UniProtKB - P51841 (GUC2F_HUMAN)
Retinal guanylyl cyclase 2
GUCY2F
Functioni
Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544).
Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity).
May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
By similarity1 PublicationCatalytic activityi
- EC:4.6.1.21 Publication
Activity regulationi
GO - Molecular functioni
- ATP binding Source: InterPro
- GTP binding Source: UniProtKB-KW
- guanylate cyclase activity Source: GO_Central
- identical protein binding Source: Ensembl
- peptide receptor activity Source: GO_Central
- protein-containing complex binding Source: Ensembl
- protein kinase activity Source: InterPro
- signaling receptor activity Source: ProtInc
GO - Biological processi
- cGMP biosynthetic process Source: GO_Central
- cGMP-mediated signaling Source: Ensembl
- detection of light stimulus involved in visual perception Source: Ensembl
- receptor guanylyl cyclase signaling pathway Source: GO_Central
- regulation of rhodopsin mediated signaling pathway Source: Reactome
- signal transduction Source: GO_Central
- visual perception Source: ProtInc
Keywordsi
Molecular function | Lyase |
Biological process | cGMP biosynthesis, Sensory transduction, Vision |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 4.6.1.2, 2681 |
PathwayCommonsi | P51841 |
Reactomei | R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade |
SignaLinki | P51841 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinal guanylyl cyclase 2 (EC:4.6.1.21 Publication)Short name: RETGC-21 Publication Alternative name(s): Guanylate cyclase 2F, retinalImported Guanylate cyclase F Short name: GC-F Rod outer segment membrane guanylate cyclase 2 Short name: ROS-GC2 |
Gene namesi | Name:GUCY2F Synonyms:GUC2F, RETGC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4691, GUCY2F |
MIMi | 300041, gene |
neXtProti | NX_P51841 |
VEuPathDBi | HostDB:ENSG00000101890 |
Subcellular locationi
Other locations
- Photoreceptor outer segment membrane By similarity; Single-pass type I membrane protein Sequence analysis
Nucleus
- nuclear outer membrane Source: ProtInc
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- photoreceptor disc membrane Source: Reactome
- rod photoreceptor outer segment Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 51 – 467 | ExtracellularSequence analysisAdd BLAST | 417 | |
Transmembranei | 468 – 490 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 491 – 1108 | CytoplasmicSequence analysisAdd BLAST | 618 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2986 |
OpenTargetsi | ENSG00000101890 |
PharmGKBi | PA29071 |
Miscellaneous databases
Pharosi | P51841, Tbio |
Genetic variation databases
BioMutai | GUCY2F |
DMDMi | 311033391 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 50 | Sequence analysisAdd BLAST | 50 | |
ChainiPRO_0000012386 | 51 – 1108 | Retinal guanylyl cyclase 2Add BLAST | 1058 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 104 ↔ 132 | By similarity | ||
Disulfide bondi | 452 | InterchainBy similarity | ||
Disulfide bondi | 460 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P51841 |
MassIVEi | P51841 |
MaxQBi | P51841 |
PaxDbi | P51841 |
PeptideAtlasi | P51841 |
PRIDEi | P51841 |
ProteomicsDBi | 56431 |
PTM databases
iPTMneti | P51841 |
PhosphoSitePlusi | P51841 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000101890, Expressed in right uterine tube and 9 other tissues |
Genevisiblei | P51841, HS |
Organism-specific databases
HPAi | ENSG00000101890, Tissue enriched (retina) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with RD3; promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109241, 6 interactors |
IntActi | P51841, 2 interactors |
MINTi | P51841 |
STRINGi | 9606.ENSP00000218006 |
Miscellaneous databases
RNActi | P51841, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 532 – 812 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 884 – 1014 | Guanylate cyclasePROSITE-ProRule annotationAdd BLAST | 131 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1023, Eukaryota |
GeneTreei | ENSGT00940000162146 |
HOGENOMi | CLU_001072_1_0_1 |
InParanoidi | P51841 |
OMAi | ICRGGID |
OrthoDBi | 229634at2759 |
PhylomeDBi | P51841 |
TreeFami | TF106338 |
Family and domain databases
CDDi | cd07302, CHD, 1 hit |
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR001828, ANF_lig-bd_rcpt IPR033484, GUCY2F IPR011645, HNOB_dom_associated IPR011009, Kinase-like_dom_sf IPR029787, Nucleotide_cyclase IPR028082, Peripla_BP_I IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
PANTHERi | PTHR11920:SF349, PTHR11920:SF349, 1 hit |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00211, Guanylate_cyc, 1 hit PF07701, HNOBA, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit SSF55073, SSF55073, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MFLGLGRFSR LVLWFAAFRK LLGHHGLASA KFLWCLCLLS VMSLPQQVWT
60 70 80 90 100
LPYKIGVVGP WACDSLFSKA LPEVAARLAI ERINRDPSFD LSYSFEYVIL
110 120 130 140 150
NEDCQTSRAL SSFISHHQMA SGFIGPTNPG YCEAASLLGN SWDKGIFSWA
160 170 180 190 200
CVNYELDNKI SYPTFSRTLP SPIRVLVTVM KYFQWAHAGV ISSDEDIWVH
210 220 230 240 250
TANRVASALR SHGLPVGVVL TTGQDSQSMR KALQRIHQAD RIRIIIMCMH
260 270 280 290 300
SALIGGETQM HLLECAHDLK MTDGTYVFVP YDALLYSLPY KHTPYRVLRN
310 320 330 340 350
NPKLREAYDA VLTITVESQE KTFYQAFTEA AARGEIPEKL EFDQVSPLFG
360 370 380 390 400
TIYNSIYFIA QAMNNAMKEN GQAGAASLVQ HSRNMQFHGF NQLMRTDSNG
410 420 430 440 450
NGISEYVILD TNLKEWELHS TYTVDMEMEL LRFGGTPIHF PGGRPPRADA
460 470 480 490 500
KCWFAEGKIC HGGIDPAFAM MVCLTLLIAL LSINGFAYFI RRRINKIQLI
510 520 530 540 550
KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQITSEVQS GRSPRLSFSS
560 570 580 590 600
GSLTPATYEN SNIAIYEGDW VWLKKFSLGD FGDLKSIKSR ASDVFEMMKD
610 620 630 640 650
LRHENINPLL GFFYDSGMFA IVTEFCSRGS LEDILTNQDV KLDWMFKSSL
660 670 680 690 700
LLDLIKGMKY LHHREFVHGR LKSRNCVVDG RFVLKVTDYG FNDILEMLRL
710 720 730 740 750
SEEESSMEEL LWTAPELLRA PRGSRLGSFA GDVYSFAIIM QEVMVRGTPF
760 770 780 790 800
CMMDLPAQEI INRLKKPPPV YRPVVPPEHA PPECLQLMKQ CWAEAAEQRP
810 820 830 840 850
TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK
860 870 880 890 900
QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS
910 920 930 940 950
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA
960 970 980 990 1000
AEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHSGPVVA GVVGLTMPRY
1010 1020 1030 1040 1050
CLFGDTVNTA SRMESTGLPY RIHVSLSTVT ILQNLSEGYE VELRGRTELK
1060 1070 1080 1090 1100
GKGTEETFWL IGKKGFMKPL PVPPPVDKDG QVGHGLQPVE IAAFQRRKAE
RQLVRNKP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036419 | 10 | R → P in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755991142Ensembl. | 1 | |
Natural variantiVAR_042233 | 40 | S → C1 PublicationCorresponds to variant dbSNP:rs34228145Ensembl. | 1 | |
Natural variantiVAR_042234 | 160 | I → N1 PublicationCorresponds to variant dbSNP:rs33971675Ensembl. | 1 | |
Natural variantiVAR_042235 | 230 | R → W1 PublicationCorresponds to variant dbSNP:rs33973457EnsemblClinVar. | 1 | |
Natural variantiVAR_009136 | 284 | L → P1 PublicationCorresponds to variant dbSNP:rs12008095Ensembl. | 1 | |
Natural variantiVAR_009137 | 296 | R → Q1 PublicationCorresponds to variant dbSNP:rs502209Ensembl. | 1 | |
Natural variantiVAR_042236 | 305 | R → Q1 PublicationCorresponds to variant dbSNP:rs55966326Ensembl. | 1 | |
Natural variantiVAR_030633 | 308 | Y → C1 PublicationCorresponds to variant dbSNP:rs16985750EnsemblClinVar. | 1 | |
Natural variantiVAR_030634 | 380 | Q → H1 PublicationCorresponds to variant dbSNP:rs2272925Ensembl. | 1 | |
Natural variantiVAR_042237 | 434 | G → R1 PublicationCorresponds to variant dbSNP:rs56293008Ensembl. | 1 | |
Natural variantiVAR_042238 | 568 | G → D in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779221554Ensembl. | 1 | |
Natural variantiVAR_030635 | 628 | R → Q1 PublicationCorresponds to variant dbSNP:rs7883913Ensembl. | 1 | |
Natural variantiVAR_042239 | 677 | V → L1 PublicationCorresponds to variant dbSNP:rs35474112Ensembl. | 1 | |
Natural variantiVAR_042240 | 794 | E → K1 PublicationCorresponds to variant dbSNP:rs35726803Ensembl. | 1 | |
Natural variantiVAR_069424 | 872 | G → D1 PublicationCorresponds to variant dbSNP:rs148663380Ensembl. | 1 | |
Natural variantiVAR_042241 | 1010 | A → V1 PublicationCorresponds to variant dbSNP:rs55735218Ensembl. | 1 | |
Natural variantiVAR_042242 | 1052 | K → R in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042243 | 1055 | E → D in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L37378 mRNA Translation: AAA74451.1 AL031387 Genomic DNA No translation available. |
CCDSi | CCDS14545.1 |
PIRi | I59385 |
RefSeqi | NP_001513.2, NM_001522.2 |
Genome annotation databases
Ensembli | ENST00000218006; ENSP00000218006; ENSG00000101890 |
GeneIDi | 2986 |
KEGGi | hsa:2986 |
MANE-Selecti | ENST00000218006.3; ENSP00000218006.2; NM_001522.3; NP_001513.2 |
UCSCi | uc065aqx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L37378 mRNA Translation: AAA74451.1 AL031387 Genomic DNA No translation available. |
CCDSi | CCDS14545.1 |
PIRi | I59385 |
RefSeqi | NP_001513.2, NM_001522.2 |
3D structure databases
SMRi | P51841 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109241, 6 interactors |
IntActi | P51841, 2 interactors |
MINTi | P51841 |
STRINGi | 9606.ENSP00000218006 |
PTM databases
iPTMneti | P51841 |
PhosphoSitePlusi | P51841 |
Genetic variation databases
BioMutai | GUCY2F |
DMDMi | 311033391 |
Proteomic databases
jPOSTi | P51841 |
MassIVEi | P51841 |
MaxQBi | P51841 |
PaxDbi | P51841 |
PeptideAtlasi | P51841 |
PRIDEi | P51841 |
ProteomicsDBi | 56431 |
Protocols and materials databases
Antibodypediai | 29460, 101 antibodies from 18 providers |
DNASUi | 2986 |
Genome annotation databases
Ensembli | ENST00000218006; ENSP00000218006; ENSG00000101890 |
GeneIDi | 2986 |
KEGGi | hsa:2986 |
MANE-Selecti | ENST00000218006.3; ENSP00000218006.2; NM_001522.3; NP_001513.2 |
UCSCi | uc065aqx.1, human |
Organism-specific databases
CTDi | 2986 |
DisGeNETi | 2986 |
GeneCardsi | GUCY2F |
HGNCi | HGNC:4691, GUCY2F |
HPAi | ENSG00000101890, Tissue enriched (retina) |
MIMi | 300041, gene |
neXtProti | NX_P51841 |
OpenTargetsi | ENSG00000101890 |
PharmGKBi | PA29071 |
VEuPathDBi | HostDB:ENSG00000101890 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1023, Eukaryota |
GeneTreei | ENSGT00940000162146 |
HOGENOMi | CLU_001072_1_0_1 |
InParanoidi | P51841 |
OMAi | ICRGGID |
OrthoDBi | 229634at2759 |
PhylomeDBi | P51841 |
TreeFami | TF106338 |
Enzyme and pathway databases
BRENDAi | 4.6.1.2, 2681 |
PathwayCommonsi | P51841 |
Reactomei | R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade |
SignaLinki | P51841 |
Miscellaneous databases
BioGRID-ORCSi | 2986, 4 hits in 684 CRISPR screens |
ChiTaRSi | GUCY2F, human |
GenomeRNAii | 2986 |
Pharosi | P51841, Tbio |
PROi | PR:P51841 |
RNActi | P51841, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101890, Expressed in right uterine tube and 9 other tissues |
Genevisiblei | P51841, HS |
Family and domain databases
CDDi | cd07302, CHD, 1 hit |
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR001828, ANF_lig-bd_rcpt IPR033484, GUCY2F IPR011645, HNOB_dom_associated IPR011009, Kinase-like_dom_sf IPR029787, Nucleotide_cyclase IPR028082, Peripla_BP_I IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
PANTHERi | PTHR11920:SF349, PTHR11920:SF349, 1 hit |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00211, Guanylate_cyc, 1 hit PF07701, HNOBA, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00044, CYCc, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit SSF55073, SSF55073, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GUC2F_HUMAN | |
Accessioni | P51841Primary (citable) accession number: P51841 Secondary accession number(s): Q9UJF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families