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Entry version 166 (13 Feb 2019)
Sequence version 1 (01 Oct 1996)
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Protein

RHO1 GDP-GTP exchange protein 2

Gene

ROM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32440-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RHO1 GDP-GTP exchange protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROM2
Ordered Locus Names:YLR371W
ORF Names:L8039.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YLR371W

Saccharomyces Genome Database

More...
SGDi
S000004363 ROM2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809692 – 1356RHO1 GDP-GTP exchange protein 2Add BLAST1355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51862

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51862

PRoteomics IDEntifications database

More...
PRIDEi
P51862

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51862

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31631, 800 interactors

Database of interacting proteins

More...
DIPi
DIP-4663N

Protein interaction database and analysis system

More...
IntActi
P51862, 16 interactors

Molecular INTeraction database

More...
MINTi
P51862

STRING: functional protein association networks

More...
STRINGi
4932.YLR371W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P51862

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51862

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini659 – 846DHPROSITE-ProRule annotationAdd BLAST188
Domaini1034 – 1336CNHPROSITE-ProRule annotationAdd BLAST303

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 265Poly-AsnAdd BLAST14
Compositional biasi329 – 336Poly-His8
Compositional biasi632 – 635Poly-Asp4

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000142356

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51862

KEGG Orthology (KO)

More...
KOi
K19842

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNFIEIR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180 CNH_dom
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780 CNH, 1 hit
PF00610 DEP, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036 CNH, 1 hit
SM00049 DEP, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219 CNH, 1 hit
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P51862-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETNVDSLG DRNDIYSQIF GVERRPDSFA TFDSDSHGDI SSQLLPNRIE
60 70 80 90 100
NIQNLNVLLS EDIANDIIIA KQRRRSGVEA AIDDSDIPNN EMKGKSSNYI
110 120 130 140 150
LSQQTNIKEV PDTQSLSSAD NTPVSSPKKA RDATSSHPIV HAKSMSHIYS
160 170 180 190 200
TSNSASRQAK HYNDHPLPPM SPRNEVYQKN KSTTAFVPKR KPSLPQLALA
210 220 230 240 250
GLKKQSSFST GSASTTPTQA RKSPLQGFGF FSRPSSKDLH EQHQHHQHIQ
260 270 280 290 300
HNNINNHNNN NTNNNGAHYQ VGSSNSNYPQ HSHSISSRSM SLNSSTLKNI
310 320 330 340 350
ASSFQSKTSN SRKATQKYDI TSNPFSDPHH HHHHHHSSNS HSSLNNVHGS
360 370 380 390 400
GNSSSVMGSS SNIGLGLKTR VSSTSLALKR YTSVSGTSLS SPRRSSMTPL
410 420 430 440 450
SASRPVMSAS SKKPQVYPAL LSRVATKFKS SIQLGEHKKD GLVYRDAFTG
460 470 480 490 500
QQAVDVICAI IRTSDRNLAL LFGRSLDAQK LFHDVVYEHR LRDSPHEVYE
510 520 530 540 550
FTDNSRFTGT GSTNAHDPLM LLPNSSSFNS GNHSYPNSGM VPSSSTSSLN
560 570 580 590 600
SDQATLTGSR LHMSSSLSQQ KNPAAIHNVN GVFTLLAECY SPTCTRDALC
610 620 630 640 650
YSISCPRRLE QQARLNLKPN GGLKRNISMA LDDDDEEKPS WTSSVSKEDW
660 670 680 690 700
ENLPKKEIKR QEAIYEVYIT EKNFVKSLEI TRDTFMKTLA ETNIISADIR
710 720 730 740 750
KNFIKHVFAH INDIYSVNRR FLKALTDRQR SSPVVRGIGD IVLRFIPFFE
760 770 780 790 800
PFVSYVASRP YAKYLIETQR SVNPYFARFD DDMMSSSLRH GIDSFLSQGV
810 820 830 840 850
SRPGRYMLLV KEIMKSTDPE KDKSDYEDLS KAMDALRDFM KRIDQASGAA
860 870 880 890 900
QDRHDVKLLK QKILFKNEYV NLGLNDERRK IKHEGILSRK ELSKSDGTVV
910 920 930 940 950
GDIQFYLLDN MLLFLKAKAV NKWHQHKVFQ RPIPLPLLFA CPGEDMPALR
960 970 980 990 1000
KYIGDHPDCS GTVIQPEYNT SNPKNAITFL YYGAKQRYQV TLYAAQYAGL
1010 1020 1030 1040 1050
QTLLEKIKQG QAAIISKTEM FNVTKMSDRF FDYTNKINSV TSCDGGRKLL
1060 1070 1080 1090 1100
IATNSGLYMS NIKRQQNKDH RHKSSAFFST PIQLVQRNNI TQIAVLEEFK
1110 1120 1130 1140 1150
SIILLIDKKL YSCPLSLIEA EGNGTSFFKK HHKELINHVS FFAEGDCNGK
1160 1170 1180 1190 1200
RLIVTAHSSS HSIKYFEHEH PLLAEKNGSG SGNKKSLKKK ITEVIFDSEP
1210 1220 1230 1240 1250
VSISFLKANL CIGCKKGFQI VSISQNAHES LLDPADTSLE FALRDTLKPM
1260 1270 1280 1290 1300
AIYRVGNMFL LCYTEFAFFV NNQGWRKKES HIIHWEGEPQ KFAIWYPYIL
1310 1320 1330 1340 1350
AFDSNFIEIR KIETGELIRC VLADKIRLLQ TSTQEILYCY EDYRGYDTVA

SLDFWG
Length:1,356
Mass (Da):152,596
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FBC542114E7BC92
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19103 Genomic DNA Translation: AAB67564.1
BK006945 Genomic DNA Translation: DAA09674.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51389

NCBI Reference Sequences

More...
RefSeqi
NP_013475.1, NM_001182260.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR371W_mRNA; YLR371W_mRNA; YLR371W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR371W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA Translation: AAB67564.1
BK006945 Genomic DNA Translation: DAA09674.1
PIRiS51389
RefSeqiNP_013475.1, NM_001182260.1

3D structure databases

ProteinModelPortaliP51862
SMRiP51862
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31631, 800 interactors
DIPiDIP-4663N
IntActiP51862, 16 interactors
MINTiP51862
STRINGi4932.YLR371W

PTM databases

iPTMnetiP51862

Proteomic databases

MaxQBiP51862
PaxDbiP51862
PRIDEiP51862

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR371W_mRNA; YLR371W_mRNA; YLR371W
GeneIDi851086
KEGGisce:YLR371W

Organism-specific databases

EuPathDBiFungiDB:YLR371W
SGDiS000004363 ROM2

Phylogenomic databases

GeneTreeiENSGT00940000176600
HOGENOMiHOG000142356
InParanoidiP51862
KOiK19842
OMAiPNFIEIR

Enzyme and pathway databases

BioCyciYEAST:G3O-32440-MONOMER
ReactomeiR-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-416482 G alpha (12/13) signalling events

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P51862

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001180 CNH_dom
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00610 DEP, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00049 DEP, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROM2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51862
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 13, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
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