GUCY2F

Functionⁱ

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Catalytic activityⁱ

GTP = 3',5'-cyclic GMP + diphosphate.

Enzyme regulationⁱ

Activated by GCAP-1; inhibited by calcium.

GO - Molecular functionⁱ

ATP binding Source: InterPro
GTP binding Source: UniProtKB-KW
guanylate cyclase activity Source: GO_Central
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
protein kinase activity Source: InterPro
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7777544

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cGMP biosynthetic process Source: GO_Central
detection of light stimulus involved in visual perception Source: Ensembl
intracellular signal transduction Source: InterPro
receptor guanylyl cyclase signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7777544
regulation of rhodopsin mediated signaling pathway Source: Reactome
visual perception
Source: ProtInc
Traceable author statementⁱ
- 7777544

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	cGMP biosynthesis, Sensory transduction, Vision
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	4.6.1.2 2681
Reactomeⁱ	R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Retinal guanylyl cyclase 2 (EC:4.6.1.2) Short name: RETGC-2 Alternative name(s): Guanylate cyclase 2F, retinal Guanylate cyclase F Short name: GC-F Rod outer segment membrane guanylate cyclase 2 Short name: ROS-GC2
Gene namesⁱ	Name:GUCY2F Synonyms:GUC2F, RETGC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101890.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4691 GUCY2F
MIMⁱ	300041 gene
neXtProtⁱ	NX_P51841

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	51 – 467	ExtracellularSequence analysisAdd BLAST	417
Transmembraneⁱ	468 – 490	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	491 – 1108	CytoplasmicSequence analysisAdd BLAST	618

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2986
Open Targets More...OpenTargetsⁱ	ENSG00000101890
PharmGKBⁱ	PA29071

Polymorphism and mutation databases

BioMutaⁱ	GUCY2F
DMDMⁱ	311033391

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 50	Sequence analysisAdd BLAST		50
ChainⁱPRO_0000012386	51 – 1108	Retinal guanylyl cyclase 2Add BLAST		1058

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	104 ↔ 132	By similarity
Disulfide bondⁱ	452	InterchainBy similarity
Disulfide bondⁱ	460	InterchainBy similarity

Post-translational modificationⁱ

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	P51841
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51841
PaxDbⁱ	P51841
PeptideAtlas More...PeptideAtlasⁱ	P51841
PRIDEⁱ	P51841
ProteomicsDBⁱ	56431

PTM databases

iPTMnetⁱ	P51841
PhosphoSitePlusⁱ	P51841

Expressionⁱ

Tissue specificityⁱ

Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.

Gene expression databases

Bgeeⁱ	ENSG00000101890
CleanExⁱ	HS_GUCY2F
Genevisibleⁱ	P51841 HS

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109241, 2 interactors
IntActⁱ	P51841, 2 interactors
Molecular INTeraction database More...MINTⁱ	P51841
STRINGⁱ	9606.ENSP00000218006

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51841
SMRⁱ	P51841
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	532 – 812	Protein kinasePROSITE-ProRule annotationAdd BLAST		281
Domainⁱ	884 – 1014	Guanylate cyclasePROSITE-ProRule annotationAdd BLAST		131

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesⁱ

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1023 Eukaryota COG2114 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118959
HOGENOMⁱ	HOG000293307
HOVERGENⁱ	HBG098487
InParanoidⁱ	P51841
KEGG Orthology (KO) More...KOⁱ	K12322
OMAⁱ	NSIYFIA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00VM
PhylomeDBⁱ	P51841
TreeFamⁱ	TF106338

Family and domain databases

Gene3Dⁱ	3.30.70.1230, 1 hit
InterProⁱ	View protein in InterPro IPR001054 A/G_cyclase IPR018297 A/G_cyclase_CS IPR001828 ANF_lig-bd_rcpt IPR033484 GUCY2F IPR011645 HNOB_dom_associated IPR011009 Kinase-like_dom_sf IPR029787 Nucleotide_cyclase IPR028082 Peripla_BP_I IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PANTHERⁱ	PTHR11920:SF349 PTHR11920:SF349, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00211 Guanylate_cyc, 1 hit PF07701 HNOBA, 1 hit PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00044 CYCc, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit SSF55073 SSF55073, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00452 GUANYLATE_CYCLASE_1, 1 hit PS50125 GUANYLATE_CYCLASE_2, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P51841-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLGLGRFSR LVLWFAAFRK LLGHHGLASA KFLWCLCLLS VMSLPQQVWT 
        60         70         80         90        100
LPYKIGVVGP WACDSLFSKA LPEVAARLAI ERINRDPSFD LSYSFEYVIL 
       110        120        130        140        150
NEDCQTSRAL SSFISHHQMA SGFIGPTNPG YCEAASLLGN SWDKGIFSWA 
       160        170        180        190        200
CVNYELDNKI SYPTFSRTLP SPIRVLVTVM KYFQWAHAGV ISSDEDIWVH 
       210        220        230        240        250
TANRVASALR SHGLPVGVVL TTGQDSQSMR KALQRIHQAD RIRIIIMCMH 
       260        270        280        290        300
SALIGGETQM HLLECAHDLK MTDGTYVFVP YDALLYSLPY KHTPYRVLRN 
       310        320        330        340        350
NPKLREAYDA VLTITVESQE KTFYQAFTEA AARGEIPEKL EFDQVSPLFG 
       360        370        380        390        400
TIYNSIYFIA QAMNNAMKEN GQAGAASLVQ HSRNMQFHGF NQLMRTDSNG 
       410        420        430        440        450
NGISEYVILD TNLKEWELHS TYTVDMEMEL LRFGGTPIHF PGGRPPRADA 
       460        470        480        490        500
KCWFAEGKIC HGGIDPAFAM MVCLTLLIAL LSINGFAYFI RRRINKIQLI 
       510        520        530        540        550
KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQITSEVQS GRSPRLSFSS 
       560        570        580        590        600
GSLTPATYEN SNIAIYEGDW VWLKKFSLGD FGDLKSIKSR ASDVFEMMKD 
       610        620        630        640        650
LRHENINPLL GFFYDSGMFA IVTEFCSRGS LEDILTNQDV KLDWMFKSSL 
       660        670        680        690        700
LLDLIKGMKY LHHREFVHGR LKSRNCVVDG RFVLKVTDYG FNDILEMLRL 
       710        720        730        740        750
SEEESSMEEL LWTAPELLRA PRGSRLGSFA GDVYSFAIIM QEVMVRGTPF 
       760        770        780        790        800
CMMDLPAQEI INRLKKPPPV YRPVVPPEHA PPECLQLMKQ CWAEAAEQRP 
       810        820        830        840        850
TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK 
       860        870        880        890        900
QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS 
       910        920        930        940        950
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA 
       960        970        980        990       1000
AEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHSGPVVA GVVGLTMPRY 
      1010       1020       1030       1040       1050
CLFGDTVNTA SRMESTGLPY RIHVSLSTVT ILQNLSEGYE VELRGRTELK 
      1060       1070       1080       1090       1100
GKGTEETFWL IGKKGFMKPL PVPPPVDKDG QVGHGLQPVE IAAFQRRKAE 

RQLVRNKP

Length:1,108

Mass (Da):124,850

Last modified:November 2, 2010 - v2

Checksum:ⁱB047BBF1A3C009F9

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036419	10	R → P in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755991142Ensembl.	1
Natural variantⁱVAR_042233	40	S → C1 PublicationCorresponds to variant dbSNP:rs34228145Ensembl.	1
Natural variantⁱVAR_042234	160	I → N1 PublicationCorresponds to variant dbSNP:rs33971675Ensembl.	1
Natural variantⁱVAR_042235	230	R → W1 PublicationCorresponds to variant dbSNP:rs33973457Ensembl.	1
Natural variantⁱVAR_009136	284	L → P1 PublicationCorresponds to variant dbSNP:rs12008095Ensembl.	1
Natural variantⁱVAR_009137	296	R → Q1 PublicationCorresponds to variant dbSNP:rs502209Ensembl.	1
Natural variantⁱVAR_042236	305	R → Q1 PublicationCorresponds to variant dbSNP:rs55966326Ensembl.	1
Natural variantⁱVAR_030633	308	Y → C1 PublicationCorresponds to variant dbSNP:rs16985750Ensembl.	1
Natural variantⁱVAR_030634	380	Q → H1 PublicationCorresponds to variant dbSNP:rs2272925Ensembl.	1
Natural variantⁱVAR_042237	434	G → R1 PublicationCorresponds to variant dbSNP:rs56293008Ensembl.	1
Natural variantⁱVAR_042238	568	G → D in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779221554Ensembl.	1
Natural variantⁱVAR_030635	628	R → Q1 PublicationCorresponds to variant dbSNP:rs7883913Ensembl.	1
Natural variantⁱVAR_042239	677	V → L1 PublicationCorresponds to variant dbSNP:rs35474112Ensembl.	1
Natural variantⁱVAR_042240	794	E → K1 PublicationCorresponds to variant dbSNP:rs35726803Ensembl.	1
Natural variantⁱVAR_069424	872	G → D1 PublicationCorresponds to variant dbSNP:rs148663380Ensembl.	1
Natural variantⁱVAR_042241	1010	A → V1 PublicationCorresponds to variant dbSNP:rs55735218Ensembl.	1
Natural variantⁱVAR_042242	1052	K → R in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_042243	1055	E → D in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L37378 mRNA Translation: AAA74451.1 AL031387 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14545.1
PIRⁱ	I59385
NCBI Reference Sequences More...RefSeqⁱ	NP_001513.2, NM_001522.2
UniGeneⁱ	Hs.123074

Genome annotation databases

Ensemblⁱ	ENST00000218006; ENSP00000218006; ENSG00000101890
GeneIDⁱ	2986
KEGGⁱ	hsa:2986
UCSC genome browser More...UCSCⁱ	uc065aqx.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P51841	UPI00044189C4		LIPVE		1144
UPI000CEB34FF		PHYCD		1137
UPI0004401AA3		BALAS		1137
UPI000D1E555A		Yangtze finless porpoise		1133
Guanylate cyclase		OTOGA		1110
+71

Protein	Similar proteins		Species	Score	Length
P51841	Retinal guanylyl cyclase 1	)	HUMAN		1103
Guanylate cyclase		Cebus capucinus imitator		1106
Guanylate cyclase		NOMLE		1103
Guanylate cyclase		PANTR		1103
Guanylate cyclase		AOTNA		1103
+153

Cross-referencesⁱ

Web resourcesⁱ

Mutations of the GUCY2F gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L37378 mRNA Translation: AAA74451.1 AL031387 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14545.1
PIRⁱ	I59385
NCBI Reference Sequences More...RefSeqⁱ	NP_001513.2, NM_001522.2
UniGeneⁱ	Hs.123074

3D structure databases

ProteinModelPortalⁱ	P51841
SMRⁱ	P51841
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109241, 2 interactors
IntActⁱ	P51841, 2 interactors
Molecular INTeraction database More...MINTⁱ	P51841
STRINGⁱ	9606.ENSP00000218006

PTM databases

iPTMnetⁱ	P51841
PhosphoSitePlusⁱ	P51841

Polymorphism and mutation databases

BioMutaⁱ	GUCY2F
DMDMⁱ	311033391

Proteomic databases

EPDⁱ	P51841
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51841
PaxDbⁱ	P51841
PeptideAtlas More...PeptideAtlasⁱ	P51841
PRIDEⁱ	P51841
ProteomicsDBⁱ	56431

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2986
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000218006; ENSP00000218006; ENSG00000101890
GeneIDⁱ	2986
KEGGⁱ	hsa:2986
UCSC genome browser More...UCSCⁱ	uc065aqx.1 human

Organism-specific databases

CTDⁱ	2986
DisGeNET More...DisGeNETⁱ	2986
EuPathDBⁱ	HostDB:ENSG00000101890.4
GeneCardsⁱ	GUCY2F
H-InvDBⁱ	HIX0056276
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4691 GUCY2F
MIMⁱ	300041 gene
neXtProtⁱ	NX_P51841
Open Targets More...OpenTargetsⁱ	ENSG00000101890
PharmGKBⁱ	PA29071
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1023 Eukaryota COG2114 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118959
HOGENOMⁱ	HOG000293307
HOVERGENⁱ	HBG098487
InParanoidⁱ	P51841
KEGG Orthology (KO) More...KOⁱ	K12322
OMAⁱ	NSIYFIA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00VM
PhylomeDBⁱ	P51841
TreeFamⁱ	TF106338

Enzyme and pathway databases

BRENDAⁱ	4.6.1.2 2681
Reactomeⁱ	R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

GenomeRNAiⁱ	2986
Protein Ontology More...PROⁱ	PR:P51841
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101890
CleanExⁱ	HS_GUCY2F
Genevisibleⁱ	P51841 HS

Family and domain databases

Gene3Dⁱ	3.30.70.1230, 1 hit
InterProⁱ	View protein in InterPro IPR001054 A/G_cyclase IPR018297 A/G_cyclase_CS IPR001828 ANF_lig-bd_rcpt IPR033484 GUCY2F IPR011645 HNOB_dom_associated IPR011009 Kinase-like_dom_sf IPR029787 Nucleotide_cyclase IPR028082 Peripla_BP_I IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PANTHERⁱ	PTHR11920:SF349 PTHR11920:SF349, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00211 Guanylate_cyc, 1 hit PF07701 HNOBA, 1 hit PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00044 CYCc, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit SSF55073 SSF55073, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00452 GUANYLATE_CYCLASE_1, 1 hit PS50125 GUANYLATE_CYCLASE_2, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GUC2F_HUMAN
Accessionⁱ	P51841Primary (citable) accession number: P51841 Secondary accession number(s): Q9UJF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 2, 2010
	Last modified:	June 20, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P51841 (GUC2F_HUMAN)

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Retinal guanylyl cyclase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

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Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Plasma Membrane

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ