Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative teratocarcinoma-derived growth factor 3

Gene

TDGF1P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway.1 Publication

Caution

Could be the product of a pseudogene. The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence.Curated

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-1181150 Signaling by NODAL
R-HSA-1433617 Regulation of signaling by NODAL

Names & Taxonomyi

Protein namesi
Recommended name:
Putative teratocarcinoma-derived growth factor 3
Alternative name(s):
Cripto-3 growth factor
Epidermal growth factor-like cripto protein CR3
Teratocarcinoma-derived growth factor 1 pseudogene 3
Gene namesi
Name:TDGF1P3
Synonyms:CRIPTO3, TDGF2, TDGF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:11703 TDGF1P3
MIMi187395 gene+phenotype
neXtProtiNX_P51864

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6998
MIMi187395 gene+phenotype

Polymorphism and mutation databases

DMDMi1706127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556271 – 188Putative teratocarcinoma-derived growth factor 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 89By similarity
Disulfide bondi83 ↔ 95By similarity
Disulfide bondi97 ↔ 106By similarity
Disulfide bondi115 ↔ 133By similarity
Disulfide bondi128 ↔ 149By similarity
Disulfide bondi131 ↔ 140By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP51864
PRIDEiP51864
ProteomicsDBi56441

Expressioni

Tissue specificityi

Expressed weakly in lung, colon and breast. Expressed also strongly in primary cancer tissues; lung and colon cancers.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP51864
SMRiP51864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 107EGF-likeAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

EGF-like domain

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
HOVERGENiHBG054705
InParanoidiP51864

Family and domain databases

InterProiView protein in InterPro
IPR017047 Cripto_growth_factor
IPR019011 Cryptic/Cripto_CFC-dom
IPR013032 EGF-like_CS
PANTHERiPTHR14949:SF26 PTHR14949:SF26, 1 hit
PfamiView protein in Pfam
PF09443 CFC, 1 hit
PIRSFiPIRSF036301 Cripto_growth_factor, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit

Sequencei

Sequence statusi: Complete.

P51864-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCRKMVRFS YSVIWIMAIS KAFELGLVAG LGHQEFARPS RGDLAFRDDS
60 70 80 90 100
IWPQEEPAIR PRSSQRVLPM GIQHSKELNR TCCLNGGTCM LESFCACPPS
110 120 130 140 150
FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD
160 170 180
GLVMDEHLVA SRTPELPPSA RTTTFMLAGI CLSIQSYY
Length:188
Mass (Da):21,181
Last modified:October 1, 1996 - v1
Checksum:iC07AC973E4D82B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96956 mRNA Translation: AAA61135.1
AF251549 Genomic DNA Translation: AAG49538.1
AF251550 Genomic DNA Translation: AAG49539.1
AC000113 Genomic DNA Translation: AAB46353.1
UniGeneiHs.592361

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96956 mRNA Translation: AAA61135.1
AF251549 Genomic DNA Translation: AAG49538.1
AF251550 Genomic DNA Translation: AAG49539.1
AC000113 Genomic DNA Translation: AAB46353.1
UniGeneiHs.592361

3D structure databases

ProteinModelPortaliP51864
SMRiP51864
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi1706127

Proteomic databases

PeptideAtlasiP51864
PRIDEiP51864
ProteomicsDBi56441

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi6998
GeneCardsiTDGF1P3
HGNCiHGNC:11703 TDGF1P3
MIMi187395 gene+phenotype
neXtProtiNX_P51864
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
HOVERGENiHBG054705
InParanoidiP51864

Enzyme and pathway databases

ReactomeiR-HSA-1181150 Signaling by NODAL
R-HSA-1433617 Regulation of signaling by NODAL

Miscellaneous databases

ChiTaRSiTDGF1P3 human
PROiPR:P51864
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR017047 Cripto_growth_factor
IPR019011 Cryptic/Cripto_CFC-dom
IPR013032 EGF-like_CS
PANTHERiPTHR14949:SF26 PTHR14949:SF26, 1 hit
PfamiView protein in Pfam
PF09443 CFC, 1 hit
PIRSFiPIRSF036301 Cripto_growth_factor, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTDGF3_HUMAN
AccessioniPrimary (citable) accession number: P51864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again