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Protein

Cyclin-G1

Gene

CCNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).By similarity

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-6804757 Regulation of TP53 Degradation
SignaLinkiP51959

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:CCNG1
Synonyms:CCNG, CYCG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113328.18
HGNCiHGNC:1592 CCNG1
MIMi601578 gene
neXtProtiNX_P51959

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi900
OpenTargetsiENSG00000113328
PharmGKBiPA26157

Polymorphism and mutation databases

BioMutaiCCNG1
DMDMi2506334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804651 – 295Cyclin-G1Add BLAST295

Proteomic databases

EPDiP51959
PaxDbiP51959
PeptideAtlasiP51959
PRIDEiP51959
ProteomicsDBi56462

PTM databases

iPTMnetiP51959
PhosphoSitePlusiP51959

Expressioni

Tissue specificityi

High levels in skeletal muscle, ovary, kidney and colon.

Developmental stagei

Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.

Inductioni

Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

Gene expression databases

BgeeiENSG00000113328
CleanExiHS_CCNG1
ExpressionAtlasiP51959 baseline and differential
GenevisibleiP51959 HS

Organism-specific databases

HPAiCAB000350

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107340, 41 interactors
ELMiP51959
IntActiP51959, 20 interactors
MINTiP51959
STRINGi9606.ENSP00000344635

Structurei

3D structure databases

ProteinModelPortaliP51959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000059559
HOVERGENiHBG050839
InParanoidiP51959
KOiK10145
OMAiSDMMRME
OrthoDBiEOG091G0HQN
PhylomeDBiP51959
TreeFamiTF101007

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028860 CCNG1
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF59 PTHR10177:SF59, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51959-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR
60 70 80 90 100
LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS
110 120 130 140 150
CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK
160 170 180 190 200
ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP
210 220 230 240 250
SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT
260 270 280 290
EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP
Length:295
Mass (Da):34,074
Last modified:November 1, 1997 - v2
Checksum:iEA0B02C83F3B6BF3
GO
Isoform 2 (identifier: P51959-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,769
Checksum:i9FE30F82BC8EF510
GO

Sequence cautioni

The sequence AAB03903 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA54821 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128R → M in AAB03903 (PubMed:10196184).Curated1
Sequence conflicti256K → E in AAH07093 (PubMed:15489334).Curated1
Sequence conflicti275 – 295RQLKH…PEMVP → LKWSLNWIITAPKNFSEAFL HNLVLWIP in AAB03903 (PubMed:10196184).CuratedAdd BLAST21

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021079178N → H1 PublicationCorresponds to variant dbSNP:rs2069352Ensembl.1
Natural variantiVAR_021080179F → L1 PublicationCorresponds to variant dbSNP:rs11541970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569431 – 134Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49504 mRNA Translation: AAC41977.1
U47413 mRNA Translation: AAC50688.1
D86077 Genomic DNA Translation: BAA13007.1
D78341 mRNA Translation: BAA11353.1
U53328 mRNA Translation: AAB03903.1 Different initiation.
AK297190 mRNA Translation: BAG59679.1
AK312913 mRNA Translation: BAG35759.1
AK316234 mRNA Translation: BAH14605.1
BT007134 mRNA Translation: AAP35798.1
AY791292 Genomic DNA Translation: AAV40836.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61528.1
CH471062 Genomic DNA Translation: EAW61529.1
CH471062 Genomic DNA Translation: EAW61530.1
BC000196 mRNA Translation: AAH00196.1
BC007093 mRNA Translation: AAH07093.1
X77794 mRNA Translation: CAA54821.1 Different initiation.
CCDSiCCDS4360.1 [P51959-1]
PIRiG02401
RefSeqiNP_004051.1, NM_004060.3 [P51959-1]
NP_954854.1, NM_199246.1 [P51959-1]
UniGeneiHs.79101

Genome annotation databases

EnsembliENST00000340828; ENSP00000344635; ENSG00000113328 [P51959-1]
ENST00000393929; ENSP00000377506; ENSG00000113328 [P51959-1]
ENST00000512163; ENSP00000424315; ENSG00000113328 [P51959-2]
GeneIDi900
KEGGihsa:900
UCSCiuc003lzb.4 human [P51959-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCNG1_HUMAN
AccessioniPrimary (citable) accession number: P51959
Secondary accession number(s): B2R7B2
, B4DLW7, D3DQK7, Q15757, Q96L32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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