We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P51908 (ABEC1_MOUSE)
Protein
C->U-editing enzyme APOBEC-1
Gene
Apobec1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
1 PublicationCatalytic activityi
- EC:3.5.4.36By similarity
Cofactori
Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 61 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 63 | Proton donorBy similarity | 1 | |
Metal bindingi | 93 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 96 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- cytidine deaminase activity Source: MGI
- cytosine deaminase activity Source: MGI
- enzyme activator activity Source: MGI
- mRNA 3'-UTR AU-rich region binding Source: MGI
- mRNA binding Source: MGI
- protein domain specific binding Source: MGI
- ribonucleoprotein complex binding Source: MGI
- RNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- cytidine to uridine editing Source: MGI
- defense response to virus Source: MGI
- DNA cytosine deamination Source: MGI
- DNA demethylation Source: UniProtKB
- lipoprotein biosynthetic process Source: MGI
- lipoprotein metabolic process Source: MGI
- lipoprotein transport Source: MGI
- mRNA modification Source: MGI
- mRNA processing Source: UniProtKB-KW
- mRNA stabilization Source: MGI
- negative regulation of DNA methylation-dependent heterochromatin assembly Source: UniProtKB
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: MGI
- negative regulation of triglyceride metabolic process Source: MGI
- positive regulation of DNA demethylation Source: ComplexPortal
- positive regulation of mRNA modification Source: MGI
- regulation of cell population proliferation Source: MGI
- response to calcium ion Source: MGI
- response to ethanol Source: MGI
- response to gamma radiation Source: MGI
- response to osmotic stress Source: MGI
- response to xenobiotic stimulus Source: MGI
- triglyceride metabolic process Source: MGI
Keywordsi
Molecular function | Hydrolase |
Biological process | mRNA processing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.5.4.1, 3474 3.5.4.36, 3474 |
Reactomei | R-MMU-72200, mRNA Editing: C to U Conversion R-MMU-75094, Formation of the Editosome |
Names & Taxonomyi
Protein namesi | Recommended name: C->U-editing enzyme APOBEC-1 (EC:3.5.4.36)Alternative name(s): Apolipoprotein B mRNA-editing enzyme 1 mRNA(cytosine(6666)) deaminase 1 |
Gene namesi | Name:Apobec1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103298, Apobec1 |
VEuPathDBi | HostDB:ENSMUSG00000040613 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- mRNA editing complex Source: ComplexPortal
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171745 | 1 – 229 | C->U-editing enzyme APOBEC-1Add BLAST | 229 |
Proteomic databases
PaxDbi | P51908 |
PeptideAtlasi | P51908 |
PRIDEi | P51908 |
ProteomicsDBi | 285746 |
PTM databases
iPTMneti | P51908 |
PhosphoSitePlusi | P51908 |
Expressioni
Tissue specificityi
Expressed in the spleen. Expressed at lower level in the kidney, testis, lung, brain and liver.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040613, Expressed in bone marrow macrophage and 198 other tissues |
ExpressionAtlasi | P51908, baseline and differential |
Genevisiblei | P51908, MM |
Interactioni
Subunit structurei
Homodimer. Part of the apolipoprotein B mRNA editing complex with APC.
Interacts with HNRPAB and SYNCRIP.
By similarityGO - Molecular functioni
- protein domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198158, 2 interactors |
ComplexPortali | CPX-1098, C-to-U editosome complex |
STRINGi | 10090.ENSMUSP00000108205 |
Miscellaneous databases
RNActi | P51908, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 134 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 125 |
Sequence similaritiesi
Belongs to the cytidine and deoxycytidylate deaminase family.Curated
Phylogenomic databases
eggNOGi | ENOG502SNW2, Eukaryota |
GeneTreei | ENSGT00940000161190 |
HOGENOMi | CLU_080056_3_0_1 |
InParanoidi | P51908 |
OMAi | MKLYALE |
OrthoDBi | 1246623at2759 |
PhylomeDBi | P51908 |
TreeFami | TF331356 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR041547, APOBEC1 IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF18774, APOBEC4_like, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P51908-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSETGPVAV DPTLRRRIEP HEFEVFFDPR ELRKETCLLY EINWGGRHSV
60 70 80 90 100
WRHTSQNTSN HVEVNFLEKF TTERYFRPNT RCSITWFLSW SPCGECSRAI
110 120 130 140 150
TEFLSRHPYV TLFIYIARLY HHTDQRNRQG LRDLISSGVT IQIMTEQEYC
160 170 180 190 200
YCWRNFVNYP PSNEAYWPRY PHLWVKLYVL ELYCIILGLP PCLKILRRKQ
210 220
PQLTFFTITL QTCHYQRIPP HLLWATGLK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SVL6 | A0A0N4SVL6_MOUSE | C->U-editing enzyme APOBEC-1 | Apobec1 | 113 | Annotation score: | ||
A0A0N4SW85 | A0A0N4SW85_MOUSE | C->U-editing enzyme APOBEC-1 | Apobec1 | 121 | Annotation score: | ||
A0A0N4SV86 | A0A0N4SV86_MOUSE | C->U-editing enzyme APOBEC-1 | Apobec1 | 43 | Annotation score: | ||
D3Z675 | D3Z675_MOUSE | C->U-editing enzyme APOBEC-1 | Apobec1 | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | R → Q in AAH03792 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21951 , U21947, U21948, U21949, U21950 Genomic DNA Translation: AAC52211.1 U22262 mRNA Translation: AAC52212.1 U22263 mRNA Translation: AAC52213.1 U22264 mRNA Translation: AAC52214.1 BC003792 mRNA Translation: AAH03792.1 |
CCDSi | CCDS20498.1 |
PIRi | I48249 |
RefSeqi | NP_001127863.1, NM_001134391.1 NP_112436.1, NM_031159.3 XP_006505464.1, XM_006505401.2 XP_011239461.1, XM_011241159.2 |
Genome annotation databases
Ensembli | ENSMUST00000112585; ENSMUSP00000108204; ENSMUSG00000040613 ENSMUST00000112586; ENSMUSP00000108205; ENSMUSG00000040613 ENSMUST00000112587; ENSMUSP00000108206; ENSMUSG00000040613 |
GeneIDi | 11810 |
KEGGi | mmu:11810 |
UCSCi | uc009dpk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21951 , U21947, U21948, U21949, U21950 Genomic DNA Translation: AAC52211.1 U22262 mRNA Translation: AAC52212.1 U22263 mRNA Translation: AAC52213.1 U22264 mRNA Translation: AAC52214.1 BC003792 mRNA Translation: AAH03792.1 |
CCDSi | CCDS20498.1 |
PIRi | I48249 |
RefSeqi | NP_001127863.1, NM_001134391.1 NP_112436.1, NM_031159.3 XP_006505464.1, XM_006505401.2 XP_011239461.1, XM_011241159.2 |
3D structure databases
AlphaFoldDBi | P51908 |
SMRi | P51908 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198158, 2 interactors |
ComplexPortali | CPX-1098, C-to-U editosome complex |
STRINGi | 10090.ENSMUSP00000108205 |
PTM databases
iPTMneti | P51908 |
PhosphoSitePlusi | P51908 |
Proteomic databases
PaxDbi | P51908 |
PeptideAtlasi | P51908 |
PRIDEi | P51908 |
ProteomicsDBi | 285746 |
Protocols and materials databases
Antibodypediai | 22955, 169 antibodies from 27 providers |
DNASUi | 11810 |
Genome annotation databases
Ensembli | ENSMUST00000112585; ENSMUSP00000108204; ENSMUSG00000040613 ENSMUST00000112586; ENSMUSP00000108205; ENSMUSG00000040613 ENSMUST00000112587; ENSMUSP00000108206; ENSMUSG00000040613 |
GeneIDi | 11810 |
KEGGi | mmu:11810 |
UCSCi | uc009dpk.1, mouse |
Organism-specific databases
CTDi | 339 |
MGIi | MGI:103298, Apobec1 |
VEuPathDBi | HostDB:ENSMUSG00000040613 |
Phylogenomic databases
eggNOGi | ENOG502SNW2, Eukaryota |
GeneTreei | ENSGT00940000161190 |
HOGENOMi | CLU_080056_3_0_1 |
InParanoidi | P51908 |
OMAi | MKLYALE |
OrthoDBi | 1246623at2759 |
PhylomeDBi | P51908 |
TreeFami | TF331356 |
Enzyme and pathway databases
BRENDAi | 3.5.4.1, 3474 3.5.4.36, 3474 |
Reactomei | R-MMU-72200, mRNA Editing: C to U Conversion R-MMU-75094, Formation of the Editosome |
Miscellaneous databases
BioGRID-ORCSi | 11810, 0 hits in 112 CRISPR screens |
ChiTaRSi | Apobec1, mouse |
PROi | PR:P51908 |
RNActi | P51908, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040613, Expressed in bone marrow macrophage and 198 other tissues |
ExpressionAtlasi | P51908, baseline and differential |
Genevisiblei | P51908, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR041547, APOBEC1 IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF18774, APOBEC4_like, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ABEC1_MOUSE | |
Accessioni | P51908Primary (citable) accession number: P51908 Secondary accession number(s): Q99L67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families