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Protein

Hepatoma-derived growth factor

Gene

Hdgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19HeparinBy similarity1
Binding sitei21HeparinBy similarity1
Binding sitei72HeparinBy similarity1
Binding sitei75HeparinBy similarity1
Binding sitei79HeparinBy similarity1
Binding sitei80HeparinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Growth factor, Heparin-binding, Repressor
Biological processTranscription, Transcription regulation
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor
Short name:
HDGF
Gene namesi
Name:Hdgf
Synonyms:Tdrm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1194494 Hdgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917011 – 237Hepatoma-derived growth factorAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-acetyllysineBy similarity1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei128PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei200PhosphothreonineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO1. Sumoylation prevents binding to chromatin (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP51859
MaxQBiP51859
PaxDbiP51859
PeptideAtlasiP51859
PRIDEiP51859
TopDownProteomicsiP51859

PTM databases

iPTMnetiP51859
PhosphoSitePlusiP51859
SwissPalmiP51859

Miscellaneous databases

PMAP-CutDBiP51859

Expressioni

Tissue specificityi

Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.

Gene expression databases

BgeeiENSMUSG00000004897 Expressed in 316 organ(s), highest expression level in ear vesicle
CleanExiMM_HDGF
ExpressionAtlasiP51859 baseline and differential
GenevisibleiP51859 MM

Interactioni

Subunit structurei

Monomer, and domain-swapped homodimer.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200265, 2 interactors
IntActiP51859, 8 interactors
MINTiP51859
STRINGi10090.ENSMUSP00000005017

Structurei

3D structure databases

ProteinModelPortaliP51859
SMRiP51859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 69PWWPPROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 80Nuclear localization signalBy similarity6
Motifi155 – 170Bipartite nuclear localization signalBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 227Glu-richAdd BLAST117

Domaini

The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.By similarity

Sequence similaritiesi

Belongs to the HDGF family.Curated

Phylogenomic databases

eggNOGiENOG410IMJ5 Eukaryota
ENOG4111IFT LUCA
GeneTreeiENSGT00530000063013
HOGENOMiHOG000112874
HOVERGENiHBG010574
InParanoidiP51859
KOiK16641
OrthoDBiEOG091G045X
PhylomeDBiP51859
TreeFamiTF105385

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P51859-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF
60 70 80 90 100
GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY
110 120 130 140 150
QSSQKKSCAA EPEVEPEAHE GDGDKKGSAE GSSDEEGKLV IDEPAKEKNE
160 170 180 190 200
KGTLKRRAGD VLEDSPKRPK ESGDHEEEDK EIAALEGERP LPVEVEKNST
210 220 230
PSEPDSGQGP PAEEEEGEEE AAKEEAEAQG VRDHESL
Length:237
Mass (Da):26,269
Last modified:August 13, 2002 - v2
Checksum:iAAE4CF574DA4733F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXA0E0CXA0_MOUSE
Hepatoma-derived growth factor
Hdgf
202Annotation score:
E0CYW7E0CYW7_MOUSE
Hepatoma-derived growth factor
Hdgf
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118A → D in BAB30979 (PubMed:16141072).Curated1
Sequence conflicti190P → H in BAA09838 (PubMed:9299445).Curated1
Sequence conflicti229Q → E in BAC36126 (PubMed:16141072).Curated1
Sequence conflicti229Q → P in BAA09838 (PubMed:9299445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63707 mRNA Translation: BAA09838.1
AF251787 mRNA Translation: AAF65469.1
AK017863 mRNA Translation: BAB30979.1
AK029475 mRNA Translation: BAC26466.1
AK076021 mRNA Translation: BAC36126.1
BC005713 mRNA Translation: AAH05713.1
BC021654 mRNA Translation: AAH21654.1
CCDSiCCDS17457.1
PIRiJC5660
RefSeqiNP_032257.3, NM_008231.4
UniGeneiMm.292208

Genome annotation databases

EnsembliENSMUST00000005017; ENSMUSP00000005017; ENSMUSG00000004897
GeneIDi15191
KEGGimmu:15191
UCSCiuc008ptc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63707 mRNA Translation: BAA09838.1
AF251787 mRNA Translation: AAF65469.1
AK017863 mRNA Translation: BAB30979.1
AK029475 mRNA Translation: BAC26466.1
AK076021 mRNA Translation: BAC36126.1
BC005713 mRNA Translation: AAH05713.1
BC021654 mRNA Translation: AAH21654.1
CCDSiCCDS17457.1
PIRiJC5660
RefSeqiNP_032257.3, NM_008231.4
UniGeneiMm.292208

3D structure databases

ProteinModelPortaliP51859
SMRiP51859
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200265, 2 interactors
IntActiP51859, 8 interactors
MINTiP51859
STRINGi10090.ENSMUSP00000005017

PTM databases

iPTMnetiP51859
PhosphoSitePlusiP51859
SwissPalmiP51859

Proteomic databases

EPDiP51859
MaxQBiP51859
PaxDbiP51859
PeptideAtlasiP51859
PRIDEiP51859
TopDownProteomicsiP51859

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005017; ENSMUSP00000005017; ENSMUSG00000004897
GeneIDi15191
KEGGimmu:15191
UCSCiuc008ptc.2 mouse

Organism-specific databases

CTDi3068
MGIiMGI:1194494 Hdgf

Phylogenomic databases

eggNOGiENOG410IMJ5 Eukaryota
ENOG4111IFT LUCA
GeneTreeiENSGT00530000063013
HOGENOMiHOG000112874
HOVERGENiHBG010574
InParanoidiP51859
KOiK16641
OrthoDBiEOG091G045X
PhylomeDBiP51859
TreeFamiTF105385

Miscellaneous databases

ChiTaRSiHdgf mouse
PMAP-CutDBiP51859
PROiPR:P51859
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004897 Expressed in 316 organ(s), highest expression level in ear vesicle
CleanExiMM_HDGF
ExpressionAtlasiP51859 baseline and differential
GenevisibleiP51859 MM

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHDGF_MOUSE
AccessioniPrimary (citable) accession number: P51859
Secondary accession number(s): Q8BPG7, Q9CYA4, Q9JK87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 13, 2002
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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