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Protein

Cytochrome P450 4F4

Gene

Cyp4f4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei328Heme (covalent; via 1 link)1 Publication1
Metal bindingi468Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: RGD
  • iron ion binding Source: InterPro

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211935 Fatty acids
R-RNO-211958 Miscellaneous substrates
R-RNO-211979 Eicosanoids
R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-RNO-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Chemistry databases

SwissLipidsiSLP:000001704

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F4 (EC:1.14.14.1)
Alternative name(s):
CYPIVF4
Gene namesi
Name:Cyp4f4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi708363 Cyp4f4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3509597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518521 – 522Cytochrome P450 4F4Add BLAST522

Proteomic databases

PaxDbiP51869
PRIDEiP51869

Expressioni

Tissue specificityi

High expression in liver and kidney. Lower expression in brain.

Gene expression databases

BgeeiENSRNOG00000032895
GenevisibleiP51869 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039545

Structurei

3D structure databases

ProteinModelPortaliP51869
SMRiP51869
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiP51869
KOiK00490
OMAiAYNHEPN
OrthoDBiEOG091G06KN

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P51869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLDLSWLG LRLETSLPWL LLLLIGASWL LVRVLTQTYI FYRTYQHLCD
60 70 80 90 100
FPQPPKWNWF LGHLGMITPT EQGLKQVTKL VATYPQGFMT WLGPILPIIT
110 120 130 140 150
LCHPDVIRSV LSASASVALK EVIFYSFLKP WLGDGLLLSD GDKWSCHRRM
160 170 180 190 200
LTPAFHFNIL KPYVKIFNDS TNIMHAKWQD LASGGSARLD MFKNISLMTL
210 220 230 240 250
DSLQKCVFSF DSNCQEKPSE YISAILELSA LVAKRYQQLL LHTDSLYQLT
260 270 280 290 300
HNGRRFHKAC KLVHNFTDAV IQGRRRALPS QHEDDILKAK ARSKTLDFID
310 320 330 340 350
VLLLTKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLARHPEY
360 370 380 390 400
QERCRQEVRE LLRDRESTEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR
410 420 430 440 450
RCTQDIVLPD GRVIPKGVIC IINIFATHHN PTVWPDPEVY DPFRFDPENI
460 470 480 490 500
KDRSPLAFIP FSAGPRNCIG QTFAMNEMKV ALALTLLRFR VLPDDKEPRR
510 520
KPELILRAEG GLWLRVEPLS TQ
Length:522
Mass (Da):60,050
Last modified:October 1, 1996 - v1
Checksum:i193EA8E7CE8864D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39206 mRNA Translation: AAC52358.1
PIRiJC4532
RefSeqiNP_775146.1, NM_173123.1
UniGeneiRn.10170

Genome annotation databases

EnsembliENSRNOT00000041034; ENSRNOP00000039545; ENSRNOG00000032895
GeneIDi286904
KEGGirno:286904
UCSCiRGD:708363 rat

Similar proteinsi

Entry informationi

Entry nameiCP4F4_RAT
AccessioniPrimary (citable) accession number: P51869
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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