Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cartilage matrix protein

Gene

Matn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.

GO - Molecular functioni

GO - Biological processi

  • chondrocyte differentiation Source: MGI
  • growth plate cartilage chondrocyte morphogenesis Source: MGI
  • regulation of bone mineralization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage matrix protein
Alternative name(s):
Matrilin-1
Gene namesi
Name:Matn1
Synonyms:Cmp, Crtm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:106591 Matn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000749630 – 500Cartilage matrix proteinAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 225Sequence analysis
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi231 ↔ 242By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 266By similarity
Disulfide bondi269 ↔ 456Sequence analysis
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP51942
PaxDbiP51942
PRIDEiP51942

PTM databases

PhosphoSitePlusiP51942

Expressioni

Gene expression databases

BgeeiENSMUSG00000040533 Expressed in 82 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MATN1
GenevisibleiP51942 MM

Interactioni

Subunit structurei

Homotrimer. Interacts with COMP (By similarity).By similarity

Protein-protein interaction databases

BioGridi201320, 1 interactor
IntActiP51942, 1 interactor
MINTiP51942
STRINGi10090.ENSMUSP00000099636

Structurei

3D structure databases

ProteinModelPortaliP51942
SMRiP51942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 226VWFA 1PROSITE-ProRule annotationAdd BLAST197
Domaini227 – 267EGF-likeAdd BLAST41
Domaini268 – 457VWFA 2PROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili471 – 499Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9M Eukaryota
ENOG410XSCQ LUCA
GeneTreeiENSGT00930000150889
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiP51942
OMAiNTWVFAA
OrthoDBiEOG091G04O4
TreeFamiTF330078

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR030751 Matrilin-1
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44857 PTHR44857, 1 hit
PfamiView protein in Pfam
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50234 VWFA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVTSGPAFA LCSLLLLLLL LLQVPDSLSL VPQPRGHLCR TRPTDLVFVV
60 70 80 90 100
DSSRSVRPVE FEKVKVFLSQ VIESLDVGPN ATRVGLVNYA STVKPEFPLR
110 120 130 140 150
AHGSKASLLQ AVRRIQPLST GTMTGLALQF AITKALSDAE GGRARSPDIS
160 170 180 190 200
KVVIVVTDGR PQDSVRDVSE RARASGIELF AIGVGRVDKA TLRQIASEPQ
210 220 230 240 250
DEHVDYVESY NVIEKLAKKF QEAFCVVSDL CATGDHDCEQ LCVSSPGSYT
260 270 280 290 300
CACHEGFTLN SDGKTCNVCR GGGSGSATDL VFLIDGSKSV RPENFELVKK
310 320 330 340 350
FINQIVDTLD VSDRLAQVGL VQYSSSIRQE FPLGRFHTKK DIKAAVRNMS
360 370 380 390 400
YMEKGTMTGA ALKYLIDNSF TVSSGARPGA QKVGIVFTDG RSQDYINDAA
410 420 430 440 450
RKAKDLGFKM FAVGVGNAVE EELREIASEP VADHYFYTAD FKTINQIGKK
460 470 480 490 500
LQKQICVEED PCACESILKF EAKVEGLLQA LTRKLEAVSG RLAVLENRII
Length:500
Mass (Da):54,421
Last modified:July 27, 2011 - v2
Checksum:iDD034F293479A882
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → S in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti184V → L in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti338T → S in AAB06521 (PubMed:8665920).Curated1
Sequence conflicti345A → R in AAB06521 (PubMed:8665920).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35035 mRNA Translation: AAB06521.1
Y13902 Genomic DNA Translation: CAC79633.1
AL669980 Genomic DNA Translation: CAM17812.1
CU210856 Genomic DNA Translation: CAQ51562.1
BC047140 mRNA Translation: AAH47140.1
CCDSiCCDS18713.1
PIRiS66522
RefSeqiNP_034899.2, NM_010769.2
UniGeneiMm.271796

Genome annotation databases

EnsembliENSMUST00000102576; ENSMUSP00000099636; ENSMUSG00000040533
GeneIDi17180
KEGGimmu:17180
UCSCiuc008uzx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35035 mRNA Translation: AAB06521.1
Y13902 Genomic DNA Translation: CAC79633.1
AL669980 Genomic DNA Translation: CAM17812.1
CU210856 Genomic DNA Translation: CAQ51562.1
BC047140 mRNA Translation: AAH47140.1
CCDSiCCDS18713.1
PIRiS66522
RefSeqiNP_034899.2, NM_010769.2
UniGeneiMm.271796

3D structure databases

ProteinModelPortaliP51942
SMRiP51942
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201320, 1 interactor
IntActiP51942, 1 interactor
MINTiP51942
STRINGi10090.ENSMUSP00000099636

PTM databases

PhosphoSitePlusiP51942

Proteomic databases

MaxQBiP51942
PaxDbiP51942
PRIDEiP51942

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102576; ENSMUSP00000099636; ENSMUSG00000040533
GeneIDi17180
KEGGimmu:17180
UCSCiuc008uzx.2 mouse

Organism-specific databases

CTDi4146
MGIiMGI:106591 Matn1

Phylogenomic databases

eggNOGiENOG410KD9M Eukaryota
ENOG410XSCQ LUCA
GeneTreeiENSGT00930000150889
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiP51942
OMAiNTWVFAA
OrthoDBiEOG091G04O4
TreeFamiTF330078

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans

Miscellaneous databases

PROiPR:P51942
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040533 Expressed in 82 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MATN1
GenevisibleiP51942 MM

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR030751 Matrilin-1
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44857 PTHR44857, 1 hit
PfamiView protein in Pfam
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50234 VWFA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMATN1_MOUSE
AccessioniPrimary (citable) accession number: P51942
Secondary accession number(s): Q80VN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again