synonyms:cyp-3
ORF Names:Y75B12B.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY75B12B.5 ; CE20374 ; WBGene00000879 ; cyn-3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641921 – 173Peptidyl-prolyl cis-trans isomerase 3Add BLAST173

Proteomic databases

EPDiP52011
PaxDbiP52011
PeptideAtlasiP52011
PRIDEiP52011

Expressioni

Tissue specificityi

Exclusively expressed in the single anterior excretory cell.1 Publication

Developmental stagei

During early larval development, peaking at the second larval stage, and dropping off in later development.1 Publication

Gene expression databases

BgeeiWBGene00000879 Expressed in 3 organ(s), highest expression level in adult organism

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_K09E4.1Q9NAP84EBI-2419150,EBI-2419154

Protein-protein interaction databases

IntActiP52011, 1 interactor
STRINGi6239.Y75B12B.5.1

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP52011
SMRiP52011
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52011

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 170PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP52011
KOiK01802
OMAiLQFGIQF
OrthoDBiEOG091G0BGL
PhylomeDBiP52011

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSKVFFDI TIGGKASGRI VMELYDDVVP KTAGNFRALC TGENGIGKSG
60 70 80 90 100
KPLHFKGSKF HRIIPNFMIQ GGDFTRGNGT GGESIYGEKF PDENFKEKHT
110 120 130 140 150
GPGVLSMANA GPNTNGSQFF LCTVKTEWLD GKHVVFGRVV EGLDVVKAVE
160 170
SNGSQSGKPV KDCMIADCGQ LKA
Length:173
Mass (Da):18,550
Last modified:October 1, 1996 - v1
Checksum:i39994FEF4941DEC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31077 mRNA Translation: AAC47129.1
AL032663 Genomic DNA Translation: CAA21762.1
PIRiT27373
RefSeqiNP_506751.1, NM_074350.6
UniGeneiCel.6363

Genome annotation databases

EnsemblMetazoaiY75B12B.5; Y75B12B.5; WBGene00000879
GeneIDi180028
KEGGicel:CELE_Y75B12B.5
UCSCiY75B12B.5.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31077 mRNA Translation: AAC47129.1
AL032663 Genomic DNA Translation: CAA21762.1
PIRiT27373
RefSeqiNP_506751.1, NM_074350.6
UniGeneiCel.6363

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DYWX-ray1.80A1-173[»]
1E3BX-ray1.85A1-173[»]
1E8KX-ray1.90A1-173[»]
2IGVX-ray1.67A1-173[»]
2IGWX-ray1.78A1-173[»]
ProteinModelPortaliP52011
SMRiP52011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52011, 1 interactor
STRINGi6239.Y75B12B.5.1

Proteomic databases

EPDiP52011
PaxDbiP52011
PeptideAtlasiP52011
PRIDEiP52011

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY75B12B.5; Y75B12B.5; WBGene00000879
GeneIDi180028
KEGGicel:CELE_Y75B12B.5
UCSCiY75B12B.5.1 c. elegans

Organism-specific databases

CTDi180028
WormBaseiY75B12B.5 ; CE20374 ; WBGene00000879 ; cyn-3

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP52011
KOiK01802
OMAiLQFGIQF
OrthoDBiEOG091G0BGL
PhylomeDBiP52011

Miscellaneous databases

EvolutionaryTraceiP52011
PROiPR:P52011

Gene expression databases

BgeeiWBGene00000879 Expressed in 3 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYP3_CAEEL
AccessioniPrimary (citable) accession number: P52011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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