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Protein

Lumican

Gene

LUM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • extracellular matrix structural constituent Source: UniProtKB
  • extracellular matrix structural constituent conferring compression resistance Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name:
KSPG lumican
Gene namesi
Name:LUM
Synonyms:LDC, SLRR2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139329.4
HGNCiHGNC:6724 LUM
MIMi600616 gene
neXtProtiNX_P51884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4060
OpenTargetsiENSG00000139329
PharmGKBiPA30486

Polymorphism and mutation databases

BioMutaiLUM
DMDMi20141464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003273319 – 338LumicanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Modified residuei20SulfotyrosineBy similarity1
Modified residuei21SulfotyrosineBy similarity1
Modified residuei23SulfotyrosineBy similarity1
Modified residuei30SulfotyrosineBy similarity1
Glycosylationi88N-linked (GlcNAc...) (keratan sulfate) asparagine3 Publications1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) (keratan sulfate) asparagine3 Publications1
Glycosylationi252N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Disulfide bondi295 ↔ 328By similarity
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Sulfated on tyrosine residue(s).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

EPDiP51884
MaxQBiP51884
PaxDbiP51884
PeptideAtlasiP51884
PRIDEiP51884
ProteomicsDBi56448
TopDownProteomicsiP51884

PTM databases

iPTMnetiP51884
PhosphoSitePlusiP51884

Miscellaneous databases

PMAP-CutDBiP51884

Expressioni

Tissue specificityi

Cornea and other tissues.

Developmental stagei

Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

Gene expression databases

BgeeiENSG00000139329
CleanExiHS_LUM
GenevisibleiP51884 HS

Organism-specific databases

HPAiCAB025783
HPA001522

Interactioni

Subunit structurei

Binds to laminin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MMP14P502812EBI-725780,EBI-992788

Protein-protein interaction databases

BioGridi110238, 19 interactors
IntActiP51884, 11 interactors
MINTiP51884
STRINGi9606.ENSP00000266718

Structurei

3D structure databases

ProteinModelPortaliP51884
SMRiP51884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66LRRNTAdd BLAST39
Repeati67 – 88LRR 1Add BLAST22
Repeati91 – 114LRR 2Add BLAST24
Repeati117 – 137LRR 3Add BLAST21
Repeati138 – 159LRR 4Add BLAST22
Repeati160 – 181LRR 5Add BLAST22
Repeati185 – 205LRR 6Add BLAST21
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 253LRR 8Add BLAST24
Repeati255 – 276LRR 9Add BLAST22
Repeati277 – 296LRR 10Add BLAST20
Repeati305 – 326LRR 11Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 53Cys-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiP51884
KOiK08122
OMAiKKLHINY
OrthoDBiEOG091G09XE
PhylomeDBiP51884
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027219 Lumican
PANTHERiPTHR24373:SF119 PTHR24373:SF119, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSAFTLFL ALIGGTSGQY YDYDFPLSIY GQSSPNCAPE CNCPESYPSA
60 70 80 90 100
MYCDELKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN
110 120 130 140 150
LLENSKIKGR VFSKLKQLKK LHINHNNLTE SVGPLPKSLE DLQLTHNKIT
160 170 180 190 200
KLGSFEGLVN LTFIHLQHNR LKEDAVSAAF KGLKSLEYLD LSFNQIARLP
210 220 230 240 250
SGLPVSLLTL YLDNNKISNI PDEYFKRFNA LQYLRLSHNE LADSGIPGNS
260 270 280 290 300
FNVSSLVELD LSYNKLKNIP TVNENLENYY LEVNQLEKFD IKSFCKILGP
310 320 330
LSYSKIKHLR LDGNRISETS LPPDMYECLR VANEVTLN
Length:338
Mass (Da):38,429
Last modified:January 23, 2002 - v2
Checksum:i905D2EBD370CC59D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27L → P in AAA85268 (PubMed:7665616).Curated1
Sequence conflicti101L → V in AAA85268 (PubMed:7665616).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065763199L → P Found in patients with amyotrophic lateral sclerosis. 1 PublicationCorresponds to variant dbSNP:rs147975710Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18728 mRNA Translation: AAA85268.1
U21128 mRNA Translation: AAA91639.1
BT006707 mRNA Translation: AAP35353.1
AK312682 mRNA Translation: BAG35562.1
CH471054 Genomic DNA Translation: EAW97449.1
BC007038 mRNA Translation: AAH07038.1
BC035997 mRNA Translation: AAH35997.1
CCDSiCCDS9038.1
RefSeqiNP_002336.1, NM_002345.3
UniGeneiHs.406475

Genome annotation databases

EnsembliENST00000266718; ENSP00000266718; ENSG00000139329
GeneIDi4060
KEGGihsa:4060
UCSCiuc001tbm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLUM_HUMAN
AccessioniPrimary (citable) accession number: P51884
Secondary accession number(s): B2R6R5, Q96QM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: July 18, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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