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Entry version 176 (08 May 2019)
Sequence version 3 (20 Apr 2010)
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Protein

Caspase-5

Gene

CASP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. EC:3.4.22.58

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei267By similarity1
Active sitei3151

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.22.58 2681

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P51878

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C14.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-5 (EC:3.4.22.58)
Short name:
CASP-5
Alternative name(s):
ICE(rel)-III
Protease ICH-3
Protease TY
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP5
Synonyms:ICH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1506 CASP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602665 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi315C → A: Abolishes protease activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
838

Open Targets

More...
OpenTargetsi
ENSG00000137757

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26089

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3131

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1621

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000046041 – 136Sequence analysisAdd BLAST136
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004605137 – 327Caspase-5 subunit p20Add BLAST191
PropeptideiPRO_0000004606328 – 346Sequence analysisAdd BLAST19
ChainiPRO_0000004607347 – 434Caspase-5 subunit p10Add BLAST88

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P51878

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P51878

MaxQB - The MaxQuant DataBase

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MaxQBi
P51878

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51878

PeptideAtlas

More...
PeptideAtlasi
P51878

PRoteomics IDEntifications database

More...
PRIDEi
P51878

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56442
56443 [P51878-2]
56444 [P51878-3]
56445 [P51878-4]
56446 [P51878-5]
56447 [P51878-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51878

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P51878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137757 Expressed in 92 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51878 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51878 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040937

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.Interacts with NOD2. Interacts with SERPINB1; this interaction regulates CASP5 activity.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107288, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P51878

Database of interacting proteins

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DIPi
DIP-40038N

Protein interaction database and analysis system

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IntActi
P51878, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376849

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P51878

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51878

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 148CARDPROSITE-ProRule annotationAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3573 Eukaryota
ENOG410ZQIE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161497

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51878

KEGG Orthology (KO)

More...
KOi
K04395

Identification of Orthologs from Complete Genome Data

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OMAi
CKENHDE

Database of Orthologous Groups

More...
OrthoDBi
1472750at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51878

TreeFam database of animal gene trees

More...
TreeFami
TF102023

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00032 CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A

The PANTHER Classification System

More...
PANTHERi
PTHR10454 PTHR10454, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00376 IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51878-1) [UniParc]FASTAAdd to basket
Also known as: caspase-5/a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP
60 70 80 90 100
NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK
110 120 130 140 150
KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE
160 170 180 190 200
AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN
210 220 230 240 250
TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA
260 270 280 290 300
RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
310 320 330 340 350
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK
360 370 380 390 400
IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF
410 420 430
RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN
Note: Most abundant isoform.
Length:434
Mass (Da):49,736
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5257C2BF15EB6D5
GO
Isoform 2 (identifier: P51878-2) [UniParc]FASTAAdd to basket
Also known as: Caspase-5/b

The sequence of this isoform differs from the canonical sequence as follows:
     5-62: Missing.

Note: Most abundant isoform.
Show »
Length:376
Mass (Da):43,261
Checksum:i7D3035A84418FE31
GO
Isoform 3 (identifier: P51878-3) [UniParc]FASTAAdd to basket
Also known as: Caspase-5/c

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: MAEDSGKKKR...MDQKITSVKP → MAA

Show »
Length:292
Mass (Da):33,304
Checksum:iFD1D1199CB76E857
GO
Isoform 4 (identifier: P51878-4) [UniParc]FASTAAdd to basket
Also known as: Caspase-5/e

The sequence of this isoform differs from the canonical sequence as follows:
     5-62: Missing.
     145-166: PLLQIEAGPPESAESTNILKLC → HLSNKKERGPQTPGSHHMQYKV
     167-434: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:108
Mass (Da):12,694
Checksum:i2A441B191C453A3C
GO
Isoform 5 (identifier: P51878-5) [UniParc]FASTAAdd to basket
Also known as: Caspase-5/f

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MAAVPRVEGVFIFLI

Show »
Length:447
Mass (Da):51,177
Checksum:i39D5955FA0419B68
GO
Isoform 6 (identifier: P51878-6) [UniParc]FASTAAdd to basket
Also known as: Caspase-5-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: Produced by alternative initiation at Met-71 of isoform 1.
Show »
Length:364
Mass (Da):41,851
Checksum:i64533BAB7E528B37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0P5H7C0P5_HUMAN
Caspase-5
CASP5
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF14C9JF14_HUMAN
Caspase-5
CASP5
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA75172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH74994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI13407 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABF47103 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG59257 differs from that shown. Reason: Frameshift at position 10.Curated
The sequence CAA64450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04721619K → N1 PublicationCorresponds to variant dbSNP:rs45483102Ensembl.1
Natural variantiVAR_04721726L → W. Corresponds to variant dbSNP:rs1792778Ensembl.1
Natural variantiVAR_02440329F → L2 PublicationsCorresponds to variant dbSNP:rs3181320Ensembl.1
Natural variantiVAR_05448075L → R1 PublicationCorresponds to variant dbSNP:rs45585331Ensembl.1
Natural variantiVAR_047218106T → A7 PublicationsCorresponds to variant dbSNP:rs507879Ensembl.1
Natural variantiVAR_024404168R → H2 PublicationsCorresponds to variant dbSNP:rs3181179Ensembl.1
Natural variantiVAR_024405217V → L2 PublicationsCorresponds to variant dbSNP:rs3181326Ensembl.1
Natural variantiVAR_054481298R → H1 PublicationCorresponds to variant dbSNP:rs45464699Ensembl.1
Natural variantiVAR_047219334L → V4 PublicationsCorresponds to variant dbSNP:rs523104Ensembl.1
Natural variantiVAR_047220353E → K1 PublicationCorresponds to variant dbSNP:rs45619739Ensembl.1
Natural variantiVAR_054482382E → Q1 PublicationCorresponds to variant dbSNP:rs45458695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389901 – 145MAEDS…TSVKP → MAA in isoform 3. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_0389911 – 70Missing in isoform 6. CuratedAdd BLAST70
Alternative sequenceiVSP_0389921 – 2MA → MAAVPRVEGVFIFLI in isoform 5. 1 Publication2
Alternative sequenceiVSP_0389935 – 62Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST58
Alternative sequenceiVSP_038994145 – 166PLLQI…ILKLC → HLSNKKERGPQTPGSHHMQY KV in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_038995167 – 434Missing in isoform 4. 1 PublicationAdd BLAST268

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ228672 mRNA Translation: ABB58698.1
DQ228673 mRNA Translation: ABB58699.1
DQ228674 mRNA Translation: ABB58700.1
DQ228676 mRNA Translation: ABB58702.1
DQ228677 mRNA Translation: ABB58703.1
AK296660 mRNA Translation: BAG59257.1 Frameshift.
AP001153 Genomic DNA No translation available.
U28015 mRNA Translation: AAA75172.1 Different initiation.
BC074994 mRNA Translation: AAH74994.1 Different initiation.
BC113406 mRNA Translation: AAI13407.1 Different initiation.
X94993 mRNA Translation: CAA64450.1 Different initiation.
DQ508420 Genomic DNA Translation: ABF47103.1 Different initiation.
CH471065 Genomic DNA Translation: EAW67054.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44718.1 [P51878-3]
CCDS44719.1 [P51878-2]
CCDS44720.1 [P51878-5]
CCDS8328.2 [P51878-1]

Protein sequence database of the Protein Information Resource

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PIRi
B57511

NCBI Reference Sequences

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RefSeqi
NP_001129581.1, NM_001136109.1 [P51878-2]
NP_001129582.1, NM_001136110.1 [P51878-3]
NP_001129584.1, NM_001136112.1 [P51878-5]
NP_004338.3, NM_004347.3 [P51878-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260315; ENSP00000260315; ENSG00000137757 [P51878-1]
ENST00000393141; ENSP00000376849; ENSG00000137757 [P51878-5]
ENST00000418434; ENSP00000398130; ENSG00000137757 [P51878-3]
ENST00000444749; ENSP00000388365; ENSG00000137757 [P51878-2]
ENST00000456200; ENSP00000408455; ENSG00000137757 [P51878-4]
ENST00000526056; ENSP00000436877; ENSG00000137757 [P51878-5]
ENST00000531367; ENSP00000434471; ENSG00000137757 [P51878-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
838

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:838

UCSC genome browser

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UCSCi
uc010ruz.1 human [P51878-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228672 mRNA Translation: ABB58698.1
DQ228673 mRNA Translation: ABB58699.1
DQ228674 mRNA Translation: ABB58700.1
DQ228676 mRNA Translation: ABB58702.1
DQ228677 mRNA Translation: ABB58703.1
AK296660 mRNA Translation: BAG59257.1 Frameshift.
AP001153 Genomic DNA No translation available.
U28015 mRNA Translation: AAA75172.1 Different initiation.
BC074994 mRNA Translation: AAH74994.1 Different initiation.
BC113406 mRNA Translation: AAI13407.1 Different initiation.
X94993 mRNA Translation: CAA64450.1 Different initiation.
DQ508420 Genomic DNA Translation: ABF47103.1 Different initiation.
CH471065 Genomic DNA Translation: EAW67054.1
CCDSiCCDS44718.1 [P51878-3]
CCDS44719.1 [P51878-2]
CCDS44720.1 [P51878-5]
CCDS8328.2 [P51878-1]
PIRiB57511
RefSeqiNP_001129581.1, NM_001136109.1 [P51878-2]
NP_001129582.1, NM_001136110.1 [P51878-3]
NP_001129584.1, NM_001136112.1 [P51878-5]
NP_004338.3, NM_004347.3 [P51878-1]

3D structure databases

SMRiP51878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107288, 4 interactors
CORUMiP51878
DIPiDIP-40038N
IntActiP51878, 2 interactors
STRINGi9606.ENSP00000376849

Chemistry databases

BindingDBiP51878
ChEMBLiCHEMBL3131
GuidetoPHARMACOLOGYi1621

Protein family/group databases

MEROPSiC14.008

PTM databases

iPTMnetiP51878
PhosphoSitePlusiP51878

Polymorphism and mutation databases

BioMutaiCASP5
DMDMi294862523

Proteomic databases

EPDiP51878
jPOSTiP51878
MaxQBiP51878
PaxDbiP51878
PeptideAtlasiP51878
PRIDEiP51878
ProteomicsDBi56442
56443 [P51878-2]
56444 [P51878-3]
56445 [P51878-4]
56446 [P51878-5]
56447 [P51878-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260315; ENSP00000260315; ENSG00000137757 [P51878-1]
ENST00000393141; ENSP00000376849; ENSG00000137757 [P51878-5]
ENST00000418434; ENSP00000398130; ENSG00000137757 [P51878-3]
ENST00000444749; ENSP00000388365; ENSG00000137757 [P51878-2]
ENST00000456200; ENSP00000408455; ENSG00000137757 [P51878-4]
ENST00000526056; ENSP00000436877; ENSG00000137757 [P51878-5]
ENST00000531367; ENSP00000434471; ENSG00000137757 [P51878-3]
GeneIDi838
KEGGihsa:838
UCSCiuc010ruz.1 human [P51878-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
838
DisGeNETi838

GeneCards: human genes, protein and diseases

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GeneCardsi
CASP5
HGNCiHGNC:1506 CASP5
HPAiHPA040937
MIMi602665 gene
neXtProtiNX_P51878
OpenTargetsiENSG00000137757
PharmGKBiPA26089

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00940000161497
InParanoidiP51878
KOiK04395
OMAiCKENHDE
OrthoDBi1472750at2759
PhylomeDBiP51878
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.58 2681
SABIO-RKiP51878

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CASP5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
838

Protein Ontology

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PROi
PR:P51878

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137757 Expressed in 92 organ(s), highest expression level in blood
ExpressionAtlasiP51878 baseline and differential
GenevisibleiP51878 HS

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51878
Secondary accession number(s): B4DKP5
, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6, Q1HBJ3, Q6DJV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: May 8, 2019
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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