UniProtKB - P51878 (CASP5_HUMAN)
Caspase-5
CASP5
Functioni
Catalytic activityi
- Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.1 Publication EC:3.4.22.58
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 267 | By similarity | 1 | |
Active sitei | 315 | 1 Publication | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: UniProtKB
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: GO_Central
- cysteine-type peptidase activity Source: ProtInc
GO - Biological processi
- apoptotic process Source: ProtInc
- cellular response to mechanical stimulus Source: UniProtKB
- execution phase of apoptosis Source: GOC
- proteolysis Source: ProtInc
- regulation of apoptotic process Source: InterPro
- regulation of inflammatory response Source: GO_Central
- substantia nigra development Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Apoptosis |
Enzyme and pathway databases
BRENDAi | 3.4.22.58, 2681 |
PathwayCommonsi | P51878 |
SABIO-RKi | P51878 |
SIGNORi | P51878 |
Protein family/group databases
MEROPSi | C14.008 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase-51 Publication (EC:3.4.22.581 Publication)Short name: CASP-51 Publication Alternative name(s): ICE(rel)-III1 Publication Protease ICH-31 Publication Protease TY1 Publication Cleaved into the following 2 chains: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137757.10 |
HGNCi | HGNC:1506, CASP5 |
MIMi | 602665, gene |
neXtProti | NX_P51878 |
Subcellular locationi
Cytosol
- NLRP1 inflammasome complex Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 315 | C → A: Abolishes protease activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 838 |
OpenTargetsi | ENSG00000137757 |
PharmGKBi | PA26089 |
Miscellaneous databases
Pharosi | P51878, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3131 |
GuidetoPHARMACOLOGYi | 1621 |
Polymorphism and mutation databases
BioMutai | CASP5 |
DMDMi | 294862523 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000004604 | 1 – 136 | Sequence analysisAdd BLAST | 136 | |
ChainiPRO_0000004605 | 137 – 327 | Caspase-5 subunit p20By similarityAdd BLAST | 191 | |
PropeptideiPRO_0000004606 | 328 – 346 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000004607 | 347 – 434 | Caspase-5 subunit p10By similarityAdd BLAST | 88 |
Post-translational modificationi
Keywords - PTMi
ZymogenProteomic databases
EPDi | P51878 |
jPOSTi | P51878 |
MassIVEi | P51878 |
MaxQBi | P51878 |
PaxDbi | P51878 |
PeptideAtlasi | P51878 |
PRIDEi | P51878 |
ProteomicsDBi | 56442 [P51878-1] 56443 [P51878-2] 56444 [P51878-3] 56445 [P51878-4] 56446 [P51878-5] 56447 [P51878-6] |
PTM databases
iPTMneti | P51878 |
PhosphoSitePlusi | P51878 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000137757, Expressed in colon and 114 other tissues |
ExpressionAtlasi | P51878, baseline and differential |
Genevisiblei | P51878, HS |
Organism-specific databases
HPAi | ENSG00000137757, Group enriched (blood, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits (By similarity).
Interacts with MEFV (PubMed:17431422).
Interacts with SERPINB1; this interaction regulates CASP5 activity (PubMed:30692621).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 107288, 5 interactors |
CORUMi | P51878 |
DIPi | DIP-40038N |
IntActi | P51878, 5 interactors |
STRINGi | 9606.ENSP00000376849 |
Chemistry databases
BindingDBi | P51878 |
Miscellaneous databases
RNActi | P51878, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 148 | CARDPROSITE-ProRule annotationAdd BLAST | 93 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000161497 |
HOGENOMi | CLU_036904_0_0_1 |
InParanoidi | P51878 |
OMAi | KHGELWV |
OrthoDBi | 1327703at2759 |
PhylomeDBi | P51878 |
TreeFami | TF102023 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP
60 70 80 90 100
NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK
110 120 130 140 150
KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE
160 170 180 190 200
AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN
210 220 230 240 250
TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA
260 270 280 290 300
RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
310 320 330 340 350
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK
360 370 380 390 400
IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF
410 420 430
RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN
The sequence of this isoform differs from the canonical sequence as follows:
5-62: Missing.
145-166: PLLQIEAGPPESAESTNILKLC → HLSNKKERGPQTPGSHHMQYKV
167-434: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JF14 | C9JF14_HUMAN | Caspase-5 | CASP5 | 165 | Annotation score: | ||
H7C0P5 | H7C0P5_HUMAN | Caspase-5 | CASP5 | 117 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047216 | 19 | K → N1 PublicationCorresponds to variant dbSNP:rs45483102Ensembl. | 1 | |
Natural variantiVAR_047217 | 26 | L → W. Corresponds to variant dbSNP:rs1792778Ensembl. | 1 | |
Natural variantiVAR_024403 | 29 | F → L2 PublicationsCorresponds to variant dbSNP:rs3181320Ensembl. | 1 | |
Natural variantiVAR_054480 | 75 | L → R1 PublicationCorresponds to variant dbSNP:rs45585331Ensembl. | 1 | |
Natural variantiVAR_047218 | 106 | T → A7 PublicationsCorresponds to variant dbSNP:rs507879Ensembl. | 1 | |
Natural variantiVAR_024404 | 168 | R → H2 PublicationsCorresponds to variant dbSNP:rs3181179Ensembl. | 1 | |
Natural variantiVAR_024405 | 217 | V → L2 PublicationsCorresponds to variant dbSNP:rs3181326Ensembl. | 1 | |
Natural variantiVAR_054481 | 298 | R → H1 PublicationCorresponds to variant dbSNP:rs45464699Ensembl. | 1 | |
Natural variantiVAR_047219 | 334 | L → V4 PublicationsCorresponds to variant dbSNP:rs523104Ensembl. | 1 | |
Natural variantiVAR_047220 | 353 | E → K1 PublicationCorresponds to variant dbSNP:rs45619739Ensembl. | 1 | |
Natural variantiVAR_054482 | 382 | E → Q1 PublicationCorresponds to variant dbSNP:rs45458695Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038990 | 1 – 145 | MAEDS…TSVKP → MAA in isoform 3. 1 PublicationAdd BLAST | 145 | |
Alternative sequenceiVSP_038991 | 1 – 70 | Missing in isoform 6. CuratedAdd BLAST | 70 | |
Alternative sequenceiVSP_038992 | 1 – 2 | MA → MAAVPRVEGVFIFLI in isoform 5. 1 Publication | 2 | |
Alternative sequenceiVSP_038993 | 5 – 62 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 58 | |
Alternative sequenceiVSP_038994 | 145 – 166 | PLLQI…ILKLC → HLSNKKERGPQTPGSHHMQY KV in isoform 4. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_038995 | 167 – 434 | Missing in isoform 4. 1 PublicationAdd BLAST | 268 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ228672 mRNA Translation: ABB58698.1 DQ228673 mRNA Translation: ABB58699.1 DQ228674 mRNA Translation: ABB58700.1 DQ228676 mRNA Translation: ABB58702.1 DQ228677 mRNA Translation: ABB58703.1 AK296660 mRNA Translation: BAG59257.1 Frameshift. AP001153 Genomic DNA No translation available. U28015 mRNA Translation: AAA75172.1 Different initiation. BC074994 mRNA Translation: AAH74994.1 Different initiation. BC113406 mRNA Translation: AAI13407.1 Different initiation. X94993 mRNA Translation: CAA64450.1 Different initiation. DQ508420 Genomic DNA Translation: ABF47103.1 Different initiation. CH471065 Genomic DNA Translation: EAW67054.1 |
CCDSi | CCDS44718.1 [P51878-3] CCDS44719.1 [P51878-2] CCDS44720.1 [P51878-5] CCDS8328.2 [P51878-1] |
PIRi | B57511 |
RefSeqi | NP_001129581.1, NM_001136109.1 [P51878-2] NP_001129582.1, NM_001136110.1 [P51878-3] NP_001129584.1, NM_001136112.1 [P51878-5] NP_004338.3, NM_004347.3 [P51878-1] |
Genome annotation databases
Ensembli | ENST00000260315; ENSP00000260315; ENSG00000137757 [P51878-1] ENST00000393141; ENSP00000376849; ENSG00000137757 [P51878-5] ENST00000418434; ENSP00000398130; ENSG00000137757 [P51878-3] ENST00000444749; ENSP00000388365; ENSG00000137757 [P51878-2] ENST00000456200; ENSP00000408455; ENSG00000137757 [P51878-4] ENST00000526056; ENSP00000436877; ENSG00000137757 [P51878-5] ENST00000531367; ENSP00000434471; ENSG00000137757 [P51878-3] |
GeneIDi | 838 |
KEGGi | hsa:838 |
UCSCi | uc010ruz.1, human [P51878-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ228672 mRNA Translation: ABB58698.1 DQ228673 mRNA Translation: ABB58699.1 DQ228674 mRNA Translation: ABB58700.1 DQ228676 mRNA Translation: ABB58702.1 DQ228677 mRNA Translation: ABB58703.1 AK296660 mRNA Translation: BAG59257.1 Frameshift. AP001153 Genomic DNA No translation available. U28015 mRNA Translation: AAA75172.1 Different initiation. BC074994 mRNA Translation: AAH74994.1 Different initiation. BC113406 mRNA Translation: AAI13407.1 Different initiation. X94993 mRNA Translation: CAA64450.1 Different initiation. DQ508420 Genomic DNA Translation: ABF47103.1 Different initiation. CH471065 Genomic DNA Translation: EAW67054.1 |
CCDSi | CCDS44718.1 [P51878-3] CCDS44719.1 [P51878-2] CCDS44720.1 [P51878-5] CCDS8328.2 [P51878-1] |
PIRi | B57511 |
RefSeqi | NP_001129581.1, NM_001136109.1 [P51878-2] NP_001129582.1, NM_001136110.1 [P51878-3] NP_001129584.1, NM_001136112.1 [P51878-5] NP_004338.3, NM_004347.3 [P51878-1] |
3D structure databases
SMRi | P51878 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107288, 5 interactors |
CORUMi | P51878 |
DIPi | DIP-40038N |
IntActi | P51878, 5 interactors |
STRINGi | 9606.ENSP00000376849 |
Chemistry databases
BindingDBi | P51878 |
ChEMBLi | CHEMBL3131 |
GuidetoPHARMACOLOGYi | 1621 |
Protein family/group databases
MEROPSi | C14.008 |
PTM databases
iPTMneti | P51878 |
PhosphoSitePlusi | P51878 |
Polymorphism and mutation databases
BioMutai | CASP5 |
DMDMi | 294862523 |
Proteomic databases
EPDi | P51878 |
jPOSTi | P51878 |
MassIVEi | P51878 |
MaxQBi | P51878 |
PaxDbi | P51878 |
PeptideAtlasi | P51878 |
PRIDEi | P51878 |
ProteomicsDBi | 56442 [P51878-1] 56443 [P51878-2] 56444 [P51878-3] 56445 [P51878-4] 56446 [P51878-5] 56447 [P51878-6] |
Protocols and materials databases
Antibodypediai | 18098, 526 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 838 |
DisGeNETi | 838 |
EuPathDBi | HostDB:ENSG00000137757.10 |
GeneCardsi | CASP5 |
HGNCi | HGNC:1506, CASP5 |
HPAi | ENSG00000137757, Group enriched (blood, intestine, lymphoid tissue) |
MIMi | 602665, gene |
neXtProti | NX_P51878 |
OpenTargetsi | ENSG00000137757 |
PharmGKBi | PA26089 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3573, Eukaryota |
GeneTreei | ENSGT00940000161497 |
HOGENOMi | CLU_036904_0_0_1 |
InParanoidi | P51878 |
OMAi | KHGELWV |
OrthoDBi | 1327703at2759 |
PhylomeDBi | P51878 |
TreeFami | TF102023 |
Enzyme and pathway databases
BRENDAi | 3.4.22.58, 2681 |
PathwayCommonsi | P51878 |
SABIO-RKi | P51878 |
SIGNORi | P51878 |
Miscellaneous databases
BioGRID-ORCSi | 838, 2 hits in 838 CRISPR screens |
ChiTaRSi | CASP5, human |
GenomeRNAii | 838 |
Pharosi | P51878, Tchem |
PROi | PR:P51878 |
RNActi | P51878, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137757, Expressed in colon and 114 other tissues |
ExpressionAtlasi | P51878, baseline and differential |
Genevisiblei | P51878, HS |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 IPR002138, Pept_C14_p10 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00114, CARD, 1 hit SM00115, CASc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50207, CASPASE_P10, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASP5_HUMAN | |
Accessioni | P51878Primary (citable) accession number: P51878 Secondary accession number(s): B4DKP5 Q6DJV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries