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Entry version 189 (16 Oct 2019)
Sequence version 2 (16 Aug 2004)
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Protein

Heterogeneous nuclear ribonucleoprotein A3

Gene

HNRNPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.1 Publication

Caution

An older version of this entry represented the conceptual translation of what was thought to be HNRNPA3 but which was in fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A3
Short name:
hnRNP A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPA3
Synonyms:HNRPA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24941 HNRNPA3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605372 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51991

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
220988

Open Targets

More...
OpenTargetsi
ENSG00000170144

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391169

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P51991

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPA3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338779

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818381 – 378Heterogeneous nuclear ribonucleoprotein A3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei14PhosphoserineCombined sources1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei43PhosphoserineCombined sources1
Modified residuei52Dimethylated arginine; alternate1 Publication1
Modified residuei52Omega-N-methylarginine; alternate1 Publication1
Modified residuei76Omega-N-methylarginineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei124PhosphothreonineCombined sources1
Modified residuei134N6-acetyllysine; alternateCombined sources1
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei214Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei214Omega-N-methylarginine; alternateCombined sources1
Modified residuei216Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei216Omega-N-methylarginine; alternateCombined sources1
Modified residuei226Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei226Omega-N-methylarginine; alternateCombined sources1
Modified residuei239Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei239Omega-N-methylarginine; alternateBy similarity1
Modified residuei246Asymmetric dimethylarginine; alternateCombined sources1 Publication1
Modified residuei246Omega-N-methylarginine; alternateCombined sources1
Modified residuei257Omega-N-methylarginineBy similarity1
Modified residuei286Asymmetric dimethylarginineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei354Omega-N-methylarginineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphotyrosineCombined sources1
Modified residuei364PhosphotyrosineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei373PhosphotyrosineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P51991

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P51991

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P51991

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51991

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51991

PeptideAtlas

More...
PeptideAtlasi
P51991

PRoteomics IDEntifications database

More...
PRIDEi
P51991

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56465 [P51991-1]
56466 [P51991-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P51991-1 [P51991-1]
P51991-2 [P51991-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1311

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51991

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51991

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P51991

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P51991

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170144 Expressed in 240 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51991 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51991 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001666
HPA005812
HPA066381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPA1P096512EBI-1050760,EBI-352662

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128670, 230 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P51991

Protein interaction database and analysis system

More...
IntActi
P51991, 60 interactors

Molecular INTeraction database

More...
MINTi
P51991

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51991

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 118RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini126 – 205RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 378Gly-richAdd BLAST168

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0118 Eukaryota
COG0724 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234442

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51991

KEGG Orthology (KO)

More...
KOi
K12741

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPNVPRG

Database of Orthologous Groups

More...
OrthoDBi
1202220at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51991

TreeFam database of animal gene trees

More...
TreeFami
TF314808

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12763 RRM1_hnRNPA3, 1 hit
cd12582 RRM2_hnRNPA3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034513 hnRNPA3_RRM1
IPR034516 hnRNPA3_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P51991-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS
60 70 80 90 100
LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV
110 120 130 140 150
DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG
160 170 180 190 200
KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK
210 220 230 240 250
ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG
260 270 280 290 300
GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
310 320 330 340 350
GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS
360 370
FGGRSSGSPY GGGYGSGGGS GGYGSRRF
Length:378
Mass (Da):39,595
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i832372C4C29547B1
GO
Isoform 2 (identifier: P51991-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MEVKPPPGRPQPDSGRRRRRRGE → M

Show »
Length:356
Mass (Da):37,029
Checksum:iC2D8451FC6D6A60A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1J8H7C1J8_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPA3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114181 – 23MEVKP…RRRGE → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY363225 mRNA Translation: AAQ63629.1
AC079305 Genomic DNA Translation: AAY14709.1
CH471058 Genomic DNA Translation: EAX11066.1
BC112027 mRNA Translation: AAI12028.1
BC113470 mRNA Translation: AAI13471.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2273.1 [P51991-1]
CCDS82536.1 [P51991-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I52962

NCBI Reference Sequences

More...
RefSeqi
NP_001317178.1, NM_001330249.1 [P51991-1]
NP_919223.1, NM_194247.3 [P51991-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392524; ENSP00000376309; ENSG00000170144 [P51991-1]
ENST00000411529; ENSP00000408487; ENSG00000170144 [P51991-2]
ENST00000435711; ENSP00000416340; ENSG00000170144 [P51991-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
220988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:220988

UCSC genome browser

More...
UCSCi
uc002ulb.2 human [P51991-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363225 mRNA Translation: AAQ63629.1
AC079305 Genomic DNA Translation: AAY14709.1
CH471058 Genomic DNA Translation: EAX11066.1
BC112027 mRNA Translation: AAI12028.1
BC113470 mRNA Translation: AAI13471.1
CCDSiCCDS2273.1 [P51991-1]
CCDS82536.1 [P51991-2]
PIRiI52962
RefSeqiNP_001317178.1, NM_001330249.1 [P51991-1]
NP_919223.1, NM_194247.3 [P51991-1]

3D structure databases

SMRiP51991
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128670, 230 interactors
CORUMiP51991
IntActiP51991, 60 interactors
MINTiP51991
STRINGi9606.ENSP00000376309

PTM databases

GlyConnecti1311
iPTMnetiP51991
PhosphoSitePlusiP51991
SwissPalmiP51991

Polymorphism and mutation databases

BioMutaiHNRNPA3
DMDMi51338779

Proteomic databases

EPDiP51991
jPOSTiP51991
MassIVEiP51991
MaxQBiP51991
PaxDbiP51991
PeptideAtlasiP51991
PRIDEiP51991
ProteomicsDBi56465 [P51991-1]
56466 [P51991-2]
TopDownProteomicsiP51991-1 [P51991-1]
P51991-2 [P51991-2]

Genome annotation databases

EnsembliENST00000392524; ENSP00000376309; ENSG00000170144 [P51991-1]
ENST00000411529; ENSP00000408487; ENSG00000170144 [P51991-2]
ENST00000435711; ENSP00000416340; ENSG00000170144 [P51991-1]
GeneIDi220988
KEGGihsa:220988
UCSCiuc002ulb.2 human [P51991-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
220988
DisGeNETi220988

GeneCards: human genes, protein and diseases

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GeneCardsi
HNRNPA3
HGNCiHGNC:24941 HNRNPA3
HPAiHPA001666
HPA005812
HPA066381
MIMi605372 gene
neXtProtiNX_P51991
OpenTargetsiENSG00000170144
PharmGKBiPA162391169

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00940000153147
HOGENOMiHOG000234442
InParanoidiP51991
KOiK12741
OMAiGPNVPRG
OrthoDBi1202220at2759
PhylomeDBiP51991
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HNRNPA3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HNRPA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
220988
PharosiP51991
PMAP-CutDBiP51991

Protein Ontology

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PROi
PR:P51991

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170144 Expressed in 240 organ(s), highest expression level in testis
ExpressionAtlasiP51991 baseline and differential
GenevisibleiP51991 HS

Family and domain databases

CDDicd12763 RRM1_hnRNPA3, 1 hit
cd12582 RRM2_hnRNPA3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034513 hnRNPA3_RRM1
IPR034516 hnRNPA3_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51991
Secondary accession number(s): D3DPF4, Q53RW7, Q6URK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: October 16, 2019
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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