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Entry version 131 (12 Aug 2020)
Sequence version 2 (11 Dec 2019)
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Protein

Guanylate cyclase 2D

Gene

Gucy2d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an olfactory receptor activated by a urine odorant, uroguanylin (PubMed:18178149). Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (By similarity). Has guanylate cyclase activity upon binding of the ligand (PubMed:18178149). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (By similarity).By similarity1 Publication

Miscellaneous

In contrast to mouse, guanylin, a urine odorant, does not stimulate GUCY2D.1 Publication

Caution

The nomenclature for members of the GUCY2 gene family is not consistent across species. In mice the GUCY2D gene encodes the protein guanylate cyclase 2D specifically expressed in a subpopulation of olfactory sensory neurons. In rat the official name is GUCY2E for guanylate cyclase 2D. In human this gene is a pseudogene.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Ca2+ (PubMed:11580282). Activated by NCALD in a Ca2+-dependent fashion (PubMed:11580282).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=71 µM for GTP1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processcGMP biosynthesis, Olfaction, Sensory transduction
    LigandGTP-binding, Nucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Guanylate cyclase 2D (EC:4.6.1.22 Publications)
    Alternative name(s):
    Guanylate cyclase, olfactory
    ONE-GC1 Publication
    Olfactory guanylyl cyclase GC-D1 Publication
    Short name:
    GC-D1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Gucy2d
    Synonyms:Gucy2eImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    69322, Gucy2e

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini67 – 475ExtracellularSequence analysisAdd BLAST409
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei476 – 500HelicalSequence analysisAdd BLAST25
    Topological domaini501 – 1110CytoplasmicSequence analysisAdd BLAST610

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 66Sequence analysisAdd BLAST66
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001238267 – 1110Guanylate cyclase 2DAdd BLAST1044

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi121 ↔ 149By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi462InterchainBy similarity
    Disulfide bondi470InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P51839

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P51839

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    P51839

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    P51839, 2 sites

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P51839

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Specifically expressed in a subpopulation of olfactory sensory neurons (PubMed:7724600). Expressed in the cilia of the olfactory epithelium (PubMed:11580282).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000015058, Expressed in heart and 4 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts (via the catalytic domain) with NCALD.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000020513

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini541 – 818Protein kinasePROSITE-ProRule annotationAdd BLAST278
    Domaini893 – 1023Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni880 – 921Interaction with NCALD1 PublicationAdd BLAST42

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The protein kinase domain is predicted to be catalytically inactive.Curated

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1023, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000162702

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_001072_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P51839

    KEGG Orthology (KO)

    More...
    KOi
    K12321

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VWLKRFE

    Database of Orthologous Groups

    More...
    OrthoDBi
    229634at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P51839

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106338

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.1230, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001054, A/G_cyclase
    IPR018297, A/G_cyclase_CS
    IPR001828, ANF_lig-bd_rcpt
    IPR011009, Kinase-like_dom_sf
    IPR029787, Nucleotide_cyclase
    IPR028082, Peripla_BP_I
    IPR000719, Prot_kinase_dom
    IPR001245, Ser-Thr/Tyr_kinase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01094, ANF_receptor, 1 hit
    PF00211, Guanylate_cyc, 1 hit
    PF07714, Pkinase_Tyr, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00044, CYCc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53822, SSF53822, 1 hit
    SSF55073, SSF55073, 1 hit
    SSF56112, SSF56112, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00452, GUANYLATE_CYCLASE_1, 1 hit
    PS50125, GUANYLATE_CYCLASE_2, 1 hit
    PS50011, PROTEIN_KINASE_DOM, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P51839-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAGLQQGCHP EGQDWTAPHW KTCRPCQGPR GLTVRHLRTV SSISVFSVVF
    60 70 80 90 100
    WGVLLWADSL SLPAWARETF TLGVLGPWDC DPIFAQALPS MATQLAVDRV
    110 120 130 140 150
    NQDASLLLGS QLDFKILPTG CDTPHALATF VAHRNTVAAF IGPVNPGYCP
    160 170 180 190 200
    AAALLAQGWG KSLFSWACGA PEGGGALVPT LPSMADVLLS VMRHFGWARL
    210 220 230 240 250
    AIVSSHQDIW VTTAQQLATA FRAHGLPIGL ITSLGPGEKG ATEVCKQLHS
    260 270 280 290 300
    VHGLKIVVLC MHSALLGGLE QTVLLRCARK EGLTDGRLVF LPYDTLLFAL
    310 320 330 340 350
    PYRNRSYLVL DDDGPLQEAY DAVLTISLDT SPESHAFTAT KMRGGTAANL
    360 370 380 390 400
    GPEQVSPLFG TIYDAVILLA HALNHSEAHG TGLSGAHLGN HIRALDVAGF
    410 420 430 440 450
    SQRIRIDGKG RRLPQYVILD TNGEGSQLVP THILDVSTQQ VQPLGTAVHF
    460 470 480 490 500
    PGGSPPARDA SCWFDPNTLC IRGVQPLGSL LTLTITCVLA LVGGFLAYFI
    510 520 530 540 550
    RLGLQQLRLL RGPHRILLTP QELTFLQRTP SRRRPHVDSG SESRSVVDGG
    560 570 580 590 600
    SPQSVIQGST RSVPAFLEHT NVALYQGEWV WLKKFEAGTA PDLRPSSLSL
    610 620 630 640 650
    LRKMREMRHE NVTAFLGLFV GPEVSAMVLE HCARGSLEDL LRNEDLRLDW
    660 670 680 690 700
    TFKASLLLDL IRGLRYLHHR HFPHGRLKSR NCVVDTRFVL KITDHGYAEF
    710 720 730 740 750
    LESHCSFRPQ PAPEELLWTA PELLRGPRRP WGPGKATFKG DVFSLGIILQ
    760 770 780 790 800
    EVLTRDPPYC SWGLSAEEII RKVASPPPLC RPLVSPDQGP LECIQLMQLC
    810 820 830 840 850
    WEEAPDDRPS LDQIYTQFKS INQGKKTSVA DSMLRMLEKY SQSLEGLVQE
    860 870 880 890 900
    RTEELELERR KTERLLSQML PPSVAHALKM GTTVEPEYFD QVTIYFSDIV
    910 920 930 940 950
    GFTTISALSE PIEVVGFLND LYTMFDAVLD SHDVYKVETI GDAYMVASGL
    960 970 980 990 1000
    PRRNGNRHAA EIANMALEIL SYAGNFRMRH APDVPIRVRA GLHSGPCVAG
    1010 1020 1030 1040 1050
    VVGLTMPRYC LFGDTVNTAS RMESTGLPYR IHVSRNTVQA LLSLDEGYKI
    1060 1070 1080 1090 1100
    DVRGQTELKG KGLEETYWLT GKTGFCRSLP TPLSIQPGDP WQDHINQEIR
    1110
    TGFAKLARVG
    Length:1,110
    Mass (Da):122,093
    Last modified:December 11, 2019 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AE40004074BC33F
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25 – 27PCQ → ALP in AAC42057 (PubMed:7724600).3
    Sequence conflicti280K → E in AAC42057 (PubMed:7724600).1
    Sequence conflicti346T → A in AAC42057 (PubMed:7724600).1
    Sequence conflicti378A → T in AAC42057 (PubMed:7724600).1
    Sequence conflicti458R → H in AAC42057 (PubMed:7724600).1
    Sequence conflicti729R → G in AAC42057 (PubMed:7724600).1
    Sequence conflicti1110G → C in AAC42057 (PubMed:7724600).1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L37203 mRNA Translation: AAC42057.1
    AABR07004868 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I59370

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_570093.1, NM_130737.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000020513; ENSRNOP00000020513; ENSRNOG00000015058

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    113911

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:113911

    UCSC genome browser

    More...
    UCSCi
    RGD:69322, rat

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L37203 mRNA Translation: AAC42057.1
    AABR07004868 Genomic DNA No translation available.
    PIRiI59370
    RefSeqiNP_570093.1, NM_130737.4

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020513

    PTM databases

    CarbonylDBiP51839
    GlyGeniP51839, 2 sites
    PhosphoSitePlusiP51839

    Proteomic databases

    PaxDbiP51839
    PRIDEiP51839

    Genome annotation databases

    EnsembliENSRNOT00000020513; ENSRNOP00000020513; ENSRNOG00000015058
    GeneIDi113911
    KEGGirno:113911
    UCSCiRGD:69322, rat

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    14919
    RGDi69322, Gucy2e

    Phylogenomic databases

    eggNOGiKOG1023, Eukaryota
    GeneTreeiENSGT00940000162702
    HOGENOMiCLU_001072_1_0_1
    InParanoidiP51839
    KOiK12321
    OMAiVWLKRFE
    OrthoDBi229634at2759
    PhylomeDBiP51839
    TreeFamiTF106338

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P51839

    Gene expression databases

    BgeeiENSRNOG00000015058, Expressed in heart and 4 other tissues

    Family and domain databases

    Gene3Di3.30.70.1230, 1 hit
    InterProiView protein in InterPro
    IPR001054, A/G_cyclase
    IPR018297, A/G_cyclase_CS
    IPR001828, ANF_lig-bd_rcpt
    IPR011009, Kinase-like_dom_sf
    IPR029787, Nucleotide_cyclase
    IPR028082, Peripla_BP_I
    IPR000719, Prot_kinase_dom
    IPR001245, Ser-Thr/Tyr_kinase_cat_dom
    PfamiView protein in Pfam
    PF01094, ANF_receptor, 1 hit
    PF00211, Guanylate_cyc, 1 hit
    PF07714, Pkinase_Tyr, 1 hit
    SMARTiView protein in SMART
    SM00044, CYCc, 1 hit
    SUPFAMiSSF53822, SSF53822, 1 hit
    SSF55073, SSF55073, 1 hit
    SSF56112, SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00452, GUANYLATE_CYCLASE_1, 1 hit
    PS50125, GUANYLATE_CYCLASE_2, 1 hit
    PS50011, PROTEIN_KINASE_DOM, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUC2D_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51839
    Secondary accession number(s): F1M245
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 11, 2019
    Last modified: August 12, 2020
    This is version 131 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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