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Protein

Ribonuclease 3

Gene

rnc

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39MagnesiumUniRule annotation1
Active sitei43UniRule annotation1
Metal bindingi112MagnesiumUniRule annotation1
Active sitei115UniRule annotation1
Metal bindingi115MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1486-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:CBU_1503
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803941 – 233Ribonuclease 3Add BLAST233

Proteomic databases

PRIDEiP51837

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1503

Structurei

3D structure databases

ProteinModelPortaliP51837
SMRiP51837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 126RNase IIIUniRule annotationAdd BLAST123
Domaini153 – 222DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHLNKLMER LGHQFNNLEL LKIALTHCSS GADNNERLEF LGDSVLGFII
60 70 80 90 100
ASELYQRRPQ AREGDLSRMR ASMVNGDELA QMSTKLGINE YLQLGVGEQK
110 120 130 140 150
SGGKRRRSIL ADALEAIVGA IYIDAGLETC RRCVLNWYGE RVDDLSKLSP
160 170 180 190 200
KKDAKSLLQE WLQARRLPLP TYEVKITGEA HAQTFTVNCY VKGLPHKTEG
210 220 230
VNTTRRRAEQ IAAKRFLELL DDGKGDGITE RDQ
Length:233
Mass (Da):26,199
Last modified:May 9, 2003 - v2
Checksum:i1A11CB5FD960784F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116A → T in AAA69690 (PubMed:7830573).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27436 Genomic DNA Translation: AAA69690.1
AE016828 Genomic DNA Translation: AAO91000.1
PIRiS60767
RefSeqiNP_820486.1, NC_002971.3
WP_010958268.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO91000; AAO91000; CBU_1503
GeneIDi1209413
KEGGicbu:CBU_1503
PATRICifig|227377.7.peg.1505

Similar proteinsi

Entry informationi

Entry nameiRNC_COXBU
AccessioniPrimary (citable) accession number: P51837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 9, 2003
Last modified: February 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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