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UniProtKB - P51871 (CP4F6_RAT)
Protein
Cytochrome P450 4F6
Gene
Cyp4f6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 468 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
GO - Biological processi
- inflammatory response Source: RGD
- leukotriene metabolic process Source: RGD
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp4f6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708365, Cyp4f6 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051854 | 1 – 537 | Cytochrome P450 4F6Add BLAST | 537 |
Proteomic databases
PaxDbi | P51871 |
PTM databases
PhosphoSitePlusi | P51871 |
Expressioni
Tissue specificityi
High expression in liver and kidney. Lower expression in brain.
Gene expression databases
Bgeei | ENSRNOG00000043233, Expressed in liver and 22 other tissues |
ExpressionAtlasi | P51871, baseline and differential |
Genevisiblei | P51871, RN |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000155021 |
InParanoidi | P51871 |
OMAi | KPWQSRR |
OrthoDBi | 1247045at2759 |
PhylomeDBi | P51871 |
TreeFami | TF105088 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51871-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC
60 70 80 90 100
FPQPPKPSWF WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR
110 120 130 140 150
LVHPNVIAPL LQASAAVAPK EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL
160 170 180 190 200
LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR LTAKGSARLD MFEHISLMTL
210 220 230 240 250
DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF LYLDFLYYLT
260 270 280 290 300
ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID
310 320 330 340 350
VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY
360 370 380 390 400
QERCRQEVRE LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR
410 420 430 440 450
CCSQDIVLPD GRVIPKGNIC VISIFGVHHN PSVWPDPEVY NPFRFDPENP
460 470 480 490 500
QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV ALALTLLRFC VLPDDKEPRR
510 520 530
KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6AZ67 | Q6AZ67_RAT | Cyp4f6 protein | Cyp4f6 | 347 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39208 mRNA Translation: AAC52360.1 |
PIRi | JC4534 |
RefSeqi | NP_695230.1, NM_153318.1 |
Genome annotation databases
Ensembli | ENSRNOT00000066095; ENSRNOP00000059924; ENSRNOG00000043233 |
GeneIDi | 266689 |
KEGGi | rno:266689 |
UCSCi | RGD:708365, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39208 mRNA Translation: AAC52360.1 |
PIRi | JC4534 |
RefSeqi | NP_695230.1, NM_153318.1 |
3D structure databases
SMRi | P51871 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000059924 |
Chemistry databases
ChEMBLi | CHEMBL3509599 |
PTM databases
PhosphoSitePlusi | P51871 |
Proteomic databases
PaxDbi | P51871 |
Genome annotation databases
Ensembli | ENSRNOT00000066095; ENSRNOP00000059924; ENSRNOG00000043233 |
GeneIDi | 266689 |
KEGGi | rno:266689 |
UCSCi | RGD:708365, rat |
Organism-specific databases
CTDi | 266689 |
RGDi | 708365, Cyp4f6 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000155021 |
InParanoidi | P51871 |
OMAi | KPWQSRR |
OrthoDBi | 1247045at2759 |
PhylomeDBi | P51871 |
TreeFami | TF105088 |
Miscellaneous databases
PROi | PR:P51871 |
Gene expression databases
Bgeei | ENSRNOG00000043233, Expressed in liver and 22 other tissues |
ExpressionAtlasi | P51871, baseline and differential |
Genevisiblei | P51871, RN |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP4F6_RAT | |
Accessioni | P51871Primary (citable) accession number: P51871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families