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Protein

Transketolase-like protein 1

Gene

TKTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.By similarity

Miscellaneous

Strong TKTL1 protein expression has been correlated with a certain type of glucose metabolism (aerobic glycolysis; Warburg effect) and to cells which are affected by chronic complications of diabetic patients.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity, Ca2+By similarity, Mn2+By similarity, Co2+By similarityNote: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.By similarity
  • thiamine diphosphateBy similarityNote: Binds 1 thiamine pyrophosphate per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46SubstrateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei46Important for catalytic activityBy similarity1
Binding sitei49Thiamine pyrophosphateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi126MagnesiumBy similarity1
Binding sitei127Thiamine pyrophosphate; via amide nitrogenBy similarity1
Metal bindingi156MagnesiumBy similarity1
Binding sitei156Thiamine pyrophosphateBy similarity1
Metal bindingi158Magnesium; via carbonyl oxygenBy similarity1
Binding sitei218Thiamine pyrophosphateBy similarity1
Binding sitei232SubstrateBy similarity1
Binding sitei232Thiamine pyrophosphateBy similarity1
Sitei232Important for catalytic activityBy similarity1
Binding sitei292SubstrateBy similarity1
Binding sitei319SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei340Proton donorBy similarity1
Binding sitei366Thiamine pyrophosphateBy similarity1
Binding sitei390SubstrateBy similarity1
Binding sitei398SubstrateBy similarity1
Binding sitei402Thiamine pyrophosphateBy similarity1
Binding sitei448SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi94 – 96Thiamine pyrophosphateBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transketolase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandCalcium, Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.2.1.1 2681

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P51854

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transketolase-like protein 1 (EC:2.2.1.1)
Alternative name(s):
Transketolase 2
Short name:
TK 2
Transketolase-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TKTL1
Synonyms:TKR, TKT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000007350.16

Human Gene Nomenclature Database

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HGNCi
HGNC:11835 TKTL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300044 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51854

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8277

Open Targets

More...
OpenTargetsi
ENSG00000007350

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36538

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TKTL1

Domain mapping of disease mutations (DMDM)

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DMDMi
122066426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918991 – 596Transketolase-like protein 1Add BLAST596

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P51854

PeptideAtlas

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PeptideAtlasi
P51854

PRoteomics IDEntifications database

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PRIDEi
P51854

ProteomicsDB human proteome resource

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ProteomicsDBi
56434
56435 [P51854-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P51854

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P51854

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal and adult heart, brain, lung, liver, and kidney, and in adult placenta, skeletal muscle and pancreas. Up-regulated in various epithelial tumors.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000007350 Expressed in 94 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_TKTL1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P51854 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51854 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032191
HPA000505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113890, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358931

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P51854

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51854

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transketolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0523 Eukaryota
COG0021 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000243868

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004036

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51854

KEGG Orthology (KO)

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KOi
K00615

Identification of Orthologs from Complete Genome Data

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OMAi
NSGHSGM

Database of Orthologous Groups

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OrthoDBi
EOG091G03M5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51854

TreeFam database of animal gene trees

More...
TreeFami
TF313097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.920, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR005474 Transketolase_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00861 Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00802 TRANSKETOLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P51854-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADAEARAEF PEEARPDRGT LQVLQDMASR LRIHSIRATC STSSGHPTSC
60 70 80 90 100
SSSSEIMSVL FFYIMRYKQS DPENPDNDRF VLAKRLSFVD VATGWLGQGL
110 120 130 140 150
GVACGMAYTG KYFDRASYRV FCLMSDGESS EGSVWEAMAF ASYYSLDNLV
160 170 180 190 200
AIFDVNRLGH SGALPAEHCI NIYQRRCEAF GWNTYVVDGR DVEALCQVFW
210 220 230 240 250
QASQVKHKPT AVVAKTFKGR GTPSIEDAES WHAKPMPRER ADAIIKLIES
260 270 280 290 300
QIQTSRNLDP QPPIEDSPEV NITDVRMTSP PDYRVGDKIA TRKACGLALA
310 320 330 340 350
KLGYANNRVV VLDGDTRYST FSEIFNKEYP ERFIECFMAE QNMVSVALGC
360 370 380 390 400
ASRGRTIAFA STFAAFLTRA FDHIRIGGLA ESNINIIGSH CGVSVGDDGA
410 420 430 440 450
SQMALEDIAM FRTIPKCTIF YPTDAVSTEH AVALAANAKG MCFIRTTRPE
460 470 480 490 500
TMVIYTPQER FEIGQAKVLR HCVSDKVTVI GAGITVYEAL AAADELSKQD
510 520 530 540 550
IFIRVIDLFT IKPLDVATIV SSAKATEGRI ITVEDHYPQG GIGEAVCAAV
560 570 580 590
SMDPDIQVHS LAVSGVPQSG KSEELLDMYG ISARHIIVAV KCMLLN
Length:596
Mass (Da):65,333
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF492A902441E2A14
GO
Isoform 2 (identifier: P51854-1) [UniParc]FASTAAdd to basket
Also known as: Brain specific

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     467-467: K → KGVSMLQDSWSSVISYQK

Show »
Length:557
Mass (Da):61,200
Checksum:i3F773DB8469447F7
GO
Isoform 1 (identifier: P51854-2)
Also known as: Heart specific
Sequence is not available
Note: Lacks the N-terminal.
Length:
Mass (Da):
Isoform 4 (identifier: P51854-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:540
Mass (Da):59,303
Checksum:i8F68BE950479A611
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ID95A2ID95_HUMAN
Transketolase-like 1
TKTL1 LL0XNC01-14B7.1-005
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF97F8WF97_HUMAN
Transketolase-like protein 1
TKTL1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y808H0Y808_HUMAN
Transketolase-like protein 1
TKTL1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti519I → N in AAA21557 (Ref. 6) Curated1
Sequence conflicti532T → S in AAA21557 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02986724L → F2 PublicationsCorresponds to variant dbSNP:rs17855509Ensembl.1
Natural variantiVAR_029868152I → T1 PublicationCorresponds to variant dbSNP:rs17852259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0222901 – 56Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_022291467K → KGVSMLQDSWSSVISYQK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X91817, X91818 mRNA Translation: CAA62925.1
AK292261 mRNA Translation: BAF84950.1
BX664723 Genomic DNA No translation available.
Z49258 Genomic DNA Translation: CAH69899.1
Z49258 Genomic DNA Translation: CAH69900.1
CH471172 Genomic DNA Translation: EAW72752.1
BC025382 mRNA Translation: AAH25382.2
U14622 Genomic DNA Translation: AAA21557.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35448.1 [P51854-3]
CCDS55541.1 [P51854-4]

NCBI Reference Sequences

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RefSeqi
NP_001139406.1, NM_001145934.1 [P51854-4]
NP_036385.3, NM_012253.3 [P51854-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.102866

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369912; ENSP00000358928; ENSG00000007350 [P51854-4]
ENST00000369915; ENSP00000358931; ENSG00000007350 [P51854-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8277

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8277

UCSC genome browser

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UCSCi
uc004fkg.4 human [P51854-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91817, X91818 mRNA Translation: CAA62925.1
AK292261 mRNA Translation: BAF84950.1
BX664723 Genomic DNA No translation available.
Z49258 Genomic DNA Translation: CAH69899.1
Z49258 Genomic DNA Translation: CAH69900.1
CH471172 Genomic DNA Translation: EAW72752.1
BC025382 mRNA Translation: AAH25382.2
U14622 Genomic DNA Translation: AAA21557.1
CCDSiCCDS35448.1 [P51854-3]
CCDS55541.1 [P51854-4]
RefSeqiNP_001139406.1, NM_001145934.1 [P51854-4]
NP_036385.3, NM_012253.3 [P51854-3]
UniGeneiHs.102866

3D structure databases

ProteinModelPortaliP51854
SMRiP51854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113890, 7 interactors
STRINGi9606.ENSP00000358931

PTM databases

iPTMnetiP51854
PhosphoSitePlusiP51854

Polymorphism and mutation databases

BioMutaiTKTL1
DMDMi122066426

Proteomic databases

PaxDbiP51854
PeptideAtlasiP51854
PRIDEiP51854
ProteomicsDBi56434
56435 [P51854-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8277
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369912; ENSP00000358928; ENSG00000007350 [P51854-4]
ENST00000369915; ENSP00000358931; ENSG00000007350 [P51854-3]
GeneIDi8277
KEGGihsa:8277
UCSCiuc004fkg.4 human [P51854-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8277
DisGeNETi8277
EuPathDBiHostDB:ENSG00000007350.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TKTL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0017149
HGNCiHGNC:11835 TKTL1
HPAiCAB032191
HPA000505
MIMi300044 gene
neXtProtiNX_P51854
OpenTargetsiENSG00000007350
PharmGKBiPA36538

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0523 Eukaryota
COG0021 LUCA
GeneTreeiENSGT00940000162426
HOGENOMiHOG000243868
HOVERGENiHBG004036
InParanoidiP51854
KOiK00615
OMAiNSGHSGM
OrthoDBiEOG091G03M5
PhylomeDBiP51854
TreeFamiTF313097

Enzyme and pathway databases

BRENDAi2.2.1.1 2681
SABIO-RKiP51854

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TKTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8277

Protein Ontology

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PROi
PR:P51854

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007350 Expressed in 94 organ(s), highest expression level in testis
CleanExiHS_TKTL1
ExpressionAtlasiP51854 baseline and differential
GenevisibleiP51854 HS

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR005474 Transketolase_N
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 2 hits
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
PROSITEiView protein in PROSITE
PS00802 TRANSKETOLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKTL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51854
Secondary accession number(s): A8K896
, Q5TYJ8, Q5TYJ9, Q8TC75
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 9, 2007
Last modified: December 5, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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