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Protein

Cyclin-G1

Gene

Ccng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.2 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-6804757 Regulation of TP53 Degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G1
Short name:
Cyclin-G
Gene namesi
Name:Ccng1
Synonyms:Ccng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:102890 Ccng1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804661 – 294Cyclin-G1Add BLAST294

Proteomic databases

PaxDbiP51945
PeptideAtlasiP51945
PRIDEiP51945

PTM databases

iPTMnetiP51945
PhosphoSitePlusiP51945

Expressioni

Tissue specificityi

Highest levels in kidney, heart and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000020326 Expressed in 290 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CCNG1
ExpressionAtlasiP51945 baseline and differential
GenevisibleiP51945 MM

Interactioni

Subunit structurei

Binds to B' regulatory B subunits of protein phosphatase A (PP2A) following induction by p53 (in vitro).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198555, 5 interactors
DIPiDIP-24179N
STRINGi10090.ENSMUSP00000020576

Structurei

3D structure databases

ProteinModelPortaliP51945
SMRiP51945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000059559
HOVERGENiHBG050839
InParanoidiP51945
KOiK10145
OMAiSDMMRME
OrthoDBiEOG091G0HQN
PhylomeDBiP51945
TreeFamiTF101007

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028860 CCNG1
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF59 PTHR10177:SF59, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequencei

Sequence statusi: Complete.

P51945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL
60 70 80 90 100
RDFEVKDLLS LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC
110 120 130 140 150
FYLAVKATEE ERNVPLATDL IRISQYRFTV SDLMRMEKIV LEKVCWKVKA
160 170 180 190 200
TTAFQFLQLY YSLVHDTLPF ERRNDLNFER LEAQLKACHC RIIFSKAKPS
210 220 230 240 250
VLALSILALE IQALKYVELT EGVECIQKHS KISGRDLTFW QELVSKCLTE
260 270 280 290
YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETIC
Length:294
Mass (Da):33,903
Last modified:November 1, 1997 - v2
Checksum:i09640ADF4E739BAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175D → G in BAA24492 (PubMed:9441755).Curated1
Sequence conflicti192 – 198IIFSKAK → SYFLRQ in BAA24492 (PubMed:9441755).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49507 mRNA Translation: AAC42082.1
Z37110 mRNA Translation: CAA85474.1
AB005559 Genomic DNA Translation: BAA24492.1
CCDSiCCDS24550.1
PIRiS51621
RefSeqiNP_033961.1, NM_009831.2
UniGeneiMm.2103

Genome annotation databases

EnsembliENSMUST00000020576; ENSMUSP00000020576; ENSMUSG00000020326
GeneIDi12450
KEGGimmu:12450
UCSCiuc007ilz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49507 mRNA Translation: AAC42082.1
Z37110 mRNA Translation: CAA85474.1
AB005559 Genomic DNA Translation: BAA24492.1
CCDSiCCDS24550.1
PIRiS51621
RefSeqiNP_033961.1, NM_009831.2
UniGeneiMm.2103

3D structure databases

ProteinModelPortaliP51945
SMRiP51945
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198555, 5 interactors
DIPiDIP-24179N
STRINGi10090.ENSMUSP00000020576

PTM databases

iPTMnetiP51945
PhosphoSitePlusiP51945

Proteomic databases

PaxDbiP51945
PeptideAtlasiP51945
PRIDEiP51945

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020576; ENSMUSP00000020576; ENSMUSG00000020326
GeneIDi12450
KEGGimmu:12450
UCSCiuc007ilz.1 mouse

Organism-specific databases

CTDi900
MGIiMGI:102890 Ccng1

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000059559
HOVERGENiHBG050839
InParanoidiP51945
KOiK10145
OMAiSDMMRME
OrthoDBiEOG091G0HQN
PhylomeDBiP51945
TreeFamiTF101007

Enzyme and pathway databases

ReactomeiR-MMU-6804757 Regulation of TP53 Degradation

Miscellaneous databases

PROiPR:P51945
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020326 Expressed in 290 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CCNG1
ExpressionAtlasiP51945 baseline and differential
GenevisibleiP51945 MM

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028860 CCNG1
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF59 PTHR10177:SF59, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNG1_MOUSE
AccessioniPrimary (citable) accession number: P51945
Secondary accession number(s): O54779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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