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Protein

Cyclin-H

Gene

CCNH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-72086 mRNA Capping
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73863 RNA Polymerase I Transcription Termination
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP51946
SIGNORiP51946

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Alternative name(s):
MO15-associated protein
p34
p37
Gene namesi
Name:CCNH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134480.13
HGNCiHGNC:1594 CCNH
MIMi601953 gene
neXtProtiNX_P51946

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5S → A: No effect on the transcriptional activity of the reconstituted TFIIH complex. 1 Publication1
Mutagenesisi304S → A: No effect on the transcriptional activity of the reconstituted TFIIH complex. 1 Publication1

Organism-specific databases

DisGeNETi902
OpenTargetsiENSG00000134480
PharmGKBiPA26159

Chemistry databases

ChEMBLiCHEMBL3038473

Polymorphism and mutation databases

BioMutaiCCNH
DMDMi1706232

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804711 – 323Cyclin-HAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine; by CDK81 Publication1
Modified residuei132PhosphoserineCombined sources1
Modified residuei304Phosphoserine; by CDK81 Publication1
Modified residuei315PhosphothreonineCombined sources1
Modified residuei322PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51946
MaxQBiP51946
PaxDbiP51946
PeptideAtlasiP51946
PRIDEiP51946
ProteomicsDBi56451

PTM databases

iPTMnetiP51946
PhosphoSitePlusiP51946

Expressioni

Gene expression databases

BgeeiENSG00000134480 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_CCNH
ExpressionAtlasiP51946 baseline and differential
GenevisibleiP51946 HS

Organism-specific databases

HPAiCAB019416
HPA044138

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi107342, 57 interactors
ComplexPortaliCPX-578 Cyclin-dependent protein kinase-activating kinase complex
CORUMiP51946
DIPiDIP-5996N
IntActiP51946, 41 interactors
MINTiP51946
STRINGi9606.ENSP00000256897

Chemistry databases

BindingDBiP51946

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00307
ProteinModelPortaliP51946
SMRiP51946
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51946

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi310 – 313Poly-Glu4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG2496 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00390000008634
HOGENOMiHOG000232149
HOVERGENiHBG050840
InParanoidiP51946
KOiK06634
OMAiNYYLTIH
OrthoDBiEOG091G0CEG
PhylomeDBiP51946
TreeFamiTF101008

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P51946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP
60 70 80 90 100
HEEMTLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH
110 120 130 140 150
PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKAL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI LENPEILRKT ADDFLNRIAL
210 220 230 240 250
TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTCLSQLLD
260 270 280 290 300
IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD
310 320
DYVSKKSKHE EEEWTDDDLV ESL
Length:323
Mass (Da):37,643
Last modified:October 1, 1996 - v1
Checksum:iBB48D55DA397A0E4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHI7D6RHI7_HUMAN
Cyclin-H
CCNH
249Annotation score:
D6RG18D6RG18_HUMAN
Cyclin-H
CCNH
255Annotation score:
A0A2R8YEM2A0A2R8YEM2_HUMAN
Cyclin-H
CCNH
325Annotation score:
A0A2R8Y4K6A0A2R8Y4K6_HUMAN
Cyclin-H
CCNH
54Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01306728R → L1 PublicationCorresponds to variant dbSNP:rs2234942Ensembl.1
Natural variantiVAR_01306854M → V1 PublicationCorresponds to variant dbSNP:rs3093785Ensembl.1
Natural variantiVAR_013069138K → R1 PublicationCorresponds to variant dbSNP:rs2266691Ensembl.1
Natural variantiVAR_013070270V → A3 PublicationsCorresponds to variant dbSNP:rs2230641Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11791 mRNA Translation: AAA21361.1
U12685 mRNA Translation: AAA57006.1
CR407658 mRNA Translation: CAG28586.1
AF477979 Genomic DNA Translation: AAL74271.1
BC005280 mRNA Translation: AAH05280.1
BC016705 mRNA Translation: AAH16705.1
BC016823 mRNA Translation: AAH16823.1
BC022351 mRNA Translation: AAH22351.1
CCDSiCCDS4064.1
PIRiI38731
RefSeqiNP_001230.1, NM_001239.3
UniGeneiHs.292524

Genome annotation databases

EnsembliENST00000256897; ENSP00000256897; ENSG00000134480
GeneIDi902
KEGGihsa:902
UCSCiuc003kjb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11791 mRNA Translation: AAA21361.1
U12685 mRNA Translation: AAA57006.1
CR407658 mRNA Translation: CAG28586.1
AF477979 Genomic DNA Translation: AAL74271.1
BC005280 mRNA Translation: AAH05280.1
BC016705 mRNA Translation: AAH16705.1
BC016823 mRNA Translation: AAH16823.1
BC022351 mRNA Translation: AAH22351.1
CCDSiCCDS4064.1
PIRiI38731
RefSeqiNP_001230.1, NM_001239.3
UniGeneiHs.292524

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JKWX-ray2.60A1-323[»]
1KXUX-ray2.60A1-323[»]
DisProtiDP00307
ProteinModelPortaliP51946
SMRiP51946
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107342, 57 interactors
ComplexPortaliCPX-578 Cyclin-dependent protein kinase-activating kinase complex
CORUMiP51946
DIPiDIP-5996N
IntActiP51946, 41 interactors
MINTiP51946
STRINGi9606.ENSP00000256897

Chemistry databases

BindingDBiP51946
ChEMBLiCHEMBL3038473

PTM databases

iPTMnetiP51946
PhosphoSitePlusiP51946

Polymorphism and mutation databases

BioMutaiCCNH
DMDMi1706232

Proteomic databases

EPDiP51946
MaxQBiP51946
PaxDbiP51946
PeptideAtlasiP51946
PRIDEiP51946
ProteomicsDBi56451

Protocols and materials databases

DNASUi902
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256897; ENSP00000256897; ENSG00000134480
GeneIDi902
KEGGihsa:902
UCSCiuc003kjb.4 human

Organism-specific databases

CTDi902
DisGeNETi902
EuPathDBiHostDB:ENSG00000134480.13
GeneCardsiCCNH
HGNCiHGNC:1594 CCNH
HPAiCAB019416
HPA044138
MIMi601953 gene
neXtProtiNX_P51946
OpenTargetsiENSG00000134480
PharmGKBiPA26159
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2496 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00390000008634
HOGENOMiHOG000232149
HOVERGENiHBG050840
InParanoidiP51946
KOiK06634
OMAiNYYLTIH
OrthoDBiEOG091G0CEG
PhylomeDBiP51946
TreeFamiTF101008

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-72086 mRNA Capping
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73863 RNA Polymerase I Transcription Termination
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP51946
SIGNORiP51946

Miscellaneous databases

ChiTaRSiCCNH human
EvolutionaryTraceiP51946
GeneWikiiCyclin_H
GenomeRNAii902
PROiPR:P51946
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134480 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_CCNH
ExpressionAtlasiP51946 baseline and differential
GenevisibleiP51946 HS

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNH_HUMAN
AccessioniPrimary (citable) accession number: P51946
Secondary accession number(s): Q53X72, Q8TBL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 194 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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