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Entry version 180 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6

Gene

FUT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants (PubMed:9451035, PubMed:1520296, PubMed:1339443, PubMed:7650030, PubMed:17604274, PubMed:9363434, PubMed:10728707). Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates to difucosylated sialyl Lewis x determinants (PubMed:17604274, PubMed:1339443). Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed:10728707). Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed:1339443, PubMed:17604274, PubMed:9363434).7 Publications
Does not have alpha(1,3)-fucosyltransferase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS08124-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.152, 2681
2.4.1.65, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P51993

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9037629, Lewis blood group biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT10, Glycosyltransferase Family 10

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001436 [P51993-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Curated (EC:2.4.1.1522 Publications)
Alternative name(s):
Fucosyltransferase 6
Fucosyltransferase VI
Short name:
Fuc-TVI
Short name:
FucT-VI
Galactoside 3-L-fucosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUT6Imported
Synonyms:FCT3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4017, FUT6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136836, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51993

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000156413.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini35 – 359LumenalSequence analysisAdd BLAST325

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi73K → T: Loss of site-specific fucosylation leading to generation of approximately equal amounts of VIM2 and sialyl-lewis x. Reverse the site-specific fucosylation pattern leading to generation of VIM2 predominantly instead of sialyl-lewis x; when associated with W-110; D-111 and I-112. Increases VIM2 glycolipid product; when associated with W-110; D-111 and I-112. 1 Publication1
Mutagenesisi110R → W: Reduces dramatically alpha(1,3)fucosyltransferase activity towards type 2 chain acceptors. Loss of site-specific fucosylation leading to generation of approximately equal amounts of VIM2 and sialyl-lewis x. Reverse the site-specific fucosylation pattern leading to generation of VIM2 predominantly instead of sialyl-lewis x; when associated with T-73; D-111 and I-112. Increases VIM2 glycolipid product; when associated with T-73; D-111 and I-112. 1 Publication1
Mutagenesisi111E → D: Reverse the site-specific fucosylation pattern leading to generation of VIM2 predominantly instead of sialyl-lewis x; when associated with T-73; W-110 and I-112. Increases VIM2 glycolipid product; when associated with T-73; W-110 and I-112. 1 Publication1
Mutagenesisi112V → I: Reverse the site-specific fucosylation pattern leading to generation of VIM2 predominantly instead of sialyl-lewis x; when associated with T-73; W-110 and D-111. Increases VIM2 glycolipid product; when associated with T-73; W-110 and D-111. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2528

MalaCards human disease database

More...
MalaCardsi
FUT6
MIMi613852, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156413

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28433

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P51993, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4443

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUT6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1730136

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211101 – 3594-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
Proteolytic cleavage releases a secreted glycoform of 43 kDa.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P51993

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P51993

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P51993

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51993

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51993

PeptideAtlas

More...
PeptideAtlasi
P51993

PRoteomics IDEntifications database

More...
PRIDEi
P51993

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56467 [P51993-1]
56468 [P51993-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P51993, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51993

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51993

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156413, Expressed in ectocervix and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51993, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51993, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156413, Tissue enhanced (esophagus, intestine, lymphoid tissue, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and monomer (PubMed:9451035). Monomer (secreted form) (PubMed:9451035).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313398

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P51993

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P51993, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 112determines site-specific fucosylation1 PublicationAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2619, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000163389

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032075_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51993

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHREVMY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51993

TreeFam database of animal gene trees

More...
TreeFami
TF316348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031481, Glyco_tran_10_N
IPR001503, Glyco_trans_10
IPR038577, GT10-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11929, PTHR11929, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17039, Glyco_tran_10_N, 1 hit
PF00852, Glyco_transf_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51993-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF
60 70 80 90 100
PDSTGTPAHS IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP
110 120 130 140 150
QADAVIVHHR EVMYNPSAQL PRSPRRQGQR WIWFSMESPS HCWQLKAMDG
160 170 180 190 200
YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH PPLNLSAKTE LVAWAVSNWG
210 220 230 240 250
PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY KFYLAFENSL
260 270 280 290 300
HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD
310 320 330 340 350
LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ

TRGIAAWFT
Length:359
Mass (Da):41,860
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67ABDF058F0999DA
GO
Isoform 2 (identifier: P51993-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-359: RYQTRGIAAWFT → SGGLIYLRTRLPEASPA

Show »
Length:364
Mass (Da):42,191
Checksum:iBD0B020AB1580EEF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS22E9PS22_HUMAN
4-galactosyl-N-acetylglucosaminide ...
FUT6
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP56E9PP56_HUMAN
4-galactosyl-N-acetylglucosaminide ...
FUT6
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ18E9PJ18_HUMAN
4-galactosyl-N-acetylglucosaminide ...
FUT6
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJB4E9PJB4_HUMAN
4-galactosyl-N-acetylglucosaminide ...
FUT6
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50191 differs from that shown. Probable cloning artifact.Curated

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIMi:613852].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024463124P → S Found in individuals with plasma alpha(1,3)-fucosyltransferase deficiency and no clinically relevant phenotype; results in partial enzyme inactivation; complete enzyme inactivation when associated with V-244 and G-303. 3 PublicationsCorresponds to variant dbSNP:rs778805Ensembl.1
Natural variantiVAR_024464230Q → K. Corresponds to variant dbSNP:rs364637Ensembl.1
Natural variantiVAR_065915244L → V Found in individuals with plasma alpha(1,3)-fucosyltransferase deficiency and no clinically relevant phenotype; complete enzyme inactivation when associated with S-124 and G-303. 1 Publication1
Natural variantiVAR_065916247E → K Found in individuals with plasma alpha(1,3)-fucosyltransferase deficiency and no clinically relevant phenotype; complete enzyme inactivation. 3 PublicationsCorresponds to variant dbSNP:rs17855739EnsemblClinVar.1
Natural variantiVAR_065917303R → G Found in individuals with plasma alpha(1,3)-fucosyltransferase deficiency and no clinically relevant phenotype; complete enzyme inactivation when associated with S-124 and V-244. 2 PublicationsCorresponds to variant dbSNP:rs61147939Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001780348 – 359RYQTR…AAWFT → SGGLIYLRTRLPEASPA in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M98825 mRNA Translation: AAA99222.1
L01698 Genomic DNA Translation: AAB03078.1
U27331 mRNA Translation: AAC50190.1
U27332 mRNA Translation: AAC50191.1 Sequence problems.
U27333 mRNA Translation: AAC50192.1
U27334 mRNA Translation: AAC50193.1
U27335 mRNA Translation: AAC50194.1
U27336 mRNA Translation: AAC50195.1
U27337 mRNA Translation: AAC50196.1
AF131211 mRNA Translation: AAD33509.1
AL031258 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69136.1
CH471139 Genomic DNA Translation: EAW69137.1
CH471139 Genomic DNA Translation: EAW69138.1
CH471139 Genomic DNA Translation: EAW69139.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12152.1 [P51993-1]

Protein sequence database of the Protein Information Resource

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PIRi
A45156
I39048
I39049

NCBI Reference Sequences

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RefSeqi
NP_000141.1, NM_000150.2 [P51993-1]
NP_001035791.1, NM_001040701.1 [P51993-1]
XP_005259583.1, XM_005259526.4
XP_011526170.1, XM_011527868.2
XP_011526171.1, XM_011527869.2
XP_011526172.1, XM_011527870.2
XP_011526174.1, XM_011527872.2 [P51993-1]
XP_011526175.1, XM_011527873.2
XP_011526176.1, XM_011527874.2
XP_011526177.1, XM_011527875.2 [P51993-1]
XP_011526178.1, XM_011527876.2
XP_011526180.1, XM_011527878.2
XP_011526181.1, XM_011527879.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286955; ENSP00000286955; ENSG00000156413 [P51993-1]
ENST00000318336; ENSP00000313398; ENSG00000156413 [P51993-1]
ENST00000524754; ENSP00000431708; ENSG00000156413 [P51993-1]
ENST00000527106; ENSP00000432954; ENSG00000156413 [P51993-1]
ENST00000592563; ENSP00000466016; ENSG00000156413 [P51993-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2528

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2528

UCSC genome browser

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UCSCi
uc002mdf.2, human [P51993-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98825 mRNA Translation: AAA99222.1
L01698 Genomic DNA Translation: AAB03078.1
U27331 mRNA Translation: AAC50190.1
U27332 mRNA Translation: AAC50191.1 Sequence problems.
U27333 mRNA Translation: AAC50192.1
U27334 mRNA Translation: AAC50193.1
U27335 mRNA Translation: AAC50194.1
U27336 mRNA Translation: AAC50195.1
U27337 mRNA Translation: AAC50196.1
AF131211 mRNA Translation: AAD33509.1
AL031258 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69136.1
CH471139 Genomic DNA Translation: EAW69137.1
CH471139 Genomic DNA Translation: EAW69138.1
CH471139 Genomic DNA Translation: EAW69139.1
CCDSiCCDS12152.1 [P51993-1]
PIRiA45156
I39048
I39049
RefSeqiNP_000141.1, NM_000150.2 [P51993-1]
NP_001035791.1, NM_001040701.1 [P51993-1]
XP_005259583.1, XM_005259526.4
XP_011526170.1, XM_011527868.2
XP_011526171.1, XM_011527869.2
XP_011526172.1, XM_011527870.2
XP_011526174.1, XM_011527872.2 [P51993-1]
XP_011526175.1, XM_011527873.2
XP_011526176.1, XM_011527874.2
XP_011526177.1, XM_011527875.2 [P51993-1]
XP_011526178.1, XM_011527876.2
XP_011526180.1, XM_011527878.2
XP_011526181.1, XM_011527879.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000313398

Chemistry databases

BindingDBiP51993
ChEMBLiCHEMBL4443
SwissLipidsiSLP:000001436 [P51993-1]

Protein family/group databases

CAZyiGT10, Glycosyltransferase Family 10

PTM databases

GlyGeniP51993, 4 sites
iPTMnetiP51993
PhosphoSitePlusiP51993

Genetic variation databases

BioMutaiFUT6
DMDMi1730136

Proteomic databases

EPDiP51993
jPOSTiP51993
MassIVEiP51993
MaxQBiP51993
PaxDbiP51993
PeptideAtlasiP51993
PRIDEiP51993
ProteomicsDBi56467 [P51993-1]
56468 [P51993-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24005, 246 antibodies

The DNASU plasmid repository

More...
DNASUi
2528

Genome annotation databases

EnsembliENST00000286955; ENSP00000286955; ENSG00000156413 [P51993-1]
ENST00000318336; ENSP00000313398; ENSG00000156413 [P51993-1]
ENST00000524754; ENSP00000431708; ENSG00000156413 [P51993-1]
ENST00000527106; ENSP00000432954; ENSG00000156413 [P51993-1]
ENST00000592563; ENSP00000466016; ENSG00000156413 [P51993-2]
GeneIDi2528
KEGGihsa:2528
UCSCiuc002mdf.2, human [P51993-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2528
DisGeNETi2528

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FUT6
HGNCiHGNC:4017, FUT6
HPAiENSG00000156413, Tissue enhanced (esophagus, intestine, lymphoid tissue, salivary gland)
MalaCardsiFUT6
MIMi136836, gene
613852, phenotype
neXtProtiNX_P51993
OpenTargetsiENSG00000156413
PharmGKBiPA28433
VEuPathDBiHostDB:ENSG00000156413.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2619, Eukaryota
GeneTreeiENSGT00940000163389
HOGENOMiCLU_032075_4_1_1
InParanoidiP51993
OMAiHHREVMY
PhylomeDBiP51993
TreeFamiTF316348

Enzyme and pathway databases

UniPathwayiUPA00378
BioCyciMetaCyc:HS08124-MONOMER
BRENDAi2.4.1.152, 2681
2.4.1.65, 2681
PathwayCommonsiP51993
ReactomeiR-HSA-9037629, Lewis blood group biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2528, 12 hits in 972 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FUT6, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FUT6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2528
PharosiP51993, Tchem

Protein Ontology

More...
PROi
PR:P51993
RNActiP51993, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156413, Expressed in ectocervix and 205 other tissues
ExpressionAtlasiP51993, baseline and differential
GenevisibleiP51993, HS

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481, Glyco_tran_10_N
IPR001503, Glyco_trans_10
IPR038577, GT10-like_sf
PANTHERiPTHR11929, PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039, Glyco_tran_10_N, 1 hit
PF00852, Glyco_transf_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51993
Secondary accession number(s): A6NEX0, D6W637, Q9UND8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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