Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase 2

Gene

cyn-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase 2 (EC:5.2.1.8)
Short name:
PPIase 2
Alternative name(s):
Cyclophilin-2
Rotamase 2
Gene namesi
Name:cyn-2
Synonyms:cyp-2
ORF Names:ZK520.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK520.5 ; CE16730 ; WBGene00000878 ; cyn-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641911 – 172Peptidyl-prolyl cis-trans isomerase 2Add BLAST172

Proteomic databases

EPDiP52010
PaxDbiP52010
PeptideAtlasiP52010
PRIDEiP52010

Expressioni

Gene expression databases

BgeeiWBGene00000878 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

IntActiP52010, 1 interactor
STRINGi6239.ZK520.5

Structurei

3D structure databases

ProteinModelPortaliP52010
SMRiP52010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 170PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP52010
KOiK01802
OMAiFFINFKD
OrthoDBiEOG091G0BGL
PhylomeDBiP52010

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52010-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRVKVFFDI TIGGKKGGRI VMELYNDIVP KTAENFRALC TGEKGKGKSG
60 70 80 90 100
KKLHFKGSKF HRIIPEFMIQ GGDFTEGNGT GGESIHGEKF DDENFKEKHT
110 120 130 140 150
GPGVLSMANC GANTNGSQFF LCTVKTTWLD GKHVVFGKVI EGMDVVKAIE
160 170
SKGSEDGAPS APCVIADCGE MK
Length:172
Mass (Da):18,535
Last modified:March 28, 2003 - v2
Checksum:i87CB148261CAC2B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8F → I in AAC47127 (PubMed:8694762).Curated1
Sequence conflicti29V → A in AAC47127 (PubMed:8694762).Curated1
Sequence conflicti82Missing in AAC47127 (PubMed:8694762).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34354 mRNA Translation: AAC47127.1
Z92822 Genomic DNA Translation: CAB07303.1
PIRiT27882
RefSeqiNP_499828.1, NM_067427.5
UniGeneiCel.6107

Genome annotation databases

EnsemblMetazoaiZK520.5; ZK520.5; WBGene00000878
GeneIDi176807
KEGGicel:CELE_ZK520.5
UCSCiZK520.5.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34354 mRNA Translation: AAC47127.1
Z92822 Genomic DNA Translation: CAB07303.1
PIRiT27882
RefSeqiNP_499828.1, NM_067427.5
UniGeneiCel.6107

3D structure databases

ProteinModelPortaliP52010
SMRiP52010
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52010, 1 interactor
STRINGi6239.ZK520.5

Proteomic databases

EPDiP52010
PaxDbiP52010
PeptideAtlasiP52010
PRIDEiP52010

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK520.5; ZK520.5; WBGene00000878
GeneIDi176807
KEGGicel:CELE_ZK520.5
UCSCiZK520.5.1 c. elegans

Organism-specific databases

CTDi176807
WormBaseiZK520.5 ; CE16730 ; WBGene00000878 ; cyn-2

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP52010
KOiK01802
OMAiFFINFKD
OrthoDBiEOG091G0BGL
PhylomeDBiP52010

Miscellaneous databases

PROiPR:P52010

Gene expression databases

BgeeiWBGene00000878 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYP2_CAEEL
AccessioniPrimary (citable) accession number: P52010
Secondary accession number(s): O46022
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2003
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again