UniProtKB - P51960 (MYBA_MOUSE)

BLAST

>sp|P51960|MYBA_MOUSE Myb-related protein A OS=Mus musculus OX=10090 GN=Mybl1 PE=1 SV=2
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTL
IASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGR
IGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW
NSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDG
NCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSF
LMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRT
LELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNS
RNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPV
KTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRT
PTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFL
KEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLM
IPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYG
KTEDQLIMTEQARRYLSTYTATSSTSRALIL

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History
Entry version 147 (10 Oct 2018)
Sequence version 2 (01 Nov 1997)
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Protein

Myb-related protein A

Gene

Mybl1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7813437, PubMed:23523368). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1 (PubMed:21750041, PubMed:23523368). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (PubMed:23523368).3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	58 – 81	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	110 – 133	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	161 – 184	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23523368
RNA polymerase II transcription factor recruiting activity Source: GO_Central
sequence-specific DNA binding Source: GO_Central
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcription regulatory region DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: GO_Central
male meiosis I
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21750041
- 23523368
mitotic cell cycle Source: GO_Central
negative regulation of transposition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23523368
piRNA biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 23523368
positive regulation of transcription, DNA-templated Source: GO_Central
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 23523368
regulation of transcription by RNA polymerase II Source: GO_Central
spermatogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21750041
- 23523368

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Differentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myb-related protein A1 Publication Short name: A-Myb1 Publication Alternative name(s): Myb-like protein 1
Gene namesⁱ	Name:Mybl1 Synonyms:Amyb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:99925 Mybl1

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	213	A → E in Repro9; male sterility due to defects in spermatogenesis. Impaired piRNA biogenesis. 2 Publications		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197055	1 – 751	Myb-related protein AAdd BLAST		751

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	199	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	393	N6-acetyllysineBy similarity	1
Cross-linkⁱ	591	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	601	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	P51960
PRIDEⁱ	P51960

PTM databases

iPTMnetⁱ	P51960
PhosphoSitePlusⁱ	P51960

Expressionⁱ

Tissue specificityⁱ

Predominantly in the testis. Very low levels in the ovaries, spleen and brain.2 Publications

Developmental stageⁱ

During embryogenesis it is predominantly expressed in several regions of the developing central nervous system and the urogenital ridge. Expression in the CNS is confined to the neural tube, the hindbrain, the neural retina and the olfactory epithelium, and coincides with the presence of proliferating immature neuronal precursor cells. In the adult mouse, A-Myb is expressed at high levels in type A spermatogonia (stem cells), and preleptotene and pachytene spermatocytes, with concomitant down-regulation of expression upon terminal differentiation of these cells into mature spermatozoa, and in B lymphocytes located in germinal centers of the spleen (PubMed:7813437, PubMed:8084617). Present in mid-late pachytene and diplotene spermatocytes, but not in late zygotene/early pachytene cells (at protein level) (PubMed:21750041).3 Publications

Gene expression databases

CleanExⁱ	MM_MYBL1

CleanExⁱ

MM_MYBL1

Interactionⁱ

Subunit structureⁱ

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).By similarity

GO - Molecular functionⁱ

RNA polymerase II transcription factor recruiting activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000086034

STRINGⁱ

10090.ENSMUSP00000086034

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51960
SMRⁱ	P51960
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	30 – 81	HTH myb-type 1PROSITE-ProRule annotationAdd BLAST	52
Domainⁱ	82 – 137	HTH myb-type 2PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	138 – 188	HTH myb-type 3PROSITE-ProRule annotationAdd BLAST	51

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	230 – 294	Transcriptional activation domainBy similarityAdd BLAST		65
Regionⁱ	297 – 552	Negative regulatory domainBy similarityAdd BLAST		256

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
HOGENOMⁱ	HOG000231021
HOVERGENⁱ	HBG007964
InParanoidⁱ	P51960
KEGG Orthology (KO) More...KOⁱ	K09421
PhylomeDBⁱ	P51960
TreeFamⁱ	TF326257

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR012642 Tscrpt_reg_Wos2-domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF07988 LMSTEN, 1 hit PF00249 Myb_DNA-binding, 3 hits
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: P51960-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV 
        60         70         80         90        100
EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE 
       110        120        130        140        150
LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII 
       160        170        180        190        200
YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS 
       210        220        230        240        250
ERSSSKLQHK PCATMDHLQT QNQFYIPVQI PGYQYVSPDG NCVEHVQTSA 
       260        270        280        290        300
FIQQPFVDED PDKEKKIKEL ELLLMSAENE VRRKRLPPQP GSFSSWSGSF 
       310        320        330        340        350
LMDDSMSNTL NNLEEHTTEF YSMDENQTVS AQQNSPTKFL AVEANAVLSS 
       360        370        380        390        400
LQTIPEFPRT LELIESDPVA WSDVTSFDLS DAAASPVKST PVKLMRIQHN 
       410        420        430        440        450
EGAMECQFNV SLVLEGKKNS RNGGDSEAIP LTSPNVVKFS TPPTISRKKK 
       460        470        480        490        500
RIRVGQSAGS ELGSASLSEV GNRRIKHTPV KTLPFSPSQF FNTCPGNEQL 
       510        520        530        540        550
NIENPSFTST PICGQKVLIT TPLQKEATPK DQKENVGFRT PTIRRSILGT 
       560        570        580        590        600
TPRTPTPFKN ALAAQEKKYG PLKIVSQPLA FLEEDIREVL KEETGTDIFL 
       610        620        630        640        650
KEEDEPAYKS CKQEHSASVK KVRKSLALES WDKEEPGTQL LTEDISDMQS 
       660        670        680        690        700
ENILTTSLLM IPLLEIHDNR CNLTPEKQDI NSANKTYTLN KKRPNPNPCK 
       710        720        730        740        750
AVKLEKSLQS NCEWETVVYG KTEDQLIMTE QARRYLSTYT ATSSTSRALI 

L

Length:751

Mass (Da):85,728

Last modified:November 1, 1997 - v2

Checksum:ⁱ20A4124BE9B82235

Isoform Short (identifier: P51960-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
649-708: Missing.

« Hide

        10         20         30         40         50
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV 
        60         70         80         90        100
EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE 
       110        120        130        140        150
LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII 
       160        170        180        190        200
YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS 
       210        220        230        240        250
ERSSSKLQHK PCATMDHLQT QNQFYIPVQI PGYQYVSPDG NCVEHVQTSA 
       260        270        280        290        300
FIQQPFVDED PDKEKKIKEL ELLLMSAENE VRRKRLPPQP GSFSSWSGSF 
       310        320        330        340        350
LMDDSMSNTL NNLEEHTTEF YSMDENQTVS AQQNSPTKFL AVEANAVLSS 
       360        370        380        390        400
LQTIPEFPRT LELIESDPVA WSDVTSFDLS DAAASPVKST PVKLMRIQHN 
       410        420        430        440        450
EGAMECQFNV SLVLEGKKNS RNGGDSEAIP LTSPNVVKFS TPPTISRKKK 
       460        470        480        490        500
RIRVGQSAGS ELGSASLSEV GNRRIKHTPV KTLPFSPSQF FNTCPGNEQL 
       510        520        530        540        550
NIENPSFTST PICGQKVLIT TPLQKEATPK DQKENVGFRT PTIRRSILGT 
       560        570        580        590        600
TPRTPTPFKN ALAAQEKKYG PLKIVSQPLA FLEEDIREVL KEETGTDIFL 
       610        620        630        640        650
KEEDEPAYKS CKQEHSASVK KVRKSLALES WDKEEPGTQL LTEDISDMQS 
       660        670        680        690 
NCEWETVVYG KTEDQLIMTE QARRYLSTYT ATSSTSRALI L

Show »

Length:691

Mass (Da):78,913

Checksum:ⁱ943A75EA1702B88B

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9QLX9	E9QLX9_MOUSE	Myb-related protein A Myb-related protein A	Mybl1	691	Annotation score:
A0A0R4J132	A0A0R4J132_MOUSE	Myb-related protein A Myb-related protein A	Mybl1	751	Annotation score:
A0A087WPK9	A0A087WPK9_MOUSE	Myb-related protein A Myb-related protein A	Mybl1	267	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	358 – 359	PR → AE in AAA62182 (PubMed:8084617).Curated	2
Sequence conflictⁱ	446	S → L in AAA62182 (PubMed:8084617).Curated	1
Sequence conflictⁱ	464 – 465	SA → DG in AAA62182 (PubMed:8084617).Curated	2
Sequence conflictⁱ	473 – 475	RRI → AAL in AAA62182 (PubMed:8084617).Curated	3
Sequence conflictⁱ	751	L → LYCY in CAA57771 (PubMed:7813437).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	48	K → R.	1
Natural variantⁱ	404	M → V.	1
Natural variantⁱ	447	R → G.	1
Natural variantⁱ	708	L → P.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003300	649 – 708	Missing in isoform Short. 1 PublicationAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82327 mRNA Translation: CAA57771.1 L35261 mRNA Translation: AAA62182.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35510.1 [P51960-1] CCDS69861.1 [P51960-2]
PIRⁱ	I49497
NCBI Reference Sequences More...RefSeqⁱ	NP_032677.2, NM_008651.3
UniGeneⁱ	Mm.459569 Mm.479

Genome annotation databases

GeneIDⁱ	17864
KEGGⁱ	mmu:17864

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P51960	Myb-related protein A		HUMAN		752	UniRef90_P51960
Myb-related protein A		MYOBR		854
A-myb protein (Fragment)		MOUSE		128
Myb-related protein A		PTEAL		774
Uncharacterized protein		MACFA		755
+182
P51960-2	myb-related protein A isoform X2		MESAU		691	UniRef90_P51960-2
Myb-related protein A		MOUSE		691
myb-related protein A isoform X3		DIPOR		690
myb-related protein A isoform X2		ERIEU		690
Uncharacterized protein		CAVPO		689
+35

Protein	Similar proteins		Species	Score	Length	Source
P51960	Myb-related protein A		HUMAN		752	UniRef50_P51960
Myb-related protein A		CHICK		757
Myb-related protein A		MYOBR		854
A-myb protein (Fragment)		MOUSE		128
Myb-related protein A		PTEAL		774
+501
P51960-2	Myb-related protein A		MOUSE		691	UniRef50_P51960-2
myb-related protein A isoform X2		MESAU		691
myb-related protein A isoform X2		ERIEU		690
myb-related protein A isoform X3		DIPOR		690
Uncharacterized protein		PROCO		689
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82327 mRNA Translation: CAA57771.1 L35261 mRNA Translation: AAA62182.1
CCDSⁱ	CCDS35510.1 [P51960-1] CCDS69861.1 [P51960-2]
PIRⁱ	I49497
RefSeqⁱ	NP_032677.2, NM_008651.3
UniGeneⁱ	Mm.459569 Mm.479

3D structure databases

ProteinModelPortalⁱ	P51960
SMRⁱ	P51960
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000086034

STRINGⁱ

10090.ENSMUSP00000086034

PTM databases

iPTMnetⁱ	P51960
PhosphoSitePlusⁱ	P51960

Proteomic databases

PaxDbⁱ	P51960
PRIDEⁱ	P51960

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	17864
KEGGⁱ	mmu:17864

Organism-specific databases

CTDⁱ	4603
MGIⁱ	MGI:99925 Mybl1

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
HOGENOMⁱ	HOG000231021
HOVERGENⁱ	HBG007964
InParanoidⁱ	P51960
KOⁱ	K09421
PhylomeDBⁱ	P51960
TreeFamⁱ	TF326257

Miscellaneous databases

ChiTaRSⁱ	Mybl1 mouse
Protein Ontology More...PROⁱ	PR:P51960
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_MYBL1

CleanExⁱ

MM_MYBL1

Family and domain databases

CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR012642 Tscrpt_reg_Wos2-domain
Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF07988 LMSTEN, 1 hit PF00249 Myb_DNA-binding, 3 hits
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYBA_MOUSE
Accessionⁱ	P51960Primary (citable) accession number: P51960
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 1, 1997
	Last modified:	October 10, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51960 (MYBA_MOUSE)

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Myb-related protein A

Mybl1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ